2002年畢業(yè)于山東大學(xué)化學(xué)院，獲理學(xué)博士學(xué)位。2003-2005年在美國Louisiana State University 化學(xué)系做博士后從事卟啉、酞菁配合物光動力治療光敏劑的設(shè)計、合成及性能研究；2007-2009在美國University of Texas Southwestern Medical Center做博士后研究員從事大環(huán)金屬配合物癌癥靶向生物探針的設(shè)計、合成及生物活性的研究；2009年7月回國，在山東大學(xué)晶體所任教授，碩士生導(dǎo)師。

1、卟啉、酞菁癌癥靶向光動力治療光敏劑及顯影劑的設(shè)計及生物性能測試

光動力治療（photodynamic therapy, PDT）是近幾十年來發(fā)展起來的一種癌癥治療技術(shù)。該技術(shù)利用光激發(fā)癌細胞內(nèi)部的光敏劑分子（photosensitizer ,PS）產(chǎn)生高細胞毒性的單線態(tài)氧從而在細胞內(nèi)部殺死癌細胞，而使正常組免受傷害。它與手術(shù)、化療和放療等三大傳統(tǒng)的治療腫瘤手段相比，具有許多優(yōu)點和特點。自上世紀70年代進入臨床研究以來，PDT在惡性腫瘤的治療中取得了令人矚目的成就，已成為腫瘤防治研究中的一個十分活躍的領(lǐng)域。它不僅能有效地治療體表腫瘤，同樣亦可治療呼吸道、胃腸道、顱腦、眼、膀胱等部位的腫瘤。美國、日本、荷蘭和加拿大等國的衛(wèi)生部門已相繼確認了這一腫瘤新療法的合法性。PDT在治療非腫瘤疾病方面也得到了廣泛的重視，在不久的將來可能成為治療皮膚病、老年黃斑病變和白血病等頑疾的有效手段。作為PDT的光敏劑，卟啉 （Porphyrin, Por）及其衍生物酞菁（Phthalocyanine, Pc）一直以來發(fā)揮著領(lǐng)銜的作用。迄今，美國食品和醫(yī)藥管理局（Food and Drug Administration, FDA）唯一批準臨床應(yīng)用于腫瘤治療的PDT光敏劑，Photofrin,就是一種血卟啉衍生物（HpD）的提純物，在美國用來治療食道癌和肺癌。在世界范圍內(nèi)，Photofrin已經(jīng)廣泛應(yīng)用于治療各種惡性腫瘤并取得了很大成功。本課題旨在設(shè)計并合成出成分單一，高單線態(tài)氧產(chǎn)率、高選擇性的酞菁類光敏劑并進行相應(yīng)的生物功能測試，為光動力治療開發(fā)新型、高效的癌癥治療及顯影藥物。

2. 酞菁類有機半導(dǎo)體的設(shè)計及器件組裝

在信息技術(shù)領(lǐng)域，半導(dǎo)體器件占著舉足輕重的作用。作為典型的盤狀有機半導(dǎo)體分子，金屬酞菁因其具有的高遷移率、高穩(wěn)定性、高有序的超薄膜生長特性，是當今有機半導(dǎo)體領(lǐng)域的研究熱點之一。酞菁作為少數(shù)幾種有實際應(yīng)用價值的分子材料之一，已經(jīng)在人類生活的多個方面得到應(yīng)用：如（1）光導(dǎo)材料，已經(jīng)應(yīng)用到復(fù)印機和激光打印機中。（2）電致變色材料，應(yīng)用到氣體傳感器中。（3）光記錄材料，應(yīng)用到商用和家用的CD-R光碟中；（4）光動力治療藥物，應(yīng)用到癌癥的治療中，正在進行后期測試；（5）非線性光學(xué)材料，可以保護精密儀器和人眼免受激光的傷害；（6）酞菁類液晶材料， 等等。 項目的工作旨在于解決酞菁類分子半導(dǎo)體研究中的局限問題，基于酞菁分子結(jié)構(gòu)多樣性特點，設(shè)計合成出溶解度高、穩(wěn)定性好、親水性好的取代酞菁。從而研發(fā)出性能優(yōu)良的酞菁分子半導(dǎo)體以及酞菁/無機復(fù)合半導(dǎo)體材料和器件。

