基本介紹
尚魯慶 性別：男 職稱：南開大學(xué)藥學(xué)院講師 學(xué)科方向：藥物化學(xué)
教師簡介
2000年9月－2004年7月 山東大學(xué)藥學(xué)院 藥學(xué)
2004年9月－2009年7月 山東大學(xué)藥學(xué)院 藥物化學(xué)博士研究生
2005年7月－2006年7月 日本和歌山縣立醫(yī)科大學(xué) 藥理學(xué)
2009年7月畢業(yè)，獲得醫(yī)學(xué)博士學(xué)位，榮獲山東省優(yōu)秀畢業(yè)生榮譽(yù)稱號(hào)。同年進(jìn)入南開大學(xué)藥學(xué)院任教，主要從事藥物化學(xué)方面的研究。
代表性作品
1. Luqing Shang, Hua Wei Zhu, Hao Fang, Xuejian Wang, Qiang Wang, Jiajia Mu, Shiroh Kishioka,Wenfang Xu. Design, synthesis and SAR studies of novel 3-phenylpropane-1,2- diamine derivates as aminopeptidase N (APN) inhibitors.
Bioorganic & Medicinal Chemistry，2009; 17(7): 2775-2784.
2. Luqing Shang, Takehiko Maeda, Wenfang Xu, Shiroh Kishioka. Evaluation of a novel aminopeptidase N inhibitor, in vitro, using two assay systems. Journal of Enzyme Inhibition and Medicinal Chemistry. 2008; 23(2): 198u2013205.
3. Luqing Shang , Qiang Wang , Hao Fang , Jiajia Mu, Xuejian Wang, Yumei
Yuan , Binghe Wang, Wenfang Xu. Novel 3-phenylpropane-1,2-diamine derivates
as inhibitors of aminopeptidase N (APN). Bioorganic & Medicinal Chemistry, 2008;16(23): 9984-9990.
4. Luqing Shang, Hamabe Wakako, Wenfang Xu, Shiroh Kishioka. Evaluation the potency of aminopeptidase N inhibitor, using Met-enkephalininduced twitch inhibition in guinea pig ileum preparation, in vitro. Acta Pharmacologica Sinica., 2006: 249.
5. 徐文方， 尚魯慶，乙二胺類肽金屬蛋白酶抑制劑及其應(yīng)用。專利號(hào)：CN 101357893 A。
6. 尚魯慶，徐文方。化學(xué)基因組學(xué)與藥物發(fā)現(xiàn)。食品與藥品，2005，7(3)，5-8.
7. Yingzi Liu, Luqing Shang, Hao Fang, Huawei Zhu, Jiajia Mu, Qiang Wang, Xuejian Wang, Yumei Yuan, Wenfang Xu. Design, synthesis, and preliminary studies of the activity of novel derivatives of N-Cinnamoyl-L-aspartic acid as inhibitors of Aminopeptidase N/CD13. Bioorganic & Medicinal Chemistry, In press.
8. Jiajia Mu, Hao Fang, Fanbo Jing, Qiang Wang, Yingzi Liu, Huawei Zhu, Luqing Shang, Xuejian Wang, Wenfang Xu. Design, synthesis and primary activity evaluation of l-arginine derivatives as amino-peptidase N/CD13 inhibitors. Bioorganic & Medicinal Chemistry, 2009; 17 (13), 4666-4673.
9. Wakako Hamabe, Takehiko Maeda, Yohji Fukazawa, Kazumasa Kumamoto,
Luqing Shang, Akihiro Yamamoto, Chizuko Yamamoto, Shogo Tokuyama, Shiroh Kishioka. P-glycoprotein ATPase activating effect of opioid analgesics and their P-glycoprotein-dependent antinociception in mice. Pharmacology, Biochemistry and Behavior, 2006; 85: 629-636.
