人物經(jīng)歷
1989年6月本科畢業(yè)于西北農(nóng)業(yè)大學(xué)獸醫(yī)系5年制獸醫(yī)專業(yè),獲農(nóng)學(xué)學(xué)士學(xué)位;2008年6月博士畢業(yè)于西北農(nóng)林科技大學(xué)動物醫(yī)學(xué)院臨床獸醫(yī)學(xué)專業(yè),獲農(nóng)學(xué)博士學(xué)位。1989年7月至1992年6 月在天津市農(nóng)工商總公司東海公司現(xiàn)代化養(yǎng)雞廠從事獸醫(yī)工作,助理獸醫(yī)師兼獸醫(yī)室主任;1992年7月至今于西北農(nóng)林科技大學(xué)動物醫(yī)學(xué)院預(yù)防獸醫(yī)學(xué)系從事教學(xué)與科研工作,先后晉升為講師、副教授、教授;2006年7月至2006年12月于加拿大圭爾夫大學(xué)細胞與分子生物學(xué)系研修。
研究方向
分子病原學(xué)與免疫學(xué)、動物疫病防制。
主要研究內(nèi)容:病原微生物致病機制、病原與宿主互作、檢測制劑及新型疫苗。
開設(shè)課程
畜牧微生物學(xué)、動物微生物與免疫學(xué)、獸醫(yī)微生物學(xué)
學(xué)術(shù)論文
[1]Wang X, Lin P, Li Y, Xiang C, Yin Y, Chen Z, Du Y, Zhou D, Jin Y, and Wang A*. Brucella suis Vaccine Strain 2 Induces Endoplasmic Reticulum Stress that Affects Intracellular Replication in Goat Trophoblast Cells In vitro.Front Cell Infect Microbiol. 2016, 6: 19. doi: 10.3389/fcimb.2016.00019.
[2]Chen F, Wang N, Yang D, Wen X, Mahmoud T N, Zhou D, Tang K, Lin P, Wang A*, and Jin Y.. Herp depletion arrests the S phase of the cell cycle and increases estradiol synthesis in mouse granulosa cells.J Reprod Dev. 2016 Jan 15. [Epub ahead of print]
[3]Chen F, Lin P, Wang N, Yang D, Wen X, Zhou D, Wang A*, and Jin Y. Herp depletion inhibits zearalenone-induced cell death in RAW 264.7 macrophages. Toxicol In Vitro. 2016, 32: 115-122
[4]Zhou J, Dai R, Lei L, Lin P, Lu X, Wang X, Tang K, Wang A, and Jin Y. Establishment and evaluation of a stable steroidogenic goat Leydig cell line. Anim Sci J. 2016, 87(4):492-502
[5]Chen F L, Li Q, Zhang J Y, Lei L J, Zhang Z, Mahmoud T N, Wang X G, Lin P F, Jin Y P, and Wang A H*. Silencing effect of lentiviral vectors encod-ing shRNA of Herp on endoplasmic reticulum stress and inflammatory responses in RAW 264.7 macrophages.Genet Mol Res.2015, 14(4): 17587-91758
[6]Lin P, Chen F, Sun J, Zhou J, Wang X, Wang N, Li X, Zhang Z, Wang A*, and Jin Y. Mycotoxin zearalenone induces apoptosis in mouse Leydig cells via an endoplasmic reticulum stress-dependent signalling pathway.Reprod Toxicol. 2015, 52: 71-77
[7]Wang X, Lin P, Yin Y, Zhou J, Lei L, Zhou X, Jin Y, and Wang A. Brucella suis vaccine strain S2-infected immortalized caprine endometrial epithelial cell lines induce non-apoptotic ER-stress.Cell Stress Chaperones. 2015, 20(3): 399-409
[8]Chen F, Li Q, Zhang Z, Lin P, Lei L, Wang A*, and Jin Y. Endoplasmic Reticulum Stress Cooperates in Zearalenone-Induced Cell Death of RAW 264.7 Macrophages.Int J Mol Sci.2015, 16(8): 19780-19795
[9]Chen F, Lin P F, Li X, Sun J, Zhang Z, Du E, Wang A, and Jin Y P. Construction and expression of lentiviral vectors encoding recombinant mouse CREBZF in NIH 3T3 cells.Plasmid.2014, 76C: 24-31
[10]Lin P, Jin Y, Lan X, Yang Y, Chen F, Wang N, Li X, Sun Y, and Wang A*. GRP78 expression and regulation in the mouse uterus during embryo implantation. J Mol Histol.2014, 45(3): 259-268
[11]Lin P, Lan X, Chen F, Yang Y, Jin Y, Wang A*. Reference gene selection for real-time quantitative PCR analysis of the mouse uterus in the peri-implantation period. PLoS One. 2013, 8(4): e62462.
[12]Lin P, Chen F, Wang N, Wang X, Li X, Zhou J, Jin Y, Wang A*. CREBZF expression and hormonal regulation in the mouse uterus. Reproductive Biology and Endocrinology, 2013;11(1):110. doi:10.1371/journal.pone.0062462
[13]Lan X, Jin Y, Yang Y, Lin P, Hu L, Cui C, Li Q, Li X, Wang A*. Expression and localization of Luman RNA and protein during mouse implantation and decidualization. Theriogenology. 2013, 80(2):138-144.
