病原細(xì)菌/人體微生物組與宿主互作-以效應(yīng)蛋白為中心

微生物與其宿主之間的相互作用是生物物種間最復(fù)雜的相互作用之一。一方面，在與人類或者其它動植物宿主億萬年共同進(jìn)化的過程中，共棲微生物（Commensal）成功適應(yīng)了宿主環(huán)境，并對宿主的發(fā)育、免疫及神經(jīng)系統(tǒng)都產(chǎn)生重要的影響；另一方面，病原菌（Pathogens）則能突破宿主的免疫屏障，實(shí)現(xiàn)感染。雖然抗生素和疫苗的發(fā)明使我們能對付大多數(shù)的病原細(xì)菌(Pathogenic bacteria)，但是，病原細(xì)菌也逐漸發(fā)展出了抵抗抗生素的策略，出現(xiàn)了超級抗性菌，使病原細(xì)菌特別是耐藥性細(xì)菌又一次成為人類的重大威脅；同時，病原細(xì)菌還發(fā)展出了精巧復(fù)雜的毒力系統(tǒng)，以適應(yīng)宿主體內(nèi)環(huán)境、躲避或克服宿主的免疫體系，導(dǎo)致各種感染癥甚至癌癥等，其中最重要的毒力系統(tǒng)就是細(xì)菌的分泌系統(tǒng)(Secretion System)。通過相當(dāng)于細(xì)菌“武器”的分泌系統(tǒng)，細(xì)菌可以向宿主體內(nèi)分泌數(shù)量眾多、功能各異的毒力蛋白-效應(yīng)蛋白（Effector proteins，也就是細(xì)菌的“子彈”），效應(yīng)蛋白與宿主細(xì)胞表面或宿主細(xì)胞中的各種靶點(diǎn)蛋白相互作用，改變宿主的各種信號傳導(dǎo)途徑如細(xì)胞凋亡、自噬和細(xì)胞周期等，從而適應(yīng)宿主環(huán)境，克服宿主免疫系統(tǒng)的攻擊，達(dá)到讓細(xì)菌自身在宿主內(nèi)增殖的目的。

研究微生物和宿主相互作用的學(xué)科稱為細(xì)胞微生物學(xué)（Cellular Microbiology），細(xì)菌效應(yīng)蛋白功能的闡明是該學(xué)科研究的重點(diǎn)。（1）闡明效應(yīng)蛋白的生化功能，可以讓我們更深入理解病原細(xì)菌致病以及適應(yīng)宿主環(huán)境的分子機(jī)制；（2）以這些效應(yīng)蛋白為工具，發(fā)現(xiàn)宿主固有免疫（Innate Immunity）調(diào)控的新途徑，是免疫學(xué)的新領(lǐng)域；（3）效應(yīng)蛋白本身還可以作為抗菌藥物作用的理想靶位點(diǎn)，研發(fā)針對這些效應(yīng)蛋白的活性先導(dǎo)物（相當(dāng)于鈍化或收繳細(xì)菌的“子彈”），有可能獲得避免耐藥性產(chǎn)生的新型抗生素；（4）可以運(yùn)用合成生物學(xué)（Synthetic Biology）策略在微生物細(xì)胞、癌細(xì)胞或免疫細(xì)胞中構(gòu)建效應(yīng)蛋白調(diào)控回路(Circuit) ，實(shí)現(xiàn)對疾病相關(guān)細(xì)胞活性的人工調(diào)控。

圍繞以上方向，我們的研究興趣具體如下（詳見主頁中的“研究興趣”欄目）：

（1）效應(yīng)蛋白的生化功能及宿主免疫反應(yīng)機(jī)制以目前臨床上典型的胞內(nèi)病原細(xì)菌嗜肺軍團(tuán)菌（Legionella pneumophila）、結(jié)核分枝桿菌（Mycobacterium tuberculosis）以及重要的植物病原細(xì)菌茄科勞爾氏菌（Ralstonia solanacearum）為模型，重點(diǎn)研究其致病的關(guān)鍵效應(yīng)蛋白的表達(dá)調(diào)控及其生化功能，闡明這些蛋白與宿主靶蛋白相互作用進(jìn)而調(diào)整宿主免疫系統(tǒng)的分子機(jī)制。

（2）靶向效應(yīng)蛋白的抗結(jié)核藥物研制結(jié)核分枝桿菌是結(jié)核病的病原，感染了我國近三分之一的人口，是國人健康的重大威脅，急需新的抗結(jié)核藥物。我們以結(jié)核分枝桿菌關(guān)鍵效應(yīng)蛋白為靶點(diǎn)，建立相應(yīng)的篩選系統(tǒng)，從微生物代謝產(chǎn)物中篩選效應(yīng)蛋白的抑制劑，并研究其作用機(jī)制，期望獲得新型的、能避免耐藥產(chǎn)生的新型抗結(jié)核藥物。

（3）腸道微生物組與宿主的互作及其分子機(jī)制腸道菌群是腸道內(nèi)寄居的種類繁多的微生物的總稱。腸道微生物是代謝的重要參與者，同時代謝產(chǎn)生的脂肪酸等促進(jìn)腸道上皮細(xì)胞生長與分化。腸道菌群之間可以通過如分泌系統(tǒng)分泌的效應(yīng)蛋白和群感效應(yīng)（Quorum sensing）等維持菌群的平衡。腸道菌群失調(diào)（dysbiosis）會增加疾病的易感性，包括胃腸道疾病、代謝類疾�。ㄈ绶逝�、糖尿病等）、免疫類疾病、精神類疾病和癌癥等。對腸道微生物組與疾病關(guān)系的研究，將為開發(fā)基于微生物的疾病診斷、疾病干預(yù)、治療和益生菌產(chǎn)品的研發(fā)等提供基礎(chǔ)。我們綜合運(yùn)用基因組學(xué)、代謝組學(xué)和生物信息學(xué)技術(shù)，研究腸道微生物組（microbiome）或腸道細(xì)菌及其效應(yīng)蛋白和代謝產(chǎn)物與炎癥和癌癥等的發(fā)生、發(fā)展的關(guān)聯(lián)性及其分子機(jī)制；同時，運(yùn)用合成生物學(xué)的相關(guān)策略，建立重要腸道菌的分子遺傳操作系統(tǒng)，以期實(shí)現(xiàn)對腸道細(xì)菌功能的精準(zhǔn)調(diào)控。

