主要在包括生物傳感器、功能化核酸類酶/蛋白酶的恒溫信號(hào)擴(kuò)增新體系、DNA超分子納米結(jié)構(gòu)、核酸納米機(jī)器、核酸分子邏輯計(jì)算器件和電路等研究領(lǐng)域開(kāi)展了系統(tǒng)工作，積累了豐富的經(jīng)驗(yàn)，取得了一些突破性進(jìn)展和原創(chuàng)性成果。研究工作受到國(guó)際同行認(rèn)可，相關(guān)成果全部以科技論文形式發(fā)表在相關(guān)領(lǐng)域國(guó)際權(quán)威學(xué)術(shù)期刊上，截至目前，已經(jīng)累計(jì)發(fā)表論文50多篇（21篇第一作者論文，其中影響因子大于40的1篇，10-40的8篇，5-9的10篇，小于5的2篇），包括在自然系列Nat. Nanotechnol.發(fā)表1篇，美國(guó)化學(xué)會(huì)Chem. Rev.發(fā)表1篇，J. Am. Chem. Soc.發(fā)表5篇，Nano lett.發(fā)表3篇，ACS Nano發(fā)表3篇，德國(guó)Angew. Chem. Int. Ed.發(fā)表3篇，Adv. Mater.發(fā)表1篇，Adv. Func. Mater.發(fā)表1篇等。申請(qǐng)美國(guó)專利一項(xiàng)，參與編寫(xiě)關(guān)于核酸納米機(jī)器和器件的書(shū)目章節(jié)兩個(gè)。發(fā)表文章總影響因子超過(guò)450，獲得他人正面引用超過(guò)1600，H因子23。歡迎報(bào)考碩士，博士；并隨時(shí)歡迎博士后加入，共同學(xué)習(xí)。

1999.09-2003.07鄭州大學(xué)化學(xué)系 化學(xué)學(xué)士
2003.09-2009.01中科院長(zhǎng)春應(yīng)化所 電分析化學(xué)國(guó)家重點(diǎn)實(shí)驗(yàn)室 分析化學(xué)博士
2009.02-2014.06 耶路撒冷希伯來(lái)大學(xué)化學(xué)研究所 博士后
2014.07-現(xiàn)在武漢大學(xué)化學(xué)與分子科學(xué)學(xué)院 教授

研究方向

1. Masayuki Endo, Yuki Suzuki, Tomoko Emura, Kumi Hidaka,Fuan Wang, Itamar Willner, Hiroshi Sugiyama. Single-Molecule Visualization of the Zn-Dependent DNAzyme Functions.Angew.Chem.Int.Ed.2015, In Press.DOI:10.1002/anie.201504656

2. Wei-Ching Liao, Chun-Hua Lu, Raimo Hartmann,Fuan Wang, Yang Sung Sohn, Wolfgang J. Parak,* Itamar Willner,* ATP-Triggered Release of Macromolecular and Nanoparticle Loads from Aptamer/DNA-Crosslinked Microcapsules.ACS Nano2015, In Press.DOI:10.1021/nn503223e

3. Sivan Lilienthal, Zohar Shpilt,Fuan Wang, Ron Orbach, Itamar Willner*. Programmed DNAzyme-Triggered Dissolution of DNA-Based Hydrogels: Means for Controlled Release of Biocatalysts and for the Activation of Enzyme Cascades.ACS Appl. Mater. Interfaces.2015, 7, 8923u20138931.DOI:10.1021/acsami.5b02156

4. Lina Freage, Alexander Trifonov, Ran Tel-Vered, Eyal Golub,Fuan Wang, John S. McCaskill, Itamar Willner*. Addressing, amplifying and switching DNAzyme functions by electrochemically-triggered release of metal ions.Chem. Sci.2015, 6, 3544-3549.DOI:10.1039/C5SC00744E

5.Fuan Wang, Xiaoqing Liu, Itamar Willner*. DNA Switches: From Principles to Applications.Angew.Chem.Int.Ed.2015, 54, 1098-1129.DOI:10.1002/anie.201404652

6. Weiwei Guo, Chun-Hua Lu, Ron Orbach,Fuan Wang, Xiu-Juan Qi, Alessandro Cecconello, Dror Seliktar, Itamar Willner*. pH Stimulated DNA Hydrogels Exhibiting Shape-Memory Properties.Adv. Mater.2015, 27, 73u201378.DOI:10.1002/adma.201403702

