1982.09-1986.03 黑龍江大學計算機科學與工程系獲理學學士學位

1986.09-1989.03 哈爾濱工業(yè)大學計算機科學與技術系獲碩士學位

1989.03-1991.11 哈工大計算機科學與技術系 助教

1991.12-1996.06 哈工大計算機科學與技術系 講師

1996.07-2001.04 哈工大計算機科學與技術系 副教授

2001.05-至今 哈工大計算機科學與技術學院 教授

2005.06-至今 哈工大計算機科學與技術學院 博士生導師

2001.08-2001.12 哈工大計算機科學與技術學院 院長助理

2001.12-2010.11 哈工大計算機科學與技術學院 副院長

2008.01-2009.01 美國印第安那大學/普渡大學 訪問教授

2011.01-2014.09 哈工大計算機科學與技術學院 院長

2014.09-至今 哈工大計算機科學與技術學院院長、軟件學院院長

哈爾濱工業(yè)大學計算機科學與技術學院院長、軟件學院院長

黑龍江省生物醫(yī)學信息技術與系統(tǒng)工程研究中心主任

黑龍江省生物信息技術重點實驗室主任

哈工大-韓國SK生物醫(yī)學信息技術聯(lián)合實驗室主任

黑龍江省政協(xié)常委

國家“863”計劃重大項目“生物大數據開發(fā)與利用關鍵技術研究”首席科學家

國家“863”計劃生物信息技術專題“十三五” 規(guī)劃專家組組長

國家“863”計劃生物信息技術主題專家組專家（2001-2011）

黑龍江省計算機學會副理事長

中國計算機學會理事

《 生物信息學》期刊編委

2014年IEEE生物信息學和生物醫(yī)學國際會議共同主席（2014 IEEE International Conference on Bioinformatics and Biomedicine Conference Co-Chair and Program Co-Chair）

機器學習， 知識工程， 數據挖掘， 生物信息學， 醫(yī)學信息處理，生物大數據分析等。

王亞東教授 在國內率先開展生物信息學的研究，作為資深專家有力地推動了我國在生物信息學方面的研究工作。

他主持完成國家科技重大工程、國家863計劃項目、 國家自然科學基金、國際合作項目等20余項，其中國家重大專項項目1項，國家科技支撐計劃重點項目1項，國家863計劃項目10余項，國家自然科學基金項目5項，國際合作項目5項。王亞東教授榮獲國家科技進步二等獎1項、省科技進步二等獎1項、省自然科學二等獎2項；在《 Nucleic Acids Research》(SCI,IF 8.278)、《 Bioinformatics》(SCI,IF 5.323)、《Human Mutation》(SCI,IF 5.213)、《BMC Genomics》(SCI,IF 4.40)、《BMC Bioinformatics》(SCI,IF 3.02)等國際著名期刊發(fā)表論文150余篇，單篇最高他引314次，入選2009年“中國百篇最具影響力國際學術論文”。王亞東教授代表性學術論文的影響因子總和超過150。

生物大數據表述索引、搜索與存儲訪問技術，國家863計劃重大項目，2015.01-2017.12

生物數字資源集成和信息服務關鍵技術研發(fā), 國家863計劃項目，2014.01-2016.12

醫(yī)療物聯(lián)網關鍵技術研究與設備開發(fā)及驗證, 國家科技重大專項，2013.01-2015.12

醫(yī)療信息集成融合技術與系統(tǒng)開發(fā), 國家863計劃項目，2011.01-2015.12

個人健康信息獲取與管理技術研究，國家863計劃項目，2012.01-2015.12

轉化生物信息學重大產品研制，國家863計劃項目，2012.01-2014.12

哈爾濱工業(yè)大學-愛思開醫(yī)療信息技術聯(lián)合研究實驗室，國際合作項目，2011.01-2014.12

基于新一代測序數據的基因組拼接組裝算法研究 ，國家自然科學基金，2011.01-2015.12

基于個體基因組單核苷酸突變的等位基因轉錄調控模型研究，國家自然科學基金，2014.01-2017.12

基于多參考基因組的高通量測序片段映射方法研究，國家自然科學基金，2014.01-2016.12

基于生物數據融合的致病microRNA識別方法研究，國家自然科學基金，2012.01-2014.12

人類復雜疾病相關的非編碼區(qū)調控性單核苷酸變異預測研究，國家自然科學基金，2014.01-2016.12

項目“農業(yè)專家系統(tǒng)及其開發(fā)工具研究”獲第一屆黑龍江省高�？茖W技術一等獎 (2002)

項目“復雜疾病基因作圖的模式識別方法研究”獲黑龍江省高�？茖W技術一等獎和黑龍江省自然科學技術二等獎（2005）

項目“J-220-2-15 農業(yè)專家系統(tǒng)研究及應用”獲國家科技進步獎 (通用項目)二等獎 (2006)