1. 主講本科生課程：必修課“生物技術(shù)學(xué)”、必修課“生物技術(shù)綜合實(shí)驗(yàn)”

2. 參講本科生課程：“生命科學(xué)引論”、逸仙學(xué)院教育部拔尖創(chuàng)新人才培養(yǎng)試驗(yàn)班課程“生物學(xué)前沿學(xué)術(shù)專題”

3. 合講研究生課程“細(xì)胞微生物學(xué)”

一、部分論文（2009--）

Qin Zeng, Junli Gong, Xiyuan Liu, Chen Chen, Xiaobo Sun, Huijuan Li, Yifan Zhou, ChunPing Cui, Yuge Wang, Yu Yang, Aimin Wu, Yaqing Shu, Xueqiang Hu, Zhengqi Lu, Song Guo Zheng*, Wei Qiu*, Yongjun Lu*.Gut dysbiosis and lack of short chain fatty acids in a Chinese cohort of patients with multiple sclerosis.Neurochemistry International,2019(129)104468.He L, Lin Y, Ge ZH, He SY, Zhao BB, Shen D, He JG, Lu YJ*. TheLegionella pneumophilaeffector WipA disrupts host F-actin polymerisation by hijacking phosphotyrosine signaling.Cellular Microbiology. 2019 Jan 31:e13014. doi: 10.1111/cmi.13014.Dongfeng Zhang, Yun Lin, Xi Chen, Wenting Zhao, Dongni Chen, Meng Gao, Qinglin Wang, Bin Wang, Haihong Huangu204e,Yongjun Luu204e, Yu Luu204e.Docking- and pharmacophore-based virtual screening for the identification of novel Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) inhibitor with a thiobarbiturate scaffold.Bioorganic Chemistry, 2019, 85:229u2013239.Jia-Hua Huang, Jian-Ming Lv, Qiao-Zhen Wang, Jian Zou, Yong-Jun Lu, Qing-Lin Wang, Dong-Ni Chen, Xin-Sheng Yao, Hao Gao and Dan Hu. Biosynthesis of an anti-tuberculosis sesterterpenoid asperterpenoid A.Organic & Biomolecular Chemistry, 2019 Jan 2; 17(2):248-251.LUO X-W, LIN Y, LU Y-J, Zhou XF, Liu YH. Peptides and polyketides isolated from the marine sponge-derived fungus Aspergillus terreus SCSIO 41008 [J].Chinese Journal of Natural Medicines, 2019, 17(2): 149-154.Sun yunhao, Li Pai, Shen Dong, Wei Qiaoling, He Jianguo, Lu Yongjun*. TheRalstonia solanacearumeffector RipN suppresses plant PAMP-triggered immunity, localizes to the endoplasmic reticulum and nucleus, and alters the NADH/NAD+ ratio in Arabidopsis.Molecular Plant Pathology.2019,20(4):533-546. First published, 2018,Nov 30. doi: 10.1111/mpp.12773.Gong JL, Qiu W, Zeng Q, Liu XY, Sun XB, Li HJ, Yang Y, Wu AM, Bao J, Wang YG, Shu YQ, Hu XQ, Bellanti JA, Zheng SG, Lu YJ*, Lu ZQ*. Lack of short-chain fatty acids and overgrowth of opportunistic pathogens define dysbiosis of neuromyelitis optica spectrum disorders: A Chinese pilot study.Multiple Sclerosis Journal, 2018, Aug 16:1352458518790396.Yu Dai, Yun Lin, Xiaoyan Pang, Xiaowei Luo, Limbadri salendra, Junfeng Wang，Xuefeng Zhou, Yongjun Lu, Bin Yang, Yonghong Liu. Peptides from the Soft Coral-associated FungusSimplicilliumsp. SCSIO41209.Phytochemistry, 2018, 154:56u201362。