個(gè)人簡(jiǎn)介
2006年獲得中國(guó)科技大學(xué)生命科學(xué)專業(yè)學(xué)士學(xué)位；2011年獲得美國(guó)Scripps研究所生物學(xué)專業(yè)博士學(xué)位；2011-2012年上海銳意生物技術(shù)有限公司董事（銳意公司創(chuàng)始人之一）。2013年9月加入上�？萍即髮W(xué)iHuman研究所任Research Associate Professor，PI。
上海市第十五屆人民代表大會(huì)代表。
研究方向
結(jié)構(gòu)生物學(xué)
研究?jī)?nèi)容
1、探索研究疾病信號(hào)通路中相關(guān)的GPCRs蛋白，2、建立整合性的GPCRs蛋白研究平臺(tái)應(yīng)用于研究干細(xì)胞和疾病模型。
代表論文
Liu W, Chun E, Thompson A.A, Chubukov P, Xu F, Katritch V, Han G-W, Roth C.B, Heitman L.H, Ijzerman A.P, Cherezov V, Stevens R.C. “Structural basis for allosteric regulation of GPCRs by sodium ions” Science, 337(6091): 232-236, (2012)
Chun E, Thompson A.A, Liu W, Roth C.B, Griffith M.T., Katritch V, Kunken J, Xu F, Cherezov V, Hanson M.A, Stevens R.C. “Fusion Partner Toolchest for the Stabilization and Crystallization of G Protein-Coupled Receptors” Structure, 20(6): 967-976, (2012)
Tosh D.K, Phan K, Gao Z-G, Gakh A.A, Xu F, Deflorian F, Abagyan R, Stevens R.C, Jacobson K.A, Katritch V. “Optimization of Adenosine 5u2019 -Carboxamide Derivatives as Adenosine Receptor Agonists Using Structure-Based Ligand Design and Fragment-Based Searching” J Med Chem, 55(9): 4297-4308, (2012)
Deflorian F, Kumar TS, Phan K, Gao Z-G, Xu F, Wu H, Katritch V, Stevens R.C, Jacobson K.A. “Evaluation of Molecular Modeling of Agonist Binding in Light of the Crystallographic Structure of an Agonist-Bound A(2A) Adenosine Receptor” J Med Chem, 55(1): 538-552, (2012)
Xu F, Stevens R.C. “Trapping small caffeine in a large GPCR pocket” Structure, 19(9): 1204-1207, (2011) Invited Review.
Xu F, Wu H, Katritch V, Han G-W, Jacobson K.A, Gao Z-G, Cherezov V, Stevens R.C. “Structure of an agonist-bound human A2A adenosine receptor” Science, 332: 322-327, (2011)
Xu F, Liu W, Hanson M, Stevens R.C, Cherezov V. “Development of an Automated High Throughput LCP-FRAP Assay to Guide Membrane Protein Crystallization in Lipid Mesophases” Crystal Growth & Design, 11(4): 1193-1201, (2011)
Guo M, Xu F, Yamada J, Egelhofer T, Gao Y, Hartzog GA, Teng M, Niu L. “Core structure of the yeast Spt4-Spt5 complex: a conserved module for regulation of transcription elongation”Structure, 16:1649-1658, (2008)
