人物經(jīng)歷
1989-1993 年 山東大學(xué) 學(xué)士
1993-1996 年山東農(nóng)業(yè)大學(xué)碩士（師從溫孚江教授）
1997-2001 年 大阪大學(xué) 博士（師從Toshiyuki Hamaoka教授）
2001-2003 年 大阪大學(xué) 交流學(xué)者/研究助理
2003-2009 年美國(guó)加州大學(xué)舊金山分校（UCSF），博士后（師從Jeffery A. Bluestone教授）
2009-至今中國(guó)科學(xué)院微生物研究所研究員、博士生導(dǎo)師
研究組研究方向
調(diào)節(jié)性T細(xì)胞（Treg）的抑制機(jī)理及其免疫調(diào)控機(jī)制研究，探索選擇性干預(yù)Treg細(xì)胞和其他效應(yīng)性T細(xì)胞，進(jìn)行腫瘤、感染性和自身免疫性疾病的治療。
研究組研究?jī)?nèi)容及意義
1.Treg細(xì)胞的抑制機(jī)理及其免疫調(diào)控機(jī)制研究
Treg細(xì)胞對(duì)維持自身免疫穩(wěn)態(tài)至關(guān)重要，但也是腫瘤抑制性微環(huán)境形成的重要原因，課題組致力于研究Treg細(xì)胞的抑制機(jī)理及其免疫調(diào)控機(jī)制，并探索通過(guò)改變Treg細(xì)胞數(shù)量活性等，對(duì)腫瘤和自身免疫性疾病進(jìn)行干預(yù)。
2.腫瘤TCR-T治療研究
利用課題組已經(jīng)成熟建立的轉(zhuǎn)基因小鼠篩選平臺(tái)和TCR驗(yàn)證系統(tǒng)，基于高通量大數(shù)據(jù)，對(duì)肝癌等重要腫瘤TCR進(jìn)行序列分析、鑒定和驗(yàn)證，以期找到行之有效的殺傷腫瘤細(xì)胞的TCR克隆，促進(jìn)腫瘤TCR-T細(xì)胞治療研究。
代表性論文
1.Zhang Z,Zhou X. Foxp3 Instability Helps tTregs Distinguish Self and Non-self.Front Immunol. 2019 Sep 24; 10: 2226. doi: 10.3389/fimmu.2019.02226. eCollection 2019.
2.Xueping Zhu, Wei Zhang, Jie Guo, Xuejie Zhang, Liping Li, Ting Wang, Jinghua Yan, Fuping Zhang, Baidong Hou, Ning Gao,George F Gao*,Xuyu Zhou*. Noc4L mediated ribosome biogenesis controls activation of regulatory T cell and conventional T cell.Cell Reports. 2019, 27(4): 1205-1220
3.Krung Phiwpan,Xuyu Zhou*. MicroRNAs in regulatory T cells.Cancer Letters, 2018, 423, 80-85.
4.Xundong Wei, Jianhua Zhang, Qianchong Gu, Man Huang, Wei Zhang, Jie Guo,Xuyu Zhou*. Reciprocal Expression of IL-35 and IL-10 Defines Two Distinct Effector Treg Subsets that Are Required for Maintenance of Immune Tolerance.Cell Reports. 2017, 21(7), 1853-1869.
5. Zhongmei Zhang, Wei Zhang, Jie Guo, Qianchong Gu, Xueping Zhu,Xuyu Zhou*. Activation and Functional Specialization of Regulatory T Cells Lead to the Generation of Foxp3 Instability.Journal of Immunology. 2017, 198(7): 2612-2625.
6.Decong Kong, Zhe Chen, Junping Wang, Qingyu Lv, Hua Jiang, Yuling Zheng, Maokai Xu,Xuyu Zhou*,Huaijie Hao*, Yongqiang Jiang*. Interaction of factor H-binding protein of Streptococcus suis with globotriaosylceramide promotes the development of meningitis.Virulence. 2017, 8(7): 1290-1302.
