人物經(jīng)歷
魏志毅博士，2007年畢業(yè)于中國(guó)科學(xué)技術(shù)大學(xué)，獲博士學(xué)位；隨后赴美國(guó)University of Washington進(jìn)行博士后研究；2009年至2013年，在香港科技大學(xué)擔(dān)任研究助理教授；2013年10月加入南方科技大學(xué)。魏博士長(zhǎng)期活躍于結(jié)構(gòu)生物學(xué)研究領(lǐng)域，主要利用結(jié)構(gòu)生物學(xué)研究手段，并結(jié)合生物化學(xué)和生物物理學(xué)的各種技術(shù)來研究大腦中神經(jīng)發(fā)育的分子機(jī)制以及蛋白質(zhì)分子機(jī)器的組裝機(jī)制和靶點(diǎn)識(shí)別機(jī)制，力圖從原子分辨率水平來解析腦功能、解釋腦疾病，為治療腦疾病提供理論基礎(chǔ)。相關(guān)研究成果得到國(guó)際同行的廣泛認(rèn)可，2009年以來，發(fā)表在《Nature》、《Science》、《Cell》、《Molecular Cell》、《Nature Structural & Molecular Biology》、《PNAS》等國(guó)際學(xué)術(shù)期刊上的論文總數(shù)超過20篇，包括第一作者文章8篇，通訊作者文章3篇。
研究領(lǐng)域
神經(jīng)發(fā)育的分子機(jī)制與相關(guān)疾病致病機(jī)理
細(xì)胞膜功能區(qū)的組裝機(jī)制
細(xì)胞內(nèi)物質(zhì)運(yùn)輸?shù)姆肿訖C(jī)制
蛋白質(zhì)分子機(jī)器
主要榮譽(yù)
2016年，廣東省特支計(jì)劃青年拔尖人才
2011 u2013 2013年，田家炳冠名研究員，香港科技大學(xué)高等研究院
2007年，優(yōu)秀畢業(yè)生，中國(guó)科學(xué)技術(shù)大學(xué)
出版著作
(* 共同第一作者，#通訊作者)
Wei ZY,Xu Z,Liu X,Lo WS,Ye F,Lau CF,Wang F,Zhou JJ,Nangle LA,Yang XL,Zhang M,Schimmel P, Alternative splicing creates two new architectures for human tyrosyl-tRNA synthetase.Nucleic Acids Res.2016 , 44(3):1247-55. Epub 2016 Jan 14
Wei ZY,Li Y,Ye F,Zhang M, Structural basis for the phosphorylation-regulated interaction between the cytoplasmic tail of cell polarity protein crumbs and the actin-binding protein moesin.J Biol Chem.2015, 290(18):11384-92. Epub 2015 Mar 19
Zhao HT, Sheng G, Wang J, Wang M, Bunkoczi G, Gong WM,Wei ZY#, Wang YL#. Crystal structure of the RNA-guided immune surveillance Cascade complex in Escherichia coli.Nature. 515:147-150 (2014)
Li YJ*,Wei ZY*, Yan Y, Wan Q, Du QS, Zhang MJ. Structure of Crumbs tail in complex with the PALS1 PDZ-SH3-GK tandem reveals a highly specific assembly mechanism for the apical Crumbs complex.Proc Natl Acad Sci USA.111:17444-17449. (2014)
Wang C*,Wei ZY*, Chen KY, Ye F, Yu C, Bennett V, Zhang MJ. Structural basis of diverse membrane target recognitions by ankyrins.Elife. 3. (2014)
Wei ZY#, Liu XT, Yu C, Zhang MJ#. Structural basis of cargo recognitions for class V myosins.Proc Natl Acad Sci USA.110: 11314-11319. (2013)
Wang C, Yu C, Ye F,Wei ZY#, Zhang MJ#. Structure of the ZU5-ZU5-UPA-DD tandem of ankyrin-B reveals interaction surfaces necessary for ankyrin function.Proc Natl Acad Sci USA. 109:4822-4827 (2012)
Wei ZY, Zheng SL, Spangler SA, Yu C, Hoogenraad C, Zhang MJ. Liprin-mediated large signaling complex organization revealed by the liprin-α/CASK and liprin-α/liprin-β complex structures.Mol Cell. 43:586-598 (2011)
Wei ZY, Yan J, Lu Q, Pan LF, Zhang MJ. Cargo Recognition Mechanism of Myosin X Revealed by the Structure of its Tail MyTH4-FERM Tandem in Complex with the DCC P3 Domain.Proc Natl Acad Sci USA. 108:3572-3577 (2011)
Wu L, Pan LF,Wei ZY, Zhang MJ. Structure of MyTH4-FERM domains in myosin VIIa tail bound to cargo.Science. 331:757-60 (2011)
Liu W, Wen WY,Wei ZY, Yu J, Ye F, Liu CH, Hardie RC, Zhang MJ. The INAD scaffold is a dynamic, redox-regulated modulator of signaling in the Drosophila eye.Cell. 145:1088-1101 (2011)
Cheng ZH, Biechele T,Wei ZY, Morrone S, Moon RT, Wang LG, Xu WQ. Crystal structures of the extracellular domain of LRP6 and its complex with DKK1.Nat Struct Mol Biol. 18:1204-1210 (2011)
Wang R*,Wei ZY*, Jin H, Wu H, Yu C, Wen W, Chan LN, Wen ZL, Zhang MJ. Autoinhibition of UNC5b revealed by the cytoplasmic domain structure of the receptor.Mol Cell. 27: 692-703 (2009)
Yu C, Feng W,Wei ZY, Miyanoiri Y, Zhao YX, Zhang MJ. Myosin VI Undergoes Cargo-Mediated Dimerization.Cell. 138: 537-548 (2009)