項目“基于機器學習的色彩自動匹配技術研究”獲黑龍江省自然科學技術二等獎 （2006）

論文《miR2Disease: a manually curated database for microRNA deregulation in human disease》獲中國百篇最具影響國際學術論文獎 (2010) 和第十二屆黑龍江省自然科學技術學術成果獎一等獎 (2011)

個人基因組瀏覽器PGB是全球首個針對個人基因組而定制的瀏覽器，相關論文《The Personal Genome Browser: Visualizing Functions of Genetic Variants》發(fā)表在Nucleic Acids Research(2014年IF：8.278)。審稿人高度評價研究的重要意義“You do a lot of great works to the world”，標志著我國在這一全新的研究領域完成了領航任務。

miR2Disease

　　miR2Disease, a manually curated database, aims at providing a comprehensive resource of miRNA deregulation in various human diseases.

Personal Genome Browser

　　Personal Genome Browser, a genome browser for visualizing individual genetic variants and their functions, with support of diverse genomic annotations and knowledge bases.

SIDD

　　SIDD aims to establish semantic associations among disease-related databases and integrate them to provide disease global view at biological levels.

PRISM

　　PRISM is a software for split read (reads which span across a structrual variant — SV ) mapping and SV calling from the mapping result. PRISM is able to detect small insertions and abitrary size deletions, inversions and tandom duplications with the direction of discordant read pairs. PRISM_CTX is a tool for detecting inter-chromosome trans-location events.

DNMFilter

ESclassifier

　　ESclassifier is a supervised machine learning-based approach for exon skipping event detection from RNA-Seq data

lncRNA2Target

　　lncRNA2Target, a manually curated database for differentially expressed genes after lncRNA knockdown or over expression.

LncRNA2Function

　　LncRNA2Function, an ontology-driven user-friendly web interface named lncRNA2Function, which enables researchers to browse the lncRNAs associated with a specific functional term, the functional terms associated with a specific lncRNA, or to assign functional terms to a set of human lncRNA genes, such as a cluster of co-expressed lncRNAs.

TF2Lncrna

　　TF2Lncrna, a web interface contains two panels on the left and right hand side, which allow users to input a set of lncRNAs for finding their common TFs or for browsing and retrieving TF-lncRNA regulatory relationships for a specific TF or lncRNA in a specific cell line of interest.

生物信息學導論（本科生課程）

知識工程（碩士研究生課程）

（*代表通訊作者）

Qing Zhan, Yongtao Ye, Tak-Wah Lam, S.M. Yiu, Hingfung Ting andYadong Wang*. Improving multiple sequence alignment by using better guide trees. BMC Bioinformatics. 2014. (Accepted)


Jiajie Peng^, Hongxiang Li^, Qinghua Jiang,Yadong Wang*and Jin Chen*. An Integrative Approach for Measuring Semantic Similarities using Gene Ontology. BMC Systems Biology. 2014. (Accepted)

Jiang QH^, Ma R^, Wang JX, Wu XL, Jin SL, Peng JJ, Tan RJ, Zhang TJ, Li Y,Wang Yadong*. LncRNA2Function: a comprehensive resource for functional investigation of human lncRNAs based on RNA-seq data. BMC genomics. 2014. (Accepted)

Yang Bai, Shufan Ji,Yadong Wang*. ESclassifier: a random forest classifier for detection of exon skipping events from RNA-Seq data. IEEE International Conference on Bioinformatics and Biomedicine (Accepted). 2014.

Cheng L, Li J, Ju P, Peng J,Wang Yadong*. SemFunSim: A New Method for Measuring Disease Similarity by Integrating Semantic and Gene Functional Association. PLoS ONE. 2014. 9(6): e99415. doi:10.1371/journal.pone.0099415

Liran Juan, Mingxiang Teng, Tianyi Zang, Yafeng Hao, Chengwu Yan, Zhenxing Wang, Yongzhuang Liu, Jie Li, Tianjiao Zhang and?Yadong Wang*. The Personal Genome Browser: Visualizing Functions of Genetic Variants. Nucleic Acids Research. (Accepted)

Liu Y, Li B, Tan R, Zhu X,?Wang Yadong*. A gradient boosting approach for filtering de novo mutations in parent-offspring trios. Bioinformatics. 2014 Mar 10. [Epub ahead of print]

Tan R,?Wang Yadong*, Kleinstein SE, Liu Y, Zhu X, Guo H, Jiang Q, Allen AS, Zhu M. An Evaluation of Copy Number Variation Detection Tools from Whole-Exome Sequencing Data. Hum Mutat. 2014 Mar 5. doi: 10.1002/humu.22537. [Epub ahead of print]

