職務(wù)
生物學(xué)博士，中南民族大學(xué)碩士生導(dǎo)師。2001年至今中南民族大學(xué)生物醫(yī)學(xué)工程研究所工作。2006年至2009年于武漢大學(xué)生命科學(xué)院攻讀并獲得生物學(xué)博士學(xué)位。近年來，主要從事疾病相關(guān)性離子通道蛋白結(jié)構(gòu)與功能關(guān)系研究，采用電生理學(xué)、分子生物學(xué)、生物信息學(xué)等技術(shù)研究生物活性肽及小分子有機(jī)物對離子通道蛋白的調(diào)節(jié)作用。主持和參與了國家自然科學(xué)基金2項(xiàng)，省自然科學(xué)基金1項(xiàng)，以及�；鸲囗�(xiàng)。 ★學(xué)科專業(yè)：生物醫(yī)學(xué)工程（生物信息學(xué)） ★所授課程：有機(jī)化學(xué)、生物化學(xué)與分子生物學(xué)、電生理學(xué) ★研究興趣：離子通道蛋白結(jié)構(gòu)與功能關(guān)系研究，離子通道蛋白與其配體相互作用的研究 ★承擔(dān)項(xiàng)目： 1）BmαTX14多肽與通道β亞基協(xié)同調(diào)節(jié)鈉通道功能的機(jī)制研究（30900239） 國家自然科學(xué)基金 課題主持人 2）鉀通道KCNQ1孔區(qū)外庭的結(jié)構(gòu)特征與功能研究（30900265） 國家自然科學(xué)基金 第一參與人 3）血竭薄膜衣片的研究（BZZ03001）。湖北省自然科學(xué)基金項(xiàng)目，項(xiàng)目號：，2003.06，項(xiàng)目參與人
學(xué)術(shù)成果
(1) Yin S.J, Jiang L., Yi H., Han S., Yang D.W., Liu M.L., Liu H., Cao Z.J., Wu Y.L. & Li W.X. Different Residues in Channel Turret Determining the Selectivity of ADWX-1 Inhibitor Peptide between Kv1.1 and Kv1.3 Channels. 2008, 7, 4890-4897.(SCI, IF 5.67) (2) Shijin,Y; Hong, Y.; Yibao, M.; Zongyun, C.; Han, S.; Yingliang, W.; Zhijian, C.; Wenxin, L. Characterization of a new Kv1.3 channel-specific blocker, J123, from the scorpion Buthus martensii Karsch. 2008，29（9）：1514-20. (SCI,IF 2.6) (3) Wu, W.; Yin, S.; Ma, Y.; Wu, Y. L.; Zhao, R.; Gan, G.; Ding, J.; Cao, Z.; Li, W. Molecular cloning and electrophysiological studies on the first K(+) channel toxin (LmKTx8) derived from scorpion Lychas mucronatus. 2007, 28, 2306-2312.（SCI, IF 2.6, 并列第一作者） (4) Han, S.; Yi, H.; Yin, S. J.; Chen, Z. Y.; Liu, H.; Cao, Z. J.; Wu, Y. L.; Li, W. X. Structural basis of a potent Peptide inhibitor designed for kv1.3 channel, a therapeutic target of autoimmune disease. 2008, 283, 19058-19065.(SCI, IF 5.7, 并列第一作者) (5) Liu, J., Ma, Y., Yin, S., Zhao, R., Fan, S., Hu, Y., Wu, Y., Cao, Z., Li, W. Molecular cloning and functional identification of a new K(+) channel blocker, LmKTx10, from the scorpion Lychas mucronatus.Peptides 2009, 30, 675-680.（SCI, IF 2.6） (6) Liu, Z.; Liu, W.; Xiao, Z.; Wang, G.; Yin, S.; Zhu, F.; Wang, H.; Cheng, J.; Wang, X.; He, X.; Li, W. A major single nucleotide polymorphism of the PDLIM5 gene associated with recurrent major depressive disorder. 2008, 33, 43-46.(SCI, IF 3.71) (7) Xiao Z, Lu Z, Liu Z, Liu W, Li L, Yin S, Yu S, Dong H, Zhu F. Ethanol inhibits voltage-gated sodium channels in cultured superior cervical ganglion neurons，Neuroreport. 2008 Dec 3;19(18):1773-6.(SCI, IF 2.16) (8)Yi, H.; Cao, Z.; Yin, S.; Dai, C.; Wu, Y.; Li, W. Interaction simulation of hERG K+ channel with its specific BeKm-1 peptide: insights into the selectivity of molecular recognition. 2007, 6, 611-620. (SCI, IF 5.67) (9)Mao, X.; Cao, Z.; Yin, S.; Ma, Y.; Wu, Y.; Li, W. Cloning and characterization of BmK86, a novel K+ -channel blocker from scorpion venom. 2007, 360, 728-734.(SCI,IF 2.9) (10)Zhijian, C.; Yun, X.; Chao, D.; Shunyi, Z.; Shijin, Y.; Yingliang, W.; Wenxin, L. Cloning and characterization of a novel calcium channel toxin-like gene BmCa1 from Chinese scorpion Mesobuthus martensii Karsch. 2006, 27, 1235-1240. (SCI,IF 2.6） (11)Zhijian, C.; Chao, D.; Shijin, Y.; Yingliang, W.; Jiqun, S.; Yonggang, S.; Wenxin, L. Splicing of scorpion toxin gene BmKK2 in HEK 293T cells. 2006, 20, 1-6.(SCI) (12)Wang, K.; Yin, S. J.; Lu, M.; Yi, H.; Dai, C.; Xu, X. J.; Cao, Z. J.; Wu, Y. L.; Li, W. X. Functional analysis of the alpha-neurotoxin, BmalphaTX14, derived from the Chinese scorpion, Buthus martensii Karsch. 2006, 28, 1767-1772.(SCI) (13)Liu, X.; Yin, S.; Chen, S.; Ma, Q. Loureirin B: An Effective Component in Dragon’s Blood Modulating Sodium Currents in TG Neurons. 2005, 5, 4962-4965. (SCI) (14) Shi-jin Yin,Xiang-ming Liu. Dual modulation of interleukin-1 beta on tetrodotoxin-sensitive sodium currents in mice trigeminal ganglion cells. Cell bilolgy international, 2005, 29(10):S16. (SCI) (15)Xiangming, L.; Su, C.; Shijin, Y.; Zhinan, M. Effects of dragon’s blood resin and its component loureirin B on tetrodotoxin-sensitive voltage-gated sodium currents in rat dorsal root ganglion neurons. 2004, 47, 340-348. (SCI)
