人物生平
1992-1996 清華大學生物科學與技術(shù)系，學士
1996-2001 清華大學生物科學與技術(shù)系，博士
2001-2006 美國勞倫斯伯克利國家實驗室生命科學部，博士后
2006-2008 美國勞倫斯伯克利國家實驗室生命科學部，研究科學家
2009-2011 美國耶魯大學分子生物物理與生物化學系，Tenure-Track助理教授
2010.12-至今 清華大學生命科學學院，教授、博導
主要成就
王宏偉教授長期致力于使用冷凍電鏡技術(shù)研究生物大分子的結(jié)構(gòu)以及其組裝機制，研究領(lǐng)域集中在細胞骨架動態(tài)機理、RNA降解、RNA干擾以及冷凍電鏡方法學。目前已獲得微管和Exosome等的高分辨電鏡結(jié)構(gòu)。此外，王宏偉教授還與其他課題組合作，解析了一批具有重要生物學意義的生物大分子的結(jié)構(gòu)。
出版著作
1. Chang S, Sun D, Liang H, Wang J, Li J, Guo L, Wang X, Guan C, Boruah BM, Yuan L, Feng F, Yang M, Wang L, Wang Y, Wojdyla J, Li L, Wang J, Wang M, Cheng G,Wang HW*, and Liu Y*. (2015) Cryo-EM Structure of Influenza Virus RNA Polymerase Complex at 4.3 ? Resolution.Mol. Cell,57, 925-935. (*co-corresponding authors)
2. Liu JJ, Bratkowski MA, Liu X, Niu CY, Ke A*, andWang HW*. (2014) Visualization of distinct substrate-recruitment pathways in the yeast exosome by EM.Nat. Struct. Mol. Biol.,21, 95-102. (*co-corresponding authors)
3. Li Y, Hsin J, Zhao L, Cheng Y, Shang W, Huang KC,Wang HW, and Ye S. (2013) FtsZ protofilaments use a hinge-opening mechanism for constrictive force generation.Science,341: 392-295.
4. Taylor DW, Ma E, Shigematsu H, Cianfrocco MA, Noland CL, Nagayama K, Nogales E, Doudna JA*, andWang HW*. (2013) Substrate-specific structural rearrangements of human Dicer.Nat. Struct. Mol. Biol.,20, 662-670. (*co-corresponding authors)
5. Chen X, Taylor DW, Fowler CC, Galan JE,Wang HW, and Wolin SL. (2013) An RNA degradation machine sculpted by Ro autoantigen and noncoding RNA.Cell,153: 166-177.
6. Shen QT, Hsiue PP, Sindelar CV, Welch MD, Campellone KG*, andWang HW*. (2012) Structural insight into WHAMM-mediated cytoskeletal coordination during membrane remodeling.J. Cell Biol.,199, 111-124. (*co-corresponding authors)
7. Zhou K, Kanai R, Lee P,Wang HW*, and Modis Y*. (2012) Toll-like receptor 5 forms asymmetric dimers in the absence of flagellin.J. Struct. Biol.,177: 402-409 (*co-corresponding authors)
8. Liu XQ andWang HW. (2011) Single particle electron microscopy reconstruction of the exosome complex using the random conical tilt method.J. Vis. Exp.,doi: 10.3791/2574.
9. Wu X, Shen QT, Stokes N, Lu C, Zheng Q, Polak L,Wang HWand Fuchs E. (2011) Skin stem cells orchestrate directional migration by regulating microtubule-ACF7 connections through GSK3β.Cell,144, 341-352.
10.WangHW*, Noland C, Siridechadilok B, Taylor DW, Ma E, Felderer K, Doudna JA*, and Nogales E*. (2009) Structural insights into RNA processing by the human RISC-loading complex.Nat. Struct. Mol. Biol.,16, 1148-1153. (* co-corresponding authors)
11.Wang HW, Long S, Ciferri C, Westermann S, Drubin DG, Barnes G, and Nogales E. (2008) Architecture and flexibility of the yeast Ndc80 kinetochore complex.J. Mol. Biol.,383, 894-903.
12.Wang HW*, Wang J, Ding F, Callahan K, Bratkowski MA, Bulter JS, Nogales E, and Ke A*. (2007) Architecture of the yeast Rrp44-exosome complex suggests routes of RNA recruitment for 3u2019-end processing.Proc. Natl. Acad. Sci. USA,104, 16844-16849. (* co-corresponding authors)
13.Wang HW, Ramey VH, Westermann S, Leschziner A, Welburn JPI, Nakajima Y, Drubin DG, Barnes G, and Nogales E. (2007) Architecture of the Dam1 kinetochore ring complex and implications for microtubule-driven assembly and force-coupling mechanisms.Nat. Struct. Mol. Biol.,14, 721-726.
14. Nogales E andWang HW.(2006)Structural intermediates in microtubule assembly and disassembly: how and why?Curr. Opin. Cell Biol.,18, 179-284.
15. Westermann W,Wang HW, Avila-Sakar A, Drubin DG, Nogales E, and Barnes G. (2006)The Dam1 kinetochore ring complex moves processively on depolymerizing microtubule ends.Nature,440, 565-563.
16.Wang HWand Nogales E. (2005) The nucleotide-dependent bending flexibility of tubulin regulates microtubule assembly.Nature,435, 911-915.
榮譽記錄
2019年9月20日，“科學探索獎”評審委員會公布2019年“科學探索獎”獲獎名單，王宏偉在列。
