人物經(jīng)歷
1996-2000 | 中國科學(xué)技術(shù)大學(xué) | 少年班 | 學(xué)士 |
2000-2006
| 中國科學(xué)技術(shù)大學(xué) | 計算機科學(xué)與技術(shù) | 博士 |
2006-2011 | 哥倫比亞大學(xué) | 生物化學(xué)和分子生物物理 | 博士 |
? 2011-2012 | ? 哥倫比亞大學(xué) | ? 計算生物和生物信息中心 | ? 博士后 |
? 2012-2015 | ? 斯坦福大學(xué)醫(yī)學(xué)院 | ? 皮膚系和遺傳系 | ? 博士后 |
科研方向
主要的研究興趣是發(fā)展計算和高通量實驗相結(jié)合的方法，并應(yīng)用于新興的結(jié)構(gòu)系統(tǒng)生物學(xué)研究，包括使用高通量深度測序的手段來探測RNA二級結(jié)構(gòu)和計算建模，RNA功能模體（motif）等有效預(yù)測或發(fā)現(xiàn)方法，蛋白-蛋白、RNA-RNA、以及蛋白-RNA相互作用網(wǎng)絡(luò)，以及結(jié)合結(jié)構(gòu)和網(wǎng)絡(luò)發(fā)展進一步疾病診斷、預(yù)后以及發(fā)展可能的治療手段。
著述成果
近期代表論文
1. Quinn JJ*,?Zhang QC*, Georgiev P, Ilik IA, Akhtar A, Chang HY.? (2016)Rapid evolutionary turnover underlies conserved lncRNAu2013genome interactions.?Genes & Development, 30 (2), 191-207. (*equal contribution)
2. Flynn RA*,?Zhang QC*, Spitale RC, Lee B, Mumbach MR, and Chang HY.? (2016)Transcriptome-wide interrogation of RNA secondary structure in living cells with icSHAPE.?Nature Protocols, 11 (2), 273-290 (*equal contribution)
3. Spitale R*, Flynn RA*,?Zhang QC*, Pete Crisalli, Byron Lee, Jong-Wha Jung, Hannes Y. Kuchelmeister, Pedro J. Batista, Eduardo A. Torre, Eric T. Kool, and Chang HY. (2015) Structural imprints in vivo decode mechanisms of RNA regulation.?Nature. 519 (7544): 486-90. (*equal contribution)
4. Chu C,?Zhang QC, Texira S, Bharadwaj M, Calabrese M, Magnuson T, Heard H and Chang HY. (2015) Developmentally regulated and modular assembly of Xist RNA binding proteins coordinate chromatin silencing.Cell. 161 (2): 404-16.
5. Wan Y*, Qu K*,?Zhang QC, Manor O, Ouyang Z, Zhang J, Snyder MP, Segal E and Chang HY. (2014) Landscape and variation of RNA secondary structure across the human transcriptome.?Nature, 505 (7485), 706-9.
6. Kasowski M*, Kyriazopoulou-Panagiotopoulou S*, Grubert F*, Zaugg JB*, Kundaje A*, Liu Y, Boyle AP,Zhang QC, Zakharia F, Spacek DV, Li J, Xie D, Steinmetz LM, Hogenesch JB, Kellis M, Batzoglou S, Snyder M. Extensive Variation in Chromatin States Across Human Individuals and Populations. (2013)?Science?342 (6159), 750-752.
7.Zhang QC, Petrey D, Garzon J, Deng L, and Honig B. (2013) PrePPI: A structure-informed database of protein-protein interactions.?Nucleic Acids Research, 41:D828-33.
8.Zhang QC*, Petrey D*, Deng L, Qiang L, Shi Y, Chan AT, Bisikirska B, Lefebvre C, Accili D, Hunter T, Maniatis T, Califano A, and Honig B. (2012) Structure-based prediction of protein-protein interactions on a genome-wide scale.?Nature, 490 (7421): 556-560 (*equal contribution)
9.Zhang QC*, Deng L*, Guan J, Honig B and Petrey D. PredUs: a web server for predicting protein interfaces using structural neighbors. (2011)?Nucleic Acids Research, 39: W283-87 (*equal contribution)
10.Zhang QC, Petrey D, Norel R, and Honig B, (2010) Protein interface conservation across structural space.Proceedings of the National Academy of Sciences, 107(24): 10896-109。