Qian Jia, Yun Lin, Xue-jing Gou, Lei He, Dong Shen, Dong-ni Chen, Wei Xie *, Yong-jun Lu*. Legionella pneumophila effector WipA, a bacterial PPP protein phosphatase with PTP activity.Acta Biochimica et Biophysica Sinica. 2018, 50(6):547-554.GONG Junli, SUN Xiaoming, LIN Zhiyong, LU Hongfeng, LU Yongjun. Geochemical and microbial characters of sediment from the gas hydrate area in the Taixinan Basin, South China Sea.Acta Oceanol. Sin., 2017, 36(9):52u201364.Senhua Chen, Meng Ding; Weiyang Liu; Xishan Huang, Zhaoming Liu, Yongjun Lu, Hongju Liu, Zhigang She. Anti-inflammatory Meroterpenoids from the Mangrove Endophytic FungusTalaromyces amestolkiaeYX1.Phytochemistry, 2017 Nov 30;146:8-15.Hui Cui, Yun Lin, Mingchu Luo, Yongjun Lu, Xishan Huang, and Zhigang She. Diaporisoindoles A?C: Three Isoprenylisoindole Alkaloid Derivatives from the Mangrove Endophytic FungusDiaporthesp. SYSU-HQ3.Organic Letters, 2017, Oct 20;19(20):5621-5624.Qianqian Ji, Caiping Guo, Chen Xie, Yingdan Wu, Pei Zhang, Hui Li, Yongjun Lu*. Genetically engineered cell lines for a1-antitrypsin expression.Biotechnology Letters, 2017, 39:1471-1476.Senhua Chen, Liqing He, Dongni Chen, Runlin Cai, Yuhua，Long, Yongjun Lu* and Zhigang She*. Talaramide A, an Unusual Alkaloid from the Mangrove Endophytic FungusTalaromycessp. (HZ-YX1) as Inhibitor of Mycobacterial PknG.New Journal of Chemistry, 2017, 146:8-15.Liu Z, Chen S, Qiu P, Tan C, Long Y, Lu Y, She Z. (+)- and (-)-Ascomlactone A: a pair of novel dimeric polyketides from a mangrove endophytic fungusAscomycotasp. SK2YWS-L.Organic & Biomolecular Chemistry. 2017, 15(48):10276-10280.Sun Yunhao, Li Pai, Deng Mengying, Shen Dong, Dai Guangyi, Yao Nan, Lu Yongjun*. TheRalstonia solanacearumeffector RipAK suppresses plant hypersensitive response by inhibiting the activity of host catalases.Cellular Microbiology, 2017, 19: e12736.Dongni Chen, Shuangshuang Ma, Lei He, Peibo Yuan, Zhigang She and Yongjun Lu*. Sclerotiorin inhibits protein kinase G fromMycobacterium tuberculosisand impairs mycobacterial growth in macrophages.Tuberculosis, 2017,103:37-43.Chunbin Tan, Zhaoming Liu, Senhua Chen, Xishan Huang, Hui Cui, Yuhua Long, Yongjun Lu and Zhigang She. Antioxidative Polyketones from the Mangrove-Derived FungusAscomycotasp. SK2YWS-L.Scientific