人物簡介
王玉田，加拿大皇家科學院院士�，F(xiàn)為青島大學神經(jīng)再生與康復(fù)研究院名譽院長，英屬哥倫比亞大學醫(yī)學系腦研究中心教授，青島院士港簽約院士。
主要研究神經(jīng)遞質(zhì)受體在神經(jīng)細胞內(nèi)轉(zhuǎn)運及膜表面動態(tài)表達和調(diào)節(jié)的分子機制及其在神經(jīng)系統(tǒng)疾病發(fā)生和發(fā)展中的作用。同時，還致力于將理論研究的突破應(yīng)用于臨床醫(yī)療實踐，尤其在學習和記憶障礙，以及腦卒中、癲癇、藥物成癮等疾病的藥物開發(fā)領(lǐng)域。王玉田院士團隊擁有強大的基礎(chǔ)研究，轉(zhuǎn)化和技術(shù)研發(fā)能力，在醫(yī)學-神經(jīng)科學領(lǐng)域發(fā)表了超過160篇文章，總引用數(shù)達12473次，h指數(shù)53。其中多篇文章發(fā)表在Science 、Nature、Cell、Neuron、Nature Neurosci、Nature Medicine、Nature Genetics等著名科學雜志上。曾獲加拿大聯(lián)邦及省政府等多項表彰，并于2002 和2006兩次獲得美國霍華德醫(yī)學院(HHMI) 國際研究學者。
教育背景
1988-1992：博士（神經(jīng)科學），加拿大紐芬蘭紀念大學醫(yī)學院
1982-1985：碩士（生理學），山東大學醫(yī)學院
1977-1982：學士（醫(yī)學），山東大學醫(yī)學院
工作經(jīng)歷
2017-至今：青島大學神經(jīng)再生與康復(fù)研究院，講席教授、榮譽院長
2006-至今：加拿大皇家科學院，院士
2005-至今：加拿大不列顛哥倫比亞大學，Killam教授
2004-至今：加拿大生理學會，J.A.F. Stevenson Lecturer
2002-至今：加拿大不列顛哥倫比亞大學，Distinguished University Scholar
2001-至今：加拿大不列顛哥倫比亞大學醫(yī)學系終生教授、BC & Y中風研究講席教授
2001-2011：美國霍華德休斯醫(yī)學研究所，國際研究員
2000-2001：加拿大多倫多大學醫(yī)學院實驗醫(yī)學和病理系，副教授
1994-2000：加拿大多倫多大學醫(yī)學院實驗醫(yī)學和病理學系，助理教授
1992-1994：加拿大多倫多大學醫(yī)學院，博士后
1985-1988：山東大學醫(yī)學院生理系，助教、講師
1981-1982：山東大學醫(yī)學院附屬醫(yī)院，實習醫(yī)師
2020- 至今：中科院深理工生命健康學院院長
學術(shù)兼職
2014 u2013至今：中華人民共和國國務(wù)院僑務(wù)辦公室海外專家咨詢委員
2007 u2013至今：長江教授海外評審專家
2002 u2013至今：中國科學院海外評審專家
2002 u2013至今：中國自然科學基金海外評審專家
創(chuàng)業(yè)經(jīng)歷
王玉田院士是加拿大NoNO Inc.制藥公司的六位聯(lián)合創(chuàng)始人之一。該公司于2003年成立于加拿大多倫多市。在王玉田院士等幾位公司創(chuàng)始人的共同努力下，NoNO Inc完成了對一個治療腦中風的一類創(chuàng)新短肽類特效專利藥物NA-1的融資和臨床一和二期的人體試驗工作，在2014年成功將其推入三期臨床人體試驗，并預(yù)計兩到三年之后可以將該藥物成功上市。
王玉田院士同時還是加拿大Primary Peptides制藥公司的三位聯(lián)合創(chuàng)始人之一。該公司于2013年成立于加拿大溫哥華市，擁有若干個全球保護的短肽類專利藥物和一項受專利保護的藥物開發(fā)新技術(shù)。該公司正在進行若干個專利藥物的臨床前期開發(fā)。
精選文章
1.Wang YT and MW Salter, Regulation of NMDA receptors by protein-tyrosine kinases and phosphatases, Nature, 369:233-235, 1994.
2. Wan Q, Xiong ZG, Man HY, Ackerley CA, Braunton J, Lu WY, Becker LE, MacDonald JF and YT Wang, Recruitment of functional GABAA receptors to postsynaptic domains by insulin, Nature, 388:686-690, 1997.
3. Wan Q, Man HY, Liu F, Niznik HB, Pang SF, Brown GM and YT Wang. Differential modulation of GABAA function by Mel1a and Mel1b receptors, Nature Neurosci., 2:401-403, 1999.
4. HY Man, J Lin, W Ju, G Ahmadian-Bahadorani, LE Becker, M Sheng and YT Wang, Regulation of AMPA receptor-mediated synaptic transmission by clathrin-dependent receptor internalization, Neuron, 25:649, 2000.
5. Liu F, Wan Q, Pristupa Z, Wang YT* and Niznik HB* (*equal corresponding authors) Direct protein-protein binding enables reciprocal dopamine D5 and GABAA receptor cross talk, Nature (Article), 403:274-280, 2000.
6. Lu WY, Man H, Trimble W, MacDonald JF and YT Wang, Activation of synaptic NMDA receptors induces LTP through insertion of AMPARs at excitatory synapses in cultured hippocampal neurons, Neuron, 29:243, 2001.
