人物經(jīng)歷
教育經(jīng)歷
1999年9月-2002年6月,中山大學(xué)化學(xué)與化學(xué)工程學(xué)院有機(jī)化學(xué)專業(yè),博士
1996年9月-1999年6月,中山大學(xué)化學(xué)與化學(xué)工程學(xué)院有機(jī)化學(xué)專業(yè),碩士
1992年9月-1996年6月,南昌大學(xué)化學(xué)與化工學(xué)院,本科
工作經(jīng)歷
2002年7月至今,中山大學(xué)化學(xué)與化學(xué)工程學(xué)院有機(jī)化學(xué)研究所工作。
2005年10月至2006年9月,在美國加州大學(xué)Santa Cruz分校(University of California at Santa Cruz)做訪問學(xué)者,從事海洋生物活性物質(zhì)研究。
講授課程
《有機(jī)波譜解析》,《天然產(chǎn)物化學(xué)及其研究技術(shù)》,《基礎(chǔ)有機(jī)化學(xué)實(shí)驗(yàn)》,《綜合化學(xué)實(shí)驗(yàn)》,《海洋生物資源的研究與應(yīng)用》。
科研方向
主要開展天然產(chǎn)物研究與開發(fā)。具體研究方向有:
(1)海洋微生物,包括細(xì)菌、真菌、放線菌等產(chǎn)生的新結(jié)構(gòu)化合物的發(fā)現(xiàn)和藥物應(yīng)用;
(2)南海海洋生物的代謝產(chǎn)物及其應(yīng)用研究;
(3)陸源植物、特色中草藥的藥用成分研究與開發(fā);
(4)微生物生物轉(zhuǎn)化的研究與應(yīng)用。
學(xué)術(shù)成果
科研項(xiàng)目
近年來,主持承擔(dān)有國家自然科學(xué)基金項(xiàng)目、廣東省科技計(jì)劃項(xiàng)目、廣東省自然科學(xué)基金項(xiàng)目、廣州市科技計(jì)劃項(xiàng)目、廣東中醫(yī)藥強(qiáng)省科研項(xiàng)目、中央高;究蒲袠I(yè)務(wù)費(fèi)專項(xiàng)基金項(xiàng)目、企業(yè)委托項(xiàng)目等20余項(xiàng)。
科研論文
1. Li-Hong Huang, Meng-Yang Xu, Hou-Jin Li, Jin-Qian Li, Yan-Xiu Chen, Wen-Zhe Ma, Yi-Ping Li, Jun Xu, De-Po Yang, and Wen-Jian Lan*. Amino Acid-Directed Strategy for Inducing the Marine-Derived Fungus Scedosporium apiospermum F41u20131 to Maximize Alkaloid Diversity.Organic Letters. 2017, 19(18), 4888?4891. DOI: 10.1021/acs.orglett.7b02238.
2. Lei Huang, Wen-Jian Lan, and Hou-Jin Li*. Two new hirsutane-type sesquiterpenoids chondrosterins N and O from the marine fungus Chondrostereum sp..Natural Product Research, 2017, GNPL-2017-1506.
3. Li-Hong Huang, Yan-Xiu Chen, Jian-Chen Yu, Jie Yuan, Hou-Jin Li, Wen-Zhe Ma, Ramida Watanapokasin, Kun-Chao Hu, Shah Iram Niaz, De-Po Yang, Wen-Jian Lan. Secondary Metabolites from the Marine-Derived Fungus Dichotomomycessp. L-8 and Their Cytotoxic Activity. Molecules 2017, 22, 444; doi:10.3390/molecules22030444
4. Qing-Xiang Cao, Jun-Hua Wei, Rong Deng, Gong-Kan Feng, Xiao-Feng Zhu, Wen-Jian Lan*, Hou-Jin Li*. Two New Pyripyropenes from the Marine Fungus Fusarium sp. 2016F18-1. Chemistry and Biodiversity,2017, 14(3), e1600298. DOI: 10.1002/cbdv.201600298.
