基本簡介
從1995年起，主要從事炎癥調(diào)控信號(hào)轉(zhuǎn)導(dǎo)機(jī)制的研究。2003年5月至2005年12月赴美國芝加哥大學(xué)Ben-May癌癥研究所做博士后。2006年晉升為副研究員。2010年晉升為研究員。在揭示炎癥信號(hào)通路異�；罨�、促進(jìn)細(xì)胞存活分子機(jī)制的同時(shí)，在國內(nèi)外率先系統(tǒng)研究具有免疫抑制、抗炎作用的第二信使環(huán)磷酸腺苷 (cAMP) 對(duì)炎癥信號(hào)通路p38途徑、JNK途徑的滅活機(jī)制，并提出了抗炎分子設(shè)計(jì)的新策略，對(duì)于改善炎癥性疾病缺乏有效治療手段的臨床困境具有重要意義。共發(fā)表SCI收錄文章30余篇，累計(jì)IF超過200，主要發(fā)現(xiàn)和觀點(diǎn)被Cell等國際權(quán)威雜志評(píng)述和他引超過300次。第一 (或共同第一) 作者和通訊 (或共同通訊) 作者SCI收錄文章23篇，其中IF>5文章11篇。獲中國科協(xié)第四屆中國青年女科學(xué)家獎(jiǎng) (2007)，入選北京市科技新星計(jì)劃 (A類，2007)，當(dāng)選總后勤部“科技新星” (2008)，入選軍隊(duì)高層次科技創(chuàng)新拔尖人才 (2012)。
文獻(xiàn)著述：
1.Guo Y, Wang W, Wang J, Feng J, Wang Q, Jin J, Lv M, Li X, Li Y, Ma Y*, Shen B*,Zhang J*. Receptor for activated C kinase 1 promotes hepatocellular carcinoma growth by enhancing mitogen-activated protein kinase kinase 7 activity.Hepatology2013; 57: 140-51.
2.Wang J, Tang R, Lv M, Wang Q, Zhang X, Guo Y, Chang H, Qiao C, Xiao H, Li X, Li Y, Shen B*,Zhang J*. Defective anchoring of JNK1 in the cytoplasm by MKK7 in Jurkat cells is associated with resistance to Fas-mediated apoptosis.Mol Biol Cell2011; 22: 117-27.
3.Zhang J*, Zhu N, Wang Q, Wang J, Ma Y, Qiao C, Li Y, Li X, Su B, Shen B*. MEKK3 over-expression contributes to the hyper-responsiveness of IL-12-overproducing cells and CD4+ T conventional cells in NOD mice.J Immunol2010;185: 3554-63.
4.Cui J, Wang Q, Wang J, Lv M, Zhu N, Li Y, Feng J*, Shen B,Zhang J*. Basal c-Jun NH2-terminal protein kinase activity is essential for survival and proliferation of T-cell acute lymphoblastic leukemia cells.Mol Cancer Ther2009; 8: 3214-22.
5.Zhang J*, Wang Q, Zhu N, Yu M, Shen B, Xiang J, Lin A. Cyclic AMP inhibits JNK activation by CREB-mediated induction of c-FLIPLand MKP-1, thereby antagonizing UV-induced apoptosis.Cell Death Differ2008; 15: 1654-62.
6.Zhang J*, Shen B, Lin A. Novel strategies for inhibition of the p38 MAPK pathway.Trends Pharmacol Sci2007; 28: 286-95.
7.Zhang J,Bui TN, Xiang J, Lin A*. cAMP inhibits p38 activation via CREB-induced Dynein light chain.Mol Cell Biol2006; 26：1223-34.
8.Zhang J, Liu J, Yu C, Lin A. BAD Ser128 is not phosphorylated by c-Jun NH2-terminal kinase for promoting apoptosis.Cancer Res2005; 65: 8372-8.
9.Yu C#, Minemoto Y#,Zhang J#, Liu J#, Tang F, Bui TN, Xiang J, Lin A. JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD.Mol Cell2004; 13: 329-40.(#Equal contribution)
10.Wang J, Tang R, Lv M,Zhang J*, Shen B*. Selective unresponsiveness to the inhibition of p38 MAPK activation by cAMP helps L929 fibroblastoma cells escape TNF-a-induced cell death.Mol Cancer2010; 9:6.
11. Wang Q, Feng J, Wang J, Zhang X, Zhang D, Zhu T, Wang W, Wang X, Jin J, Cao J, Li X, Peng H, Li Y*, Shen B,Zhang J*.Disruption of TAB1/p38α interaction using a cell-permeable peptide limits myocardial ischemia/reperfusion injury.Mol Ther. 2013 Sep;21(9):1668-77.
