人物經(jīng)歷
2016.07-至今 四川大學(xué)生物治療國(guó)家重點(diǎn)實(shí)驗(yàn)室研究員
2013.08-2016.06美國(guó)加州大學(xué)伯克利分校博士后
2011.10-2013.07美國(guó)NIH訪問(wèn)學(xué)者
2006.09-2011.07清華大學(xué)博士
2002.09-2006.07山東大學(xué)學(xué)士
科研方向
主要以結(jié)構(gòu)生物學(xué)的方法研究細(xì)胞凋亡、細(xì)胞自噬的的分子機(jī)制，探索病原劫持哺乳動(dòng)物細(xì)胞自噬分子機(jī)器的機(jī)制。
著述成果
代表性文章
1:Qi S, Kim do J, Stjepanovic G, Hurley JH.Structure of the Human Atg13-Atg101?HORMA Heterodimer: an Interaction Hub within the ULK1 Complex. Structure. 2015 Oct 6;23(10):1848-57. 2:Qi S, O’Hayre M, Gutkind JS, Hurley JH. Insights into β2-adrenergic receptor binding from structures of the N-terminal lobe of ARRDC3. Protein Sci. 2014 Dec;23(12):1708-16. 3:Qi S, O’Hayre M, Gutkind JS, Hurley JH. Structural and biochemical basis for ubiquitin ligase recruitment by arrestin-related domain-containing protein-3 (ARRDC3). J Biol Chem. 2014 Feb 21;289(8):4743-52. 4: Huang W, Jiang T, Choi W, Qi S, Pang Y, Hu Q, Xu Y, Gong X, Jeffrey PD, Wang J, Shi Y. Mechanistic insights into CED-4-mediated activation of CED-3. Genes Dev. 2013 Sep 15;27(18):2039-48. 5: Deng D, Yin P, Yan C, Pan X, Gong X, Qi S, Xie T, Mahfouz M, Zhu JK, Yan N, Shi Y. Recognition of methylated DNA by TAL effectors. Cell Res. 2012Oct;22(10):1502-4. 6:Qi S, Pang Y, Hu Q, Liu Q, Li H, Zhou Y, He T, Liang Q, Liu Y, Yuan X, Luo G, Li H, Wang J, Yan N, Shi Y. Crystal structure of the Caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4. Cell. 2010 Apr30; 141(3):446-57. |