近五年來，先后在國際學(xué)術(shù)刊物《Current Medicinal Chemistry》、《International Journal of Cancer》、《Biochemical & Biophysical Research Communication》、《Bioorganic & Medicinal Chemistry》、《Bioorganic & Medicinal Chemistry Letters》、《Cancer Biology Therapy》、《European Journal of Medicinal Chemistry》、《Food Chemistry》、《Chemical & Pharmac eutical Bulletin》、《Acta Pharmacologica Sinica》等上發(fā)表SCI收錄論文32篇，其中第一作者（含通訊作者）19篇，IF >3.0的16篇，IF >4.5的2篇�，F(xiàn)擔(dān)任國際學(xué)術(shù)刊物《European Journal of Medicinal Chemistry》、《Applied Biochemistry and Biotechnology》和《Letters in Drug Design and Discovery》審稿人。

· 1989.9－1993.6 湖南師范大學(xué)生命科學(xué)學(xué)院生物學(xué)系 學(xué)士

· 1993.9－1996.6 武漢大學(xué)生命科學(xué)學(xué)院病毒學(xué)系 碩士

· 2001.9－2004.6 中山大學(xué)生命科學(xué)學(xué)院生物化學(xué)系 博士

· 1996.7－2000.11 珠海金沙制藥有限公司藥物研究所

· 2000.12－2001.3 深圳云大科技實(shí)業(yè)開發(fā)有限公司技術(shù)部 項(xiàng)目經(jīng)理

· 2001.4－2001.8 深圳創(chuàng)新慧生物技術(shù)開發(fā)有限公司 項(xiàng)目經(jīng)理

· 2004.8－2007.11 中山大學(xué)化工學(xué)院/新疆華世丹藥物研究有限公司 博士后

· 2007.12－至今 中山大學(xué)化學(xué)與化學(xué)工程學(xué)院有機(jī)研究所 副教授

目前主講本科生必修課程《細(xì)胞生物學(xué)》、研究生必修課程《結(jié)構(gòu)生物學(xué)》�！痘�礎(chǔ)有機(jī)化學(xué)實(shí)驗(yàn)》《綜合化學(xué)實(shí)驗(yàn)》-化學(xué)生物學(xué)專題實(shí)驗(yàn)。

主要從事天然來源活性單體的分子設(shè)計(jì)、化學(xué)合成、活性篩選及分子機(jī)理等研究。曾主持或參與鹽酸氮卓斯汀、羅格列酮、格列美脲、纈沙坦、伊貝沙坦、坎地沙坦酯等多個(gè)國家二類和四類新藥的成功開發(fā)，主持并完成了 中國博士后科學(xué)基金項(xiàng)目《去氫駱駝蓬堿結(jié)構(gòu)改造與抗腫瘤構(gòu)效關(guān)系的初步研究》、中山大學(xué)有害生物防治與資源利用 國家重點(diǎn)實(shí)驗(yàn)室開放式課題《去氫駱駝蓬堿衍生物抗腫瘤作用機(jī)理初步研究》。

1. 基于拓?fù)洚悩?gòu)酶I靶點(diǎn)的新型抗腫瘤化合物β-咔啉堿的優(yōu)化設(shè)計(jì)、合成及構(gòu)效關(guān)系研究 （項(xiàng)目負(fù)責(zé)人 教育部高等學(xué)校青年培育項(xiàng)目 2009.1-2011.12）

2. 新型拓?fù)洚悩?gòu)酶I抑制劑β-咔啉堿的分子設(shè)計(jì)與生物活性研究 （項(xiàng)目負(fù)責(zé)人 教育部博士點(diǎn)基金新教師基金 2011.1-2013.12）

3. 基于魚腥草素結(jié)構(gòu)優(yōu)化的新型抗菌藥物研究 （項(xiàng)目負(fù)責(zé)人 廣東省科技計(jì)劃項(xiàng)目 2010.1-2012.12）

4. 高性能氯化聚丙烯改性樹脂的研發(fā) （項(xiàng)目負(fù)責(zé)人 廣東省科技廳省部產(chǎn)學(xué)研項(xiàng)目 2009.1－2010.12）

5. 去氫駱駝蓬堿結(jié)構(gòu)改造與抗腫瘤構(gòu)效關(guān)系研究 （項(xiàng)目負(fù)責(zé)人 中國博士后科學(xué)基金 2005.1－2007.12）

