科研成就
主要從事人類疾病致病或易感基因的鑒定及其相關(guān)細胞和基因功能研究。
項榮主持和參與包括國家自然科學(xué)基金面上項目、國家科技重大專項子課題、863子課題、軍口項目子課題、省自然科學(xué)基金等在內(nèi)的各級科研項目20余項;在Circulation、J Neurosci、Eur Heart J、Apoptosis等雜志上發(fā)表論文30余篇;參與申請發(fā)明專利10余項,已授權(quán)4項。主編教材1部,參編國家級規(guī)劃教材2部;參與教改課題4項;指導(dǎo)國家級、省級大學(xué)生創(chuàng)新課題3項,指導(dǎo)大學(xué)生國家級競賽一等獎2項、三等獎2項、省級競賽一等獎、二等獎等;連續(xù)獲校教學(xué)質(zhì)量優(yōu)秀獎3次、校級教學(xué)成果一等獎1次、教學(xué)“三十佳”1次等,被評為中南大學(xué)學(xué)科競賽優(yōu)秀指導(dǎo)教師、創(chuàng)客空間優(yōu)秀指導(dǎo)老師,湖南省“挑戰(zhàn)杯”優(yōu)秀指導(dǎo)老師、長沙市大學(xué)生科創(chuàng)大賽優(yōu)秀指導(dǎo)教師等。
研究方向
主要開展兩個方面的研究:
(1)運用新一代測序、色譜、細胞免疫等技術(shù),從基因、分子、細胞、模式動物及人體水平探討動脈粥樣硬化、高血脂、心肌病等心血管相關(guān)疾病的發(fā)病機理,并結(jié)合臨床篩選相關(guān)疾病的早期檢測診斷分子和預(yù)后標(biāo)志物;
(2)研究病原微生物感染、腫瘤、原發(fā)性多囊腎等疾病發(fā)生過程中相關(guān)細胞器、細胞信號轉(zhuǎn)導(dǎo)、細胞物質(zhì)運輸、細胞代謝等細胞結(jié)構(gòu)和功能的異常。
人物經(jīng)歷
【教育經(jīng)歷】
湖南師范大學(xué)| 生物科學(xué) | 學(xué)士學(xué)位 | 大學(xué)本科畢業(yè)
武漢大學(xué)| 微生物學(xué) | 博士學(xué)位 | 博士研究生畢業(yè)
【工作經(jīng)歷】
2007.5-2009.9 細胞生物學(xué)系 | 中南大學(xué)生命科學(xué)學(xué)院 講師
2009.9-2014.9 細胞生物學(xué)系 | 中南大學(xué)生命科學(xué)學(xué)院 | 副教授
2014.9-至今 細胞生物學(xué)系 |中南大學(xué)生命科學(xué)學(xué)院| 教授
【社會兼職】
湖南省遺傳學(xué)會青年委員
近五年論文發(fā)表情況
[1] Xiang R, Fan L L, Huang H, et al.Increased RTN3 Leads to Obesity and Hypertriglyceridemia by Interacting with HSPA5[J].Circulation, 2018.
[2] Guo S, Fan X F, Jin J Y, et al.A novel proximal 3q29 chromosome microdeletion in a Chinese patient with Chiari malformation type II and Sprengelu2019s deformity[J].Molecular Cytogenetics, 2018, 11(1):8.
[3] Ding D B, Fan L L, Xiao Z, et al.A novel mutation of dipeptidyl aminopeptidase-like protein-6 in a family with suspicious idiopathic ventricular fibrillation[J].QJM: An International Journal of Medicine, 2018.
[4] Huang H, Ding D B, Fan L L, et al.Whole-exome sequencing identifies a NovelSCN5Amutation (C335R) in a Chinese family with arrhythmia[J].Cardiology in the Young, 2018, 28(5):1-4.
[5] Li J J, Chen Y, Fan L L, et al.Microduplication of 10q26. 3 in a Chinese hypertriglyceridemia patient[J].Molecular and cellular probes, 2018, 37: 28-31.
[6] Fan L L, Huang H, Jin J Y, et al.Whole exome sequencing identifies a novel mutation (c. 333+ 2T> C) ofTNNI3Kin a Chinese family with dilated cardiomyopathy and cardiac conduction disease[J].Gene, 2018, 648: 63-67.
[7] Huang H, Chen Y Q, Fan L L, et al.Whole-exome sequencing identifies a novel mutation ofGPD1L(R189X) associated with familial conduction disease and sudden death[J].Journal of cellular and molecular medicine, 2018, 22(2): 1350-1354.
[8] Xiang R, Du R, Guo S, et al.Microduplications of 10q24 Detected in Two Chinese Patients with Split-hand/foot Malformation Type 3[J].Annals of Clinical & Laboratory Science,2017, 47(6): 754-757.