5. Ting Chen, Chi-Keung Lam, Wen-Dan Chen, Xiao-Hong Chen, Gong-Kan Feng, Xiao-Feng Zhu, Wen-Jian Lan*, Hou-Jin Li*. NMR Screening Approach for Discovery of New 6-Methylpyridinone Derivatives from the Marine-Derived Fungus Leptosphaerulina sp.. Arabian Journal of Chemistry, 2017, 10(2), 288-294. doi:10.1016/j.arabjc.2015.06.015
6. Kun-Chao Hu, Meng-Yang Xu, Hou-Jin Li, Jie Yuan, Ge Tang, Jun Xu, De-Po Yang and Wen-Jian Lan*. Discovery of aromadendrane anologues from the marine-derived fungus Scedosporium dehoogii F41-4 by NMR-guided isolation. RSC Advances, 2016, 6, 94763u201394770.
7. Kun-Teng Wang, Meng-Yang Xu, Wei Liu, Hou-Jin Li, Jun Xu, De-Po Yang, Wen-Jian Lan, Lai-You Wang*. Two Additional New Compounds from the Marine-Derived Fungus Pseudallescheria ellipsoidea F42-3. Molecules, 2016, 21(4), 442; doi:10.3390/molecules21040442
8. Wen-Jian Lan, Kun-Teng Wang, Meng-Yang Xu, Jing-Jing Zhang, Chi-Keung Lam, Guo-Hua Zhong, Jun Xu,De-Po Yang, Hou-Jin Li*, Lai-You Wang*. Secondary Metabolites with Chemical Diversity from the Marine-derived Fungus Pseudallescheria boydii F19-1 and Their Cytotoxic Activity. RSC Advances, 2016, 6(80), 76206-76213.
9. Lei Huang, Wen-Jian Lan, Rong Deng, Gong-Kan Feng, Qing-Yan Xu, Zhi-Yu Hu, Xiao-Feng Zhu*, Hou-Jin Li*. Additional New Cytotoxic Triquinane-Type Sesquiterpenoids Chondrosterins Ku2013M from the Marine Fungus Chondrostereum sp.. Marine Drugs, 2016, 14(9), 157; doi:10.3390/md14090157
10. Wen-Jian Lan, Sheng-Jiao Fu, Meng-Yang Xu, Wan-Ling Liang, Chi-Keung Lam, Guo-Hua Zhong, Jun Xu, De-Po Yang, Hou-Jin Li. Five New Cytotoxic Metabolites from the Marine Fungus Neosartorya pseudofischeri. Marine Drugs, 2016, 14(1), 18; doi:10.3390/md14010018
11. Wei Liu, Hou-Jin Li, Meng-Yang Xu, Ying-Chen Ju, Lai-You Wang, Jun Xu, De-Po Yang, and Wen-Jian Lan. Pseudellones Au2013C, Three Alkaloids from the Marine-Derived Fungus Pseudallescheria ellipsoidea F42u20133. Organic Letters, 2015, 17(21), 5156-5159.
12. Dan-Feng Yan, Wen-Jian Lan, Kun-Teng Wang, Lei Huang, Cai-Wu Jiang, Hou-Jin Li. Two chlorinated benzofuran derivatives from marine fungus Pseudallescheria boydii. Natural Product Communications, 2015, 10(4), 621-622.
13. Kun-Teng Wang, Lai-You Wang, Wen-Jian Lan, Dan-Feng Yan, Hou-Jin Li. Hydroxylated Biotransformation of Flavone by Marine Fungi Induced Degradation of Benzene and Toluene. Chinese Journal of Applied Chemistry, 2015, 32(6): 671-675.
14. Wan-Ling Liang, Xiu Le, Hou-Jin Li, Xiang-Ling Yang, Jun-Xiong Chen,Jun Xu, Huan-Liang Liu, Lai-You Wang, Kun-Teng Wang, Kun-Chao Hu, De-Pong Yang, Wen-Jian Lan. Exploring the chemodiversity and biological activities of the secondary metabolites from the marine fungus Neosartorya pseudofischeri. Marine Drugs, 2014, 12(11), 5657-5676.
