腫瘤學(xué)生物化學(xué)與分子生物學(xué)醫(yī)學(xué)微生物學(xué)

惡性腫瘤發(fā)病機(jī)制、早期診斷和預(yù)后研究

腫瘤病毒感染、致癌機(jī)制與免疫調(diào)控腫瘤疫苗分子影像及靶向治療

1988年畢業(yè)于江西醫(yī)學(xué)院撫州分院（現(xiàn)南昌大學(xué)撫州醫(yī)學(xué)院）

1994年畢業(yè)于中山大學(xué)（原中山醫(yī)科大學(xué)），獲腫瘤學(xué)碩士學(xué)位

1998年畢業(yè)于中山大學(xué)（原中山醫(yī)科大學(xué)），獲微生物學(xué)博士學(xué)位

1999-2000年在美國田納西州立大學(xué)生物系（Tennessee State University）從事維甲酸在細(xì)胞發(fā)育及分化中作用的研究

2000-2003年美國波士頓塔夫茨大學(xué)-紐英倫醫(yī)學(xué)中心(Tufts University-New England Medical Center)腫瘤生物學(xué)實(shí)驗(yàn)室腫瘤生物學(xué)實(shí)驗(yàn)室從事HPV致癌機(jī)制研究

2003年8月回國后，繼續(xù)從事鼻咽癌的研究

回國后組建腫瘤病毒學(xué)和腫瘤分子標(biāo)志研究組，首次完成鼻咽癌相關(guān)EBV全序列分析，發(fā)現(xiàn)鼻咽癌相關(guān)的EBV序列特征【J Virol 2005，入選第一屆中國百篇最具影響優(yōu)秀國際學(xué)術(shù)論文（科技部直屬中國科學(xué)技術(shù)信息研究所評選）】，證實(shí)高發(fā)區(qū)NPC相關(guān)EBV亞型的假設(shè)；揭示吸煙可以通過激活EBV參與鼻咽癌發(fā)病的新機(jī)制。發(fā)現(xiàn)EBV-LMP2A通過誘導(dǎo)上皮間質(zhì)轉(zhuǎn)化和腫瘤啟動(dòng)細(xì)胞群體參與鼻咽癌發(fā)生發(fā)展的新機(jī)制；發(fā)現(xiàn)EBV可以誘導(dǎo)原癌基因Bmi-1的表達(dá)，闡明Bmi-1在鼻咽上皮細(xì)胞早期轉(zhuǎn)化和鼻咽癌侵襲和轉(zhuǎn)移中的作用，揭示PTEN/PI3K/Akt/Snail通路介導(dǎo)Bmi-1誘導(dǎo)上皮間質(zhì)轉(zhuǎn)化和腫瘤轉(zhuǎn)移的新機(jī)制。建立首個(gè)單一原癌基因誘導(dǎo)的鼻咽上皮細(xì)胞永生化模型和EBV高效感染上皮細(xì)胞的體外模型，鑒定出EBV感染上皮細(xì)胞的關(guān)鍵受體或共受體（NRP1、MHC-IIA、EphA2等），系統(tǒng)闡明EBV進(jìn)入鼻咽上皮細(xì)胞的機(jī)制，近期聯(lián)合上海藥物研究所余學(xué)奎課題組報(bào)道了高分辨率EBV病毒衣殼全原子結(jié)構(gòu)模型，為鼻咽癌預(yù)防和干預(yù)研究提供了新思路。揭示了食管鱗狀上皮細(xì)胞癌的癌前病變的基因組特征及其與腫瘤的演化發(fā)展關(guān)系，發(fā)現(xiàn)新融合基因RARS-MAD1L1及其在鼻咽癌和頭頸腫瘤中作用與機(jī)制。至2020年止，作為主持人牽頭國家重點(diǎn)研發(fā)計(jì)劃1項(xiàng)、主持國家自然科學(xué)基金重點(diǎn)項(xiàng)目和國際合作重大項(xiàng)目共4項(xiàng)、“863”課題及“973”課題各1項(xiàng)等。發(fā)表SCI收錄論文70余篇，包括國際上重要專業(yè)性雜志Nature Microbiol, Cell Res, Cancer Cell, J Clin Invest, Nature Commun, PNAS, J Natl Cancer Inst, PLoS Pathog, EMBO Mol Med, EMBO Rep, Cancer Res, Clin Cancer Resh, Ann Oncol, Mol Cancer, J Virol, J Biol Chem等。

