個人簡介
性 別: 男
職 稱: 研究員
簡歷
2005年在 中國科學(xué)院上海藥物研究所獲得有機化學(xué) 博士學(xué)位。2005-2006年在 美國猶他大學(xué)從事博士后研究,2006-2010年在 美國馬里蘭大學(xué)任研究助理,2010-2012年在美國馬里蘭大學(xué)任助理教授。
研究方向
發(fā)展和運用新穎的糖蛋白/糖肽/糖復(fù)合物合成方法和功能性糖組學(xué)分析方法，在化學(xué)和生物學(xué)交叉領(lǐng)域，具體在蛋白糖基化與重大疾病的關(guān)聯(lián)、糖參與的粘附GPCR信號介導(dǎo)、新型糖復(fù)合物在生物醫(yī)藥中的應(yīng)用、基于糖結(jié)構(gòu)的藥物及疫苗研發(fā)等方向上深入探討研究。
職務(wù)
中科院上海藥物研究所研究組長；博士生導(dǎo)師
專家類別
研究員
科研成果
1．發(fā)展和完善了一套酶催化糖蛋白合成方法并應(yīng)用于各種功能性糖蛋白的修飾改造
2．完成了單克隆抗體藥物的糖基化優(yōu)化和ADC藥物的優(yōu)化與篩選
承擔科研項目情況
1．NSFC面上項目，酶催化合成多糖作為多功能藥物載體的研究，項目負責人，2014.01-2017.12
2．上海市浦江人才計劃，蛋白糖基化與疾病，項目負責人，2014.01-2015.12
社會任職
2008- Member, American Chemical Society
2008- Member, Sigma Xi, the Scientific Research Society
2011- Editorial Board, Medicinal Chemistry: Current Research
2011- Editorial Board, Virology & Mycology
2011- Reviewer, Journal of the American Chemical Society
2008- Reviewer, Chemical Communications
2008- Reviewer, Organic and Biomolecular Chemistry
2008- Reviewer, Journal of Organic Chemistry
2008- Reviewer, Journal of Combinatorial Chemistry
2008- Reviewer, ChemMedChem
2008- Reviewer, European Journal of Organic Chemistry
2008- Reviewer, Carbohydrate Chemistry
2010- Reviewer, New Journal of Chemistry
獲獎及榮譽
2001年，中國藥學(xué)會年會優(yōu)秀論文一等獎；
2010年，美國馬里蘭大學(xué)“教員發(fā)展基金”。
代表論著
Amin, M.N.; McLellan, J.S.; Huang, W.; Orwenyo, J.; Burton, D.R.; Koff, W.C.; Kwong, P.D.; Wang, L.X. (2013) “Synthetic glycopeptides reveal the glycan specificity of HIV-neutralizing antibodies.” Nat. Chem. Biol. In press
Huang, W.; Giddens, J.; Fan, S.-Q.; Toonstra, C.; and Wang, L.-X. (2012) “Chemoenzymatic Glycoengineering of Intact IgG Antibodies for Gain of Functions.” J. Am. Chem. Soc
Zou, G.; Ochiai, H.; Huang, W.; Yang, Q.; Li, C.; and Wang, L.-X. (2011) “Chemoenzymatic Synthesis and Fc Receptor Binding of Homogeneous Glycoforms of Antibody Fc Domain. Presence of a Bisecting Sugar Moiety Enhances the Affinity of Fc to FcIIIa Receptor.” J. Am. Chem. Soc
Amin, M.; Huang, W.; Rahman, M.; Wang, L.-X. (2011) Convergent synthesis of homogeneous Glc1Man9GlcNAc2-protein and derivatives as ligands of molecular chaperones in protein quality control. J. Am. Chem. Soc.
Huang, W., Li, J., and Wang, L.X. (2011). Unusual transglycosylation activity of flavobacterium meningosepticum endoglycosidases enables convergent chemoenzymatic synthesis of core fucosylated complex N-glycopeptides. ChemBioChem
Schwarz, F., Huang, W., Li, C., Schulz, B.L., Lizak, C., Palumbo, A., Numao, S., Neri, D., Aebi, M., and Wang, L.X. (2010). A combined method for producing homogeneous glycoproteins with eukaryotic N-glycosylation. Nature Chem. Biol.
Huang, W.; Yang, Q.; Umekawa, M.; Yamamoto, K.; Wang, L.-X. (2010) Arthrobacter Endo-beta-N-acetylglucosaminidase shows transglycosylation Activity on complex type N-glycan oxazolines. One-pot conversion of ribonuclease B to sialylated ribonuclease C. ChemBioChem
Huang, W., Li, C., Li, B., Umekawa, M., Yamamoto, K., Zhang, X., and Wang, L.X. (2009). Glycosynthases enable a highly efficient chemoenzymatic synthesis of N-glycoproteins carrying intact natural N-glycans. J. Am. Chem. Soc.,
Huang, W., Wang, D.N., Yamada, M, and Wang, L.X. (2009). Chemoenzymatic synthesis and lectin array characterization of a class of N-glycan clusters. J. Am. Chem. Soc.
Ochiai, H., Huang, W., and Wang, L.X. (2008). Expeditious chemoenzymatic synthesis of homogeneous N-glycoproteins carrying defined oligosaccharide ligands. J. Am. Chem. Soc.
Huang, W., Zhang, H., Dayrazou, F., Kutateladze, T.G., Shi, X., Gozani, O., and Prestwich, G.D. (2007). Stabilized phosphatidylinositol-5-phosphate analogues as ligands for the nuclear protein ING2: chemistry, biology and molecular modeling. J. Am. Chem. Soc..