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  • 殷燕

    殷燕(殷燕)

    殷燕,女,現(xiàn)任上海應(yīng)用技術(shù)大學(xué)副教授。


    人物經(jīng)歷

    1998年本科畢業(yè)于四川大學(xué)化學(xué)系,后分配到山東省德州學(xué)院任教,2001年考入上海有機(jī)化學(xué)研究所,2007年到美國(guó)的Emory大學(xué)進(jìn)行博士后研究,同年8月轉(zhuǎn)到美國(guó)Scripps研究所,2011年進(jìn)入上海應(yīng)用技術(shù)學(xué)院。

    社會(huì)學(xué)術(shù)團(tuán)體兼職

    (1)?Letter in organic chemistry (SCI, IF=0.8)的常邀審稿專家;?

    (2)?上海市教育評(píng)估院的評(píng)審專家。?

    科研方向

    教授課程

    主講的研究生課程有《現(xiàn)代制藥工程實(shí)驗(yàn)》。

    殷燕

    研究方向

    實(shí)驗(yàn)室綜合運(yùn)用計(jì)算機(jī)輔助藥物設(shè)計(jì)、化學(xué)合成、活性測(cè)試、代謝研究等方法開發(fā)抗流感病毒、降血脂、抗心血管疾病、抗癌癥的小分子藥物,同時(shí)也對(duì)雜環(huán)化合物的構(gòu)建方法學(xué)進(jìn)行研究。

    在研項(xiàng)目

    (1)“高活性的、ROCK2/1亞型選擇性的ROCK2抑制劑的設(shè)計(jì)與合成研究”,2016年國(guó)家自然基金,負(fù)責(zé)人

    (2)?u2018“可再生燃料電池用一體化雙功能催化劑的開發(fā)”,上海市科促會(huì)2016年聯(lián)盟計(jì)劃,負(fù)責(zé)人。

    (3)“3,3u2019-聯(lián)二噻吩衍生物的合成及其應(yīng)用研究”,2016年上海市分子催化和功能材料重點(diǎn)實(shí)驗(yàn)室研究基金,負(fù)責(zé)人?。

    (4)“含氟Limk1抑制劑的設(shè)計(jì)、合成及應(yīng)用研究”, 2017年中國(guó)科學(xué)院有機(jī)氟化學(xué)重點(diǎn)實(shí)驗(yàn)室開放基金,負(fù)責(zé)人。

    (5) “基于“應(yīng)用型”本科人才培養(yǎng)的《高分子材料基礎(chǔ)》課程教學(xué)改革的探索與實(shí)踐”, 2015年上海應(yīng)用技術(shù)學(xué)院校級(jí)教改項(xiàng)目,負(fù)責(zé)人。

    (6) “關(guān)于提高學(xué)術(shù)學(xué)位研究生創(chuàng)新能力的探索與實(shí)踐”,2016年上海應(yīng)用技術(shù)學(xué)院研究生教改項(xiàng)目,負(fù)責(zé)人。

    ?(7)“阿司匹林的制備及其質(zhì)量控制”,2016年校企合作實(shí)驗(yàn)項(xiàng)目,負(fù)責(zé)人

    (8)“大學(xué)生科創(chuàng)與制藥工程專業(yè)應(yīng)用型人才培養(yǎng)模式研究”,2016年上海應(yīng)用技術(shù)大學(xué)高教課題,負(fù)責(zé)人

    著述成果

    已在JMC、JOC、Dyes and Pigments、Acs Med. Chem. Lett. Synthesis、BMC、BMCL、Tetrehedron、JFC、Chin. J. Chem.、Heterocycles 、synth. Commun.、J. Heterocycl. Chem.等國(guó)際著名期刊上發(fā)表SCI論文30多篇,申請(qǐng)專利20多項(xiàng),授權(quán)4項(xiàng)。在美國(guó)化學(xué)會(huì)國(guó)際大會(huì)、國(guó)際氟化學(xué)大會(huì)等會(huì)議上發(fā)表論文10多篇。累計(jì)主持國(guó)家級(jí)、省部級(jí)和校級(jí)研究項(xiàng)目20余項(xiàng)。

    代表性論文

    (1)?Fengkai Cheng, Yan Yin*, Guozhen Zhang,*, Yuan Wang, Wei Deng, Fanhong Wu “Optoelectronic and thermal properties of highly fluorescence emissive 2,2u2019-distyryl-[3,3’]-bithiophenes “ Dyes and pigments 2017, 140, 222-228 (SCI, IF = 4.0).

    (2) Ruihong Tao, Yan Yin*, Yongbin Duan, Yuxing Sun, Yue Sun, ?Fengkai Cheng, Jinpeng Pan, Chen Lu, Yuan Wang Tetrahedron 2017,10.1016/j.tet.2017.02.030?(SCI, IF = 2.6)

    (3)Zhao Zhao, Jiaxin Cui, Yan Yin,*?Heng Zhang, Yecheng Liu, Rui Zeng, Chao Fang, Zhenpeng Kai, Zhonghua Wang,* Fanhong Wua* “Synthesis and biological evaluation of gem-difluoromethylenated statin derivatives as highly potent HMG-CoA reductase inhibitors Chin. J. Chem. 2016, 34, 801-808(SCI, IF = 1.9).

    (4) Guofeng Sun, Fengkai Cheng, Ruiheng Tao, Yuxing Sun, Jinpeng Pang, Zhonghua, Yaohua Zhu, Zhonghua Wang, Fanhong Wu, Yan Yin*?“Superacid- catalyzed Tandem Meyer-Schuster Rearrangement/Intramolecular Hydroamination of o-Aniliopropargy Alcohols to Synthesize 2, 3-Dihydro-4(1H)-quinolones” Synth. Commun. 2016, 46,1249-1256 (SCI, IF = 1.0).