國家自然科學(xué)基金重點(diǎn)項(xiàng)目，81830090，鼻咽癌中YTHDF1復(fù)合體降解病毒m6A修飾RNA調(diào)控EBV感染狀態(tài)及腫瘤進(jìn)展，2019-2023國家重點(diǎn)研發(fā)計(jì)劃項(xiàng)目負(fù)責(zé)人“基于基因組不穩(wěn)定性的新型蛋白質(zhì)機(jī)器在腫瘤發(fā)生發(fā)展中的作用、機(jī)制及干預(yù)”，2017-2022國家重點(diǎn)研發(fā)計(jì)劃子課題參與人“皰疹病毒感染與致病過程中蛋白質(zhì)機(jī)器的功能機(jī)制”2016-2021國家自然科學(xué)基金國際(地區(qū))合作與交流項(xiàng)目，81520108022，EB病毒進(jìn)入鼻咽上皮細(xì)胞受體鑒定及感染機(jī)制，2016-2020國家自然科學(xué)基金重大研究計(jì)劃，91440106，RNA結(jié)合蛋白R(shí)BM24調(diào)控miR-25-3p及l(fā)ncRNA MALAT1抑制鼻咽癌的機(jī)制，2015-2017國家自然科學(xué)基金重點(diǎn)項(xiàng)目，81230045，融合基因AARS-MADx誘導(dǎo)基因組不穩(wěn)定性及參與鼻咽癌發(fā)生的機(jī)制，2013-2017“973”課題：“致瘤病毒感染和致癌機(jī)制”，2011-2017國家自然科學(xué)基金杰出青年基金，81025014，頭頸腫瘤，2011-2014國家自然科學(xué)基金重點(diǎn)項(xiàng)目，30630068，鼻咽癌早期診斷的基礎(chǔ)研究，2007-2010“863”計(jì)劃課題（2007AA02Z477）鼻咽癌早期診斷新方法研究，2007-2010