15. Wen-Jian Lan, Wei Liu, Wan-Ling Liang, Zeng Xu, Xiu Le, Jun Xu, Chi-Keung Lam, De-Po Yang, Hou-Jin Li, Lai-You Wang. Pseudaboydins A and B, novel isobenzofuranone derivatives from marine fungus Pseudallescheria boydii associated with starfish Acanthaster planci. Marine Drugs, 2014, 12 (7), 4188-4199.
16. Zeng Xu, Lei Huang, Xiao-Hong Chen, Xiao-Feng Zhu, Xiao-Jun Qian , Gong-Kan Feng, Wen-Jian Lan, Hou-Jin Li. Cytotoxic prenylated xanthones from the pericarps of Garcinia mangostana. Molecules, 2014, 19(2), 1820-1827.
17. Hou-Jin Li, Wen-Han Jiang, Wan-Ling Liang, Jia-Xin Huang, Yu-Fei Mo, Yan-Qing Ding, Chi-Keung Lam, Xiao-Jun Qian, Xiao-Feng Zhu, Wen-Jian Lan. Induced marine fungus Chondrostereum sp. as a means of producing new sesquiterpenoids Chondrosterins I and J by using glycerol as the carbon source. Marine Drugs, 2014, 12(1), 167-175.
18. Hou-Jin Li, Ting Chen, Ying-Lu Xie, Wen-Dan Chen, Xiao-Feng Zhu, Wen-Jian Lan. Isolation and structure elucidation of Chondrosterins Fu2013H from the marine fungus Chondrostereum sp.. Marine Drugs, 2013, 11(2), 551-558.
19. Zhong-Liang Xie, Hou-Jin Li*, Lai-You Wang, Wan-Ling Liang, Wei Liu, and Wen-Jian Lan. Trichodermaerin, a novel diterpenoid lactone from the marine fungus Trichoderma erinaceum associated with seastar Acanthaster planci. Natural Product Communications, 2013, 8(1), 67-68.
20. Yang Zhao, Shu-Qing Li, Hou-Jin Li*, Wen-Jian Lan. Lanostane triterpeoids from the fungus Ceriporia lacerate associated with Acanthaster planci. Chemistry of Natural Compounds, 2013, 49(4), 653-656.
21. Fen Yang, Wen-Dan Chen, Rong Deng, Hui Zhang, Jun Tang, Ke-Wei Wu, Dan-Dan Li, Gong-Kan Feng, Wen-Jian Lan, Hou-Jin Li*, Xiao-Feng Zhu. Hirsutanol A, a novel sesquiterpene compound from fungus Chondrostereum sp., induces apoptosis and inhibits tumor growth through mitochondrial-independent ROS production: Hirsutanol A inhibits tumor growth through ROS production. Journal of Translational Medicine, 2013, 11:32. Doi:10.1186/1479-5876-11-32.
22. Wen-Jian Lan, Yang Zhao, Zhong-Liang Xie, Li-Zhen Liang, Wei-Yan Shao, Long-Ping Zhu, De-Po Yang, Xiao-Feng Zhu, Hou-Jin Li*. Novel sorbicillin analogues from the marine fungus Trichoderma sp. associated with the seastar Acanthaster planci. Natural Product Communications, 2012, 7(10), 1337-1340.
23. Hou-Jin Li, Da-Lang Zhou, Ting-Juan Xu, Chi-Keung Lam, Wen-Jian Lan. 5,6,7,5u2019-Tetramethoxy-3u2019,4u2019-methylenedioxyflavone monohydrate. Acta Cryst. (2012). E68, o1390 [ doi:10.1107/S1600536812015139 ]
24. Fen Yang, Wen-Dan Chen, Deng Rong, Dan-Dan Li, Ke-Wei Wu, Gong-Kan Feng, Hou-Jin Li*, Xiao-Feng Zhu. Hirsutanol A induces apoptosis and autophagy via reactive oxygen species accumulation in breast cancer MCF-7 cells. Journal of Pharmacological Sciences, 2012, 119(3), 214-220.
