1、Editor, Scientific Reports（2010-）

2、國家自然科學(xué)基金委專家組成員（2010-2013）

3、國家自然科學(xué)基金委重大研究計劃專家組成員（2010-2017）

天然免疫系統(tǒng)是多細胞生物抵抗病原微生物感染的第一道防線。天然免疫受體通過識別病原體和內(nèi)源有害分子所特有的分子特征，激活細胞內(nèi)的一系列信號轉(zhuǎn)導(dǎo)通路，繼而引起特異性細胞因子的表達，快速發(fā)揮免疫防御作用。同時，天然免疫反應(yīng)還可以進一步激活獲得性免疫反應(yīng)。天然免疫應(yīng)答與機體抗病原感染的能力，自身免疫病的發(fā)生，過敏性疾病及炎癥引起的癌癥等密切相關(guān)。

本實驗室利用多種技術(shù)：大規(guī)模、高通量克隆表達及功能篩選、規(guī)�；�酵母雙雜交和蛋白質(zhì)分離-肽譜技術(shù)，對調(diào)控天然免疫的相關(guān)蛋白進行大規(guī)模、高通量篩選、克隆及功能研究，尋找并發(fā)現(xiàn)天然免疫中調(diào)控不同細胞信號通路的新基因及已知基因在天然免疫中的新功能；利用免疫學(xué)、細胞生物學(xué)、分子生物學(xué)、生物化學(xué)、遺傳學(xué)、結(jié)構(gòu)生物學(xué)等技術(shù)來研究這些基因的功能及作用機制，深入而系統(tǒng)地研究天然免疫反應(yīng)的分子機制，為相關(guān)疾病的預(yù)防和治療提供理論依據(jù)。

圍繞細胞受到病原微生物感染后天然免疫激活，并最終產(chǎn)生、分泌細胞因子這一重要生理過程，通過新基因、新通路的發(fā)現(xiàn)與機制研究，探討細胞進行天然免疫反應(yīng)的分子機制，揭示天然免疫應(yīng)答失控導(dǎo)致各種與感染免疫相關(guān)的疾病，包括過敏性反應(yīng)、自身免疫病、慢性炎癥（及導(dǎo)致腫瘤發(fā)生）的可能原因。

1） 細胞識別胞質(zhì)內(nèi)病原微生物，激活天然免疫的分子機制；

2） 泛素化參與抗病毒信號通路的機制；

3） 病原微生物感染引發(fā)I型干擾素及其它重要細胞因子產(chǎn)生與調(diào)控的分子機制；

4） 天然免疫活化后細胞因子分泌的機制；

5） 多種天然免疫系統(tǒng)關(guān)鍵信號轉(zhuǎn)導(dǎo)分子的調(diào)節(jié)和多種疾�。ㄟ^敏反應(yīng)、自身免疫病及慢性炎癥）的相互關(guān)系，及如何通過瞄準這些分子以達到治療疾病的目的；

6） 重要信號轉(zhuǎn)導(dǎo)分子的結(jié)構(gòu)及功能。

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