Zhang A; Xing J; Xia T; Zhang H; Fang M; Li S; Du Y; Li X C; Zhang Z*;Zeng M S*, EphA2 phosphorylates NLRP3 and inhibits inflammasomes in airway epithelial cells.EMBO Rep, 2020,21(7):e49666.Li S B; Liu Y Y; Yuan L; Ji M F; Zhang A; Li H Y; Tang L Q; Fang S G; Zhang H; Xing S; Li M Z; Zhong Q; Lin S J; Liu W L; Huang P; Zeng Y X; Zheng Y M; Ling Z Q*; Sui J H*;Zeng M S*, Autocrine INSL5 promotes tumor progression and glycolysis via activation of STAT5 signaling.EMBO Mol Med, 2020,:e12050.Li Z; Zhang X; Dong L; Pang J; Xu M; Zhong Q;Zeng M S*; Yu X*, CryoEM structure of the tegumented capsid of Epstein-Barr virus.Cell Res, 2020,.Zhang X; Zhao B; Ding M; Song S; Kang Y; Yu Y; Xu M; Xiang T; Gao L; Feng Q; Zhao Q;Zeng M S*; Krummenacher C*; Zeng Y X*, A novel vaccine candidate based on chimeric virus-like particle displaying multiple conserved epitope peptides induced neutralizing antibodies against EBV infection.Theranostics, 2020,10(13):5704-5718.Xue R; Chen L; Zhang C; Fujita M; Li R; Yan S M; Ong C K; Liao X; Gao Q; Sasagawa S; Li Y; Wang J; Guo H; Huang Q T; Zhong Q; Tan J; Qi L; Gong W; Hong Z; Li M; Zhao J; Peng T; Lu Y; Lim K; Boot A; Ono A; Chayama K; Zhang Z; Rozen S G; Teh B T; Wang X W; Nakagawa H*;Zeng M S*; Bai F*; Zhang N*, Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes.Cancer Cell, 2019,35(6):932-947.e8.Wu Y; Liu S X; Wang F;Zeng M S*, Room Temperature Detection of Plasma Epstein-Barr Virus DNA with CRISPR-Cas13.Clin Chem, 2019,65(4):591-592.Wang C; Jiang S; Ke L; Zhang L; Li D; Liang J; Narita Y; Hou I; Chen C H; Wang L; Zhong Q; Ling Y; Lv X; Xiang Y; Guo X; Teng M; Tsao S W; Gewurz B E;Zeng M S*; Zhao B*, Genome-wide CRISPR-based gene knockout screens reveal cellular factors and pathways essential for nasopharyngeal carcinoma.J Biol Chem, 2019,294(25):9734-9745.Feng G K; Ye J C; Zhang W G; Mei Y; Zhou C; Xiao Y T; Li X L; Fan W*; Wang F*;Zeng M S*, Integrin α6 targeted positron emission tomography imaging of hepatocellular carcinoma in mouse models.J Control Release, 2019,310:11-21.Zhang H; Li Y; Wang H B; Zhang A; Chen M L; Fang Z X; Dong X D; Li S B; Du Y; Xiong D; He J Y; Li M Z; Liu Y M; Zhou A J; Zhong Q; Zeng Y X; Kieff E; Zhang Z; Gewurz B E; Zhao B*;Zeng M S*, Ephrin receptor A2 is an epithelial cell receptor for Epstein-Barr virus entry.Nat Microbiol, 2018,3(2):1-8.Zhong Q; Liu Z H; Lin Z R; Hu Z D; Yuan L; Liu Y M; Zhou A J; Xu L H; Hu L J; Wang Z F; Guan X Y; Hao J J; Lui V; Guo L; Mai H Q; Chen M Y; Han F; Xia Y F; Grandis J R; Zhang X*;Zeng M S*, The RARS-MAD1L1 Fusion Gene Induces Cancer Stem Cell-like Properties and Therapeutic Resistance in Nasopharyngeal Carcinoma.Clin Cancer Res, 2018,24(3):659-673.Wang Q; Li S B; Zhao Y Y; Dai D N; Du H; Lin Y Z; Ye J C; Zhao J; Xiao W; Mei Y; Xiao Y T; Liu S C; Li Y; Xia Y F; Song E W; Tang G H; Zhang W G; Li Z J; Zheng X B; Cao D H; Li M Z; Zhong Q; Chen Z P; Qian C N; Fan W; Feng G K;Zeng M S*, Identification of a sodium pump Na(+)/K(+) ATPase α1-targeted peptide for PET imaging of breast cancer.J Control Release, 2018,281:178-188.Chen X X; Zhong Q; Liu Y; Yan S M; Chen Z H; Jin S Z; Xia T L; Li R Y; Zhou A J; Su Z; Huang Y H; Huang Q T; Huang L Y; Zhang X; Zhao Y N; Yun J P; Wu Q L; Lin D X; Bai F*;Zeng M S*, Genomic comparison of esophageal squamous cell carcinoma and its precursor lesions by multi-region whole-exome sequencing.Nat Commun, 2017,8(1):524.Xing J; Zhang A; Zhang H; Wang J; Li X C*;Zeng M S*; Zhang