主要研究方向
一直從事藥物化學(xué)科研工作，研究方向?yàn)椋?/p>
1、先導(dǎo)化合物的尋找與結(jié)構(gòu)優(yōu)化。
2、神經(jīng)系統(tǒng)藥物的初期藥理活性篩選。
主要參與的科研項(xiàng)目
1、二苯甲基哌嗪類衍生物的合成和抗癲癇作用及作用機(jī)制研究。
國家自然科學(xué)基金課題，2009-2011.
2、三唑酮并喹啉類化合物的合成及抗癲癇作用研究，教育部留學(xué)回
國啟動(dòng)項(xiàng)目，2008-2010.
申請(qǐng)專利
1、用作抗抑郁藥的5-烷氧基-四唑并[1,5-a]喹啉酮衍生物及其可藥用鹽，申請(qǐng)?zhí)?00910004690.7，發(fā)明人：全哲山，鄧先清。
主要發(fā)表的論文
1. Synthesis and Studies on Anticonvulsant and Antidepressant Activities of 5-Alkoxy-tetrazolo[1,5-a] quinolines. Xian-Qing Deng, Cheng-Xi Wei, Ming-Xia Song, Kyu-Yun Chai, Zhi-Gang Sun, and Zhe-Shan Quan. Bull. Korean Chem. Soc. 2010, Vol. 31, No. 2, 447
2. Design and synthesis of 10-alkoxy-5, 6-dihydro-triazolo[4,3-d]benzo[f][1,4]oxazepine derivativeswith anticonvulsant activity. Xian-Qing Deng, Cheng-Xi Wei, Fu-Nan Li, Zhi-Gang Sun and Zhe-ShanQuan. European Journal of Medicinal Chemistry [In press]
3. Synthesis and antidepressant-like action of 9-alkoxy -7H-furo[3,2-g]chromen-7-ones in mice. Xian-Qing Deng, Cheng-Xi Wei, Ming-Xia Song, and Zhe-Shan Quan. Arzneimittelforschung.[In press]
4. Synthesis and anticonvulsant activity of some 7-alkoxy-2H-1,4-benzothiazin-3(4H)-ones and 7-alkoxy-4H-[1,2,4]triazolo[4,3-d]benzo[b][1,4]thiazines. Zhang LQ, Guan LP, Wei CX, Deng XQ, Quan ZS.
Chem Pharm Bull (Tokyo). 2010;58(3):326-31.
5. Synthesis and anticonvulsant activity of a new 6-alkoxy-[1,2,4]triazolo[4,3-b]pyridazine. Guan LP, Sui X, Deng XQ, Quan YC, Quan ZS. Eur J Med Chem. 2010 May;45(5):1746-52. Epub 2010 Jan 14.
6. Synthesis and evaluation on anticonvulsant and antidepressant activities of 5-Alkoxy-tetrazolo[1,5-a]quinazolines. Wang HJ, Wei CX, Deng XQ, Li FL, Quan ZS. Arch Pharm (Weinheim). 2009 Nov;342(11):671-5.
7. Synthesis and anticonvulsant activity of N-(2-hydroxyethyl) cinnamamide derivatives. Guan LP, Wei CX, Deng XQ, Sui X, Piao HR, Quan ZS. Eur J Med Chem. 2009 Sep;44(9):3654-7. Epub 2009 Feb 21.
