教育經(jīng)歷
2001.9-2004.7中國醫(yī)學(xué)科學(xué)院/中國協(xié)和醫(yī)科大學(xué)北京協(xié)和醫(yī)院, 醫(yī)學(xué)博士學(xué)位1991.9-1998.7湖南醫(yī)科大學(xué)臨床醫(yī)學(xué)系七年制, 醫(yī)學(xué)碩士學(xué)位。
工作經(jīng)歷
2008.6- 南開大學(xué)醫(yī)學(xué)院,副教授
2004.8-2008.5 University of Pittsburgh Medical center, Pathology Department 博士后
1998.8-2001.8 中南大學(xué)湘雅醫(yī)學(xué)院附屬第二醫(yī)院 醫(yī)生。
2018年1月12日,政協(xié)天津市第十三屆委員會常務(wù)委員會第二十四次會議,當(dāng)選政協(xié)天津市第十四屆委員會委員。
研究方向
1.上皮向間充質(zhì)轉(zhuǎn)分化在腫瘤轉(zhuǎn)移及纖維化形成中的作用;
2. Vitamin D及其受體的表達(dá)在治療纖維化以及預(yù)防腫瘤轉(zhuǎn)移方面的作用。
科研項(xiàng)目
國家自然科學(xué)基金青年基金(30900540) 2010-2013 維生素受體介導(dǎo)炎癥促進(jìn)腎小管上皮細(xì)胞向間充質(zhì)轉(zhuǎn)分化的作用研究 項(xiàng)目負(fù)責(zé)人 天津市應(yīng)用基礎(chǔ)與前沿技術(shù)研究計(jì)劃重點(diǎn)項(xiàng)目(09JCZDJC20100) 2009-2012 維生素D治療慢性腎間質(zhì)纖維化的機(jī)理研究 項(xiàng)目負(fù)責(zé)人 教育部回國留學(xué)人員啟動基金 2010-2012 維生素D受體激動劑在慢性腎病中的治療作用 項(xiàng)目負(fù)責(zé)人 國家973計(jì)劃項(xiàng)目子課題 2011-2015 哺乳動物后腎發(fā)育重要環(huán)節(jié)及關(guān)鍵調(diào)控因子的研究 子課題學(xué)究術(shù)骨干
學(xué)術(shù)兼職
1. Member of AACR (美國腫瘤研究協(xié)會會員)
2. Member of ASN (美國腎臟病協(xié)會會員)
3. 中國抗癌協(xié)會會員
近年論文
1. Tan X, He W, Liu Y. Combination therapy with paricalcitol and trandolapril reduces renal fibrosis in obstructive nephropathy. Kidney Int. 2009;76:1248-1257. (IF= 6.193)
2. Li Y, Tan X, Dai C, Stolz DB, Wang D, Liu Y. Inhibition of integrin-linked kinase attenuates renal interstitial fibrosis. J Am Soc Nephrol. 2009;20:1907-1918. (IF= 7.689)
3. Tan X, Wen X, Liu Y. Paricalcitol inhibits renal inflammation by promoting vitamin D receptor-mediated sequestration of NF-kappaB signaling. J Am Soc Nephrol. 2008;19:1741-1752. (IF= 7.689)
4. Giannopoulou M*, Dai C*, Tan X*, Wen X, Michalopoulos GK, Liu Y. Hepatocyte growth factor exerts its anti-inflammatory action by disrupting nuclear factor-kappaB signaling. Am J Pathol. 2008;173:30-41. (*:co-first author) (IF= 5.673)
5. Hu K, Lin L, Tan X, Yang J, Bu G, Mars WM, Liu Y. .tPA protects renal interstitial fibroblasts and myofibroblasts from apoptosis. J Am Soc Nephrol. 2008;19:503-514. (IF= 7.689)
6. Tan X, Li Y and Liu Y. Therapeutic role and potential mechanisms of active Vitamin D in renal interstitial fibrosis.J Steroid Biochem Mol Biol. 2007: 103: 491-496. (IF= 2.655)
7. Tan X, Li Y, Liu Y. Paricalcitol attenuates renal interstitial fibrosis in obstructive nephropathy.J Am Soc Nephrol. 2006;17:3382-3393(IF= 7.689)
8. Tan X, Zheng FL, Yang JH, Duan L, Li Y, Zhou QG. Effect of BMP-7 on the transdifferentiation of cultured human tubular epithelial cell induced by TGF-beta1. ACTA ACADEMIAE MEDICINAE SINICAE, 2004;26:274-278. 9. Tan X, Zheng FL, Zhou QG, Duan L, Li Y. Effect of bone morphogenetic protein-7 on monocyte chemoattractant protein-1 induced epithelial-myofibroblast transition and TGF-beta1-Smad 3 signaling pathway of HKC cells. National Journal of China. 2005;85: 2607-2612.
10. Giannopoulou M, Iszkula SC, Dai C, Tan X, Yang J, Michalopoulos GK, Liu Y. Distinctive role of Stat3 and Erk-1/2 activation in mediating interferon-gamma inhibition of TGF-beta1 action. Am J Physiol Renal Physiol. 2006;290:F1234-1240. (IF=3.731)
11. Tan R, Zhang J, Tan X, Zhang X, Yang J, Liu Y. Downregulation of SnoN expression in obstructive nephropathy is mediated by an enhanced ubiquitin-dependent degradation. J Am Soc Nephrol. 2006;17:2781-2791. (IF= 7.689)
12. Zhou QG, Zheng FL, Wen YB, Tan X, Duan L, Li Y. Altered expression of vascular endothelial growth factor and its receptors in transdifferentiated human proximal tubular epithelial cells induced by transforming growth factor beta1. ACTA ACADEMIAE MEDICINAE SINICAE.2005;27: 325-331.
講授課程
1. 病理學(xué)(臨床醫(yī)學(xué)系七年制&臨床醫(yī)學(xué)系八年制&口腔醫(yī)學(xué)系五年制)
2. 病理學(xué)技術(shù)
3. 病理學(xué)進(jìn)展
4. 科研方法論