report, 2016 Nov 4;6:36609.Meng-ying Deng, Yun-hao Sun, Pai Li, Bei Fu, Dong Shen, Yong-jun Lu*. The phytopathogenic virulent effector protein RipI induces apoptosis in budding yeastSaccharomyces cerevisiae.Toxicon, 2016, 121:109-118.Bei-bei Zhao, Xiang-hui Li, Yong-lun Zeng and Yong-jun Lu*. ClpP-deletion impairs the virulence of Legionella pneumophila and the optimal translocation of effector proteins.BMC Microbiology, 2016, 16(1):174-185.Hui Cui, Yayue Liu, Yang Nie, Zhaoming Liu, Zhengrui Zhang, Yongjun Lu, Lei He, Xishan Huang *, Zhigang She*. Polyketides from the Mangrove-Derived Endophytic FungusNectriasp. HN001 and Their α-Glucosidase Inhibitory Activity.Marine Drugs,2016, 14(5)：86.Liu, Zhaoming; Chen, Yan; Chen, Senhua; Liu, Yayue; Lu, Yongjun; Chen, Dongni; Lin, Yongcheng; Huang, Xishan; She, Zhigang. Aspterpenacids A and B, Two Sesterterpenoids from a Mangrove Endophytic FungusAspergillus terreusH010.Organic Letters, 2016, 18:1406-1409.Dong-ni Chen, Hong Chen, Zhi-gang She, Yong-jun Lu*. Identification of Bostrycin Derivatives on Inhibition of MptpB Phosphatase fromMycobacterium tuberculosis.Medicinal Chemistry, 2016;12(3):296-302.Li J, Xue YY, Yuan J, Lu YJ, Zhu X, Lin YC, Liu L*. Lasiodiplodins from Mangrove Endophytic FungusLasiodiplodiasp. 318#.Natural Product Research, 2016, 30(7), 755-760.Senhua Chen, Zhaoming Liu, Hanxiang Li, Guoping Xia, Yongjun Lu, Lei He, Shaodong Huang, Zhigang She. β-Resorcylic acid derivatives with a-glucosidase inhibitory activity fromLasiodiplodiasp. ZJ-HQ1, an endophytic fungus in the medicinal plantAcanthus ilicifolius,Phytochem. Lett. 2015,13, 141u2013146.Senhua Chen, Zhaoming Liu, Yayue Liu, Yongjun Lu, Lei He, Zhigang She. New Depsidones and Isoindolones from the Mangrove Endophytic FungusMeyerozyma guilliermondii(HZ-Y2) Isolated from the South China Sea,Beilstein J. Org. Chem.2015,11,1187u20131193.Liu Y, Yang Q, Xia G, Huang H, Li H, Ma L, Lu Y, He L, Xia X, She Z. Polyketides with α-Glucosidase Inhibitory Activity from a Mangrove Endophytic Fungus,Penicilliumsp. HN29-3B1.J Nat Prod. 2015，78(8):1816-22.He Lei, Deng Qing-li, Chen Mou-tong, Wu Qing-ping, Lu Yong-jun*. Proteomics analysis ofListeria monocytogenesATCC 19115 in response to simultaneous triple stresses.Archives of Microbiology, 2015, 197(6):833-841.Yayue Liu, Senhua Chen, Zhaoming Liu, Yongjun Lu, Guoping Xia, Hongju Liu, Lei He and Zhigang She. Bioactive Metabolites from Mangrove Endophytic FungusAspergillussp. 