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  • 鄒衛(wèi)國

    鄒衛(wèi)國

    鄒衛(wèi)國,1994-1998年,南開大學(xué)生物化學(xué)系,理學(xué)學(xué)士。1998-2003年,中國科學(xué)院生物化學(xué)與細(xì)胞生物學(xué)研究所,理學(xué)博士。2003年-2007年,美國Scripps研究所,博士后。2007-2012年,美國哈佛大學(xué)公共衛(wèi)生學(xué)院,博士后,Yerby Fellow。2012年8月起,在中國科學(xué)院生物化學(xué)與細(xì)胞生物學(xué)研究所任研究員,研究組長。


    基本內(nèi)容

    研究方向:
    骨發(fā)育及相關(guān)衰老與疾病的分子基礎(chǔ)骨質(zhì)疏松癥引起的骨折,是老齡化社會(huì)里非常普遍的公共健康問題。50歲以上人群,大約55%罹患骨質(zhì)疏松癥。骨質(zhì)疏松癥的起因是骨的代謝平衡異常。骨的代謝主要涉及兩類細(xì)胞,一是成骨細(xì)胞(Osteobalst),來源于間充質(zhì)干細(xì)胞,負(fù)責(zé)形成新的骨組織,二是破骨細(xì)胞(Osteoclast),來源于骨髓造血干細(xì)胞,負(fù)責(zé)吸收(降解)舊的骨組織。正常成年人體內(nèi),骨的形成和吸收是一個(gè)不斷循環(huán)、動(dòng)態(tài)平衡的過程。骨的代謝平衡異常,導(dǎo)致多種疾病,包括骨質(zhì)疏松癥、先天性骨發(fā)育畸形、骨性關(guān)節(jié)炎等。本研究組主要研究成骨細(xì)胞、破骨細(xì)胞的分化和功能,研究成骨細(xì)胞和破骨細(xì)胞之間的動(dòng)態(tài)平衡及相互影響,希望能綜合運(yùn)用多種體內(nèi)體外研究手段,為治療骨質(zhì)疏松癥等骨發(fā)育相關(guān)疾病提供新的思路和靶位點(diǎn)。
    代表論著:
      Zou, W., Chen, X., Shim, J.H., Huang, Z., Brady N., Hu, D.Z, Drapp, R., Sigrist, K., Glimcher, L.H. and Jones, D.C. (2011) The E3 ubiquitin ligase Wwp2 regulates craniofacial development through monoubiquitination of Goosecoid.Nature Cell Biology. 13, 59u201365.Zou, W.*, Greenblatt, M.B.* (*co-first author), Shim, J.H., Kant, S., Zhai, B., Brady, B., Hu, D.Z., Gygi, S.P., Davis, R., Jones, D.C. and Glimcher, L.H. (2011) MLK3 regulates bone development downstream of the Faciogenital Dysplasia protein FGD1.J Clin Invest. 121, 4383-92.Wan, L.*,Zou, W.* (*co-first author), Gao, D., Inuzuka, H., Drapp, R., Shaik, S., Eguren, M., Hu, D.Z., Malumbres, M., Glimcher L.H. and Wei W. (2011) Cdh1 Regulates Osteoblast functions through an APC/C-independent modulation of Smurf1.Molecular Cell. 44, 721-33.Greenblatt, M.B., Shim, J.H.,Zou, W., Sitara, D., Schweitzer, M., Hu, D., Lotinun, S., Sano, Y., Baron, R., Park, J.M., Arthur, S., Xie, M., Schneider, M.D., Zhai, B., Gygi, S., Davis, R., Glimcher, L.H. (2010) The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice.J Clin Invest. 120, 2457-73.Shim J,H., Greenblatt, M.B., Xie, M., Schneider, M.D.,Zou, W., Zhai, B., Gygi, S., Glimcher, L.H. (2009) TAK1 is an essential regulator of BMP signalling in cartilage.EMBO J. 28, 2028-41.Zou, W., Kim, J.H., Handidu, A., Li, X., Kim, K.I., Yan, M., Li, J., Zhang D.E. (2007). Microarray analysis reveals that Type I interferon strongly increases the expression of immune-response related genes in Ubp43 (Usp18) deficient macrophages.Biochem Biophys Res Commun. 356, 193-9.Zou,W., Wang, J., and Zhang,D.E. (2007). Negative regulation of ISG15 E3 ligase EFP through its autoISGylation.Biochem Biophys Res Commun., 354, 321-327.Okumura, F.,Zou, W., and Zhang, D.E. (2007).ISG15 modification of the eIF4E cognate 4EHP enhances cap structure-binding activity of 4EHP.Genes Dev., 21, 255 u2013 260.Malakhova, O.A., Kim, K.I., Luo, J.K.,Zou, W., Kumar, K.G., Fuchs, S.Y., Shuai, K., Zhang, D.E. (2006) UBP43 is a novel regulator