人物經(jīng)歷
教育經(jīng)歷
2008 u2013 2011 博士后,美國(guó)哈佛大學(xué)醫(yī)學(xué)院, MGH麻省總醫(yī)院2002 - 2007 免疫學(xué)博士, 美國(guó)杜克大學(xué)。
2002 u2013 2007 細(xì)胞分子生物學(xué)專業(yè),美國(guó)杜克大學(xué)。
1995 u2013 2002 七年制臨床醫(yī)學(xué)本碩連讀,南開(kāi)大學(xué),醫(yī)學(xué)院。
工作經(jīng)歷
2011.11 至今 南開(kāi)大學(xué) 醫(yī)學(xué)院 副教授。
2008 u2013 2011 博士后,哈佛大學(xué)醫(yī)學(xué)院,麻省總醫(yī)院,波士頓。
2004 u2013 2007 博士研究生,杜克大學(xué)醫(yī)學(xué)中心,免疫系,北卡羅來(lái)納州。
主講課程
主講醫(yī)學(xué)免疫學(xué)。
研究方向
研究領(lǐng)域?yàn)镮karos基因在T淋巴細(xì)胞發(fā)育和急性淋巴細(xì)胞白血病的控制機(jī)制。 Ikaros基因編碼調(diào)控早期造血系和淋巴系的轉(zhuǎn)錄因子。 DNA結(jié)合區(qū)域缺陷的Ikaros小鼠缺乏T,B和自然殺傷細(xì)胞,并且缺乏早期淋巴系前體干細(xì)胞。因此Ikaros調(diào)控全能造血干細(xì)胞向淋巴系分化。研究在基因敲除小鼠中, 確定Ikaros基因敲除導(dǎo)致transitional 過(guò)渡T細(xì)胞的分化和增殖,在第三期中產(chǎn)生急性T淋巴細(xì)胞白血病并有Notch1高表達(dá),并運(yùn)用Chip-seq和基因芯片進(jìn)行三期T淋巴細(xì)胞的表觀遺傳信息和基因轉(zhuǎn)錄表達(dá)。
1. T lymphocyte commitment and differentiation
2. role of chromatin binding protein in the regulation of gene expression and epigenetics
3. molecular mechanism of leukemic development
主要貢獻(xiàn)
- Jiangwen Zhang, Audrey F Jackson, Taku Naito, Marei Dose, John Seavitt, Feifei Liu, Elizabeth J Heller, Mariko Kashiwagi, Toshimi Yoshida, Fotini Gounari, Howard T Petrie & Katia Georgopoulos. Harnessing of the nucleosome-remodeling-deacetylase complex controls lymphocyte development and prevents leukemogenesis. Nature Immunology. 2011 Nov. 13;13(1):86-94 (Fourth author)
2. Pablo Gómez-del Arco, Mariko Kashiwagi, Audrey Jackson, Taku Naito, Jiangwen Zhang, Feifei Liu, Barbara Kee, Marc Vooijs, Freddy Radtke, Juan Miguel Redondo and Katia Georgopoulos. Alternative Promoter Usage at the Notch1 Locus Supports Ligand-Independent Signaling in T Cell Development and Leukemogenesis. Immunity. 2010 Nov; Vol. 33(5) p. 685 u2013 698. (Fourth author)
3. Marco Davila*, Feifei Liu*, Lindsay G. Cowell, Anne E. Lieberman, Emily Heikamp, Anjali Patel, Garnett Kelsoe. Multiple, conserved cryptic recombination signals in VH gene segments: detection of cleavage products only in pro-B cells. Journal of Experimental Medicine. 2007 Dec 24; Vol. 204, p3195-3208. (* co-first author)
4. Feifei Liu, Ying Hu, Wei Ge, Robert Chunhua Zhao. Biological characteristics and multiple differentiation pathways of human embryonic stem cells. Shanxi Medical Journal. 2002, Vol. 31, p524-527.科研項(xiàng)目項(xiàng)目負(fù)責(zé)人:國(guó)家自然科學(xué)基金青年基金:B細(xì)胞骨髓免疫耐受機(jī)制-抗原非依賴性IgH和Igkappa 的V(D)J基因重排(2013-2015)。南開(kāi)大學(xué)校內(nèi)基金特別資助類: (2012-2014)。
榮譽(yù)記錄
2006 - 2007 Duke Conference Travel Fellowship, Duke University2006 Bernard Amos Research Award
2006 Certificate for professionalism and academic excellence
The Graduate School, Duke University
專業(yè)協(xié)會(huì)
American Association of Immunologists (AAI)
American Association for the Advancement of Science (AAAS)
Member of the Leukemia & Lymphoma Society