一、研究方向：幽門螺桿菌耐藥機(jī)制；消化道菌群與健康

二、科研成果

（一）承擔(dān)課題

1、SpoT(ppGpp)調(diào)控幽門螺桿菌適應(yīng)抗生素壓力分子機(jī)制研究（81471991），國家自然基金面上項目，72萬，2015-2018。

2、壓力加重幽門螺桿菌胃炎分子機(jī)制研究（81671978），國家自然基金面上項目，70萬，2017-2020。

3、幽門螺桿菌SpoT基因適應(yīng)INF-γ表達(dá)調(diào)控機(jī)制研究（81071313），國家自然基金面上項目，32萬，2011-2013。

4、SpoT調(diào)控幽門螺旋桿菌氧應(yīng)激嚴(yán)謹(jǐn)應(yīng)答分子機(jī)制研究(30800037)，國家自然基金青年基金，20萬，2009-2011。

5、σ調(diào)控幽門螺桿菌平臺期氧損傷分子機(jī)制研究（中國博士后特別資助），10萬，2010-2011。

（二）發(fā)表論文（*：通訊作者，#：共同第一）

1、Sun Y, Zhang M, Chen CC, Gillilland M 3rd, Sun X, El-Zaatari M, Huffnagle GB, Young VB, Zhang J, Hong SC, Chang YM, Gumucio DL, Owyang C, Kao JY*. Stress-induced corticotropin-releasing hormone-mediated NLRP6 inflammasome inhibition and transmissible enteritis in mice. Gastroenterology. 144(7):1478-87, 1487.e1-8; 2013 Jun.（消化類雜志排名第一，IF=18.18）

2、Geng X, Li W, Chen Z, Gao S, Hong W, Ge X, Hou G, Hu Z, Zhou Y, Zeng B, Li W, Jia J,Sun Y*.Bifunctional enzyme SpoT is involved in the clarithromycin tolerance ofu2002Helicobacter pyloriu2002by up-regulating the transporters HP0939, HP1017, HP0497, and HP0471.Antimicrob Agents Chemother（微生物耐藥研究TOP期刊）. 2017 Feb 27. pii: AAC.02011-16. doi:10.1128/AAC.02011-16. [Epub ahead of print]

3、Zhekai Hu, Yu Zhang, Zhiyu Li, Yuedi Yu, Wenyan Kang, Yingnan Han, Xiwen Geng, Shaohua Ge*,Yundong Sun*.Effect of Helicobacter pylori infection on chronic periodontitis by the change of microecology and inflammation.Oncotarget.2016August 20.doi:10.18632/oncotarget.9573.

4、Yuqun Shan, Xingxiao Lu, Yingnan Han, Xinpeng Li, Xiao Wang, Chunhong Shao,Lixiang Wang, Zhifang Liu, Wei Tang,Yundong Sun*and Jihui Jia. Helicobacter pylori Outer Membrane Protein 18 (Hp1125) Is Involved in Persistent Colonization by Evading Interferon-γ Signaling.Biomed Res Int. 2015;2015:571280. doi:10.1155/2015/571280. Epub 2015 Apr6

5、Sun Y*, Liu S, Li W, Shan Y, Li X, Lu X, Li Y, Guo Q, Zhou Y, Jia J*. Proteomic analysis of the function of sigma factor σ54 in Helicobacter pylori survival with nutrition deficiency stress in vitro. PLoS One. 8(8):e72920;2013 Aug 28. doi: 10.1371

6、Sun Y, Li X, Li W, Zhao M, Wang L, Liu S, Zeng J, Liu Z, Jia J*. Proteomic analysis of the function of SpoT in Helicobacter pylori anti-oxidative stress in vitro and colonization in vivo. J Cell Biochem.113(11):3393-402; 2012 Nov.

7、Sun YD, Fu LD, Jia YP, Du XJ, Wang Q, Wang YH, Zhao XF, Yu XQ, Wang JX. A hepatopancreas-specific C-type lectin from the Chinese shrimp Fenneropenaeus chinensis exhibits antimicrobial activity. Mol Immunol. 2008 Jan;45(2):348-61. Epub 2007 Aug 6.

8、Sun YD, Zhao XF, Kang CJ, Wang JX. Molecular cloning and characterization of Fc-TSP from the Chinese shrimp Fennerpenaeus chinensis. Mol Immunol. 2006 Mar;43(8):1202-10. Epub 2005 Aug 18

9、Shao, Chunhong,Sun, Yundong, Wang, Na, Yu, Han, Zhou, Yabin, Chen, Chunyan, Jia, Jihui* Changes of proteome components of Helicobacter pylori biofilms induced by serum starvation. Molecular Medicine Reports, 8(6), pp 1761-1766, 2013/12.

10、Wang H#,Sun Y#, Liu S, Yu H, Li W, Zeng J, Chen C, Jia J *. Upregulation of progranulin by Helicobacter pylori in human gastric epithelial cells via p38MAPK and MEK1/2 signaling pathway: role in epithelial cell proliferation and migration. FEMS Immunol Med Microbiol, 63(1), pp 82-92.（它引9次）

11、Liu SSun YLi W, Yu H, Li X, Liu Z, Zeng J, Zhou Y, Chen C, Jia J.The antibacterial mode of action of allitridi for its potential use as a therapeutic agent against Helicobacter pylori infection(2009). FEMS Microbiol Lett. 2010 Feb 1;303(2):183-9（它引7次）

12、Yu-Ping Jia,Yun-Dong Sun，Qian Wang, Xiao-fan Zhao, Jin-Xing Wang.A single whey acidic protein domain (SWD)-containing peptide from the fleshy prawn with antimicrobial and proteinase inhibition activities. Aquaculture，Volume 284, Issues 1-4, 1 November 2008, Pages 246-259（它引42次）

三、教學(xué)成果

1、醫(yī)學(xué)微生物學(xué)山東省精品課程骨干成員。

2、2014年山東大學(xué)中青年教師講課比賽優(yōu)秀獎。

3、作為醫(yī)學(xué)微生物系中青年教學(xué)骨干教師參加山東大學(xué)教學(xué)與促進(jìn)發(fā)展中心舉辦的教學(xué)能力提升研修班。

4、山東省微課比賽三等獎

5、全國醫(yī)學(xué)類微課比賽鼓勵獎

四、其它工作（指導(dǎo)本科生創(chuàng)新實驗）

1、指導(dǎo)口腔學(xué)院校長獎學(xué)金獲得者馬駟骎大學(xué)生創(chuàng)新實驗

2、指導(dǎo)口腔學(xué)院本本科生胡哲凱等大學(xué)生創(chuàng)新實驗，并在《oncotarget》發(fā)表文章

3、指導(dǎo)醫(yī)學(xué)院七年制學(xué)生趙朗等大學(xué)生創(chuàng)新實驗

4、指導(dǎo)醫(yī)學(xué)院六年制本科生崔岳被賓夕法尼亞大學(xué)錄取為全額獎學(xué)金博士生

5、指導(dǎo)口腔學(xué)院本科生李淑彤，榮興等獲得國家級大學(xué)生創(chuàng)新項目