人物經(jīng)歷
李登文,于1993年進入南開大學(xué)微生物系學(xué)習(xí)。 1997年本科畢業(yè),同年免試?yán)^續(xù)攻讀碩士研究生,研究的主要內(nèi)容是“酵母金屬硫蛋白的研究”,于2000年獲得碩士學(xué)位。2002年進入南開大學(xué)生物化學(xué)與分子生物學(xué)系,開始博士研究生階段的學(xué)習(xí),研究方向是“組蛋白 H3 磷酸化與細(xì)胞有絲分裂的關(guān)系研究”,2005年獲得博士學(xué)位,并留校工作。參與“生物化學(xué)”、“普通生物學(xué)”等課程的教學(xué)工作;科研工作主要集中在細(xì)胞形態(tài)結(jié)構(gòu)與功能方面的研究,以第一作者在國際和國內(nèi)核心刊物發(fā)表多篇論文。
學(xué)術(shù)論文
- Xie Songbo, Yang Yang, Lin Xiaochen, Zhou Jun,Li Dengwen*, Liu Min*, Characterization of a novel EB1 acetylation site important for the regulation of microtubule dynamics and cargo recruitment, Journal of Cellular Physiology, 2018, 233(3): 2581-2589Shi Xingjuan*,Li Dengwen, Wang Yujue, Liu Shiyu, Qin, Juan, Wang Jun, Ran Jie, Zhang Yu, Huang Qinghai, Liu Xiangdong, Zhou Jun, Liu Min*, Discovery of centrosomal protein 70 as an important player in the development and progression of breast cancer, American Journal of Pathology, 2017, 187(3): 679-688Yang Yang, Mu Tianhao, Li Te, Xie Songbo, Zhou Jun, Liu Min*,Li Dengwen*, Effects of FSTL1 on the proliferation and motility of breast cancer cells and vascular endothelial cells, Thoracic Cancer, 2017, 8(6):606-612Zhang Yijun, Luo Youguang, Lyu Rui, Chen Jie, Liu Ruming,Li Dengwen, Liu Min, Zhou Jun*, Proto-Oncogenic Src Phosphorylates EB1 to regulate the microtubule-focal adhesion crosstalk and stimulate cell migration, Theranostics, 2016, 6(12):2129-2140Yang Yunfan, Liu Min,Li Dengwen, Ran Jie, Gao Jinmin, SuoShaojun, Sun Shao-Cong, Zhou Jun, CYLD regulates spindle orientation by stabilizing astral microtubules and promoting dishevelled-NuMA-dynein/dynactin complex formation,Proceedings of the National Academy of Sciences of the United States of America,2014, 111(6): 2158-2163LiDengwen, GaoJinmin, YangYunfan, SunLei, SuoShaojun, LuoYouguang, ShuiWenqing, ZhouJun*, LiuMin*, CYLDcoordinates with EB1 to regulate microtubule dynamics and cell migration, Cell Cycle, 2014, 13(6): 974-983LiDengwen, SunXiaodong, ZhangLinlin, YanBing, XieSongbo, LiuRuming, LiuMin, ZhouJun*, Histone deacetylase 6 and cytoplasmic linker protein 170 function together to regulate the motility of pancreatic cancer cells, Protein & Cell, 2014, 5(3): 214-223Zhang Linlin, Liu Ningning, Xie Songbo, He Xianfei, Zhou Jun, LiuMin,Li Dengwen*, HDAC6 regulates neuroblastoma cell migration and may play a role in the invasion process, Cancer Biology & Therapy, 2014, 15(11): 1561-1570Peng Guoyuan, Ren Yuan, Sun Xiaodong, Zhou Jun,Li Dengwen*, Inhibition of farnesyltransferase reduces angiogenesis by interrupting endothelial cell migration. Biochemical Pharmacology 2012, 83(10):1374-1382Li Dengwen, Xie Songbo, Ren Yuan, Huo Lihong, Gao Jinmin, Cui Dandan, Liu Min, Zhou Jun*, Microtubule-associated deacetylase HDAC6 promotes angiogenesis by regulating cell migration in an EB1-dependent manner. Protein & Cell 2011, 2(2):150-160