個(gè)人履歷
出生年月： 1945.12.26
職稱(chēng)： 教授
簡(jiǎn)歷：
教授（博導(dǎo)），復(fù)旦大學(xué)遺傳所常務(wù)副所長(zhǎng)，遺傳學(xué)科“211工程”設(shè)備管理組組長(zhǎng)，生命學(xué)院學(xué)術(shù)委員會(huì)委員。1969年畢業(yè)于復(fù)旦大學(xué)生物學(xué)系，1971-1981于軍事醫(yī)學(xué)科學(xué)院從事微生物學(xué)研究，1981-1991于解放軍總醫(yī)院從事免疫學(xué)研究，1985-1987美國(guó)費(fèi)城WISTAR研究所訪問(wèn)學(xué)者進(jìn)行微生物的分子生物學(xué)研究。1991－至今，復(fù)旦大學(xué)遺傳學(xué)研究所，從事微生物免疫與遺傳工程研究。2000年享受?chē)?guó)務(wù)院頒發(fā)的政府特殊津貼。兼任上海市免疫學(xué)會(huì)理事，國(guó)外醫(yī)學(xué)《微生物學(xué)》分冊(cè)副主編，《微生物與感染》雜志副主編。發(fā)表學(xué)術(shù)論文120篇，其中SCI論文47篇。申請(qǐng)專(zhuān)利8項(xiàng)。培養(yǎng)碩士生、博士生、博士后20多人。目前主要從事結(jié)核病防治的基礎(chǔ)研究，先后承擔(dān)國(guó)家863、973、十五攻關(guān)、國(guó)家自然科學(xué)基金、上海市科委基金等10個(gè)科研項(xiàng)目。2005－2006年發(fā)表關(guān)于結(jié)核研究的學(xué)術(shù)論文在國(guó)內(nèi)處于領(lǐng)先水平。
主要研究方向
分子免疫學(xué)與遺傳工程；結(jié)核病防治基礎(chǔ)研究
獲獎(jiǎng)情況
參與的軍事醫(yī)學(xué)科研“xxx 裝置的研制”獲國(guó)家科技進(jìn)步獎(jiǎng)壹等獎(jiǎng)（獎(jiǎng)勵(lì)證號(hào)：后－1－001，1990）�！翱袢《窘Y(jié)構(gòu)蛋白抗原決定簇的篩選及其化學(xué)合成多肽疫苗的研究”獲軍隊(duì)科技進(jìn)步獎(jiǎng)叁等獎(jiǎng)（90－3－65－1）�！盎蚬こ虒�(shí)驗(yàn)技術(shù)”獲上海市優(yōu)秀教材壹等獎(jiǎng)（1999）。酵母表達(dá)人a 干擾素的研究和開(kāi)發(fā)獲上海市科技進(jìn)步貳等獎(jiǎng)（2001）。“免疫學(xué)導(dǎo)論”獲教育部?jī)?yōu)秀教材貳等獎(jiǎng)（2002）。
代表性論文和專(zhuān)著
1. Bernhard Dietzschold, Honghai Wang, Charrles E.Rupprecht, Esteban Cells, Maria Tollis, Hildegund Ertl, Ellen Heber-Katz, and Hilary Koprowski. Induction of protective immunity against rabies by immunization with rabies Virus ribonucleoprotein. Proc. Natl. Acad. Sci. USA 1987;84:9165
2. Jun Yue, Wei Shi, Jianping Xie, Yao Li, Erliang Zeng and Honghai Wang. Mutations of rpoB gene of multidrug-resistant Mycobacterium tuberculosis Isolates from China. Journal of Clinical Microbiology 2003,41(5):2209-2212
3. J.Yue, J.P.Xie, L.R.Liu and H.H.Wang. Detection of Rifampin-resistant Mycobacterium tuberculosis strains by using a specializated oligonucleotide microarray. Diagnostic microbiology and infectious disease.2004,48(1):47-54
4. Jianqiang Lei, Chunlan Wu, Xiaolei Wang, Honghai Wang. p38 MAPK-dependent YY1-mediated the chemokine receptors CCR5 and CXCR4 up-regulation in U937 cell line infected by Mycobacterium tuberculosis. B.B.R.C. 2005; 329:610-615
5. Min Zhang, Jun Yue, Yanping Yang, Hongmei Zhang, Jianqiang Lei, Ruiliang Jin, Xuelian Zhang, Honghai Wang. Detection of mutations associated with Isoniazid resistance in Mycobacterium tuberculosis isolates from China. Journal of Clinical Microbiology, 2005,43(11):5477－5482
6. Xiaoling Gu, Mao Chen, Hongbo Shen, Xin Jiang , Yishu Huang, Honghai Wang. Rv2131c gene product: an unconventional enzyme that is both inositol monophosphatase and fructose-1,6-bisphosphatase. B.B.R.C. 2006,339:897-904
7. Yishu Huang， Jing Ge， Yongchao Yao， Hongbo Shen， Honghai Wang. Characterization and site-directed mutagenesis of the putative novel acyl carrier protein Rv0033 and Rv1344 from Mycobacterium tuberculosis. BBRC 2006，342(2):618-24. (IF=3.0)
8、Hongmei Zhang, Jiuling Wang, Jianqiang Lei, Min Zhang, Yanping Yang, Yu Chen , Honghai Wang . PPE protein (Rv3425) from DNA segment RD11 of Mycrobacterium tuberculosis: a potential B-cell antigen used for serological diagnosis to distinguish vaccinated controls from tuberculosis patients Clinical Microbiology and Infection 2007：13(2)：139-145
9. Min Zhang, Yanping Yang, Ying Xu, Yaqing Qie, Jiu-ling Wang, Bingdong Zhu, Qingzhong Wang, Rui-liang Jin, Shengfeng Xu, Honghai Wang. Trehalose-6-phosphate phosphatase from Mycobacterium tuberculosis induces humoral and cellular immune responses. FEMS Immunology & Medical Microbiology 2007；49(1)：68-74
10. Xin Jiang, Wen Hong Zhang, Feng Gao, Jia Lin Jin, Xue Lian Zhang, Jing Chen, Honghai Wang. Identification of unique genetic markers in Rv0927c among Mycobacterium tuberculosis W-Beijing strains. Microbes and infection. 2007;9(2):241-246
