武漢大學(xué)公共衛(wèi)生學(xué)院教授、博士生導(dǎo)師、衛(wèi)生毒理學(xué)科帶頭人

　　研究方向

　　衛(wèi)生與環(huán)境分子毒理學(xué)

　　1．“二惡英”和其它重要環(huán)境污染物分子毒理學(xué)；環(huán)境污染物與生物相互作用的分子機(jī)理

　　2．實(shí)時(shí)環(huán)境“二惡英”水平監(jiān)測(cè)的轉(zhuǎn)基因動(dòng)物模型與系統(tǒng)研究與開發(fā)

　　3．食品“二惡英”污染的生物檢測(cè)

　　發(fā)表的相關(guān)文章

　　Yuan Z, Courtenay S, Chambers RC, Wirgin I. Evidence of spatially extensive resistance to PCBs in an anadromous fish of the Hudson River. 2006. Environ Health Perspect. 144 (1): 77-84. (2005影響因子: 5.342)

　　Yuan Z, Courtenay S, Wirgin I. Comparison of hepatic and extra hepatic induction by graded doses of aryl hydrocarbon receptor agonists in Atlantic tomcod from two populations. 2006. Aquatic Toxicology 76(3)：306-320. (2005影響因子: 2.719)

　　Roy NK, Courtenay S, Maxwell G, Yuan Z, Chambers RC, Wirgin I. Cytochrome P4501A1 is induced by PCB 77 and benzo[a]pyrene treatment but not by exposure to the Hudson River environment in Atlantic tomcod (Microgadus tomcod) post-yolk sac larvae, 2002. Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals. 7(2): 162-173. (影響因子: 0.929)

　　Yuan Z, Wirgin M, Courtenay S, Ikonomou M, Wirgin I. Is hepatic cytochrome P4501A1 expression predictive of hepatic burdens of dioxins, furans, and PCBs in Atlantic tomcod from the Hudson River estuary? 2001. Aquatic Toxicology (Amsterdam, Netherlands). 54(3-4): 217-230. (影響因子: 1.708)

　　Roy NK, Courtenay S, Yuan Z, Ikonomou M, Wirgin I. An evaluation of the etiology of reduced CYP1A1 messenger RNA expression in the Atlantic tomcod from the Hudson River, New York, USA, using reverse transcriptase polymerase chain reaction. 2001. Environmental Toxicology and Chemistry / Setac, 20(5), 1022-1030. (影響因子: 1.964)

　　Yuan Z, Warren N, Courtenay S, Wirgin I. Genetic evidence of resistance to halogenated aryl hydrocarbons (HAHs) in Atlantic tomcod (Microgadus tomcod) from the Hudson River. 2001. AACR 92nd Annual Meeting Proceedings, page 606.

　　Yuan Z, Roy N, Sorrentino C, Wirgin I. Identification and characterization of aryl hydrocarbon receptor polymorphisms in Atlantic tomcod (Microgadus tomcod) from coastal Atlantic populations. 2000. Society of Toxicology 2000 Annual Meeting, Akron, Ohio, Toxicological Sciences. 54(1) Supplement, page 78. (SCI源刊)

　　個(gè)人簡(jiǎn)介

　　1987年武漢大學(xué)生物系理學(xué)學(xué)士；1997紐約大學(xué)醫(yī)學(xué)院基礎(chǔ)醫(yī)學(xué)碩士(分子腫瘤發(fā)生)；2003紐約大學(xué)醫(yī)學(xué)院環(huán)境醫(yī)學(xué)博士�，F(xiàn)為International Network of Tropical Aquaculture Scientists of the International Center for Living Aquatic Resources Management (1992)、美國(guó)毒理學(xué)會(huì)(1999)、美國(guó)癌癥研究學(xué)會(huì) (2000) 會(huì)員，中華預(yù)防醫(yī)學(xué)會(huì)武漢分會(huì)環(huán)境衛(wèi)生學(xué)專業(yè)委員會(huì)委員（2006.6-現(xiàn)今）。

　　先后在水利部、中科院水工程生態(tài)研究所(1987 u2013 1994)從事人類活動(dòng)和環(huán)境因素對(duì)魚類遺傳影響及其在資源管理中應(yīng)用的研究；在紐約醫(yī)學(xué)院（New York Medical College, Valhalla, NY）醫(yī)療系（2000 - 2003）作為咨詢科學(xué)家從事一種具商業(yè)應(yīng)用前景物質(zhì)對(duì)DNA雙鏈斷裂修復(fù)與細(xì)胞周期調(diào)控的研究；作為助理研究員 (research associate)在Rutgers大學(xué) (Rutgers University, New Brunswick, NJ)生物化學(xué)與微生物學(xué)系（2003 u2013 2006）從事水生環(huán)境分子毒理學(xué) - 高污染水體中魚類綜合生物標(biāo)記物研究；2006.3加入武漢大學(xué)公共衛(wèi)生學(xué)院。

　　國(guó)際交流

　　現(xiàn)是武漢大學(xué)醫(yī)學(xué)部中法（歐）國(guó)際合作項(xiàng)目成員，與美國(guó)紐約大學(xué)、俄亥俄州立大學(xué)和加拿大Sherbrooke大學(xué)保持著緊密的研究合作。