所獲獎勵：

2002山東省高校優(yōu)秀科研成果獎（自然科學(xué)類）一等獎

2003國家教育部推薦國家科學(xué)技術(shù)進步獎（自然科學(xué)類）二等獎

2003山東省科學(xué)技術(shù)獎 （自然科學(xué)類）二等獎

2008 Conference Award from University of Texas Southwestern MedicalCenter USA

近期代表性論文

1. Dongmei Xu, Jing Qiao,u2021 Nannan Wu,Wei Liu,*, Fenglong Wang, Longfei Lv, Jiabao Pan,Yazhuo Dong,§ and Jiurong Liu*,Facile Synthesis of Three-Dimensional Porous Co/MnO CompositesDerived from Bimetal Oxides for Highly Efficient ElectromagneticWave AbsorptionACS Sustainable Chem. Eng.2019, 7, 8687?8695

2.Kai Le, Zhou Wang, Fenglong Wang, Qi Wang, Qian Shao,Vignesh Murugadoss,Shide Wu,Wei Liu,*a Jiurong Liu, * Qiang Gao* and Zhanhu Guo *Sandwich-like NiCo layered double hydroxide reduced graphene oxide nanocomposite cathodes for high energy density asymmetric supercapacitorsDalton Trans.,2019, 48,5193

3.Jiabao Pan, Yang Yang, Wenjuan Fang,Wei Liu*, Kai Le, Dongmei Xu, and Xiangzhi Li*Fluorescent phthalocyanine?graphene conjugate with enhanced NIR absorbance for imaging and multi-modality therapyACS Appl. Nano Mater.2018,1, 2785?2795

4.Yuxing Ni , Kai Le, Wenjing Du, Wenjuan Fang, Xi Chen,Wei Liu,?Yana Wang, Jiurong Liu.High response to nitrogen dioxide derived from antimony peroxide modified tin oxide porous nanocomposites serving as gas sensing materialSensors and Actuators B: Chemical2017,247,216u2013223

5.Wenjing Du, Nannan Wu, Zhou Wang, Jiurong Liu,?Dongmei Xu,Wei LiuHigh response and selectivity of platinum modified tin oxide porous spheres for nitrogen dioxide gas sensing at low temperature.Sensors and Actuators B,2018257, 427u2013435

6.Song Qiu, Hailong Lyu, Jiurong Liu*, Yuzhen Liu, Nannan Wu, andWei Liu. Facile Synthesis of Porous Nickel/Carbon Composite Microspheres with Enhanced Electromagnetic Wave Absorption by Magnetic and Dielectric Losses.ACS Appl. Mater. Interfaces2016, 8, 20258?20266

7.Liqiang Luan, Wenjuan Fang,Wei Liu,* Minggang Tian, Yuxing Ni, Xi Chen and Xiaoqiang Yu.Phthalocyanine-cRGD conjugate: synthesis, photophysical properties and in vitro biological activity for targeting photodynamic therapy.Org. Biomol. Chem.,2016, 14, 2985u20132992

8.Yuxiang Chen, Wenjuan Fang, Kang Wang*,Wei Liu, and Jianzhuang Jiang,*NonperipheralTetrakis(dibutylamino)phthalocyanines. New Types of 1,8,15,22-Tetrakis(substituted)phthalocyanine Isomers,Inorg. Chem.2016,55, 9289?9296.

9.Huili Cao, Xinzhen Wang, Hongbo Gu, Jiurong Liu,* Liqiang Luan,Wei Liu,*Yiran Wang and Zhanhu Guo*Carbon coated manganese monoxide octahedron negative-electrode for lithium-ion batteries with enhanced performance.RSC Adv., 2015, 5, 34566

10.Shimei Guo, Shenyu Wang, Nannan Wu, Jiurong Liu,* Yuxing Ni andWei Liu*Facile synthesis of porous Fe2TiO5 microparticulates serving as anode material with enhanced electrochemical performances.RSC Adv., 2015,5, 103767.

11.Liqiang Luan, Wenjuan Fang,Wei Liu*, nggang Tian, Yuxing Ni, Xi Chen, Xiaoqiang Yu, Jing He, Yang Yang and Xiangzhi Li. 4-tert-Butylphenoxy substituted phthalocyanine with RGD motif as highly selective one-photon and two-photon imaging probe for mitochondria and cancer cell,Journal of Porphyrins and Phthalocyanines,2016, 20: 397u2013406.

12.Guiyang Hao，Wei Liu，Gedaa Hassan，Orhan K. ?z，Zoltan Kovacs Xiankai Sun*A comparative study of trans- and cis-isomers of a bone-seeking agent, DO2A2P.Bioorg.& Med. Chem. Lett.2015, 25，571u2013574.

