工作經(jīng)歷
1999年10月至2001年1月 美國(guó)肯塔基大學(xué)生理系 博士后
2001年1月至2004年 美國(guó)德克薩斯州西南醫(yī)學(xué)中心病理系 博士后
2004年至2008年 美國(guó)德克薩斯州西南醫(yī)學(xué)中心病理系Instructor
2008年3月至2009年8月 美國(guó)德克薩斯州西南醫(yī)學(xué)中心病理系 助理教授
2009年-至今中國(guó)科學(xué)院北京基因組研究所“百人計(jì)劃”研究員
研究領(lǐng)域
學(xué)科類別:生物化學(xué)與分子生物學(xué)
環(huán)境致癌物與基因組不穩(wěn)定性及疾病相關(guān)性研究
承擔(dān)項(xiàng)目
1、國(guó)家自然科學(xué)基金委面上項(xiàng)目
2、中科院百人擇優(yōu)支持
3、國(guó)家自然科學(xué)基金委面上項(xiàng)目
4、國(guó)家重點(diǎn)基礎(chǔ)研究發(fā)展計(jì)劃
代表論著
1、 Guo C, Savage L, Sarge KD, Park-Sarge OK (2001) Gonadotropins decrease the stability of estrogen receptor beta mRNA in rat granulosa cells. Endocrinology
2、 Schenten D, Gerlach VL, Guo C, Velasco-Miguel S, Hladik CL, White CL, Friedberg EC, Rajewsky K, Esposito G (2002) DNA polymerase kappa deficiency does not affect somatic hypermutation in mice. Eur J Immunol
3、 Guo C, Fischhaber PL, Luk-Paszyc MJ, Masuda Y, Zhou J, Kamiya K, Kisker C, Friedberg EC (2003) Mouse Rev1 protein interacts with multiple DNA polymerases involved in translesion DNA synthesis. EMBO J
4、Guo C, Gao T, Confer N, Velasco-Miguel S and Friedberg EC (2005) Multiple PolK (POLK) transcripts in mammalian testis. DNA Repair
5、Takenaka K, Ogi T, Okada T, Sonoda E, Guo C, Friedberg EC, Takeda S (2006) Involvement of vertebrate Polkappa in translesion DNA synthesis across DNA monoalkylation damage. J Biol Chem
6、Guo C, Tang TS, Bienko M, Sonoda E, Parker JL, Bielen AB, Takeda S, Ulrich HD, Dikic I, Friedberg EC. (2006) Ubiquitin-Binding Motifs in Rev1 Protein are Required for Its Role in the Tolerance of DNA Damage. Mol Cell Biol
7、Guo C, Sonoda E, Tang TS, Parker JL, Bielen AB, Takeda S, Ulrich HD, Friedberg EC. (2006) REV1 protein interacts with PCNA: significance of the REV1 BRCT domain in vitro and in vivo. Mol Cell
8、 Guo C, Tang TS, Bienko M, Dikic I and Friedberg EC. (2008) Requirements for the Interaction of Mouse Polkappa With Ubiquitin, and its Biological Significance. J Biol Chem
9、Kosarek JN, Woodruff RV, Rivera-Begeman A, Guo C, Du2019Souza S, Koonin EV, Walker GCand Friedberg EC. (2008) Comparative Analysis of in vivo Interactions Between Rev1 Protein and Other Y-Family DNA Polymerases in Animals and Yeasts. DNA Repair
10、 Tang TS, Guo C, Wang H, Chen X, Bezprozvanny I. (2009) Neuroprotective effects of inositol 1,4,5-trisphosphate receptor C-terminal fragment in a Huntington’s disease mouse model. J Neurosci
11、Guo C*，Kosarek JN, Tang TS and Friedberg EC. (2009) Y-Family DNA Polymerases in Mammalian Cells. Cell Mol Life Sci
12、 Stancel JN, McDaniel LD, Velasco S, Richardson J, Guo C, Friedberg EC. (2009) Polk mutant mice have a spontaneous mutator phenotype. DNA repair.
13、 Guo C, Tang TS, Friedberg EC. (2010) Snapshot: Nucleotide excision repair. Cell
14、呂翎娜，唐鐵山，郭彩霞*. (2011) 哺乳動(dòng)物跨損傷DNA聚合酶Polk研究進(jìn)展. 生物化學(xué)和生物物理進(jìn)展.
15、 Wang Z,Wang F, Tang T, Guo C*. (2012) The role of PARP1 in the DNA damage response and its application in tumor therapy. Front Med
16、Zhang X, Lv L, Chen Q, Yuan F, Zhang T, Yang Y, Zhang H, Wang Y, Jia Y, Qian L, Chen B, Zhang Y, Friedberg C, Tang T and Guo C*.（2013）Mouse DNA polymerase kappa has a functional role in the repair of DNA strand breaks. DNA Repair
17、Wang J, Chen Q, Wang X, Wang Q, Wang Y, Cheng H, Guo C, Sun Q, Chen Q, Tang TS (2013) Dysregulation of Mitochondrial Calcium Signaling and Superoxide Flashes Cause Mitochondrial Genomic DNA Damage in Huntingtonu2019s Disease. J. Biol. Chem
18、Wang F, Yang Y, Lin X, Wang JQ, Wu YS, Xie W, Wang D, Zhu S, Liao YQ, Sun Q, Yang YG, Luo HR, Guo C*, Han C* , Tang TS*. (2013). Genome-wide loss of 5-hmC is a novel epigenetic feature of Huntingtonu2019s disease. Hum Mol Genet
19、Bétous R, Pillaire MJ, Pierini L, van der Laan S, Recolin B, Ohl-Séguy E, Guo C, Niimi N, Grúz P, Nohmi T, Friedberg E, Cazaux C, Maiorano D, Hoffmann JS. (2013). DNA polymerase κ- dependent DNA synthesis at stalled replication forks is important for CHK1 activation. EMBO J
20、Lv L, Wang F, Ma X, Yang Y, Wang Z, Liu H, Li X, Liu Z, Zhang T, Huang M, Friedberg E, Tang TS, Guo C*. (2013). Mismatch repair protein MSH2 regulates translesion DNA synthesis following exposure of cells to UV radiation. Nucleic Acid Research.
