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  • 林俊生

    林俊生(華大教授)

    林俊生,男,華僑大學(xué)分子藥物所教授,有關(guān)Connexi43的研究已由新西蘭和英國投資贊助開發(fā)新產(chǎn)品。


    發(fā)明經(jīng)歷

    開發(fā)和鑒定的抗Connexin50單克隆抗體已由美國Zymed公司推向市場.本人論文被指定為該產(chǎn)品應(yīng)用的主要指導(dǎo)文件(Zymed research products 2000-2001, P66) 。

    發(fā)明專利(基因重組成纖維細(xì)胞生長因子-8a)已獲中國國家知識(shí)產(chǎn)權(quán)局正式授權(quán)。

    基因重組卵泡刺激素卵 (FSH) 已申請(qǐng)發(fā)明專利,正在更新。

    學(xué)習(xí)經(jīng)歷

    ◆1994-1997 博士(生物化學(xué)與分子生物學(xué)) 新西蘭奧克蘭大學(xué)生物學(xué)院

    ◆1990-1991 工商管理畢業(yè)文憑 澳大利亞Regent商學(xué)院

    林俊生

    ◆1978-1983 醫(yī)學(xué)士 福建醫(yī)大

    工作經(jīng)歷

    2007- 華僑大學(xué)分子藥物所教授

    2002-2006 新西蘭皇家科學(xué)院Wallaceville研究中心資深科學(xué)家

    2003- 福建檢驗(yàn)檢疫局客座高級(jí)研究員

    2001- 福建醫(yī)大客座教授

    2001- 福建省骨科研究所副所長

    2001-2002 新西蘭皇家農(nóng)牧研究院Wallaceville研究中心科學(xué)家(生物工程)

    1999-2000 新西蘭奧克蘭大學(xué)醫(yī)學(xué)院教學(xué)研究員(生物醫(yī)學(xué))

    1997-1999 新西蘭奧克蘭大學(xué)醫(yī)學(xué)院博士后(分子生物學(xué))

    1991-1993 澳大利亞皇家阿爾弗王子醫(yī)院整形外科醫(yī)師 (新南威爾士注冊(cè))

    1988-1989 福建醫(yī)大附屬第一醫(yī)院總住院醫(yī)師

    1983-1987 福建醫(yī)大附屬第一醫(yī)院住院醫(yī)師

    發(fā)明專利

    · 基因重組成纖維細(xì)胞生長因子-8a (FGF8a)(ZL01109400.1中國)

    · Recombinant ovine follicle-stimulating hormone (522256, is renewing 新西蘭)

    · Aptamer to ovine FSH alpha (in processing新西蘭)

    學(xué)術(shù)論文

    代表性論文:

    Journal articles:

    Fidler, A. E., Lin, J, S., Lun, S., Ng Chie, W., Western, A., Stent, V., and McNatty, K. P. (2003) Production of biologically active tethered ovine FEHba by the methylotrophic yeast Pichia pastoris. Journal of Molecular Endocrinology, 30, 213-225

    Law, L.Y., Lin, J.S., Becker, D.L., and Green, C.R. (2002 Dec) Knockdown of connexin43-mediated regulation of the zone of polarizing activity in the developing chick limb leads to digit truncation. Dev Growth Differ. 44(6):537-47.

    Wright, C. S., Becker, D.L., Lin, J.S., Warner, A.E. and Hardy, K. (2001) Stage specific and differential expression of gap junctions in the mouse ovary points to connexin specific roles in follicular regulation. Reproduction, 121(1): 77-88

    Eckert, R., Donaldson P., Lin, J S., Bond, J., Green C. Adams B., Merriman-Smith R., Tunstall M., and Kistler J. (2000). Gating of gap junction channels and hemichannels in the lens: a role in cataract? Current Topics in Membranes. 49:343-356.

    Kistler, J; Merriman-Smith, R., Young, M., Gonen, T., Cowan, D., Chee, K-S., Lin, J S; Green, C; Hasiler, L., Engel, A. and Donaldson, P. (1999). Molecular solutions to lens transparency. NZ BioScience 7, 35-37

    Lin, J.S., Eckert, R., Kistler, J., and Donaldson, P., (1998). Spatial differences in gap junction gating in the lens are a consequence of connexin cleavage. European Journal of Cell Biology. 76, 236-250.

    Lin, J.S., Fitzgerald, S., Dong, Y., Knight, C. Donaldson, P., and Kistler, J. (1997). Processing of the gap junction protein connexin50 in the ocular lens is accomplished by calpain. European Journal of Cell Biology. 73, 141-149.

    Book Chapters:

    Becker, D L., Lin, J S. and Green, C R., (1999) Pluronic gel as a means of antisense delivery. In Antisense technology in the central nervous system., Edited by Leslie, R A., Hunter, A J., and Robertson, H A., Oxford University press, New York, pp149-157.

    Green, C.R., Law, L.Y., Lin, J.S. and Becker. D.L. (2000). Spatiotemporal depletion of connexins using antisense oliogonucleotides. In Connexin Methods and Protocols. Part I Chapter 10, Edited by Bruzzone, R. and Giaume, C., Humana Press, New Jersey, pp175-185.

    Kistler, J., Lin, J.S., Bond, J., Green, C., Eckert, R., Merriman, R., Tunstall, M. and Donaldson, P. (1999) Connexins in the lens: are they to blame in diabetic cataractogenesis? In Gap junction-mediated intercellular signalling in health and disease. Edited by Gilula, N.B. John Wiley & Sons Ltd, London, pp97-112.

    Selected Conference Proceedings:

    Lin, J. M., Watson, M., Callon, K., Lin, J., S., Grey, A., B., Naot, D., Reit I., and Cornish, F. (2005) FGF-8 Is Anabolic to Bone. Australian and New Zealand Bone and Mineral Society Annual Meeting

    Lin, J. S., Western A., Lun, S., Hudson N., Bauer, E., Ng Chie, W. and McNatty, K. (2004) Production of tethered ovine FSHβα from insect cells. Queenstown Molecular Biology meeting, NZ.

    Lin, J. S., Zhang, W., Law, L.Y., Stott, N. S. and Green, C.R. (2000). Upregulation of connexin43 by recombinant fibroblast growth factor (rFGF) 8a and its functional implications. Molecular Biology of the Cell, 11 (Supplement): pp225a.

    Lin, J. S., Zhang, W., Law, L.Y., Stott, N. S. and Green, C.R. (2000). Connexin43 gap junction modulation of chondrogenic differentiation. Cell Biology International, 24: pp934.

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