    (5) Yan Yin, Ke Zheng, Nibal Eid, Shannon Howard, Ji-Hak Jeong, Fei Yi, Jia Guo, Chui Min Park, ?Mathieu Bibian, Weilin Wu, Pamela Hernandez, HaJeung Park, Yuntao Wu, Jun-Li Luo, Philip V. Lograsso, Yangbo Feng “Bis-aryl derivatives as potent and selective Lim kinase inhinitors” J. Med. Chem. 2015, 58, 1846-1861. (SCI, IF = 5.6)

    (6) Mei Ding, Yan Yin*, Fanhong Wu, Jiaxing Cui, Hong Zhou, Guofeng Sun, Yu Jiang, Yangbo Feng* “Discovery of potent and selective urea-based ROCK inhibitors: Exploring the inhibitoru2019s potency and ROCK2/PKA selectivity by 3D-QSAR, molecular docking and molecular dynamics simulations” Bioorg. Med. Chem. 2015, 23, 2505-2517 (SCI, IF = 2.9).

    (7) Jiaxin Cui, Mei Ding,Yan Yin*, Wei Deng, Zhonghua Wang, Yu Jiang, Hong Zhou, Guofeng Sun, Yangbo Feng “Discovery of bis-ary urea derivatives as potent and selective Limk inhibitors: Exploring Limk1 activity and Limk1/ROCK2 selectivity through computational studies” Bioorg. Med. Chem. 2015, 23, 7464-7477 (SCI, IF = 2.9)

    (8) Yan Yin*, Hong Zhou, Xichen Liu, Haiying Chen, Fanhong Wu, Heng Zhang, Ruiheng Tao, Fengkai Cheng, Yangbo Feng“A Metal-Free and Recyclable Synthesis of Benzothiazoles using Thiourea as a Sulfur Surrogate”Tetrahedron Lett, 2015,?56, 1709-1712. (SCI, IF = 2.4)

    (9) Yan Yin*, Hong Zhou, Guofeng Sun, Xichen Liu“m-CPBA Mediated Intramolecular Aminohydroxylation of N-Sulfonyl Aminoalkenes to Synthesize β-hydroxyl Cyclic Amines ”Journal of Heterocyclic Chemistry?2015, 1337-1345 (SCI, IF = 0.8)

    (10) Yan Yin*, Guo-Feng Sun, Heng Zhang, Hong Zhou, Fan-Hong, Wu “Enatioselective Chalcogeno-Baylis-Hillman Reaction of Benzaldehydes with MVK and Acrylates Catalyzed by Chiral Thiepin-TiCl4 Complex” Chin. J. Chem. 2014, 32, 365-369. (SCI, IF = 1.9)

    (11)Yan Yin; Li Lin; Claudia Ruiz; Susan Khan; Michael D Cameron; Wayne Grant; Jennifer Pocas; Nibal Eid; Hajeung Park; Thomas Schroeter; Philip V. LoGrasso; Yangbo Feng “Synthesis and Biological Evaluation of Urea Derivatives as Highly Potent and Selective Rho Kinase Inhibitors”J. Med. Chem.?2013, 56,3568-3581。(SCI, IF = 5.6)

    (12) Yan Yin, Michael D. Cameron, Li Lin, Susan Khan, Thomas Schr?ter, Wayne Grant, Jennifer Pocas, Yen Ting Chen, Stephan Sch?rer, Alok Pachori, Philip LoGrasso*, Yangbo Feng* “Discovery of Highly Potent and Selective Urea-based ROCK inhibitors and their effects on the intraocular pressure in rats” ACS Med. Chem. Lett. 2010, 1, 175-179. (SCI, IF = 3.2)

    (13) Yan Yin, Li Lin, Claudia Ruiz, Michael D. Cameron, Jennifer Pocas, Wayne Grant, Thomas Schr?ter, Weimin Chen, Derek Duckett, Stephan Sch?rer, Philip LoGrasso, Yangbo Feng* “Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors” Bioorg. Med. Chem. Lett. 2009, 19, 6686-6690. (SCI, IF = 2.4)

    (14) Yan Yin, Zhuo Chai, Wen-Ying Ma, Gang Zhao* “Synthesis of indoles via diethylzinc-mediated intramolecular hydroamination reaction of alkynyl sulfonamides” Synthesis?2008, 24, 4036-4040.

    (15) Yan Yin, Wenying Ma, Zhuo Chai, Gang Zhao* “Et2Zn-Catalyzed Intramolecular Hydroamination of Aminoalkynes and Tandem Cyclization/Nucleophilic Addition through the Indole Zinc Salt Intermediate” J. Org. Chem. 2007, 72, 5731-5736.

    (16) Yan Yin, Gang Zhao* “Heptadecafluorooctanesulfonic Acid (C8F17SO3H) Catalyzed Intramolecular Hydroamination of Olefinic Sulfonamides in Fluorous Biphase System (FBS)” J. Fluorine Chem. 2007, 128, 40-45.

    (17) Yan Yin, Gang Zhao*u2019”Perfluorous superacid C8F17SO3H-catalyzed intramolecular hydroamination reaction of N-protected 2-alkynylanilines: a novel synthetic method for indoles” Chimica Oggi-Chemistry Today?2007, 25, 42-45.

    (18) Yan Yin, Gang Zhao* “Synthesis of Indolines and Quinoline via Cyclization of N-Arylsulfonyl-2-allylanilines Catalyzed by Br?nsted Acid” Heterocycles?2006, 68, 23。

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