7. Lina Freage,Fuan Wang, Itamar Willner*. Multiplexed Analysis of Genes and of Metal Ions Using Enzyme/DNAzyme Amplification Machineries.Anal. Chem.2014, 86, 11326u201311333.DOI:10.1021/ac5030667

8. Natalie Enkin,Fuan Wang, Etery Sharon, Itamer Willner*. Multiplexed Analysis of Genes Using Nucleic Acid-Stabilized Ag Nanocluster Quantum Dots.ACS Nano2014, 8, 11666u201311673.DOI:10.1021/nn504983j

9. Yuwei Hu,Fuan Wang, Chun-Hua Lu, Julia Girsh, Eyal Golub, Itamar Willner*. Switchable Enzyme/DNAzyme Cascades by the Reconfiguration of DNA Nanostructures.Chem. Eur. J.2014, 20, 16203u201316209.DOI:10.1002/chem.201404122

10. Zhanxia Zhang,Fuan Wang, Sohn Yang Sung, Rachel Nechushtai, Itamar Willner*. Gated Mesoporous SiO2Nanoparticles using K-Stabilized G-Quadruplexes.Adv. Funct. Mater.2014, 36, 5662u20135670).DOI:10.1002/adfm.201400939 (selected as theCoverof the issue36on2014.)

11. Zhanxia Zhang,Fuan Wang, Dora Balogh, Itamar Willner*. pH-Controlled Release of Substrates from Mesoporous SiO2Nanoparticles Gated By Metal Ion-Dependent DNAzymes.J. Mater. Chem. B2014, 2, 4449u20134455.DOI:10.1039/c4tb00558a

12. Ron Orbach,Fuan Wang, Oleg Lioubashevski, Raphael D. Levine, Fran?oise Remacle, Itamar Willner*. A Full-Adder Based on Reconfigurable DNA-Hairpin Inputs and DNAzyme Computing Modules.Chem. Sci.2014, 5, 3381u20133387.DOI:10.1039/C4SC00914B (selected as theBack Coverof the issue5on2014.)

13.Fuan Wang, Chun-Hua Lu, Itamar Willner*.From Cascaded Catalytic Nucleic Acids to Enzyme-DNA Nanostructures: Controlling Reactivity, Sensing, Logic Operations and Assembly of Complex Structures.Chem. Rev.2014, 114, 2881u20132941.DOI:10.1021/cr400354z (selected as theCoverof the issue5on2014.)

14.Fuan Wang, Chun-Hua Lu, Xiaoqing Liu, Lina Freage, Itamar Willner*. Amplified and Multiplexed Detection of DNA Using the Dendritic Rolling Circle Amplified Synthesis of DNAzyme Reporter Units.Anal. Chem.2014, 86, 1614u20131621.DOI:10.1021/ac4033033

15. Ron Orbach, Weiwei Guo,Fuan Wang, Oleg Lioubashevski, Itamar Willner*. Self-Assembly of Luminescent Ag Nanocluster Nanowires.Langmuir2013, 29, 13066u201313071.DOI:10.1021/la402888b

16. Zhanxia Zhang, Dora Balogh,Fuan Wang, Sohn Yang Sung, Rachel Nechushtai, Itamar Willner*. Biocatalytic Release of an Anticancer Drug from Nucleic-Acids-Capped Mesoporous SiO2Using DNA or Molecular Biomarkers as Triggering Stimuli.ACS Nano2013, 7, 8455u20138468.DOI:10.1021/nn403772j

17.Fuan Wang, Lina Freage, Ron Orbach, Itamar Willner*. Autonomous Replication of Nucleic Acids by Polymerization/Nicking Enzyme/DNAzyme Cascades for the Amplified Detection of DNA and the Aptamer-Cocaine Complex.Anal. Chem.2013, 85, 8196u20138203.DOI:10.1021/ac4013094 Highlight by HispanicBusiness

18. Xiaoqing Liu,Fuan Wang, Ruth Aizen, Omer Yehezkeli, Itamar Willner*. Graphene Oxide/Nucleic Acid-Stabilized Silver Nanoclusters: Functional Hybrid Materials for Optical Aptamer Sensing and Multi-plexed Analysis of Pathogenic DNAs.J. Am. Chem. Soc.2013, 135, 11832u201311839.DOI:10.1021/ja403485r