6. 香豆素衍生物構(gòu)效關(guān)系研究 （項(xiàng)目負(fù)責(zé)人 企業(yè)橫向課題 2009.9 -2010.10）

7. 去氫駱駝蓬堿結(jié)構(gòu)改造與抗腫瘤構(gòu)效關(guān)系研究 （項(xiàng)目負(fù)責(zé)人 企業(yè)橫向課題 2008.1-2008.12）

1. Chunming Ma, Rihui Cao*, Buxi Shi, Xiantai Zhou, Qin Ma, Jie Sun, Liang Guo, Wei Yi, Zhiyong Chen, Huacan Song*. Synthesis and cytotoxic evaluation of 1-carboxamide and 1-amino side chain substituted β-carbolines. European Journal Medicinal Chemistry. 2010, 45, 5513-5519. （通訊作者,SCI收錄，IF=3.269）.

2. Zhiyong Chen, Rihui Cao*, Liang Yu, Buxi Shi, Jie Sun, Liang Guo, Qin Ma, Wei Yi, Xiao Song, Huacan Song*. Synthesis, cytotoxic activities and DNA binding properties of β-carboline derivatives. European Journal Medicinal Chemistry. 2010, 45, 4740-4745. （通訊作者,SCI收錄，IF=3.269）.

3. Liang Yu, Rihui Cao, Wei Yi, Qin Yan, Zhiyong Chen, Lin Ma, Huacan Song. Design, synthesis and evaluation of difunctionalized 4-hydroxybenzaldehyde derivatives as novel cholinesterase inhibitors. Chemical & Pharmaceutical Bulletin. 2010, 58 （9）, 1216-1220. （SCI收錄，IF=1.698 ）.

4. Zhiyong Chen, Rihui Cao*, Buxi Shi, Wei Yi, Liang Yu, Huacan Song*, Zhenhua Ren, Wenlie Peng. Synthesis of novel β-carbolines with efficient DNA-binding capacity and potent cytotoxicity. Bioorganic & Medicinal Chemistry Letters. 2010, 20, 3876-3879. （通訊作者,SCI收錄，IF=2.650）.

5. Liang Yu, Rihui Cao, Wei Yi, Qin Yan, Zhiyong Chen, Lin Ma, Wenlie Peng, Huacan Song*. Synthesis of 4-[（diethylamino）methyl]-phenol derivatives as novel cholinesterase inhibitors with selectivity towards butyrylcholinesterase. Bioorganic & Medicinal Chemistry Letters. 2010, 20, 3254-3258. （SCI收錄，IF=2.650）.

6. Wei Yi, Rihui Cao, Zhiyong Chen, Liang Yu, Huan Wen, Qin Yan, Lin Ma and Huacan Song*. Rational Design and Synthesis of 4-O-Substituted Phenylmethylene thiosemicarbazones as Novel Tyrosinase Inhibitors. Chemical & Pharmaceutical Bulletin. 2010, 58, 752-754. （SCI收錄，IF=1.698 ）.

7. Zhiyong Chen, Rihui Cao, Buxi Shi, Wei Yi, Liang Yu, Huacan Song*, Zhenhua Ren*. Synthesis and Biological Evaluation of Novel β-Carbolines as Potent Cytotoxic and DNA Intercalating Agents. Chemical & Pharmaceutical Bulletin. 2010, 58 （7）, 901-907. （SCI收錄，IF=1.698 ）.

8. Rihui Cao*, Xiangdong Guan, Buxi Shi, Zhiyong Chen, Zhenhua Ren, Wenlie Peng, Huacan Song. Design, synthesis and 3D-QSAR of β-carboline derivatives as potent antitumor agents. European Journal Medicinal Chemistry. 2010, 45 （6） 2503-2515. （通訊作者,SCI收錄，IF=3.269）.

9. Chunming Ma, Rihui Cao*, Buxi Shi, Shaoxue Li, Zhiyong Chen, Wei Yi, Wenlie Peng, Zhenhua Ren, Huacan Song*. Synthesis and cytotoxic evaluation of N2-benzylated quaternary β-carboline amino acid ester conjugates. European Journal Medicinal Chemistry. 2010, 45：1515-1523. （通訊作者,SCI收錄，IF=3.269）.