25. Hou-jin Li, Ying-lu Xie, Zhong-liang Xie, Ying Chen, Chi-Keung Lam, Wen-jian Lan. Chondrosterins Au2013E, triquinane-type sesquiterpenoids from soft coral-associated fungus Chondrostereum sp.. Marine Drugs, 2012, 10(3), 627-638.
26. Hou-Jin Li, Wen-Jian Lan*, Chi-keung Lam, Fen Yang, Xiao-Feng Zhu. Hirsutane sesquiterpenoids from the marine-derived fungus Chondrostereum sp.. Chemistry & Biodiversity, 2011, 8(2), 317-324.
27. Hou-Jin Li, Yong-Tong Cai, Yun-Yun Chen, Chi-keung Lam, Wen-Jian Lan*. Metabolites of marine fungus Aspergillus sp. collected from soft coral Sarcophyton tortuosum. Chemical Research in Chinese Universities, 2010, 26 (3), 415-419.
28. Fen Yang, You-Heng Gao, Ke-Wei Wu, Rong Deng, Dan-Dan Li, Zhi-Xiong Wei, Shan Jiang, Xiao-Qi Wu, Gong-Kan Feng, Hou-Jin Li, Xiao-Feng Zhu. A novel sesquiterpene Hirsutanol A induces autophagical cell death in human hepatocellular carcinoma cells by increasing reactive oxygen species. Chinese Journal of Cancer, 2010, 29(7), 655-660.
29. Wen-Jian Lan, Shou-Liang Wang, Hou-Jin Li*. Additional New Tetracyclic Tetraterpenoid, Methyl Tortuoate D from Soft Coral Sarcophyton tortuosum. Natural Product Communications, 2009, 4(9), 1193-1196.
30. Li, Guoxi, Zeng, Ren Sen, Li, Houjin, Yang, Zhongyi, Xin, Guorong, Yuan, Jiangang, Luo, Yi . Allelopathic effects of decaying Italian ryegrass (Lolium mutiflorum Lam.) residues on rice. Allelopathy Journal, 2008, 22(1), pp 15-23.
31. Wen-Jian Lan, Lin-Feng Mo, Chuang-Hua Cai, Yi-Pin Zhou, Jun-Hua Yao, Hou-Jin Li*. Studies on Culture Condition of New Marine Bacterium Zooshikella sp. SY01. Frontiers of Chemical Engineering in China, 2008, 2(4), 443-446.(Full Text Available at http://www.springer.com/chemistry/journal/ 11705.)
32. Wen-Jian Lan, Hong-Ping Wan, Guo-Xi Li, Hou-Jin Li*, Yun-Yun Chen, Cheng-Zhu Liao, Ji-Wen Cai. New Sesquiterpene Formamides from the Marine Sponge Axinyssa sp.. Helvetica Chimica Acta, 2008, 91(3), 426-434.
33. Hou-Jin Li, Taro Amagata, Karen Tenney, Phillip Crews. Additional Scalarane Sesterterpenes from the Sponge Phyllospongia papyracea. Journal of Natural Products, 2007, 70(5), 802-807.
34. Wen-Jian Lan, Hou-Jin Li*. New Sesterterpenoids from the Sponge Phyllospongia papyracea. Helvetica Chimica Acta, 2007, 90(6), 1218-1222.
35. Wen-Jian Lan, Hou-Jin Li, Su-Jun Yan, Jing-Yu Su, Long-Mei Zeng. New tetraterpenoids from the soft coral Sarcophyton tortuosum. Journal of Asian Natural Products Research, 2007, 9(3), 267-271.