19.Fuan Wang, Xiaoqing Liu, Chun-Hua Lu, Itamar Willner. Cysteine-Mediated Aggregation of Au Nanoparticles: A Process for the Sensitive Detection of H2O2and the Development of Oxidase-Based Biosensors.ACS Nano2013, 7, 7278u20137286.DOI:10.1021/nn402810x

20.Fuan Wang, Bilha Willner, Itamar Willner* DNA Nanotechnology with One-Dimensional Self-Assembled Nanostructures.Curr. Opin. Biotechnol.2013, 24, 562u2013574.DOI:10.1016/j.copbio.2013.02.005

21. Zhanxia Zhang, Dora Balogh,Fuan Wang, Ran Tel-Vered, Naomi Levy, Sohn Yang Sung, Rachel Nechushtai, Itamar Willner*. Light-Induced and Redox-Triggered Uptake and Release of Substrates to and from Mesoporous SiO2Nanoparticles.J. Mater. Chem. B2013, 1, 3159u20133166.DOI:10.1039/C3TB20292E

22. Zhanxia Zhang, Dora Balogh,Fuan Wang, Itamar Willner*. Smart Mesoporous SiO2Nanoparticles for the DNAzyme-Induced Multiplexed Release of Substrates.J. Am. Chem. Soc.2013, 135, 1934u20131940.DOI:10.10021/ja311385y

23.Fuan Wang, Xiaoqing Liu, Itamar Willner* Integration of Photoswitchable Proteins, Photosynthetic Reaction Centers and Semiconductor/Biomolecule Hybrids with Electrode Supports for Optobioelectronic Applications.Adv. Mater.2013, 25, 349u2013377.DOI:10.1002/adma.201201772

24. Xiaoqing Liu,Fuan Wang, Angelica Niazov-Elkan, Weiwei Guo, Itamar Willner*. Probing Biocatalytic Transformations with Luminescent DNA/Silver Nanoclusters.Nano Lett.2013, 13, 309u2013314.DOI:10.1021/nl304283c

25. Xiaoqing Liu, Angelica Niazov-Elkan,Fuan Wang, Itamar Willner*. Switching Photonic and Electrochemical Functions of a DNAzyme by DNA Machines.Nano Lett.2013, 13, 219u2013225.DOI:10.1021/nl303894h

26. Johann Elbazu2020,Fuan Wangu2020, Raphael D. Levine, Francoise Remacle, Itamar Willner*. Programmable Functional Logic Circuits Driven by Modular DNAzyme Libraries.Nano Lett.2012, 12, 6049?6054.DOI:10.1021/nl300051g(u2020 Equal contributor) (selected as theCoverof the issue 12 on 2012.)

27.Fuan Wang, Ron Orbach, Itamar Willner* Detection of Metal Ions (Cu, Hg) and of Cocaine Using a Ligation DNAzyme Machinery.Chem. Eur. J.2012, 18, 16030u201316036.DOI:10.1002/chem.201201479

28. Ron Orbach, Lena Mostinski,Fuan Wang, Itamar Willner* Nucleic Acid-Driven DNA Machineries Synthesizing Mg-Dependent DNAzymes: An Interplay Between DNA Sensing and Logic Gate Operations.Chem. Eur. J.2012, 18, 14689u201314694.DOI:10.1002/chem.201201995

29.Fuan Wang, Johann Elbaz, Itamar Willner*. Enzyme-Free Amplified Detection of DNA by an Autonomous Ligation and Replication DNAzyme Machinery.J. Am. Chem. Soc.2012, 134, 5504u20135507.DOI:10.1021/ja300616w

30. Chunhua Luu2020,Fuan Wangu2020, Itamar Willner* Zn-Ligation DNAzyme-Driven Enzymatic and Non-Enzymatic Cascades for the Amplified Detection of DNA.J. Am. Chem. Soc.2012, 134, 10651u201310658. (u2020Equal contributor),DOI:10.1021/ja3037838

31. Chunhua Luu2020,Fuan Wangu2020, Itamar Willner* Amplified Optical Aptasensors through the Endonuclease-Stimulated Regeneration of the Analyte.Chem. Sci.2012, 3, 2616u20132622. (u2020Equal contributor),DOI:10.1039/C2SC20426F

32. Johann Elbaz, Zhengang Wang,Fuan Wang, Itamar Willner*. Programmed Dynamic Topologies in DNA Catenanes.Angew.Chem.Int.Ed.2012,51, 2349-2353.DOI:10.1002/anie.201107591(Selected as theInside Coverof the issue 10 on 2012.)