10. Wei Yi, Rihui Cao*, Wenlie Peng, Huan Wen, Qin Yan, Binhua Zhou, Lin Ma, Huacan Song*. Synthesis and biological evaluation of novel 4-hydroxybenzaldehyde derivatives as tyrosinase inhibitors. European Journal Medicinal Chemistry. 2010, 45，639-646. （通訊作者,SCI收錄，IF=3.269）.

11. Wei Yi, Rihui Cao, Zhiyong Chen, Liang Yu, Lin Ma, Huacan Song*. Design, synthesis and biological evaluation of hydroxy- or methoxy-substituted phenylmethylene thiosemicarbazones?as tyrosinase inhibitors. Chemical & Pharmaceutical Bulletin. 2009, 57, 1273-1277. （SCI收錄，IF=1.698 ）.

12. Wei Yi, Rihui Cao*, Huan Wen, Qin Yan, Binhua Zhou, Lin Ma, Huacan Song*. Discovery of 4-functionalized phenyl-O-β-D-glycosides as a new class of mushroom tyrosinase inhibitors. Bioorganic & Medicinal Chemistry Letters. 2009, 19, 6157-6160. （通訊作者,SCI收錄，IF=2.650）.

13. Qin Yan, Rihui Cao*, Wei Yi, Liang Yu, Zhiyong Chen, Lin Ma, Huacan Song*. Synthesis and evaluation of 5-benzylidene（thio）barbiturate-β-D-glycosides as mushroom tyrosinase inhibitors. Bioorganic & Medicinal Chemistry Letters. 2009, 19, 4055-4058. （通訊作者,SCI收錄，IF=2.650）.

14. Qin Yan, Rihui Cao*, Wei Yi, Zhiyong Chen, Huan Wen, Lin Ma, Huacan Song*. Inhibitory effects of 5-benzylidene barbiturate derivatives on mushroom tyrosinase and their antibacterial activities. European Journal Medicinal Chemistry. 2009, 44, 4235-4243. （通訊作者,SCI收錄，IF=3.269）.

15. Yi Wei, Xiaoqin Wu, Rihui Cao, Huacan Song, Lin Ma*. Biological evaluations of novel vitamin C esters as mushroom tyrosinase inhibitors and antioxidants. Food Chemistry. 2009, 117, 381-386. （SCI收錄，IF=3.146 ）.

16. Jinbing Liu, Rihui Cao*, Wei Yi, Chunming Ma, Yiqian Wan, Binhua Zhou, Lin Ma, Huacan Song*. A class of potent tyrosinase inhibitors: Alkylidene thiosemicarbazide?compounds. European Journal Medicinal Chemistry. 2009, 44: 1773-1778. （通訊作者,SCI收錄，IF=3.269）.

17. Wei Yi, Rihui Cao*, Huan Wen, Qin Yan, Binhua Zhou, Yiqian Wan, Lin Ma, Huacan Song*. Synthesis and biological evaluation of helicid analogues as mushroom tyrosinase inhibitors. Bioorganic & Medicinal Chemistry Letters. 2008, 18: 6490-6493. （通訊作者,SCI收錄，IF=2.650）.

18. Jinbing Liu, Rihui Cao, Qifeng Wu, Chunming Ma, Zihou Wang, Wenlie Peng, Huacan Song*. Synthesis and antibacterial evaluation of novel 4-alkyl substituted phenyl β-aldehyde ketone derivatives. European Journal Medicinal Chemistry. 2009, 44: 1737-1744. （SCI收錄，IF=3.269）.

19. Qifeng Wu, Rihui Cao*, Manxiu Feng, Xiangdong Guan, Chunming Ma, Jinbing Liu, Huacan Song, Wenlie Peng*. Synthesis and in vitro cytotoxic evaluation of novel 3,4,5-trimethoxyphenyl substituted β-carboline derivatives. European Journal Medicinal Chemistry. 2009, 44, 533-540. （通訊作者，SCI收錄，IF=3.269）.

20. Rihui Cao*, Wei Yi, Qifeng Wu, Xiangdong Guan, Manxiu, Feng, Chunming Ma, Zhiyong Chen, Huacan Song, Wenlie Peng*. Synthesis and cytotoxic activities of 1-benzylidine substituted β-carboline derivatives. Bioorganic & Medicinal Chemistry Letters. 2008, 18 : 6558-6561. （通訊作者，SCI收錄，IF=2.650）.

21. Rihui Cao, Wenlie Peng, Zihou Wang，Anlong Xu*. β-Carboline alkaloids: Biochemical & pharmacological functions. Current Medicinal Chemistry. 2007, 14 : 479-500. （SCI收錄，IF=4.708）.

