中山大學(xué)教授
基本信息 姓名： 黎明濤 職稱(chēng)： 教授 導(dǎo)師類(lèi)別： 博士生導(dǎo)師 學(xué)科專(zhuān)業(yè)： 藥理學(xué)；分子神經(jīng)生物學(xué) 研究方向： 神經(jīng)元凋亡的信號(hào)轉(zhuǎn)導(dǎo)、基因調(diào)控； 帕金森��；蛋白質(zhì)組學(xué) 學(xué)術(shù)兼職：個(gè)人簡(jiǎn)介 2001年回國(guó)，獲得“211”基金200萬(wàn)元，組建了一流的分子、細(xì)胞生物學(xué)實(shí)驗(yàn)室。自2002年以來(lái)，作為負(fù)責(zé)人獲得一期“985”學(xué)科建設(shè)經(jīng)費(fèi)700萬(wàn)元，籌建了一流的蛋白質(zhì)組學(xué)實(shí)驗(yàn)室并正在開(kāi)展蛋白質(zhì)科學(xué)的前沿性工作。近年來(lái)，培養(yǎng)和匯聚了一支從事蛋白質(zhì)組學(xué)、細(xì)胞和分子生物學(xué)研究的高素質(zhì)科研隊(duì)伍�！ 〗陙�(lái)，黎明濤作為第一主持人獲得18項(xiàng)基金，包括5項(xiàng)國(guó)家自然科學(xué)基金，5項(xiàng)廣東省自然科學(xué)基金，4項(xiàng)廣州市科技局項(xiàng)目以及教育部、衛(wèi)生部的重點(diǎn)項(xiàng)目基金近500萬(wàn)元。在各項(xiàng)基金的支持下，課題組共發(fā)表了SCI論文20篇，其中黎明濤作為第一作者在國(guó)際核心雜志Molecular and Cellular Biology(IF, 10.03)和 Journal of Neuroscience(IF, 8.4)發(fā)表了具有創(chuàng)新性的文章；作為通訊作者，在Neuroscience Research(IF, 2.4) 和Neuroscience Letters （IF，2.2）上發(fā)表了3篇開(kāi)拓性文章，并在 Drug News Perspect（IF，0.524） 上發(fā)表了相關(guān)專(zhuān)題綜述。
代表性研究項(xiàng)目
1、分子神經(jīng)生物學(xué) 海外或港、澳杰出青年學(xué)者合作研究基金 2007.1-2009.12 項(xiàng)目批準(zhǔn)號(hào)：30629002 40萬(wàn) 2、c-Jun靶基因及其對(duì)神經(jīng)元凋亡的調(diào)控 聯(lián)合資助基金項(xiàng)目/重點(diǎn)項(xiàng)目2007.1-2010.12 項(xiàng)目編號(hào)：U0632006 140萬(wàn) 3、神經(jīng)元凋亡時(shí)SP1對(duì)BH3-only蛋白Bim的轉(zhuǎn)錄調(diào)控 國(guó)家自然科學(xué)基金2006.1-2008.12 項(xiàng)目編號(hào)：30570562 35萬(wàn) 4、靛玉紅衍生物治療帕金森病的研究與開(kāi)發(fā) 廣東省科技計(jì)劃項(xiàng)目——國(guó)際科技合作計(jì)劃 2007.1-2009.12 項(xiàng)目編號(hào)2006B50103001 10萬(wàn) 5、轉(zhuǎn)錄因子MEF2對(duì)神經(jīng)元凋亡調(diào)控作用及其信號(hào)轉(zhuǎn)導(dǎo) 國(guó)家自然科學(xué)基金2004.1-2006.12 項(xiàng)目編號(hào)：30370450 25萬(wàn)
近五年SCI論文
1. Mingtao Li，Xiaomin Wang，Mary Kay Meintzer，Tracey Laessig，Morris J. Birnbaum and Kim A. Heidenreich. Cyclic AMP promotes neuronal survival by phosphorylation of glycogen synthase kinase 3β. Mol Cell Biol. 2000, 20（24）：9356-9363. 2. Mingtao Li，Daniel A. Linsenman，Melissa P.Allen，Mary Kay Meintzer， Xiaomin Wang，Tracey Laessig，Margaret E. Wierman & Kim A. Heidenreich. MEF2A and MEF2D undergo phosphorylation and caspase-mediated degradation during apoptosis of rat cerebellar granule neurons. J. Neurosci. 2001, 21(17):6544-6552. 3. Leyu Shi , Shoufang Gong, Zhongmin Yuan , Chi Ma, Yanling Liu, Chuanfu Wang , Wenming Li, Rongbiao Pi, Shoujian Huang, Ruzhu Chen , Yifan Han , Zixu Mao, and Mingtao Li(通訊作者). Activity deprivation-dependent induction of the proapoptotic BH3-only protein Bim is independent of JNK/c-Jun activation during apoptosis in cerebellar granule neurons. Neurosci Lett. 2005, 375:7-12. 4. Wenya Wang, Chi Ma, Zixu Mao and Mingtao Li. (通訊作者). JNK inhibition as a potential strategy in treating Parkinsonsu2019s disease. Drug News Perspect. 2004, 17(10):646-654. 5. Wenya Wang, Leyu Shi, Yuanbin Xie, Chi Ma, Wenming Li, Xingwen Su, Shoujian Huang, Ruzhu Chen, Zhenyu Zhu, Zixu Mao, Yifan Han and Mingtao Li. (通訊作者). SP600125, a new JNK inhibitor, protects dopaminergic neurons in the MPTP model of Parkinsonu2019s disease. Neurosci Res 2004,48:195-202. 6. Yuanbin Xie, Yanling Liu, Chi Ma, Zhongmin Yuan, Wenya Wang, Zhenyu Zhu, , Guoquan Gao, Xianguo Liu, Hengxin Yuan, Ruzhu Chen, Shoujian Huang, Xuelan Wang, Xiaonan Zhu, Xuemin Wang, Zixu Mao and Mingtao Li (通訊作者). Indirubin-3u2032-oxime inhibits c-Jun NH2-terminal kinase: anti-apoptotic effect in cerebellar granule neurons. Neurosci Lett. 2004, 367:355-359. 7. Rongbiao Pi, Wenming Li Nelson T.K.Lee, Hugh H.N.Chan, Yongmei Pu, Ling Nga Chan, Nikolaus J.Sucher, Doanld C. Chang, Mingtao Li and Yifan Han. Minocycline prevents glutamate-induced apoptosis of cerebellar granule neurons by differential regulation of p38 and Akt pathways. J Neurochem. 