33. Simcha Shimronu2020,Fuan Wangu2020, Ron Orbach, Itamar Willner* Amplified Detection of DNA through the Enzyme-Free Autonomous Assembly of Hemin/G-Quadruplex DNAzyme Nanowires.Anal. Chem.2012, 84, 1042-1048.DOI:10.1021/ac202643y(u2020 Equal contributor)

34.Fuan Wang, Johann Elbaz, Ron Orbach, Nimrod Magen, Itamar Willner*. Amplified Analysis of DNA by the Autonomous Assembly of Polymers Consisting of DNAzyme Wires.J. Am. Chem. Soc.2011, 133, 17149-17151.DOI:10.1021/ja2076789 Highlight byLife Science Weeklyon December 20, 2011

35.Fuan Wang, Johann Elbaz, Carsten Teller, Itamar Willner*. Amplified Detection of DNA through the Autocatalytic, Catabolic Generation of the Analyte by a DNAzyme.Angew.Chem.Int.Ed.2011, 50, 295-299.DOI:10.1002/anie.201005246

36. Johann Elbaz, Oleg Lioubashevski,Fuan Wang, Fran?oise Remacle, Raphael D. Levine, Itamar Willner*. DNA computing circuits using libraries of DNAzyme subunits.Nat.Nanotechnol.2010, 5, 417-422.DOI:10.1038/nnano.2010.88 Highlight by New Scientist

37. Ming Zhou,Fuan Wang, Shaojun Dong *. Boolean logic gates based on oxygen-controlled biofuel cell in "one pot".Electrochim. Acta2011, 56, 4112-4118.DOI:10.1016/j.electacta.2011.01.113

38. Xiaoqing Liu,Fuan Wang, Shuang Han, Lihong Shi, Guobao Xu*. Self-Assembly of gold nanoparticles/electroactive polyelectrolyte multilayer films for tunable electrocatalysis.Electroanalysis2010, 22, 963-968.DOI:10.1002/elan.200900479

39. Li Wang,Fuan Wang, Li Shang, Chengzhou Zhu, Wen Ren, Shaojun Dong*. AuAg bimetallic nanoparticles film fabricated based on H2O2-mediated silver reduction and its application.Talanta2010, 82, 113-117.DOI:10.1016/j.talanta.2010.04.009

40. Xiaoqing Liu, Haijuan Li,Fuan Wang, Yuling Wang, Shuyun Zhu, Guobao Xu*. Functionalized single-walled carbon nanohorns for electrochemical biosensing.Biosens.Bioelectron.2010, 25, 2194-2199.DOI:10.1016/j.bios.2010.02.027

41.Fuan Wang, Xiaoqing Liu, Gaiping Li, Dan Li, Shaojun Dong*. Selective Electrodissolution of Inorganic Ions/DNA Multilayer Film for Tunable DNA Release.J. Mater. Chem.2009, 19, 286-291.DOI:10.1039/B812940A

42. Jianlong Wang,Fuan Wang, Shaojun Dong*. Methylene Blue as an Indicator for Sensitive Electrochemical Detection of Adenosine Based on Aptamer Switch.J. Electroanal. Chem.2009, 626, 1-5.DOI:10.1016/j.jelechem.2008.08.008

43. Yan Du, Bingling Li,Fuan Wang, Shaojun Dong*. Au Nanoparticles Grafted Sandwich Platform Used Amplified Small Molecule Electrochemical Aptasensor.Biosens.Bioelectron.2009, 24, 1979-1983.DOI:10.1016/j.bios.2008.10.019

44. Liu Deng, Lihua Zhang, Li Shang, Shaojun Guo, Dan Wen,Fuan Wang, Shaojun Dong*. Electrochemiluminescence Detection of NADH, Ethanol Based on Partial Sulfonation of Sol-gel Network with Gold Nanoparticles.Biosens. Bioelectron.2009, 24, 2273-2276.DOI:10.1016/j.bios.2008.10.031

45. Ming Zhou, Yuling Wang, Yueming Zhai, Junfeng Zhai, Wen Ren,Fuan Wang, Shaojun Dong*. Controlled Synthesis of Large-Area and Patterned Electrochemically Reduced Graphene Oxide Films.Chem. Eur. J.2009, 15, 6116-6120.DOI:10.1002/chem.200900596