22. Rihui Cao, Wenlie Peng, Hongsheng Chen，Yan Ma, Xiaodong Liu, Xuerui Hou, Huaji Guan, Wenlie Peng, Anlong Xu*. DNA binding properties of 9-substituted harmine derivatives. Biochemical and Biophysical Research Communication. 2005, 338: 1157-1563. （SCI收錄，IF=2.548）.

23. Rihui Cao, Wenlie Peng, Hongsheng Chen, Xuerui Hou, Huaji Guan, Qi Chen, Yan Ma, Anlong Xu*. Synthesis and in vitro cytotoxic evaluation of 1,3-bisubstituted and 1,3,9-trisubstituted beta-carboline derivatives. European Journal Medicinal Chemistry. 2005, 40: 249 -257. （SCI收錄，IF=3.269）.

24. Rihui Cao, Qi Chen, Xuerui Hou, Hongsheng Chen, Huaji Guan, Yan Ma, Wenlie Peng, Anlong Xu*. Synthesis, acute toxicities and antitumor effects of novel 9-substituted β-carboline derivatives. Bioorganic & Medicinal Chemistry. 2004, 12: 4613- 4623. （SCI收錄，IF=2.822）.

25. Rihui Cao, Hongsheng Chen, Wenlie Peng, Yan Ma, Xuerui Hou, Huaji Guan, Xiaodong Liu, Anlong Xu*. Design, synthesis and in vitro and in vivo antitumor activities of novel β-carboline derivatives. European Journal Medicinal Chemistry. 2005, 40: 991-1001. （SCI收錄，IF=3.269）.

26. Qi Chen, Rihui Chao, Hongsheng Chen, Xuerui Hou, Huifang Yan, Shufeng Zhou, Wenlie Peng, Anlong Xu*. Antitumor and neurotoxic effects of novel harmine derivatives and structure-activity relationship analysis. International Journal of Cancer, 2004, 114 : 675-682 （并列第一作者, SCI收錄，IF=4.722）.

27. Jing Zhang, Yan Li, Liang Guo, Rihui Cao, Pei Zhao, Wei Jiang, Qin Ma, Hong Yi, Zhuorong Li, Jiandong Jiang, Jialin Wu, Yanchang Wang, Shuyi Si*. DH166, a beta-carboline derivative, inhibits the kinase activity of PLK1. Cancer Biology Therapy. 2009, 8: 2374-2383. （SCI收錄，IF=2.711）.

28.Yan Li, Fengshan Liang, Wei Jiang, Fusheng Yu, Rihui Cao, Qinghe Ma, Xiuyong Dai, Jiandong Jiang, Yanchang Wang*, Shuyi Si*. DH334, a β-carboline anti-cancer drug, inhibits the CDK activity of budding yeast. Cancer Biology Therapy. 2007, 6: 1193-1199. （SCI收錄，IF=2.711）.

29. Huaji Guan, Hongsheng Chen, Wenlie Peng, Yan Ma, Rihui Cao, Xiaodong Liu, Anlong Xu*. Design of β-carboline derivatives as DNA-targeting antitumor agents. European Journal Medicinal Chemistry. 2006, 41:1167-1179. （SCI收錄，IF=3.269）.

30. Huaji Guan, Xiaodong Liu, Wenlie Peng, Rihui Cao, Yan Ma, Hongsheng Chen, Anlong Xu*. β-carboline derivatives－Novel photosensitizers that intercalate into DNA to cause direct DNA damage in photodynamic therapy. Biochemical and Biophysical Research Communication. 2005, 342: 894-901. （SCI收錄，IF=2.548）.

31. Xue-rui HOU, Qi CHEN, Ri-hui CAO, Wen-lie PENG, An-long XU*. A comparative molecular field analysis of cytotoxic beta-carboline analogs. Acta Pharmacologica Sinica. 2004；25 （7）: 959-965. （SCI收錄，IF=1.783）.

32. Huan Wen, Chonglan Lin, Ling Que, Hui Ge, Lin Ma, Rihui Cao, Yiqian Wan, Wenlie Peng, Zihou Wang, Huacan Song*. Synthesis and biological evaluation of helicid analogues as novel acetylcholinesterase inhibitors. European Journal of Medicinal Chemistry 2008, 43: 166-173. （SCI收錄，IF=3.269）.