人物經(jīng)歷
2001年畢業(yè)于復(fù)旦大學(xué)物理系,獲理學(xué)學(xué)士學(xué)位。
2001至2007年,在紐約州立石溪分校物理系和冷泉港實(shí)驗(yàn)室就讀,并獲得物理學(xué)博士學(xué)位。
2008年在霍華德休斯醫(yī)學(xué)研究所/詹寧斯農(nóng)場研究院 (Janelia Farm, HHMI),2009至2013年在哈佛大學(xué)物理系和腦科學(xué)研究中心做博士后研究。
2013年底加入中國科學(xué)技術(shù)大學(xué)生命科學(xué)學(xué)院。通過結(jié)合數(shù)學(xué)建模、物理、工程、分子生物學(xué),光學(xué)成像等理論和實(shí)驗(yàn)手段,著重研究神經(jīng)環(huán)路結(jié)構(gòu)和功能的關(guān)系,以及神經(jīng)環(huán)路的相互作用是如何支配動(dòng)物行為等基本問題。
研究方向
1、小型動(dòng)物(秀麗線蟲,果蠅幼蟲,斑馬魚幼體等)的運(yùn)動(dòng)控制原理及其神經(jīng)環(huán)路基礎(chǔ)
2、小型動(dòng)物的多感官整合,以及感官和運(yùn)動(dòng)環(huán)路整合的機(jī)制和原理
3、光學(xué)工程;連接組學(xué);神經(jīng)環(huán)路結(jié)構(gòu)和功能的關(guān)系
科研成果
首次提出并運(yùn)用統(tǒng)計(jì)優(yōu)化數(shù)學(xué)理論來定量解釋大腦皮層神經(jīng)元樹突的復(fù)雜結(jié)構(gòu)和多樣性。首次從理論和實(shí)驗(yàn)上闡明了秀麗線蟲是如何運(yùn)用本體感受這個(gè)反饋機(jī)制來控制其運(yùn)動(dòng)狀態(tài)和方式。研究工作發(fā)表在Neuron, Nature Neuroscience, PNAS, PloS Computational Biology 等雜志上。Neuron 以及 Faculty 1000雜志對(duì)相關(guān)成果作了全面評(píng)述和重點(diǎn)推薦。
論文專著
- A statistical theory of dendritic morphologyQuan Wen, invited book chapter in The Computing Dendrite, From Structure To Function.Springer Series in Computational Neuroscience, Vol. 11, 2014.
2.Proprioceptive couplings within motor neurons driveC. elegansforward locomotionQuan Wen*, Michelle Po, Elizabeth Hulme, Sway Chen, Xinyu Liu, Marc Gershow, Andrew Leifer, Victoria Butler, Christopher Fang-Yen, William Schafer, George Whitesides, Matthieu Wyart, Dmitri Chklovskii, Mei Zhen and Aravinthan Samuel*,Neuron76, 750u2013761, November 21, 2012. *Corresponding author.
Also see New Scientist, ScienceNews and Preview in Neuron 76, 669-670, 2012. Commented and rated as exceptional by Faculty of 1000 biology.
3.Biomechanical analysis of gait adaptation in the nematodeCaenorhabditis ele- gansChristopher Fang-Yen, Matthieu Wyart, Julie Xie, Risa Kawai, Tom Kodger, Sway Chen, Quan Wenand Aravinthan Samuel,PNAS, 2010 Nov 23, 107(47) 20323-28。
4.Experience-dependent compartmentalized dendritic plasticity in rat hippocampal CA1 pyramidal neurons Judit Makara, Attila Losonczy,Quan Wenand Jeffery Magee,Nature Neuroscience, 2009 Dec;12(12):1485-7.
5.Maximizing the connectivity repertoire as a statistical principle governing the dendritic arbor shapeQuan Wen, Armen Stepanyants, Guy Elston, Alexander Grosberg and Dmitri Chklovskii,PNAS, 2009 Jul 28;106(30):12536-41. Commented and recommended by Faculty of 1000 biology.
6.A cost-benefit analysis of neuronal morphologyQuan Wenand Dmitri Chklovskii, Journal of Neurophysiology, 99, 2320 (May, 2008)。
7.Segregation of the brain into gray and white matter: a design minimizing con- duction delaysQuan Wenand Dmitri Chklovskii,PloS Computational Biology, 1(7): e78, Dec 2005.
Also see article Highways and byways in the brain, Seed magazine, January 31, 2006.