個(gè)人簡介
1997－2001年就讀于山東大學(xué)生命科學(xué)院，獲微生物學(xué)學(xué)士學(xué)位
2001－2004年就讀于山東大學(xué)生命科學(xué)院，獲微生物學(xué)碩士學(xué)位
2004－2009年就讀于清華大學(xué)生命科學(xué)院，獲生物物理學(xué)博士學(xué)位
2009－2012年在耶魯大學(xué)從事博士后研究
2012－2014年在威斯康星大學(xué)麥迪遜分校從事博士后研究
2014－2016年在加州大學(xué)伯克利分校從事博士后研究
2016年7月加入上�？萍即髮W(xué)，在iHuman研究所任PI（Research Associate Professor），在生命科學(xué)與技術(shù)學(xué)院任助理教授
研究方向
冷凍電子顯微學(xué)，膜分子生物學(xué)
研究內(nèi)容
主要研究內(nèi)容是利用冷凍電子顯微學(xué)作為主要技術(shù)手段研究蛋白與膜相互作用系統(tǒng)，并結(jié)合生物化學(xué)，熒光超分辨成像，X-射線晶體學(xué)以及分子動(dòng)態(tài)模擬來深刻理解蛋白與膜相互作用的機(jī)制；同時(shí)，利用胞內(nèi)系統(tǒng)進(jìn)一步驗(yàn)證所得到的作用機(jī)制。希望通過這些研究來加深理解重要蛋白與膜系統(tǒng)的分子機(jī)制，為解決蛋白與膜系統(tǒng)紊亂引起的疾病提供堅(jiān)實(shí)的結(jié)構(gòu)生物學(xué)基礎(chǔ)。
主要集中在以下幾個(gè)方向：
1.轉(zhuǎn)運(yùn)必需內(nèi)體復(fù)合體（ESCRT）剪切膜系統(tǒng)的分子機(jī)制
2.G蛋白偶聯(lián)受體（GPCR）的結(jié)構(gòu)生物學(xué)研究
3.嵌合于脂雙層的膜蛋白結(jié)構(gòu)冷凍電鏡解析方法的開發(fā)與應(yīng)用
代表論文
1. Lars-Anders Carlson, Qing-Tao Shen, Mark Remec Pavlin, James H. Hurley (2015) ESCRT filaments as spiral springs.Developmental Cell, 35(4): 397-398
2. Qing-Tao Shen, Xuefeng Ren, Rui Zhang, II-Hyung Lee, James H. Hurley (2015) HIV-1 Nef hijacks clathrin coats by stabilizing AP-1:Arf1 polygons.Science, 350(6259): aac5137 (Faculty 1000 recommended)
3. Bei Yang, Goran Stjepanovic, Qing-Tao Shen, Andreas Martin, James H. Hurley (2015) The AAA+ ATPase dissembles ESCRT-III by global unfolding and pore translocation. Nature Structural & Molecular Biology, 22(6): 492-498
4. Qing-Tao Shen, Amber L. Schuh, Yuqing Zheng, Marisa S Otegui, Paul Alquist, Qiang Cui, Anjon Audhya (2014) Structural analysis and modeling reveals new mechanisms governing ESCRT-III spiral filament assembly.Journal of Cell Biology(Cover Story), 206(6):763-777 (Highlighted in Journal of Cell Biology 206(5)) (Faculty 1000 recommended)
5. Zi-Chao Yu, Xiu-Lan Chen, Qing-Tao Shen, Dian-Li Zhao, Bai-Lu Tang, Hai-Nan Su, Zhao-Yu Wu, Qi-Long Zhao, Bin-Bin Xie, Xiying Zhang, Yong Wu, Bai-Cheng Zhou, Bo Chen, Yu-Zhong Zhang (2014)Filamentous phages prevalent in Psuedoalteromonas spp. confer properties advantageous to host survival in Arctic sea ice. ISME Journal, 1-11
6. Lei Shi, Kevin Howan, Qing-Tao Shen, Yong Jian Wang, James E Rothman, Frederic Pincet (2013) Preparation and characterization of SNARE-containing nanodiscs and direct study of cargo release through fusion pores. Nature Protocols, 8:935-948
7. Qing-Tao Shen, Peter Hsiue, Charles V. Sindeler, Matthew D. Weltch, Ken G. Campellone, Hong-Wei Wang (2012) Structural insights into WHAMM-mediated cytoskeletal coordination during membrane remodeling. Journal of Cell Biology (Cover Story), 199(1): 111-124(In focus by Journal of Cell Biology 199(1))
8. Lei Shi, Qing-Tao Shen, Alexander Kiel, Jing Wang, Hong-Wei Wang, Thomas J. Melia, James E. Rothman, Frederic Pincet (2012) SNARE Proteins: One to Fuse and Three to Keep the Nascent Fusion Pore Open. Science, 335(6074):1355-1359
9. Xiaoyang Wu, Qing-Tao Shen, Daniel S. Oristian, Catherine P. Lu, Qinsi Zheng, Hong-Wei Wang and Elaine Fuchs (2010) Skin Stem Cells Orchestrate Directional Migration by Regulating Microtubule-ACF7 Connections through GSK3β.Cell, 144(3):341-352
10. Qing-Tao Shen, Xiao-Chen Bai, Lei-Fu Chang, Yi Wu, Hong-Wei Wang, Sen-Fang Sui (2009) Bowl-shaped oligomeric structures on membranes as DegP’s new functional forms in protein quality control. Proc. Natl. Acad. Sci. USA, 106:4858-4863
11. Xiao-Yan Song, Qing-Tao Shen, Shu-Tao Xie, Xiu-Lan Chen, Cai-Yun Sun, Yu-Zhong Zhang (2006) Broad-spectrum antimicrobial activity and high stability of Trichokonins from Trichoderma koningii SMF2 against plant pathogens. FEMS Microbial Lett., 260(1):119-125
12. Chang-Zhen Liu, Li He, Qing-Tao Shen, Xiang-Hui Li, Sen-Fang Sui (2005) Leucine zipper domain is important for actin binding of p57. Progress in Biochemistry and Biophysics, 32(8):718-725
13. Qing-Tao Shen, Xiu-Lan Chen, Cai-Yun Sun, Yu-Zhong Zhang (2004) Dissecting and exploiting nonribosomal peptide synthetases. Acta Biochim Biophys Sin (Shanghai), 36(4):243-249