16-5B.Marine Drugs, 2015, 13: 3091-3102.Ze’en Xiao, Shao’e Lin, Chunbin Tan, Yongjun Lu, Lei He, Xishan Huang, Zhigang She. Asperlones A and B, Dinaphthalenone Derivatives from a Mangrove Endophytic FungusAspergillussp. 16-5C.Marine Drugs,2015, 13: 366-378.Sun Meng-yi, Lu Yong-jun*. A simple method for constructing magneticEscherichia coli.BioRxiv, 2014, October 10, doi: http://doi.org /10.1101/ 010249Yayue Liu, Guoping Xia, Hanxiang Li, Lin Ma, Bo Ding , Yongjun Lu , Lei He , Xuekui Xia *, Zhigang She*, Vermistatin Derivatives with α-Glucosidase Inhibitory Activity from the Mangrove Endophytic FungusPenicilliumsp. HN29-3B1.Planta Med., 2014, 80, 912-917.Li Jing，Yang Xin, Lin Yingying, Yuan Jie, Lu Yongjun, Zhu Xun, Li Jun, Li Mengfeng, Lin Yongcheng, He Jianguo, Liu Lan. Meroterpenes and azaphilones from marine mangrove endophytic fungusPenicillium303#.Fitoterapia, 2014, 97:241-246.Guoping Xia, Jia Li, Hanxiang Li, Yuhua Long, Shaou2019e Lin, Yongjun Lu, Lei He, Yongcheng Lin, Lan Liu and Zhigang She. Alterporriol-Type Dimers from the Mangrove Endophytic Fungus,Alternaria sp. (SK11), and Their MptpB Inhibitions.Marine Drugs, 2014, 12：2953-2969.Li HX, Jiang J, Liu Z, Lin S, Xia G, Xia X, Ding B, He L, Lu Y*, She Z*. Peniphenones A-D from the Mangrove FungusPenicillium dipodomyicolaHN4-3A as Inhibitors ofMycobacterium tuberculosisPhosphatase MptpB.J Nat Prod. 2014,77(4): 800?806.Ding B, Yuan J, Huang X, Wen W, Zhu X, Liu Y, Li H, Lu Y, He L, Tan H, She Z. New dimeric members of the phomoxanthone family: phomolacton-exanthones A, B and deacetylphomoxanthone C isolated from the fungusPhomopsissp.Marine Drugs. 2013 , 11(12):4961-72.Du J, Xiao K, Li L, Ding X, Liu H, Lu Y, Zhou S. Temporal and spatial diversity of bacterial communities in coastal waters of the South china sea.PLoS One. 2013, 8(6):e66968.Xiao Z, Huang H, Shao C, Xia X, Ma L, Huang X, Lu Y, Lin Y, Long Y, She Z. Asperterpenols A and B, new sesterterpenoids isolated from a mangrove endophytic fungusAspergillussp. 085242.Organic Letters.2013, 15(10):2522-5.Du J, Li L, Ding X, Hu H, Lu Y, Zhou S. Isolation and characterization of a novel cyanophycin synthetase from a deep-sea sediment metagenomic library.Appl Microbiol Biotechnol.2013, 97(19):8619-28.Huang, Xishan; Huang, Hongbo; Li, Hanxiang; Sun, Xuefeng; Huang, Huarong; Lu, Yongjun; Lin, Yongcheng; Long, Yuhua*; She, Zhigang *. Asperterpenoid A, a New Sesterterpenoid as an Inhibitor ofMycobacterium tuberculosisProtein Tyrosine Phosphatase B from the Culture ofAspergillussp. 