人物經(jīng)歷
1998年畢業(yè)于南京師范大學(xué)，獲博士學(xué)位。
1992年10月-1993年11月德國國立環(huán)境與健康研究中心訪問學(xué)者。
1996年10月-1997年12月作為聯(lián)合培養(yǎng)博士生在德國國立環(huán)境與健康研究中心(GSF-National Research Center for Environment and Health, Germany)學(xué)習(xí)。
1998年11月－2001年12月加拿大卡加里大學(xué)(University of Calgary, Canada)博士后。
2002年1月－2004年12月哈佛大學(xué)醫(yī)學(xué)院(Harvard Medical School, USA)Research Fellow。
2004年入選中國科學(xué)院“引進(jìn)國外杰出人才”項(xiàng)目，同年12月全職全時(shí)回國，現(xiàn)為中國科技大學(xué)合肥微尺度物質(zhì)科學(xué)國家實(shí)驗(yàn)室PI(Principal Investigator)和生命科學(xué)學(xué)院教授、博士生導(dǎo)師。
2005年7月通過中科院”百人計(jì)劃”擇優(yōu)支持。
科研成果
工作以來共發(fā)表研究論文30余篇,已作為第一或聯(lián)系作者在Nature、Am J Hum Genet(影響因子12.34) 等SCI雜志上發(fā)表論文11篇，被他引200余次；在2005年，論文被引用80余次。
擔(dān)任《PloS One》、《遺傳》、《中國細(xì)胞生物學(xué)報(bào)》和《生命科學(xué)》等多家雜志的常務(wù)編委或編委。作為第一或通訊作者在Nature、American Journal of Human Genetics、Human Genetics、Cell Cycle、Bioinformatics和Cell Research等雜志上發(fā)表SCI論文30余篇，被他人引用1000余次。
科研項(xiàng)目
中國科學(xué)院“百人計(jì)劃”啟動(dòng)經(jīng)費(fèi)課題、國家自然科學(xué)基金項(xiàng)目
研究方向
1、分子細(xì)胞遺傳學(xué)/腫瘤染色體異常的發(fā)生途徑
2、生殖生物學(xué)/配子發(fā)生的遺傳調(diào)控
論文專著
1) Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines. - NATURE - 200510 - 437:1038－1042
2) Absence of age effect on meiotic recombination between human X and Y chromosomes - AMERICAN JOURNAL OF HUMAN GENETICS - 2002 - 71(2):254-261
3) Lagging chromosomes entrapped in micronuclei are notu2018lostu2019by cells - Cell Research - 201202 - 2012
4) Recurrent trisomy and Robertsonian translocation of chromosome 14 in murine iPS cell lines - Chromosome Research - 201110 - 19(7):857-68
5) Complex relationship between meiotic recombination frequency and autosomal synaptonemal complex length per cell in normal human males - American Journal of Medical Genetics - 201202 - Epub ahead of print
6) Proliferating cell nuclear antigen (PCNA) regulates primordial follicle assembly by promoting apoptosis of oocytes in fetal and neonatal mouse ovaries - PLoS One - 201101 - 6(1):e16046
7) Prediction of novel pre-microRNAs with high accuracy through boosting and SVM - Bioinformatics - 201103 - 27(10):1436-1437
8) The fate of micronucleated cells post X-irradiation detected by live cell imaging - DNA Repair (Amst) - 201103 - 10:629-638
9) Multiple origins of spontaneously arising micronuclei in HeLa cells: Direct evidence from long-term live cell imaging - MUTATION RESEARCH - 200811 - 646(1-2):41-49
10) Abnormal synapsis and recombination in an azoospermic male carrier of a reciprocal translocation t(1;21). - FERTILITY AND STERILITY - 200902 - 91(4):1293 e17-22
11) Cryopreservation has no effect on meiotic recombination and synapsis in testicular tissues - FERTILITY AND STERILITY - 200808 - 91(4):1404-7
12) Cigarette smoking and aneuploidy in human sperm - MOLECULAR REPRODUCTION AND DEVELOPMENT - 200108 - 59(4):417-421
13) Recombination in the pseudoautosomal region in a 47, XYY male - HUMAN GENETICS - 200108 - 109(2):143-145
14) Increased nondisjunction of chromosome 21 with age in human peripheral lymphocytes - MUTATION RESEARCH - 200007 - 452(1):27-36
15) Incidence of mosaic cell lines in vivo and malsegregation of chromosome 21 in lymphocytes in vitro of trisomy 21 patients: detection by fluorescence in situ hybridization on binucleated lymphocytes - HUMAN GENETICS - 200001 - 106(1):29-35
16) Aneuploidy in human spermatozoa: FISH analysis in men with constitutional chromosomal abnormalities, and in infertile men - REPRODUCTION - 200105 - 121(5):655-666
17) Single sperm typing demonstrates that reduced recombination is associated with the production of aneuploid 24,XY human sperm - AMERICAN JOURNAL OF MEDICAL GENETICS - 200102 - 99(1):34-38
18) Multicolor fluorescence in situ hybridization analysis of meiotic chromosome segregation in a 47,XYY male and a review of the literature - AMERICAN JOURNAL OF MEDICAL GENETICS - 200007 - 936(1):40-46
19) Spontaneous frequencies of aneuploid and diploid sperm in 10 normal Chinese men: assessed by multicolor fluorescence in situ hybridization - CYTOGENETICS AND CELL GENETICS - 2000 - 90(1-2):79-83
20) Aneuploidy in human sperm: a review of the frequency and distribution of aneuploidy, effects of donor age and lifestyle factors - CYTOGENETICS AND CELL GENETICS - 2000 - 90(3-4):219-226
21) The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells - J Clin Invest - 200912 - 119(12):3626-36
22) Comparative proteome profile of immature rat ovary during primordial follicle assembly and development - Proteomics - 200907 - 9(13):3425-34
23) Nucleophosmin/B23 inhibits Eg5-mediated microtubule depolymerization by inactivating its ATPase activity - J Biol Chem - 201006 - 285(25):19060-7