36. Hou-Jin Li *, Wen-Jian Lan, Chuang-Hua Cai, Yi-Pin Zhou, Yong-Cheng Lin. The Bioactive Pigments from Marine Bacteria Pseudomonas sp.. NATURAL PRODUCTS-Essential Resources for Human Survival, World Scientific Publishing Company, Feburary, 2007, p188-194.
37. Wen-Jian Lan, Hou-Jin Li *. New Bioactive Triterpenoid from Oldenlandia cantonensis How. Frontiers of Chemistry in China, 2007, 2(3), 307u2013310.
38. Hou-Jin Li *, Wen-Jian Lan, Chuang-Hua Cai, Yi-Pin Zhou, Yong-Cheng Lin. Biotransformation of limonene by marine bacteria. Chinese Journal of Analytical Chemistry, 2006, 34(7), 946-950. (Full Text Available at http://www.sciencedirect.com/science/journal/ 18722040)
39. Xiong-Yu Wu, Xiao-Hong Liu, Yong-Cheng Lin, Jing-Hui Luo, Zhi-Gang She, Hou-Jin Li, Wing-Lai Chan, Sandor Antus, Tibor Kurtan, Brigitta Elsasser, Karsten Krohn. Xyloketal F: A strong L-calcium channel blocker from the mangrove fungus Xylaria sp. (#2508) from the south China sea coast, European Journal of Organic Chemistry, 2005, (19), 4061-4064.
40. Hou-Jin Li, Yong-Cheng Lin, Jun-Hua Yao, L. L. P. Vrijmoed, E. B. Gareth Jones. A new cytotoxic sterol produced by an endophytic fungus from Castaniopsis fissa from the south China sea. Chinese Chemical Letters, 2004, 15(4), 419-422.
41. Hou-Jin Li, Yong-Cheng Lin, Jun-Hua Yao, L. L. P. Vrijmoed, E. B. Gareth Jones. Two new metabolites from the mangrove endophytic fungus No.2524. Journal of Asian Natural Products Research, 2004, 6(3), 185-191.
42. Hou-Jin Li, Yi-Guang Chen, Chuang-Hua Cai, Yi-Pin Zhou, Yong-Cheng Lin. The bioactive pigments from marine bacteria Pseudomonas sp., 2004, 3rd International Conference on Natural Products.
43. Lu Wen, Bao-Hong Yuan, Hou-Jin Li, Yong-Cheng Lin. Study on the antitumour blue pigment isolated from a marine bacteria from the South China Sea, 2004, International Symposium on Chemicals and Pharmaceuticals.
44. Yong-Cheng Lin, Hou-Jin Li, Guang-Ce Jiang, Shi-Ning Zhou, L. L. P. Vrijmoed, E. B. G. Jones. A novel gamma-lactone, eutypoid-A and other metabolites from marine fungus Eutypa sp. (#424) from the south China sea. Indian Journal of Chemistry, Section B, 2002, 41(7), 1542-1544.