Z*, TRIM29 promotes DNA virus infections by inhibiting innate immune response.Nat Commun, 2017,8(1):945.Tang L Q; Li C F; Li J; Chen W H; Chen Q Y; Yuan L X; Lai X P; He Y; Xu Y X; Hu D P; Wen S H; Peng Y T; Zhang L; Guo S S; Liu L T; Guo L; Wu Y S; Luo D H; Huang P Y; Mo H Y; Xiang Y Q; Sun R; Chen M Y; Hua Y J; Lv X; Wang L; Zhao C; Cao K J; Qian C N; Guo X; Zeng Y X*; Mai H Q*;Zeng M S*, Establishment and Validation of Prognostic Nomograms for Endemic Nasopharyngeal Carcinoma.J Natl Cancer Inst, 2016,108(1).Hua W F; Zhong Q; Xia T L; Chen Q; Zhang M Y; Zhou A J; Tu Z W; Qu C; Li M Z; Xia Y F; Wang H Y; Xie D; Claret F X; Song E W;Zeng M S*, RBM24 suppresses cancer progression by upregulating miR-25 to target MALAT1 in nasopharyngeal carcinoma.Cell Death Dis, 2016,7(9):e2352.Wang H B; Zhang H; Zhang J P; Li Y; Zhao B; Feng G K; Du Y; Xiong D; Zhong Q; Liu W L; Du H; Li M Z; Huang W L; Tsao S W; Hutt-Fletcher L; Zeng Y X; Kieff E;Zeng M S*, Neuropilin 1 is an entry factor that promotes EBV infection of nasopharyngeal epithelial cells.Nat Commun, 2015,6:6240.Ni C; Chen Y;Zeng M(co-first author); Pei R; Du Y; Tang L; Wang M; Hu Y; Zhu H; He M; Wei X; Wang S; Ning X; Wang M; Wang J; Ma L; Chen X; Sun Q; Tang H; Wang Y; Wang X*, In-cell infection: a novel pathway for Epstein-Barr virus infection mediated by cell-in-cell structures.Cell Res, 2015,25(7):785-800.Xiong D; Du Y; Wang H B; Zhao B; Zhang H; Li Y; Hu L J; Cao J Y; Zhong Q; Liu W L; Li M Z; Zhu X F; Tsao S W; Hutt-Fletcher L M; Song E; Zeng Y X; Kieff E*;Zeng M S*, Nonmuscle myosin heavy chain IIA mediates Epstein-Barr virus infection of nasopharyngeal epithelial cells.Proc Natl Acad Sci U S A, 2015,112(35):11036-41.Feng G K; Liu R B; Zhang M Q; Ye X X; Zhong Q; Xia Y F; Li M Z; Wang J; Song E W; Zhang X*; Wu Z Z*; Zeng M S*, SPECT and near-infrared fluorescence imaging of breast cancer with a neuropilin-1-targeting peptide.J Control Release, 2014,192:236-42.Yuan L; Liu Z H; Lin Z R; Xu L H; Zhong Q*;Zeng M S*, Recurrent FGFR3-TACC3 fusion gene in nasopharyngeal carcinoma.Cancer Biol Ther, 2014,15(12):1613-21.Zhang J P; Zhang H; Wang H B; Li Y X; Liu G H; Xing S; Li M Z;Zeng M S*, Down-regulation of Sp1 suppresses cell proliferation, clonogenicity and the expressions of stem cell markers in nasopharyngeal carcinoma.J Transl Med, 2014,12:222.Tang L Q; Chen Q Y; Fan W; Liu H; Zhang L; Guo L; Luo D H; Huang P Y; Zhang X; Lin X P; Mo Y X; Liu L Z; Mo H Y; Li J; Zou R H; Cao Y; Xiang Y Q; Qiu F; Sun R; Chen M Y; Hua Y J; Lv X; Wang L; Zhao C; Guo X; Cao K J; Qian C N;Zeng M S*; Mai H Q*, Prospective study of tailoring whole-body dual-modality [18F]fluorodeoxyglucose positron emission tomography/computed tomography with plasma Epstein-Barr virus DNA for detecting distant metastasis in endemic nasopharyngeal carcinoma at initial staging.J Clin Oncol, 2013,31(23):2861-9.Wang H B; Liu G H; Zhang H; Xing S; Hu L J; Zhao W F; Xie B; Li M Z; Zeng B H; Li Y;Zeng M S*, Sp1 and c-Myc regulate transcription of BMI1 in nasopharyngeal carcinoma.FEBS J, 2013,280(12):2929-44.Zou Q F; Du JK; Zhang H; Wang H B; Hu Z D; Chen S P; Du Y; Li M Z; Xie D; Zou J; Sun H D; Pu J X*;Zeng M S*, Anti-tumour activity of longikaurin A (LK-A), a novel natural diterpenoid, in nasopharyngeal carcinoma.J Transl Med, 2013,11:200.Xu F H; Xiong D; Xu Y F; Cao S M; Xue W Q; Qin H D; Liu W S; Cao J Y; Zhang Y; Feng Q S; Chen L Z; Li M Z; Liu Z W; Liu Q; Hong M H; Shugart Y