of interferon signaling independent of its ISG15isopeptidase activity.EMBO J. 25, 2358-2367.Zou,W. and Zhang,D.E. (2006). The interferon-inducible ubiquitin-protein isopeptide ligase (E3) EFP also functions as an ISG15 E3 ligase.J Biol. Chem. 281, 3989-3994.Kim, K.I., Yan, M., Malakhova, O., Luo, J.K., Shen, M.F.,Zou, W., de la Torre, J.C., Zhang, DE. (2006). Ube1L and protein ISGylation are not essential for alpha/beta interferon signaling.Mol Cell Biol. 26, 472-479.Zou,W., Papov,V., Malakhova,O., Kim,K.I., Dao,C., Li,J., and Zhang,D.E. (2005). ISG15 modification of ubiquitin E2 Ubc13 disrupts its ability to form thioester bond with ubiquitin. Biochem.Biophys. Res. Commun. 336, 61-68.Liu, X., Qiu, S.,Zou, W., Pei, Z., Gu, J., Luo, C., Ruan, H., Chen, Y., Qi, Y., Qian, C.. (2005) Effective gene-virotherapy for complete eradication of tumor mediated by the combination of hTRAIL (TNFSF10) and plasminogen k5.Mol Ther. 11, 531-541.Zhang, Z.,Zou, W., Wang, J., Gu, J., Dang, Y., Li, B., Zhao, L., Qian, C., Qian, Q., Liu, X. (2005) Suppression of tumor growth by oncolytic adenovirus-mediated delivery of an antiangiogenic gene, soluble Flt-1.Mol Ther. 11, 553-562.Zou,W., Luo,C., Zhang,Z., Liu,J., Gu,J., Pei,Z., Qian,C., and Liu,X. (2004). A novel oncolytic adenovirus targeting to telomerase activity in tumor cells with potent antitumoral efficiency.Oncogene23, 457-464.Xu, W., Yu, F., Yan, M., Lu, L.,Zou, W., Sun, L., Zheng, Z., Liu, X. (2004). Geldanamycin, a heat shock protein 90-binding agent, disrupts Stat5 activation in IL-2-stimulated cells.J Cell Physiol. 198, 188-96.Pei, Z., Chu, L.,Zou, W., Zhang, Z., Qiu, S., Qi, R., Gu, J., Qian, C., Liu, X. (2004) An oncolytic adenoviral vector of Smac increases antitumor activity of TRAIL against HCC in human cells and in mice.Hepatology. 39, 1371-1381.Zhang, Z*,Zou,W* (*co-first author), Luo,C., Li,B., Wang,J., Sun,L., Qian,Q., and Liu,X. (2003). An armed oncolytic adenovirus system, ZD55-gene, demonstrating potent antitumoral efficacy.Cell Res. 13, 481-489.Zou,W*., Zeng,J.* (*co-first author), Zhuo,M., Xu,W., Sun,L., Wang,J., and Liu,X. (2002). Involvement of caspase-3 and p38 mitogen-activated protein kinase in cobalt chloride-induced apoptosis in PC12 cells.J Neurosci. Res. 67, 837-843.Zou,W., Wang,D., Lang,M., Jin,D., Xu,D., Zheng,Z., Wu,Z., and Liu,X. (2002). Human interleukin 10 gene therapy decreases the severity and mortality of lethal pancreatitis in rats.J Surg. Res. 103, 121-126.Liu,J.,Zou,W., Lang,M., Luo,J., Sun,L., Wang,X., Qian,Q., and Liu,X. (2002). Cancer-specific killing by the CD suicide gene using the human telomerase reverse transcriptase promoter.Int. J Oncol. 21, 661-666.Zou,W., Yan,M., Xu,W., Huo,H., Sun,L., Zheng,Z., and Liu,X. (2001). Cobalt chloride induces PC12 cells apoptosis through reactive oxygen species and accompanied by AP-1 activation.J Neurosci. Res. 64, 646-653.
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