科研項(xiàng)目
曾主持和參加多項(xiàng)國(guó)家自然科學(xué)基金面上項(xiàng)目，美國(guó)NIH研究項(xiàng)目的工作，在Cell，Arteriosclerosis, Thrombosis, and Vascular Biology，Hypertension，Kidney International，Cell Research，American Journal of Physiology - Heart and Circulatory Physiology，Journal of Cerebral Blood Flow and Metabolism，The Journal of Neuroscience，Journal of Neurochemistry，Neuroscience，Neuroscience Letters，Experimental Neurology，Neuropharmacology，Brain Research，Acta Physiologica 等國(guó)際國(guó)內(nèi)著名雜志發(fā)表論文40余篇。參與研究生《Human Physiology》（人類生理學(xué)），《Ion channels》（離子通道學(xué)），《現(xiàn)代生理學(xué)進(jìn)展》和《高級(jí)生理學(xué)》等課程教學(xué)工作。
實(shí)驗(yàn)室主要運(yùn)用膜片鉗、細(xì)胞成像和生物化學(xué)等多種技術(shù)和方法研究骨骼肌、心肌、神經(jīng)細(xì)胞的鈣離子通道、細(xì)胞內(nèi)鈣釋放通道在人類疾病中的功能和調(diào)節(jié)作用。
代表性論文
1. Durham WJ*, Aracena-Parks P*, Long C*, Rossi AE, Goonasekera SA, Boncompagni S, Galvan DL, Gilman1 CP, Baker M, Shirokova N, Protasi F, Dirksen R, Hamilton SL. （2008） RyR1 S-Nitrosylation underlies environmental heat stroke and sudden death in Y522S RyR1 knock-in mice. Cell. 133: 53-65 （* 共同第一作者）。
2. Long C, Cook LG, Wu GY, Mitchell BM. （2007） Removal of FKBP12/12.6 from endothelial ryanodine receptors leads to an intracellular calcium leak and endothelial dysfunction. Arteriosclerosis, Thrombosis, and Vascular Biology. 27: 1580-1586.
3. Long C, Cook LG, Hamilton SL, Wu GY, Mitchell BM. （2007） FK506 binding protein 12/12.6 depletion increases endothelial nitric oxide synthase threonine 495 phosphorylation and blood pressure. Hypertension. 49: 569-576.
4. Long C, Yang L, Evans MS, Faingold CL. （2007） Excitatory amino acid receptor-mediated responses in periaqueductal gray neurons are increased during ethanol withdrawal. Neuropharmacology. 52: 802-811.
5. Long C, Chen MF, Sarwinskia S, Chen PY, Si ML, Hoffer BJ, Evans MS, Lee TJF. （2006） Monoamine uptake inhibitors block a7-nAChR-mediated cerebral nitrergic neurogenic vasodilation. American Journal of Physiology - Heart and Circulatory Physiology. 291: H202-H209.