13.Shimei Guo, Jiurong Liu,* Song Qiu,Wei Liu,*Yiran Wang, Nannan Wu, Jiang Guo and Zhanhu Guo.Porous ternary TiO2/MnTiO3@C hybrid microspheres as anode materials with enhanced electrochemical performances.J. Mater. Chem. A,2015, 3, 23895

14.Jiawei Shi, Liqiang Luan, Wenjuan Fang, Tianyu Zhao,Wei Liu*, Deliang Cui. High-sensitive low-temperature NO₂sensor based on Zn(II) phthalocyanine with liquid crystalline properties.Sensors and Actuators B2014,204, 218u2013223.

15.Liqiang Luan, Lanlan Ding, Jiawei Shi, Wenjuan Fang, Yuxing Ni,Wei Liu*Effect of Axial Ligands on the Molecular Configurations, Stability, Reactivity and Photodynamic Activities of Silicon Phthalocyanines.Chem. Asian J. 2014,9，3491-3497.

16.Xinzhen Wang, Song Qiu, Guixia Lu, Cuizhu He, Jiurong Liu,* Liqiang Luan andWei Liu*Fabrication of porous MnO microspheres with carbon coating for lithium ion battery application.CrystEngComm, 2014, 16, 1802u20131809

17.Ding Lanlan, Luan Liqiang, Jiawei Shi,Wei Liu*. Phthalocyanine Based Photosensitizers for Photodynamic Therapy.Chinese Journal of Inorganic Chemistry.2013, 29, 1591-1598.

18.Liqiang Luan, Lanlan Ding, Weijia Zhang, Jiawei Shi, Xiaoqiang Yu,Wei Liu*. A Naphthalocyanine Based Near-Infrared Photosensitizer: Synthesis and In Vitro Photodynamic Activities.Bioorg. & Med. Chem. Lett.2013, 23，3775-3779.

19.Xinzhen Wang,Wei Liu,Jiurong Liu*,Fenglong Wang,Jing Kong,Song Qiu,Cuizhu He, andLiqiang Luan.Synthesis of Nestlike ZnO Hierarchically Porous Structures and Analysis of Their Gas Sensing Properties.ACS Appl. Mater. Interfaces,2012,4(2), 817u2013825

20.Cuizhu He, Song Qiu, Xinzhen Wang, Jiurong Liu,* Liqiang Luan,Wei Liu*,Masahiro Itoh and Ken-ichi Machida. Facile synthesis of hollow porous cobalt spheres and their enhanced electromagnetic properties.J. Mater. Chem.,2012,22, 22160

21.Liqiang Luan, Jingwei Chen, Lanlan Ding, Junjie Wang, Xiufeng Cheng, Quan Ren,Wei Liu*.Tetrabrominated Naphthalocyaninatozinc Complex with Terminal Carboxylate Functionalities.Chemistry Letters2012, 41(9), 1012-1014

Jing Kong，Wei Liu*, FenglongWang, XinzhenWang, LiqiangLuan, JiurongLiu , YuanWang, Zijun Zhang , MasahiroItoh , Ken-ichiMachida. Fabrication of monodispersed nickel flower-like architectures via a solvent-thermal process and analysis of their magnetic and electromagnetic properties.Journal of Solid State Chemistry,2011, 184, 2994u20133001Ajay N. Singh,Wei Liu, Guiyang Hao, Amit Kumar, Anjali Gupta, Orhan K.Oz, Jer-Tsong Hsieh, and Xiankai Sun.Multivalent Bifunctional Chelator Scaffolds for Gallium-68 Based Positron Emission Tomography Imaging Probe Design: Signal Amplification via Multivalency.Bioconjugate Chem.,2011,22(8), 1650u20131662Jian Zhou,Wei Liu, Rey-Chen Pong, Guiyang Hao and XiankaiSun et.al. Analysis of Oligo-arginine Cell-permeable Peptides Uptake by Prostate Cells.Amino Acid，2012, 42, 1253-60Hao, Guiyang; Singh, Ajay N.;Liu, Wei; Sun, Xiankai. PET with Non-standard Nuclides.Current Topics in Medicinal Chemistry,2010, 10, 1096-1112.Liu, Wei; Hao, Guiyang; Long, Michael A.; Anthony, Tiffani; Hsieh, Jer-Tsong; Sun, Xiankai*. Imparting Multivalency to a Bifunctional Chelator: A Scaffold Design for Targeted PET Imaging Probes.Angewandte Chemie, International Edition,2009, 48, 7346-7349