46.Fuan Wang, Jianlong Wang, Yueming Zhai, Dan Li, Gaiping Li, Shaojun Dong*. Layer-by-layer Assembly of Biologically Inert Inorganic Ions/DNA Multilayer Films for Tunable DNA Release by Chelation.J. Controlled Release2008, 132, 65-73.DOI:10.1016/j.jconrel.2008.08.016

47.Fuan Wang, Dan Li, Gaiping Li, Xiaoqing Liu, Shaojun Dong*. Electrodissolution of Inorganic ions/DNA Multilayer Film for Tunable DNA Release.Biomacromolecules2008, 9, 2645-2652.DOI:10.1021/bm800766t

48.Fuan Wang, Jianlong Wang, Xiaoqing Liu, Shaojun Dong*. Nanoparticle-amplified Surface Plasmon Resonance Study of Protein Conformational Change at Interface.Talanta2008, 77, 628-634.DOI:10.1016/j.talanta.2008.06.042

49. Liu Deng,Fuan Wang, Hongjun Chen, Li Shang, Liang Wang, Tie Wang, Shaojun Dong*. A Biofuel Cell with Enhanced Performance by Multilayer Biocatalyst Immobilized on Highly Ordered Macroporous Electrode.Biosens. Bioelectron.2008, 24, 329-333.DOI:10.1016/j.bios.2008.04.006

50. Jianlong Wang,Fuan Wang, Hongjun Chen, Xiaohua Liu, Shaojun Dong*. Electrochemical Surface Plasmon Resonance Detection of Enzymatic Reaction in Bilayer Lipid Membranes.Talanta2008, 75, 666-670.DOI:10.1016/j.talanta.2007.11.062

51. Lihua Zhang,Fuan Wang, Shaojun Dong*. Layer-by-layer Assembly of Functional Silica and Au Nanoparticles for Fabricating Electrogenerated Chemiluminescence Sensor.Electrochim. Acta2008, 53, 6423-6427.DOI:10.1016/j.electacta.2008.04.059

52. Liu Deng, Yizhe Wang, Li Shang, Dan Wen,Fuan Wang, Shaojun Dong*. A Sensitive NADH and Glucose Biosensor Tuned by Visible Light Based on Thionine Bridged Carbon Nanotubes and Gold Nanoparticles Multilayer.Biosens. Bioelectron.2008, 24, 951-957.DOI:10.1016/j.bios.2008.07.066

53.Fuan Wang, Jianlong Wang, Hongjun Chen, Shaojun Dong*. Assembly Process of CuHCF/MPA Multilayers on Gold Nanoparticles Modified Electrode and Characterization by Electrochemical SPR.J. Electroanal. Chem.2007, 600, 265-274.DOI:10.1016/j.jelechem.2006.10.008

54. Jianlong Wang,Fuan Wang, Xiangqin Zou, Zhiai Xu, Shaojun Dong*. Surface Plasmon Resonance and Electrochemistry for Detection of Small Molecules Using Catalyzed Deposition of Metal Ions on Gold Substrate.Electrochem. Commun.2007, 9, 343-347.DOI:10.1016/j.elecom.2006.09.011

55. Jianlong Wang,Fuan Wang, Zhiai Xu, Yizhe Wang, Shaojun Dong*. Surface Plasmon Resonance and Electrochemistry Characterization of Layer-by-Layer Self-Assembled DNA and Zr Thin Films and Their Interaction with Cytochrome c.Talanta2007,74, 104-109.DOI:10.1016/j.talanta.2007.05.033

56. Na Gao, Zhiai Xu,Fuan Wang, Shaojun Dong*. Sensitive Biomimetic Sensor Based on Molecular Imprinting at Functionalized Indium Tin Oxide Electrodes.Electroanalysis2007, 19, 1655-1660.DOI:10.1002/elan.200703919

57. Liu Deng, Ying Liu, Guocheng Yang, Li Shang, Dan Wen,Fuan Wang, Zhiai Xu, Shaojun Dong*. Molecular "Wiring" Glucose Oxidase in Supramolecular Architecture.Biomacromolecules2007, 8, 2063-2071.DOI:10.1021/bm061049l

58. Jianlong Wang, Yong Shao, Yongdong Jin,Fuan Wang, Shaojun Dong*. Electrochemical Thinning of Thick Gold Film with Controlled Thickness for SPR Sensing.Anal. Chem.2005, 77, 5760-5765.DOI:10.1021/ac0507035