Y; Zeng Y X;Zeng M S*; Jia W H*, An epidemiological and molecular study of the relationship between smoking, risk of nasopharyngeal carcinoma, and Epstein-Barr virus activation.J Natl Cancer Inst, 2012,104(18):1396-410.Guo B H; Feng Y; Zhang R; Xu L H; Li M Z; Kung H F; Song L B;Zeng M S*, Bmi-1 promotes invasion and metastasis, and its elevated expression is correlated with an advanced stage of breast cancer.Mol Cancer, 2011,10(1):10.Guo B H; Zhang X; Zhang H Z; Lin H L; Feng Y; Shao J Y; Huang W L; Kung H F;Zeng M S*, Low expression of Mel-18 predicts poor prognosis in patients with breast cancer.Ann Oncol, 2010, 21(12):2361-2369.Kong Q L; Hu L J; Cao J Y; Huang Y J; Xu L H; Liang Y; Xiong D; Guan S; Guo B H; Mai H Q; Chen Q Y; Zhang X; Li M Z; Shao J Y; Qian C N; Xia Y F; Song L B; Zeng Y X;Zeng M S*, Epstein-Barr virus-encoded LMP2A induces an epithelial-mesenchymal transition and increases the number of side population stem-like cancer cells in nasopharyngeal carcinoma.PLoS Pathog, 2010,6(6):e1000940.Cao J Y; Liu L; Chen S P; Zhang X; Mi Y J; Liu Z G; Li M Z; Zhang H; Qian C N; Shao J Y; Fu L W; Xia Y F*;Zeng M S*, Prognostic significance and therapeutic implications of centromere protein F expression in human nasopharyngeal carcinoma.Mol Cancer, 2010,9:237.Song L B; Li J; Liao W T; Feng Y; Yu C P; Hu L J; Kong Q L; Xu L H; Zhang X; Liu W L; Li M Z; Zhang L; Kang T B; Fu L W; Huang W L; Xia Y F; Tsao S W; Li M; Band V; Band H; Shi Q H*; Zeng Y X*;Zeng M S*, The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells.J Clin Invest, 2009,119(12):3626-36.Liao W T; Song L B; Zhang H Z; Zhang X; Zhang L; Liu W L; Feng Y; Guo B H; Mai H Q; Cao S M; Li M Z; Qin H D; Zeng Y X;Zeng M S*, Centromere protein H is a novel prognostic marker for nasopharyngeal carcinoma progression and overall patient survival.Clin Cancer Res, 2007,13(2 Pt 1):508-14.Song L B;Zeng M S*; Liao W T; Zhang L; Mo H Y; Liu W L; Shao J Y; Wu Q L; Li M Z; Xia Y F; Fu L W; Huang W L; Dimri G P; Band V; Zeng Y X, Bmi-1 is a novel molecular marker of nasopharyngeal carcinoma progression and immortalizes primary human nasopharyngeal epithelial cells.Cancer Res, 2006,66(12):6225-32.Jiang R C; Qin H D;Zeng M S(co-first author); Huang W; Feng B J; Zhang F; Chen H K; Jia W H; Chen L Z; Feng Q S; Zhang R H; Yu X J; Zheng M Z; Zeng Y X*, A functional variant in the transcriptional regulatory region of gene LOC344967 cosegregates with disease phenotype in familial nasopharyngeal carcinoma.Cancer Res, 2006,66(2):693-700.Zeng M; Zhang Y; Bhat I; Wazer D E; Band H; Band V*, The human kallikrein 10 promoter contains a functional retinoid response element.Biol Chem, 2006,387(6):741-7.Zeng M S; Li D J; Liu Q L; Song L B; Li M Z; Zhang R H; Yu X J; Wang H M; Ernberg I; Zeng Y X*, Genomic sequence analysis of Epstein-Barr virus strain GD1 from a nasopharyngeal carcinoma patient.J Virol, 2005,79(24):15323-30.Zeng M; Kumar A; Meng G; Gao Q; Dimri G; Wazer D; Band H; Band V*, Human papilloma virus 16 E6 oncoprotein inhibits retinoic X receptor-mediated transactivation by targeting human ADA3 coactivator.J Biol Chem, 2002,277(47):45611-8

國際EB病毒及相關(guān)疾病協(xié)會(huì)理事會(huì)成員（2012－2014）

中國抗癌協(xié)會(huì)理事

中國抗癌協(xié)會(huì)腫瘤微環(huán)境專業(yè)委員會(huì)副主任委員（2019-）

中國抗癌協(xié)會(huì)腫瘤標(biāo)志專業(yè)委員會(huì)副主任委員 （2016-）

中國抗癌協(xié)會(huì)腫瘤轉(zhuǎn)移專業(yè)委員會(huì)常務(wù)委員 （2017-）

廣東省抗癌協(xié)會(huì)秘書長

Scientific Data雜志編委（2014-）

Cancer communication雜志編委