16-5c.OrganicLetters. 2013，15（4）：721-723.Huang C, Jin H, Song B, Zhu X, Zhao H, Cai J, Lu Y, Chen B, Lin Y. The cytotoxicity and anticancer mechanisms of alterporriol L, a marine bianthraquinone, against MCF-7 human breast cancer cells.Appl Microbiol Biotechnol. 2012, 93(2):777-85.Ding X, Yin B, Qian L, Zeng Z, Yang Z, Li H, Lu Y, Zhou S. Screening for novel quorum-sensing inhibitors to interfere with the formation ofPseudomonas aeruginosabiofilm.J Med Microbiol. 2011, 60(Pt 12):1827-34.Hanxiang Li, Hongbo Huang, Changlun Shao, Huarong Huang, Jieyi Jiang, Xun Zhu,Yayue Liu Lan Liu,Yongjun Lu, Mengfeng Li, Yongcheng Lin,and Zhigang She. Cytotoxic Norsesquiterpene Peroxides from the Endophytic FungusTalaromyces flavusIsolated from the Mangrove PlantSonneratia apetala.Journal of Natural Products，2011, 74, 1230u20131235.Cai-Huan Huang, Jia-Hui Pan, Bin Chen, Miao Yu, Hong-Bo Huang, Xun Zhu,Yong-Jun Lu, Zhi-Gang She and Yong-Cheng Lin. Three Bianthraquinone Derivatives from the Mangrove Endophytic FungusAlternariasp. ZJ9-6B from the South China Sea.Marine Drugs, 2011, 9(5):832-843.Hongbo Huang, Xiaojun Feng,Zeu2019en Xiao, Lan Liu, Hanxiang Li, Lin Ma, Yongjun Lu, Jianhua Ju, Zhigang She, and Yongcheng Lin. Azaphilones and p-Terphenyls from the Mangrove Endophytic FungusPenicillium chermesinum(ZH4-E2) Isolated from the South China Sea.Journal of Natural Products，2011 74, 997u20131002.Huixian Li, Yali Huang, Jiong Zhang, Jikun Du, Hongming Tan, Yongjun Lu, Shining Zhou. Identification and characterization of a novel methionine c-lyase gene from deep-sea sediment metagenomic library.World J Microbiol Biotechnol, 2011, 27:2729u20132736.Jikun Du, Kai Xiao, Yali Huang, Huixian Li, Hongming Tan, Lixiang Cao, Yongjun Lu ,Shining Zhou. Seasonal and spatial diversity of microbial communities in marine sediments of the South China Sea.Antonie van Leeuwenhoek, 2011,100（3）：317-331.Fenju Lai, Rentian Wu, Jiafeng Wang, Chunming Li, Lan Zou, Yongjun Lu and Chun Liang. Far3p domains involved in the interactions of Far proteins and pheromone-induced cell cycle arrest in budding yeast.FEMS Yeast Research,2011 Feb;11(1):72-9.Lijuan Ma, Yuanliang Zhai, Daorong Feng, Tsz-choi Chan, Yongjun Lu, Xinrong Fu, Jiafeng Wang, Yanhong Chen, Jianna Li, Ke Xu, and Chun Liang. Identification of Novel Factors Involved in or