[14]Yang Y, Jin Y, Martyn AC, Lin P, Song Y, Chen F, Hu L, Cui C, Li X, Li Q, Lu R, Wang A* . Expression pattern implicates a potential role for luman recruitment factor in the process of implantation in uteri and development of preimplantation embryos in mice. Journal Reproduction and Development. 2013, 59(3): 245-251.
[15]Yang Y, Jin Y, Lin P, Hu L, Cui C, Li X, Li Q, Wang A*.The expression and localization of LRF in the female reproductive tract of cycling mice throughout the estrous cycle. Journal of Immunoassay and Immunochemistry. 2013, 34(4): 313-322.
[16]Xuefeng Qi, Yanyan Qu, Zhichun Nan, Yaping Jin, Xianjun Zhao, Aihua Wang* Stromal-epithelial interactions modulate the effect of ovarian steroids on goat uterine epithelial cell interleukin-18 release. Domestic Animal Endocrinology, 2012, 42: 210-21.
[17]Lin PF, Chen FL, Yang YZ, Song YJ, Li X, Lan XL, Jin YP, Wang. AH*.GRP78 expression and immunohistochemical localization in the female reproductive tract of mice. Theriogenology, 2012, 78: 1824-1829.
[18]Xuefeng Qi, Yanyan Qu, Zhichun Nan, Yaping Jin, Xianjun Zhao, Aihua Wang*. Caprine endometrial stromal cells modulate the effects of steroid hormones on cytokine secretion by endometrial epithelial cells in vitro. Reproductive Biology, 2012, 12(3):309-315.
[19]Hu L,Cui C, Song Y,Wang X,Jin Y, Wang A*, Zhang Y. An alternative method for cDNA cloning from surrogate eukaryotic cells transfected with the corresponding genomic DNA. Biotechnology Letters, 2012, 34: 1251-1255.
[20]Yanyan Zhang, Aihua Wang*, Qingxia Wu, Hongxia Sheng, Yaping Jin. Establishment and characteristics of immortal goat endometrial epithelial cells and stromal cells with hTERT. Journal of animal and veterinary advances, 2010, 9(21): 2738-2747.
[21] Lei Yang, Xiangguo Wang, Lanjie lei, Guangdong Zhang, Qin Xu, Jianpo Zhang, Chunnan Zhang, Jiao Yu, Pengfei Lin, Yaping Jin, Aihua Wang*. Construction of eukaryotic expression vector of main B. Melitensis S19 outer membrane proteins. Journal of Pure and Applied Microbiology, 2014, 8(1),
[22]胡林勇, 陳華濤, 李倩, 徐曉彬, 王愛華, 靳亞平. 山羊β-乳球蛋白基因打靶載體的構(gòu)建[J]. 中國農(nóng)業(yè)科學(xué), 2011, 44(11):2364-2370
[23]《畜牧微生物學(xué)實驗指導(dǎo)》王愛華編著.北京:中國農(nóng)業(yè)出版社. ISBN 978-7-109-17194-72012.國家級動物科學(xué)實驗教學(xué)示范中心系列資助教材
[24]國家發(fā)明專利:一種法氏囊素的提取方法及其在疾病治療和免疫中的應(yīng)用,ZL200310105809. 第1發(fā)明人
科研項目
1. Luman在布魯氏菌調(diào)節(jié)非折疊蛋白反應(yīng)和細胞凋亡抑制中的作用及其機制研究,國家自然科學(xué)基金(31672584),主持,直接經(jīng)費58萬元,2017.01-2020.12
2. 奶山羊重大疫病防控關(guān)鍵技術(shù)研究與示范,陜西省科技廳(2016KTZDNY02-06),直接經(jīng)費15萬元,2017.01-2019.12
3.羊布魯菌病防控與預(yù)警關(guān)鍵技術(shù)研究,陜西省農(nóng)業(yè)創(chuàng)新(2012NKC01-17),主持,10萬元,2012-2014
4.畜禽疫病檢測診斷技術(shù)與疫苗研制,陜西省科技攻關(guān)(2009K01-19),主持,3萬元,2009-2011
5.內(nèi)質(zhì)網(wǎng)應(yīng)激在布魯氏菌感染調(diào)控中的作用及其機制,家畜疫病病原生物學(xué)國家重點實驗室(蘭州獸醫(yī)研究所)開放基金(SKLVEB2015KFKT-0017),主持,5萬元,2015-2017
6.β-乳球蛋白基因敲除奶山羊新品種培育,農(nóng)業(yè)部生物新品種培育重大專項(2014 ZX08008-004),子課題,60萬,2014-2015
7.奶山羊新品種培育,農(nóng)業(yè)部生物新品種培育重大專項(2011ZX08008-004),子課題,55萬元,2011-2013
8.LRF介導(dǎo)的內(nèi)質(zhì)網(wǎng)應(yīng)激在胚胎著床過程中的作用及其調(diào)節(jié)機制,國家自然科學(xué)基金(31372499),主要參加,80萬元,2014-2017
榮譽獎項
2009年獲校級優(yōu)秀青年教師指導(dǎo)教師