人物經(jīng)歷
1996.7－2000.10山東省醫(yī)學(xué)科學(xué)院基礎(chǔ)醫(yī)學(xué)研究所助理研究員；
2000.11－2001.8山東省醫(yī)學(xué)科學(xué)院基礎(chǔ)醫(yī)學(xué)研究所副研究員；
2001.9－2005.12中國(guó)科學(xué)技術(shù)大學(xué)生命學(xué)院副教授；
2005.12－至今中國(guó)科學(xué)技術(shù)大學(xué)生命學(xué)院教授;
1993.8-1996.7山東省醫(yī)學(xué)科學(xué)院碩士研究生；
2000.8-2003.7山東大學(xué)博士研究生
研究方向
1、天然免疫識(shí)別及其分子機(jī)制
2、腫瘤免疫學(xué)與腫瘤生物治療
3、天然免疫系統(tǒng)與重大疾病
論文專著
1) Polyinosinic-polycytidylic acid liposome induces human hepatoma cells apoptosis which correlates to the up-regulation of RIG-I like receptors. - Cancer Sci. - 200903 - 2009 Mar;100(3):529-36.
2) Diagnostic utility of LunX mRNA in peripheral blood and pleural fluid in patients with primary non-small cell lung cancer. - BMC Cancer - 200805 - 2008 May 31;8:156.
3) Involvement of CD226+ NK cells in immunopathogenesis of systemic lupus erythematosus - Journal of Immunology - 2011 - 186(6):3421-3431
4) IFN-r induced by IL-12 administration prevents diabetes by inhibiting pathogenic IL-17 production in NOD mice - Journal of Autoimmunity - 2012 - 38(1):20-28
5) CD11b and CD27 reflect distinct population and functional specialization in human natural killer cells - Immunology - 2011 - 133(3):350-359
6) IGF-1 promotes the development and cytotoxic activity of human NK cells. - Nat Commun. - 2013 - 4:1479
7) Natural killer cells promote immune tolerance by regulating inflammatory TH17 cells at the human maternal-fetal interface. - Proc Natl Acad Sci U S A. - 2013 - 2013 Jan 15;110(3):E231-40
8) TGF-β1 down-regulation of NKG2D/DAP10 and 2B4/SAP expression on human NK cells contributes to HBV persistence. - PLoS Pathog. - 2012 - 2012;8(3):e1002594
9) Down-regulation of surface fractalkine by RNA interference in B16 melanoma reduced tumor growth in mice - BBRC - 2007 - 2007 Dec;28;364(4):978-84
10) Toll-like receptor 3 agonist induces impairment of uterine vascular remodeling and fetal losses in CBAxDBA/2 mice - J Reprod Immunol. - 200706 - 2007;74(1-2):61-7
11) Involvement of Human natural killer (NK) cells in asthma pathogenesis: NK2 cells in type-two cytokine predominance. - J Allergy Clin Immunol. - 200504 - 2005;115(4): 841-7
12) Tumor-induced suppression of interferon production and enhancement of interleukin-10 production by natural killer (NK) cells: paralleled to CD4+ T cells. - Molecular Immunology - 200505 - 2005;42(9):1023-31
13) NKG2D Recognition Mediates TLR3 Signaling-Induced Breakdown of Epithelial Homeostasis in Acute Small Intestine Injury of Mice - PNAS - 200705 - 2007;104(18):7512-5
14) Therapeutic RNA silencing of Cys-X3-Cys chemokine ligand 1 gene prevents mice from adenovirus vector-induced acute liver injury. - Hepatology. - 200802 - 2008;47(2):648-58.
15) IFN-producing Killer Dendritic Cells Contribute to the Inhibitory Effect of Poly I:C on the Progression of Murine Melanoma. - J Immunother. - 200807 - 2008;31(6):555-62.
16) Hepatocytes proteomic alteration and seroproteome analysis of HBV-transgenic mice. - Proteomics. - 200901 - 2009;9(1):87-105
17) Toll-like receptor 3 agonist enhances IFN-rand TNF-a production by murine uNK cells - Int Immunopharmacol - 200705 - 2007 May;7(5):588-96
18) Synthetic short peptides, mimicking MICA and targeting at NKG2D receptors, inhibit the function of human NK cells: implication in therapy of autoimmune liver injury. - Peptides - 200503 - 2005; 26(3): 405-12.
19) Recognition of Double-Stranded RNA by TLR3 induces Severe Small Intestinal Injury in Mice. - J Immunol. - 200704 - 2007;178(7):4548-56
20) Application of optical tweezers in the research of molecular interaction between lymphocyte function associated antigen-1 and its monoclonal antibody. - Cell Mol Immunol. - 200706 - 2007;4(3):221-5.
研究課題
“重大新藥創(chuàng)制”科技重大專項(xiàng)1項(xiàng)，國(guó)家863課題1項(xiàng)，國(guó)家973課題1項(xiàng)，國(guó)家自然科學(xué)基金重點(diǎn)項(xiàng)目1項(xiàng)。
2002年以來(lái)為首承擔(dān)參加了9項(xiàng)科研項(xiàng)目，其中國(guó)家863課題2項(xiàng)，國(guó)家973課題2項(xiàng)，國(guó)家自然科學(xué)基金項(xiàng)目重點(diǎn)項(xiàng)目1項(xiàng)、面上項(xiàng)目2項(xiàng)，國(guó)家新藥創(chuàng)制重大專項(xiàng)1項(xiàng)，國(guó)家杰出青年科學(xué)基金B(yǎng)類(lèi)1項(xiàng)(國(guó)內(nèi)負(fù)責(zé)人)。
榮譽(yù)記錄
2010年獲中華醫(yī)學(xué)科技一等獎(jiǎng)
2008年獲國(guó)家自然科學(xué)二等獎(jiǎng)
2007年獲中華醫(yī)學(xué)科技一等獎(jiǎng)
2020年9月8日，被黨中央、國(guó)務(wù)院、中央軍委授予“全國(guó)抗擊新冠肺炎疫情先進(jìn)個(gè)人”稱號(hào)。
