人物經(jīng)歷
1999和2002年獲蘭州大學(xué)生物學(xué)學(xué)士和細(xì)胞生物學(xué)碩士學(xué)位。2005年畢業(yè)于中國(guó)醫(yī)學(xué)科學(xué)院基礎(chǔ)醫(yī)學(xué)研究所，獲生化與分子生物學(xué)專業(yè)博士學(xué)位。2005-2009年在美國(guó)麻省大學(xué)醫(yī)學(xué)院從事博士后工作，主要進(jìn)行成骨細(xì)胞分化相關(guān)miRNA的功能研究。2010.3-2012.8在浙江大學(xué)生命科學(xué)研究院任副研究員，之后加入中國(guó)科技大學(xué)生命科學(xué)學(xué)院。
主要研究成果發(fā)表于PNAS和JBC等國(guó)際學(xué)術(shù)期刊。
研究興趣
1） 細(xì)胞內(nèi)非編碼RNA的功能及作用機(jī)理
2） 癌癥、癌癥干細(xì)胞相關(guān)的非編碼RNA的功能研究
代表性論文
1.Hassan MQ, Maeda Y, Taipaleenmaki H, Zhang W, Jafferji M, Gordon JA, Li Z, Croce CM, van Wijnen AJ, Stein JL, Stein GS, Lian JB. miR-218 Directs a Wnt Signaling Circuit to Promote Differentiation of Osteoblasts and Osteomimicry of Metastatic Cancer Cells. Journal of Biological Chemistry, 2012, 287(50): 42084-42092.
2.Dai F, Shen T, Li Z, Lin X, Feng XH. PPM1A dephosphorylates RanBP3 to enable efficient nuclear export of Smad2 and Smad3. EMBO Reports, 2011, 12(11):1175-1181.
3. Li Z, Hassan MQ, Jafferji M, Aqeilan RI, Garzon R, Croce CM, van Wijnen AJ, Stein JL, Stein GS, Lian JB. Biological Functions of miR-29b Contribute to Positive Regulation of Osteoblast Differentiation. Journal of Biological Chemistry. 2009, 284(23)
4. Li Z, Hassan MQ, Volinia S, van Wijnen AJ, Stein JL, Croce CM, Lian JB, Stein GS. A MicroRNA Signature for a BMP2-Induced Lineage Commitment Program. Proc. Natl. Acad. Sci. U. S. A. 2008, 105(37)
5.Zhang Y, Hassan MQ, Li ZY, Stein JL, Lian JB, van Wijnen AJ, Stein GS. Intricate Gene Regulatory Networks of Helix-Loop-Helix (HLH) Proteins Support Regulation of Bone-Tissue Related Genes during Osteoblast Differentiation. Journal of Cellular biochemistry, 2008, 105(2):487-496.
6. Li ZY, Yang J, Gao X, Lu JY, Zhang Y, Wang K, Cheng MB, Wu NH, Zhang Y, Wu Z, Shen YF. Sequential recruitment of PCAF and BRG1 contributes to myogenin activation in 12-O-tetradecanoylphorbol-13-acetate induced early differentiation of Rhabdomyosarcoma-derived cells. Journal of Biological Chemistry, 2007, 282(26)