7. Man HY, QH Wang, WY Lu, G Ahmadian, S Du2019Souza, L Liu, W. Ju, LE Becker, MP Wymann, JF MacDonald, YT Wang, Activation of PI3-kinase is required for AMPA receptor insertion during LTP of mEPSCs in cultured hippocampal neurons, Neuron, 38:611-624, 2003.
8. Nong Y, YQ Huang, W Ju, LV Kalia, G Ahmadian, YT Wang*, MW Salter* (*equal corresponding authors), Glycine binding primes NMDA receptor internalization, Nature, 422:302-307, 2003.
9. Wang QH, LD Liu, L Pei, W Ju, G. Ahmadian, J Lu, YS Wang, F Liu, YT Wang, Control of synaptic strength, a novel function of Akt, Neuron, 38:915-928, 2003.
10. Ahmadian G, W Ju, LD Liu, A Dunah, M Wyszynski, M Sheng, YT Wang, Tyrosine phosphorylation of GluR2 is required for regulated AMPA receptor endocytosis and LTD, EMBO J, 23:1040-1050, 2004.
11. Collingridge GL, JTR Isaac, YT Wang, Receptor trafficking and synaptic plasticity, Nature Neurosci. Rev.5:952-962, 2004.
12. Liu L, TP Wong, MF Pozza, K Lingenhoehl, Y Wang, M Sheng, YP Auberson, YT Wang, Subtypes of NMDA receptors govern the direction of hippocampal synaptic plasticity, Science, 304:1021-1024, 2004.
13. Brebner K, TP Wong, L Liu, Y Liu, P Campsall, S Gray, L Phelps, AG Phillips*, YT Wang* (*equal corresponding authors), Nucleus Accumbens Long-Term Depression and the Expression of Behavioral Sensitization, Science, 310:1340-1343, 2005.
14. Liu Y, TP Wong, M Aarts, A Rooyakkers, L Liu, T Lai, DC Wu, J Lu, M Tymianski, AM Craig, YT Wang, NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo, J Neurosci, 27:2846-2857, 2007.
15. Wong TP, JG Howland, JM Robillard, Y Ge, W Yu, AK Titterness, K Brebner, L Liu, J Weinberg, BR Christie, AG Phillips, YT Wang. Hippocampal long-term depression mediates acute stress-induced spatial memory retrieval impairment, Proc Natl Acad Sci, 104:11471u201311476, 2007.
16. Peineau S, C Taghibiglou, C Bradley, TP Wong, L Liu, J Lu, E Lo, DC Wu, E Saule, T Bouschet, P Matthews,P Isaac, Z Bortolotto, YT Wang, G Collingridge, LTP inhibits LTD in the hippocampus via regulation via GSK3β, Neuron, 53: 703-717, 2007
17. Taghibiglou C, HGS Martin, TW Lai, T Cho, S Prasad, L Kojic, J Lu, Y Liu, E Lo, S Zhang, YP Li, JZZ Wu, YH，Wen, JH Imm, M Cynader and YT Wang, Role of NMDA receptor-dependent activation of SREBP1 in excitotoxic and ischemic neuronal injuries, Nature Medicine, 15:1399-1406, 2009.
18. Martin HGS and YT Wang, Blocking the Deadly Effects of the NMDA Receptor in Stroke, Cell 140:174, 2010.
19. Colligridge G, Peineau S, Howland JG and YT Wang, Long-Term Depression in the CNS, Nature Rev. Neurosci.,11:459-473, 2010.
20. Liu L, Wu DC and YT Wang, Allosteric potentiation of glycine receptor chloride channels by glutamate, Nature Neurosci., 13:1225-1235, 2010.
21. Lai T, and YT Wang, Fashioning drugs for stroke, Nature Medicine, 16:1376-1378, 2010.
22. Ge Y, ZF Dong, R Bagot, J Howland, A Phillips, TP Wong, and YT Wang, Hippocampal long-term depression is required for the consolidation of spatial memory, PNAS, 107:16697-16702, 2010.
23. Bartlett TE and YT Wang. Illuminating synapse-specific homeostatic plasticity, Neuron, 72(5):682-5, 2011.
24. Dong Z, B Gong, H Li, Y Bai, X Wu, Y Huang, W He, T Li, and YT Wang, Mechanisms of hippocampal long-term depression are required for memory enhancement by novelty exploration, J. Neurosci.,32:11980, 2012.
25. Xu, W, YC Tse, FA Dobie, M Baudry, AM Craig, TP Wong and YT Wang, Simultaneous monitoring of presynaptic transmitter release and postsynaptic receptor trafficking reveals an enhancement of presynaptic activity in metabotropic glutamate receptor-mediated long-term depression, J. Neurosci, 33:5867-5877, 2013.
26. Zhang S, C Taghibiglou, K Girling, Z Dong, SZ Lin, W Lee, WC Shyu, and YT Wang, Critical role of increased PTEN nuclear translocation in excitotoxic/ischemic neuronal injuries, J. Neurosci, 33:7997, 2013.
27. Fan X, Jin WY, Lu J, Wang J and YT Wang, Rapid and reversible knockdown of endogenous proteins by peptide-directed lysosomal degradation, Nature Neurosci., 17:471-480, 2014.
28. ZF Dong, HL Han, HJ Li, YR Bai, W Wang, M Tu, Y Peng, LM Zhou, WT He, XB Wu, T Tan, MJ Liu, XY Wu, WH Zhou, WY Jin, S Zhang, T Sacktor, TY Li, WH Song, YT Wang, Long-term potentiation decay and memory loss are mediated by AMPAR endocytosis, J. Clin. Invest., 125:234-247, 2015.