Regulating Initiation of DNA Replication by a Phenotypic Screen inSaccharomyces cerevisiae.Cell Cycle, 2010,9(21):4399-4410.Hong-Bo Huang, Xiao-Jun Feng, Lan Liu, Bin Chen, Yong-Jun Lu, Lin Ma, Zhi-Gang She, Yong-Cheng Lin. Three Dimeric Naphtho-γ-Pyrones from the Mangrove Endophytic FungusAspergillus tubingensisIsolated fromPongamia pinnata.Planta Medica, 2010,76: 1888u20131891Kai-Kai Li, Yong-Jun Lu, Xiao-Hong Song, Zhi-Gang She, Xi-Wei Wu, Lin-Kun An,Chuang-Xing Ye, Yong-Cheng Lin. The metabolites of mangrove endophytic fungus Zh6-B1 from the South China Sea.Bioorganic & Medicinal Chemistry Letters, 2010,20: 3326u20133328.Xiang-hui Li, Yong-lun Zeng, Ye Gao, Xiao-cong Zheng, Qin-fen Zhang, Shi-ning Zhou, Yong-jun Lu*. The ClpP protease homologue is required for the transmission traits and cell division of the pathogenLegionella pneumophila.BMC Microbiology,2010, 10(1):54.Zhen Xu, Xue Cheng, Jiafeng Wang, Yuanliang Zhai, Yongjun Lu and Chun Liang. ATP-Dependent Pre-Replicative ComplexAssembly Is Facilitated by Adk1p in Budding Yeast.J. Biological Chemistry, 2010 ,285(39):29974-80.Jiafeng Wang, Rentian Wu, Yongjun Lu and Chun Liang. Ctf4p Facilitates Mcm10p to Promote Initiation of DNA Replication in Budding Yeast.Biochemical and Biophysical Research Communications, 2010, 395:336u2013341.Chun-ling Xu, Jia-feng Wang, Ye Gao, Huang-yu Lin, Lin Du, Shan-shan Yang, Si-mei Long, Zhi-gang She, Xiao-ling Cai, Shi-ning Zhou, Yong-jun Lu*. The anthracenedione compound bostrycin induces mitochondria-mediated apoptosis in the yeastSaccharomyces cerevisiae.FEMS Yeast Research,2010, 10（3）: 297u2013308.Yiguang Chen, Jiahui Pan, Fan Liu, JianXiang Yang, Caihuan Huang, Xiaolin Cai, Yongjun Lu, Zhigang She and Yongcheng Lin. A new indene derivative from the marine fungusPhomopsissp. (No. GX7-4A).Chem Nat Commpd. 2010,2:1-2.Wen-han Zhu, Lan Luo, Jia-yi Wang, Xiao-hong Zhuang, Ling Zhong, Kang Liao, Yan Zeng, Yong-jun Lu* . Complete nucleotide sequence of pCTX-M360, an intermediate plasmid between pEL60 and pCTX-M3, from a multidrug resistantKlebsiella pneumoniaeisolated in China.Antimicrobial Agents and Chemotherapy, 2009, 53(12):5291-5293Ming-jia Yu, Jun Ren, Yong-lun Zeng, Shi-ning Zhou and Yong-jun Lu*. TheLegionella pneumophilaDps homolog is regulated by iron and involved in multiple stress tolerance.Journal of Basic Microbiology，2009, 49: 1u20138.

二、 主編教材：《生物技術(shù)綜合實(shí)驗(yàn)》, 2017，中山大學(xué)出版社，第1版；2019年第二次印刷。