研究領(lǐng)域
工業(yè)生物技術(shù)、納米生物技術(shù)、生物材料、微膠囊膜技術(shù)、藥物/基因釋放系統(tǒng)
主要業(yè)績
目前負(fù)責(zé)國家“973”項(xiàng)目子課題1項(xiàng)，中國科學(xué)院知識(shí)創(chuàng)新工程重要方向項(xiàng)目子課題1項(xiàng)和大連市科技計(jì)劃項(xiàng)目1項(xiàng)。完成國家自然科學(xué)基金（執(zhí)行）、遼寧省科學(xué)技術(shù)基金（負(fù)責(zé)）和中科院大連化學(xué)物理研究所博士探索基金（負(fù)責(zé)）各1項(xiàng)，國家 “863”項(xiàng)目2項(xiàng)（骨干）。發(fā)表論文40篇，其中在Biomaterials（IF5.196）、Molecular Therapy（IF5.841）、Journal of Materials Chemistry（IF4.287）等雜志發(fā)表SCI論文20篇；申請(qǐng)國家發(fā)明專利4項(xiàng)，授權(quán)2項(xiàng)，申請(qǐng)美國專利1項(xiàng)；參編著作章節(jié)4章。
代表性成果
1. XD Liu, KA. Howard, MD Dong, et al. The influence of polymeric properties on chitosan/siRNA nanoparticle formulation and gene silencing. Biomaterials, 2007, 28, 1280-1288 .(SCI)
2. XD Liu, WT Yu, JZ Lin, et al. Diffusion of acetic acid across oil/water interface in emulsification/internal gelation process for the preparation of alginate gel beads. Chemical Research in Chinese Universities, In press. (SCI)
3. 劉袖洞，于煒婷，王為，等. 海藻酸鈉和殼聚糖聚電解質(zhì)微膠囊的研究與生物醫(yī)學(xué)應(yīng)用. 化學(xué)進(jìn)展（Progress in Chemistry），接受. (SCI)
4. 劉袖洞，馬小軍，袁權(quán). 藥物釋放系統(tǒng). 化工學(xué)報(bào)，2005, 56(6): 955-961. (EI)
5. XD Liu, WM Xue, Q Liu, et al, Swelling behaviour of alginateu2013chitosan microcapsules prepared by external gelation or internal gelation technology. Carbohydrate Polymers, 2004, 56, 459-464. (SCI)
6. XD Liu, DC Bao, WM Xue, et al, Preparation of uniform calcium alginate gel beads by membrane emulsification coupled with internal gelation. Journal of Applied Polymer Science, 2003, 87(5), 848-852. (SCI)
7. XD Liu, WY Yu, Y Zhang, et al, Characterization of structure and diffusion behaviour of Ca-alginate beads prepared with external or internal calcium sources. Journal of Microencapsulation, 2002, 19(6), 775-782. (SCI)
8. SL Xu, MD Dong, XD Liu, et al. Direct force measurements between siRNA and chitosan molecules. Biophysical Journal, 2007, 93, 952-959. (SCI)
9. KA Howard, UL Rahbek, XD Liu, et al. RNA Interference in Vitro and in Vivo Using a Novel Chitosan/siRNA Nanoparticle System. Molecular Therapy, 2006, 14(4), 476-484. (SCI)
W Wang, XD Liu, YB Xie, et al. Microencapsulation using natural polysaccharides for drug delivery and cell implantation. Journal of Materials Chemistry, 2006, 16, 3252-3267. (SCI)