2004, 91:1212-1230. 8. Wenming Li, Rongbiao Pi, Hugh H. N. Chan, Hongjun Fu, Nelson T. K. Lee, Hing Wai Tsang, Yongmei Pu, Donald C. Chang, Chaoying Li, Jialie Luo, Keming Xiong, Zhiwang Li, Hong Xue, Paul R. Carlier, Yuanping Pang, Karl W. K. Tsim, Mingtao Li and Yifan Han. Novel dimeric AChE inhibitor Bis(7)-tacrine, but not Donepezil, prevents glutamate-induced neuronal apoptosis by blocking NMDA receptors. J Biol Chem. 2005, 280(18):18179-18188. 9. Xuemin Wang, Xiaoli Tang, Mingtao Li, John Marshall, Zixu Mao. Regulation of neuroprotective activity of myocyte enhancer factor 2 by cAMP-PKA signaling pathway in neuronal survival. J Biol Chem. 2005, 280(17):16705-167013. 10. Daniel A. Linseman, Christopher M. Bartley, Shoshona S. Le, Tracey A. Laessig, Ron J. Bouchard, Mary Kay Meintzer, Mingtao Li and Kim A. Heidenreich . Inactivations in Hepatocytes of Normal and Cirrhotic Rat Livers Under Normal and Regenerating Conditions. J Cell Biochem. 2004, 91:1269u20131279. 12. Hongwei Yang, Xiaodong Hu, Hongmei Zhang, Wenjun Xin, Mingtao Li, Tong Zhang, Lijun Zhou and Xianguo Liu. Roles of CaMKII, PKA, and PKC in the induction and mainternance of LTP of C-fiber-evoked field potentials in rat spinal dorsal horn. J Neurophysiol. 2004, 91: 1122-1133. 13. Nengwei Hu, Hongmei Zhang, Xiaodong Hu , Mingtao Li, Tong Zhang, Lijun Zhou and Xianguo Liu. Protein Synthesis Inhibition Blocks the Late-Phase LTP of C-Fiber Evoked Field Potentials in Rat Spinal Dorsal Horn. J Neurophysiol. 2003,89: 2354- 2359. 14. Juan Sun, Mingtao Li, Jiahuai Han and Jun Gu. Sensitization of differentiated PC12 cells to apoptosis by presenilin-2 is mediated by p38. Biochem. Biophy. Res. Commun. 2001, 287: 536-541. 15. Marcus Wiedmann, Xuemin Wang, Xiaoli Tang, Mingtao Li, Zixu Mao. PI3K/Akt-dependent regulation of the transcription factor myocyte enhancer factor-2 in insulin-like growth factor-1- and membrane depolarization-mediated survival of cerebellar granule neurons. J Neurosci Res. 2005, 81(2):226-234. 16. Weibin Cai, Jianfang Ma , Chaoyang Li, Zhonghan Yang, Xia Yang, Wei Liu , Zuguo Liu , Mingtao Li, Guoquan Gao. Enhanced anti-angiogenic effect of a deletion mutant of plasminogen kringle 5 on neovascularization. J Cell Biochem. 2005,96(6):1254-1261. 17. Ming Yang, Wei Liu, Chunyou Wang, Tao Liu, Feng Zhou, Jing Tao, Yang Wang, Mingtao Li. Proteomic Analysis in the Early Process of Pancreatic Regeneration in the Pancreatectomized Rat. Acta Pharmacol Sin. 2006, 27(5):568-578. 18. Hongjun Fu, Wenming Li, Yuanzhi Lao, Jialie Luo, Nelson T. K. Lee, Kelvin K. W. Kan, Hing Wai Tsang, Karl W. K. Tsim, Yuanping Pang, Zhiwang Li, Donald C. Chang, Mingtao Li and Yifan Han. Bis(7)-tacrine attenuates beta amyloid-induced neuronal apoptosis by regulating L-type calcium channels. J Neurochem. 2006 Jun 12; [Epub ahead of print] 19. Wenming Li, Nelson T.K. Lee, Hongjun Fu, Kelvin K.W. Kan, Yuanping Pang, Mingtao Li, Tsim, W.K. Karl, Xiaoyuan Li, Yifan Han. Neuroprotection via inhibition of nitric oxide synthase by bis(7)-tacrine. Neuroreport. 2006,17(5):471-474. 20. Rong Deng, Wenming Li, Zhong Guan, Junmin Zhou, Yi Wang, Yuping Mei, Mingtao Li, Gongkan Feng, Wenlin Huang, Zongchao Liu, Yifan Han, Yixin Zeng and Xaofeng Zhu. Acetylcholinesterase expression mediated by c-Jun-NH2-terminal kinase pathway during anticancer drug-induced apoptosis. Oncogene. 2006 May 22; [Epub ahead of print]