[9] Xiang R, Fan L L, Lin M J, et al.The genetic spectrum of familial hypercholesterolemia in the central south region of China[J].Atherosclerosis, 2017, 258: 84-88.
[10] Liu J S, Fan L L, Li J J, et al.Whole-Exome Sequencing Identifies a Novel Mutation of Desmocollin 2 in a Chinese Family With Arrhythmogenic Right Ventricular Cardiomyopathy[J].American Journal of Cardiology, 2017, 119(9): 1485-1489.
[11] Liu J S, Fan L L, Zhang H, et al.Whole-exome sequencing identifies two novelTTNmutations in Chinese families with dilated cardiomyopathy[J].Cardiology, 2017, 136(1): 10-14.
[12] Xiang R, Fan L L, Huang H, et al.Whole-exome sequencing identifies a novel mutation ofDSG2(Y198C) in a Chinese arrhythmogenic right ventricular cardiomyopathy patient[J].International journal of cardiology, 2016, 214: 1-3.
[13] Wu P F, Guo S, Fan X F, et al.A novelZRSmutation in a Chinese patient with preaxial polydactyly and triphalangeal thumb[J].Cytogenetic and genome research, 2016, 149(3): 171-175.
[14] Du R F, Huang H, Fan L L, et al.A Novel Mutation ofFOXC1(R127L) in an Axenfeldu2013Rieger Syndrome Family with Glaucoma and Multiple Congenital Heart Diseases[J].Ophthalmic genetics, 2016, 37(1): 111-115.
[15] Chen Y, Wu Z, Zhao S, et al.Chemical chaperones reduce ER stress and adipose tissue inflammation in high fat diet-induced mouse model of obesity[J].Scientific reports, 2016, 6: 27486.
[16] Fan L, Lin M, Chen Y, et al.Novel mutations of low-density lipoprotein receptor gene in China patients with familial hypercholesterolemia[J].Applied biochemistry and biotechnology,2015, 176(1): 101-109.
[17] Xiang R, Fan L L, Huang H, et al.A novel mutation ofGATA4(K319E) is responsible for familial atrial septal defect and pulmonary valve stenosis[J].Gene, 2014, 534(2): 320-323.
[18] Yu B, Xiang R, Hu D, et al.A novel MYH7 mutation in a family with cardiomyopathy presenting with restrictive physiology and varying degrees of left ventricle hypertrophy[J].European heart journal, 2014, 36(3): 178-178.
[19] Shi Q, Ge Y, Sharoar M G, et al.Impact of RTN3 deficiency on expression of BACE1 and amyloid deposition[J].Journal of Neuroscience, 2014, 34(42): 13954-13962.
[20] 項榮, 丁棟博, 范亮亮, 等.稀土氧化鋅晶須抗菌效能及安全性研究[J].功能材料, 2013, 44: 186-191+ 197.
[21] 杜然, 范亮亮, 黃皓, 等.原發(fā)性厚皮性骨膜病的遺傳學(xué)研究進展[J].中華醫(yī)學(xué)遺傳學(xué)雜志, 2016 (2016 年 01): 105-107.
[22] 陳雨, 周帥鋒, 孫倩萊, 等. 2012-2014 年湖南省感染性腹瀉哨點醫(yī)院兒童諾如病毒感染及基因型別分析[J].實用預(yù)防醫(yī)學(xué), 2016, 23(7): 773-776.
[23] 范亮亮, 馬立寧, 彭元亮, 等. PI3K/AKT 信號通路與心力衰竭[J].生命科學(xué)研究, 2015, 19(1): 85-90.
[24] 黃皓, 范亮亮, 項榮.HIV-1 輔助蛋白負性調(diào)節(jié)因子下調(diào)細胞膜表面分子的研究進展[J].細胞與分子免疫學(xué)雜志, 2015 (6): 848-852.
[25] 項榮, 丁棟博, 范亮亮, 等.氧化鋅的抗菌機制及其安全性研究進展[J].中國組織工程研究, 2014, 18(3): 470-475.
[26] 項榮, 嚴(yán)經(jīng)緯, 范亮亮, 等.動脈粥樣硬化中炎性反應(yīng)與內(nèi)質(zhì)網(wǎng)應(yīng)激的相互作用[J].基礎(chǔ)醫(yī)學(xué)與臨床, 2014, 34(2): 253-256.
[27] 曹貝貝, 范亮亮, 項榮.動脈粥樣硬化中自噬與凋亡在內(nèi)質(zhì)網(wǎng)的交叉對話[J].生物物理學(xué)報, 2013 (12): 911-918.
[28] 項榮, 胡艷, 曹貝貝.β-Arrestins 參與 GPCRs 信號通路的分子機制[J].中國生物化學(xué)與分子生物學(xué)報, 2013, 29(2): 122-127.