Jin Shuilin, Tan Renjie, Jiang Qinghua, Xu Li, Peng Jiajie, Wang Yong,?Wang Yadong*. A Generalized Topological Entropy for Analyzing the Complexity of DNA Sequences. PLOS ONE. FEB 12 2014;9(2):e88519. 10.1371/journal.pone.0088519

Peng Jiajie,?Wang Yadong*, Chen Jin. Towards integrative gene functional similarity measurement. BMC BIOINFORMATICS. JAN 24 2014;15(Suppl 2):UNSP S5. 10.1186/1471-2105-15-S2-S5

Zhang Denan, Wang Guohua,?Wang Yadong*. Transcriptional regulation prediction of antiestrogen resistance in breast cancer based on RNA polymerase II binding data. BMC BIOINFORMATICS. JAN 24 2014;15(Suppl 2):S10. 10.1186/1471-2105-15-S2-S10

Jiang Qinghua, Wang Jixuan,?Wang Yadong*, Ma Rui, Wu Xiaoliang, Li Yu. TF2LncRNA: Identifying Common Transcription Factors for a List of lncRNA Genes from ChIP-Seq Data. BIOMED RESEARCH INTERNATIONAL. 2014:317642. 10.1155/2014/317642

Zhang Shaojun, Wang Fang, Wang Hongzhi, Zhang Fan, Xu Bin, Li Xia,?Wang Yadong*. Genome-wide identification of allele-specific effects on gene expression for single and multiple individuals. GENE. JAN 1 2014;533(1). 366-73. 10.1016/j.gene.2013.09.029

Cheng Liang, Wang Guohua, Li Jie, Zhang Tianjiao, Xu Peigang,?Wang Yadong*. SIDD: A Semantically Integrated Database towards a Global View of Human Disease. PLOS ONE. OCT 11 2013;8(10):e75504. 10.1371/journal.pone.0075504

Zhu Shijia, Wang Guohua, Liu Bo,?Wang Yadong*. Modeling Exon Expression Using Histone Modifications. PLOS ONE. JUL 2013;8(6):e67448. 10.1371/journal.pone.0067448

Juan Liran, Wang Guohua, Radovich Milan, Schneider Bryan P., Clare Susan E.,?Wang Yadong*, Liu Yunlong. Potential roles of microRNAs in regulating long intergenic noncoding RNAs. BMC MEDICAL GENOMICS. JAN 23 2013;6(Suppl 1):S7. 10.1186/1755-8794-6-S1-S7

Wang Guohua, Qi Ke, Zhao Yuming, Li Yu, Juan Liran, Teng Mingxiang, Li Lang, Liu Yunlong,?Wang Yadong*. Identification of regulatory regions of bidirectional genes in cervical cancer. BMC MEDICAL GENOMICS. JAN 23 2013;6(Suppl 1):S5. 10.1186/1755-8794-6-S1-S5

Peng Jiajie, Chen Jin,?Wang Yadong*. Identifying cross-category relations in gene ontology and constructing genome-specific term association networks. BMC BIOINFORMATICS. JAN 21 2013;14(Suppl 2):S15. 10.1186/1471-2105-14-S2-S15

Jiang Yue,?Wang Yadong*, Brudno Michael. PRISM: Pair-read informed split-read mapping for base-pair level detection of insertion, deletion and structural variants. BIOINFORMATICS. OCT 15 2012;28(20). 2576-83. 10.1093/bioinformatics/bts484

Teng Mingxiang, Ichikawa Shoji, Padgett Leah R.,?Wang Yadong*, Mort Matthew, Cooper David N., Koller Daniel L., Foroud Tatiana, Edenberg Howard J., Econs Michael J., Liu Yunlong. regSNPs: a strategy for prioritizing regulatory single nucleotide substitutions. BIOINFORMATICS. JUL 15 2012;28(14). 1879-86. 10.1093/bioinformatics/bts275

Teng Mingxiang, Balch Curt, Liu Yunlong, Li Meng, Huang Tim H. M.,?Wang Yadong*, Nephew Kenneth P., Li Lang. The Influence of cis-Regulatory Elements on DNA Methylation Fidelity. PLOS ONE. MAR 6 2012;7(3):e32928. 10.1371/journal.pone.0032928

Hu Yang, Liu Yunlong, Jung Jeesun, Dunker A. Keith,?Wang Yadong*. Changes in predicted protein disorder tendency may contribute to disease risk. BMC GENOMICS. DEC 23 2011;12(Suppl 5):S2. 10.1186/1471-2164-12-S5-S2