7.Man Huang, Wei Zhang, Jie Guo, Xundong Wei, Krung Phiwpan, Jianhua Zhang*,Xuyu Zhou*. Improved Transgenic Mouse Model for Studying HLA Class I Antigen Presentation.Scientific Reports. 2016, doi:10.1038/srep33612.
8.Tanyu Hu, Krung Phiwpan, Jitao Guo, Wei Zhang, Jie Guo, Zhongmei Zhang, Mangge Zou, Xuejie Zhang, Jianhua Zhang,Xuyu Zhou*. MicroRNA-142-3p Negatively Regulates Canonical Wnt Signaling Pathway.PLoS One, 2016, DOI:10.1371/journal.pone.0158432
9.Jitao Guo andXuyu Zhou*. Regulatory T cells turn pathogenic.Cellular & Molecular Immunology(2015), 1u20138.
10.Krung Phiwpan, Jie Guo, Wei Zhang, Tanyu Hu, Bhargavi M Boruah, Jianhua Zhang,Xuyu Zhou*. A novel transgenic mouse line for tracing microRNA-155-5p activity in vivo.PLoS One. 2015, 10(6):e0128198.
11.Jitao Guo, Jianhua Zhang, Xuejie Zhang, Zhongmei Zhang, Xundong Wei andXuyu Zhou*. Constitutive activation of MEK1 promotes Treg cell instability in vivo.Journal of Biological Chemistry. 2014, 289(51):35139-48.
12.Peipei Liu, Di Liu, Xi Yang, Jing Gao, Yan Chen, Xue Xiao, Fei Liu1, Jing Zou, Jun Wu, Juncai Ma, Fangqing Zhao,Xuyu Zhou*, George F. Gao*, Baoli Zhu*. Characterization of human αβTCR repertoire and discovery of D-D fusion in TCR β chains.Protein & Cell. 2014, 5(8):603-15.
13.Lv Q, Hao H, Bi L, Zheng Y,Zhou X*, Jiang Y*. Suilysin remodels the cytoskeletons of human brain microvascular endothelial cells by activation RhoA and Rac1 GTPase.Protein & Cell. 2014, 5(4):261-4
14.Hao H, Hui W, Liu P, Lv Q, Zeng X, Jiang H, Wang Y, Zheng X, Zheng Y, Li J*,Zhou X*, Jiang Y*. Effect of licochalcone A on growth and properties of Streptococcus suis.PLoS One. 2013, 8(7):e67728.
15.Zhou X, Bailey-Bucktrout S, Jeker LT, Bluestone JA*. Plasticity of CD4(+) FoxP3(+) T cells.Curr Opin Immunol. 2009 Jun, 21(3):281-5. Review.
16.Zhou X, Bailey-Bucktrout SL, Jeker LT, Penaranda C, Martínez-Llordella M, Ashby M, Nakayama M, Rosenthal W, Bluestone JA*. Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo.Nat Immunol. 2009 Sep, 10(9):1000-7.
17.Zhou X, Jeker LT, Fife BT, Zhu S, Anderson MS, McManus MT, Bluestone JA*. Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity.J Exp Med. 2008 Sep 1, 205(9):1983-91.
18.Zhou, XY, Yashiro-Ohtani, Y, Toyo-oka, K, Park, CS, Tai, XG, Hamaoka, T, Fujiwara, H*. CD5 costimulation up-regulates the signaling to extracellular signal-regulated kinase activation in CD4(+)CD8(+) thymocytes and supports their differentiation to the CD4 lineage.The Journal of Immunology, 164(3): 1260-1268.
19.Zhou, XY, Yashiro-Ohtani, Y, Nakahira, M, Park, WR, Abe, R, Hamaoka, T, Naramura, M, Gu, H, Fujiwara, H*. Molecular mechanisms underlying differential contribution of CD28 versus non-CD28 costimulatory molecules to IL-2 promoter activation.The Journal of Immunology, 168(8): 3847-3854.