教改論文
1. 李厚金*,陳六平。有機(jī)化學(xué)實(shí)驗(yàn)教學(xué)方法探索與實(shí)踐。大學(xué)化學(xué),2018, 33 (1), 1-5。doi: 10.3866/PKU.DXHX201707030
2. 李厚金*,賴瑢,朱可佳,張利,陳六平。基礎(chǔ)有機(jī)化學(xué)實(shí)驗(yàn)教學(xué)內(nèi)容的改革探索。大學(xué)化學(xué),2017, 32 (4), 21-24。
3. 李曉潔,李厚金*,賴瑢,朱可佳,李蓮云。一步法綠色氧化環(huán)己烷制備己二酸的研究進(jìn)展。大學(xué)化學(xué),2016, 31 (5), 1-7。
4. 李厚金*, 朱可佳, 鄭賽利, 陳六平。 2-苯基吲哚的合成——推薦一個大學(xué)有機(jī)化學(xué)實(shí)驗(yàn)。大學(xué)化學(xué),2014, 29(5), 75-78。
5. 李厚金*,朱可佳,陳六平。黃酮化合物的合成——推薦一個大學(xué)有機(jī)化學(xué)實(shí)驗(yàn)。大學(xué)化學(xué),2013, 28(5), 47-50。
著作
1. 李厚金,石建新,鄒小勇!痘A(chǔ)化學(xué)實(shí)驗(yàn)(第二版)》。北京:科學(xué)出版社,2015年6月。
2. 李厚金,副主編,《海洋生物活性化合物手冊》,化學(xué)工業(yè)出版社,2006年7月。
3. 李厚金,海洋真菌的代謝產(chǎn)物,p224-293,見林永成主編《海洋微生物及其代謝產(chǎn)物》第七章,華夏英才出版基金資助,化學(xué)工業(yè)出版社,2003年1月。
專利
1. 李厚金,王坤騰,藍(lán)文健,王來友。一種黃酮化合物的微生物羥基化轉(zhuǎn)化方法與應(yīng)用。中國發(fā)明專利授權(quán)號:ZL 201410633262.1。
2. 李厚金,藍(lán)文健,蔣文涵,朱孝峰,馮公侃,錢小軍。一種抗腫瘤化合物Chondrosterin J及其制備方法與應(yīng)用。中國發(fā)明專利授權(quán)號:ZL 201310692093.4。
3. 李厚金,藍(lán)文健,梁麗珍。一種從威靈仙中提取木脂素類化合物的方法及應(yīng)用。中國發(fā)明專利申請?zhí)枺?01210038141.3。
4. 藍(lán)文健,李厚金,謝瑩璐;衔锛捌湓谥苽淇鼓[瘤藥物中的應(yīng)用。中國發(fā)明專利授權(quán)號:ZL 2011 1 0148628.2。
5. 李厚金,藍(lán)文健。一種提高微生物活性代謝產(chǎn)物產(chǎn)量的方法。中國發(fā)明專利申請?zhí)枺?01110045347.4。
6. 李厚金,藍(lán)文健,朱孝峰,鄧蓉、楊芬。Hirsutanol A在制備抗腫瘤藥物中的應(yīng)用。中國發(fā)明專利授權(quán)號:ZL 2009 1 0037541.0。
7. 李厚金,藍(lán)文健。間二硝基苯的微生物生物轉(zhuǎn)化方法及間硝基苯胺間苯二胺的制備方法。 中國發(fā)明專利授權(quán)號:ZL 2008 1 0218879.1。
8. 林永成,吳雄宇,佘志剛,李厚金。一種化合物的制備方法及其應(yīng)用。國際專利申請?zhí)朠CT/CN003/00877。
9. 林永成,吳雄宇,佘志剛,李厚金,劉曉紅,羅景慧,周世寧,王煥章,瞿東方,關(guān)利平。一種化合物的制備方法及其應(yīng)用。中國發(fā)明專利申請?zhí)?00310111830.3,授權(quán)日:2006年04月19日。
10. 林永成,李厚金,周世寧,佘志剛,關(guān)利平。抗腫瘤化合物及其制備方法和制藥用途。中國發(fā)明專利申請?zhí)?02134711.5,授權(quán)日:2004年07月21日。
11. 林永成,陳光英,佘志剛,李厚金,周世寧。一種海洋真菌培養(yǎng)物的提取物及其用途。中國發(fā)明專利申請?zhí)?02134966.5,授權(quán)日:2005年06月15日。
獲獎情況
2017年榮獲中山大學(xué)第八屆校級教學(xué)成果獎二等獎1項(xiàng)。獲獎題目:深化《基礎(chǔ)化學(xué)實(shí)驗(yàn)》教學(xué)改革,培養(yǎng)厚基礎(chǔ)、強(qiáng)創(chuàng)新、高素質(zhì)的化學(xué)拔尖人才。
2008年榮獲廣東省科學(xué)技術(shù)一等獎1項(xiàng)。獲獎題目:南海海洋微生物及其代謝產(chǎn)物研究。