個人簡介
1998.09-2002.07 臺灣中山醫(yī)學大學 營養(yǎng)學 學士
2002.09-2004.07 臺灣中山醫(yī)學大學 醫(yī)學分子毒理學研究所 碩士
2004.09-2010.03 臺灣中興大學 生物科技學研究所 博士
2010.03-2013.07 臺灣中興大學 生物科技學研究所 博士后
2013.08-2015.08 中科院 上海植物逆境生物學研究中心 青年研究組長
2015.09-至今 西南大學 生命科學學院 教授、博士生導師
研究方向
植物分子遺傳學
植物逆境生物學
研究工作
在植物中,DNA甲基化的形成、保持和去甲基化是一個受到許多調(diào)節(jié)因子調(diào)控的動態(tài)過程，其分子機制一直是表觀遺傳學研究的熱點之一。過去研究發(fā)現(xiàn),模式植物擬南芥中的小分子RNAs（Short interfering RNAs，siRNAs）可以引導DNA甲基化發(fā)生，以及異染色質(zhì)組蛋白修飾，從而導致序列特異性轉(zhuǎn)錄基因沉默，這一路徑稱為RNA介導的DNA甲基化路徑（RNA-directed DNA methylation，簡稱RdDM）。同時RdDM路徑與組蛋白修飾及DNA去甲基化間存在密切的聯(lián)系,調(diào)控著細胞內(nèi)DNA甲基化的平衡。迄今雖已有一系列植物DNA甲基化的相關(guān)研究報導，但DNA甲基化的建立與維持之間的分子機制非常復雜,仍待進一步探究。研究室工作將深入研究植物DNA甲基化的分子機制，同時也將針對DNA甲基化在植物發(fā)育及環(huán)境脅迫方面的作用機理開展相關(guān)研究。
代表性論文：( IF:5-Year Impact Factor )
1.Hsu Y-F*, Hsiao Y-C, Wang C-S, Zhan X, Zhang H, Wang C-S* (2014) AtRRP6L1, a Homolog of Conserved Yeast Exosomal Rrp6p, Plays an Important Role in Transcriptional Gene Silencing in Arabidopsis. Mol Plant, 7: 1490-1493. (* corresponding author) (IF: 6.534)
2.Hsu Y-F, Chen Y-C, Hsiao Y-C, Wang B-J, Lin S-Y, Cheng W-H, Jauh G-Y, Harada JJ, Wang C-S (2014) AtRH57, a DEAD-box RNA helicase, is involved in feedback inhibition of glucose-mediated abscisic acid accumulation during seedling development and additively affects pre-ribosomal RNA processing with high glucose. Plant J, 77:119-135. (IF: 6.963)
3. Wang B-J,Hsu Y-F, Chen Y-C, Wang C-S (2014) Characterization of a lily anther-specific gene encoding cytoskeleton binding glycoproteins and overexpression of the gene causes severe inhibition of pollen tube growth. Planta, 240:525-537. (IF: 3.632)
4. Wang C-S, Hsu S-W,Hsu Y-F(2013) New insights into desiccation-associated gene regulation by Lilium longiflorum ASR during pollen maturation. Intl Rev Cell and Mol Biol 301: 37-94. (IF: 4.172)
5.Hsu Y-F, Yu S-C, Yang C-Y, Wang C-S (2011) Lily ASR protein-conferred cold and freezing resistance in Arabidopsis. Plant Physiol Biochem 49: 937-945. (IF: 3.330)
6. He XJ*,Hsu Y-F*, Zhu S, Liu HL, Pontes O, Zhu J, Cui X, Wang C-S, Zhu JK (2009) A conserved transcriptional regulator is required for RNA-directed DNA methylation and plant development. Genes Dev 23: 2717-2722. (*co-first author) (IF: 12.305)
7. He XJ*,Hsu Y-F*, Zhu S, Wierzbicki AT, Pontes O, Pikaard CS, Liu HL, Wang C-S, Jin H, Zhu JK (2009) An effector of RNA-directed DNA methylation in Arabidopsis is an ARGONAUTE 4- and RNA-binding protein. Cell 137: 498-508. (*co-first author) (IF: 35.532)
8. He XJ*,Hsu Y-F*, Pontes O, Zhu J, Lu J, Bressan RA, Pikaard C, Wang C-S, Zhu JK (2009) NRPD4, a protein related to the RPB4 subunit of RNA polymerase II, is a component of RNA polymerase IV and V and is required for RNA-directed DNA methylation. Genes Dev 23: 318-330. (*: co-first author) (IF: 12.305)
9. Tzeng J-D, Hsu S-W, Chung M-C, Yeh F-L, Yang C-Y, Liu M-C,Hsu Y-F, Wang C-S (2009) Expression and regulation of two novel anther-specific genes in Lilium longiflorum. J Plant Physiol 166: 417-427. (IF: 3.037)
10.Hsu Y-F, Tzeng J-D, Liu M-C, Yei F-L, Chung M-C, Wang C-S (2008) Identification of anther-specific/predominant genes regulated by gibberellin during development of lily anthers. J Plant Physiol 165: 553-563. (IF: 3.037)
11.Hsu Y-F, Wang C-S, Raja R (2007) Gene expression pattern at desiccation in the anther of Lilium longiflorum. Planta 226:311-322. (IF: 3.632)
12. Cheng YW, Tsai HJ, Wu JY,Hsu Y-F, Chen CY, Hao NJ, Lee H. (2007) A possible role for dihydrodiol dehydrogenase in the formation of benzo[a]pyrene-DNA adducts in lung cancer cells and tumor tissues. Environ Mol Mutagen 48:14-21 (IF: 2.938)
13. Chiang J-Y, Balic N, Hsu S-W, Yang C-Y, Ko C-W,Hsu Y-F, Swoboda I, Wang C-S (2006) A pollen-specific polygalacturonase from lily is related to major grass pollen allergens. Plant Physiol Biochem 44: 743-751. (IF: 3.330)