Zhu Shijia, Jiang Qinghua, Wang Guohua, Liu Bo, Teng Mingxiang,?Wang Yadong*. Chromatin structure characteristics of pre-miRNA genomic sequences. BMC GENOMICS. JUN 25 2011;12:329. 10.1186/1471-2164-12-329

Shen Changyu, Huang Yiwen, Liu Yunlong, Wang Guohua, Zhao Yuming, Wang Zhiping, Teng Mingxiang,?Wang Yadong, Flockhart David A., Skaar Todd C., Yan Pearlly, Nephew Kenneth P., Huang Tim H. M., Li Lang. A modulated empirical Bayes model for identifying topological and temporal estrogen receptor alpha regulatory networks in breast cancer. BMC SYSTEMS BIOLOGY. MAY 9 2011;5:67. 10.1186/1752-0509-5-67

Wang Guohua,?Wang Yadong*, Shen Changyu, Huang Yiwen, Huang Kun, Huang Tim H. M., Nephew Kenneth P., Li Lang, Liu Yunlong. RNA Polymerase II Binding Patterns Reveal Genomic Regions Involved in MicroRNA Gene Regulation. PLOS ONE. NOV 2 2010;5(11):e13798. 10.1371/journal.pone.0013798

Wang Guohua,?Wang Yadong*, Teng Mingxiang, Zhang Denan, Li Lang, Liu Yunlong. Signal Transducers and Activators of Transcription-1 (STAT1) Regulates microRNA Transcription in Interferon gamma-Stimulated HeLa Cells. PLOS ONE. JUL 26 2010;5(7):e11794. 10.1371/journal.pone.0011794

Jiang Qinghua, Hao Yangyang, Wang Guohua, Juan Liran, Zhang Tianjiao, Teng Mingxiang, Liu Yunlong,?Wang Yadong*. Prioritization of disease microRNAs through a human phenome-microRNAome network. BMC SYSTEMS BIOLOGY. MAY 28 2010;4(Suppl 1):S2. 10.1186/1752-0509-4-S1-S2

Wang Yadong, Wang Guohua, Yang Bo, Tao Haijun, Yang Jack Y., Deng Youping, Liu Yunlong. Reconstruct gene regulatory network using slice pattern model. BMC GENOMICS. 2009;10(Suppl 1):S2. 10.1186/1471-2164-10-S1-S2

Jiang Qinghua,?Wang Yadong*, Hao Yangyang, Juan Liran, Teng Mingxiang, Zhang Xinjun, Li Meimei, Wang Guohua, Liu Yunlong. miR2Disease: a manually curated database for microRNA deregulation in human disease. NUCLEIC ACIDS RESEARCH. JAN 2009;37. D98-104. 10.1093/nar/gkn714

Jiang Wei, Li Xia, Rao Shaoqi, Wang Lihong, Du Lei, Li Chuanxing, Wu Chao, Wang Hongzhi,?Wang Yadong, Yang Baofeng. Constructing disease-specific gene networks using pair-wise relevance metric: Application to colon cancer identifies interleukin 8, desmin and enolase 1 as the central elements. BMC SYSTEMS BIOLOGY. AUG 10 2008;2:72. 10.1186/1752-0509-2-72

Dong Qiwen, Wang Xiaolong, Lin Lei,?Wang Yadong. Analysis and prediction of protein local structure based on structure alphabets. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. JUN 2008;72(1). 163-72. 10.1002/prot.21904

Wang Guohua,?Wang Yadong, Feng Weixing, Wang Xin, Yang Jack Y., Zhao Yuming, Wang Yue, Liu Yunlong. Transcription factor and microRNA regulation in androgen-dependent and -independent prostate cancer cells. BMC GENOMICS. 2008;9(Suppl 2):S22. 10.1186/1471-2164-9-S2-S22

Wang Guohua, Wang Xin,?Wang Yadong, Yang Jack Y., Li Lang, Nephew Kenneth P., Edenberg Howard J., Zhou Feng C., Liu Yunlong. Identification of transcription factor and microRNA binding sites in responsible to fetal alcohol syndrome. BMC GENOMICS. 2008;9(Suppl 1):S19. 10.1186/1471-2164-9-S1-S19

Zhang Wei, Li Li, Li Xia, Jiang Wei, Huo Jianmin,?Wang Yadong, Lin Meihua, Rao Shaoqi. Unravelling the hidden heterogeneities of diffuse large B-cell lymphoma based on coupled two-way clustering. BMC GENOMICS. SEP 22 2007;8:332. 10.1186/1471-2164-8-332

Li X, Rao SQ,?Wang YD, Gong BS. Gene mining: a novel and powerful ensemble decision approach to hunting for disease genes using microarray expression profiling. NUCLEIC ACIDS RESEARCH. MAY 2004;32(9). 2685-94. 10.1093/nar/gkh563