2002年本科畢業(yè)后，尹燁加入華大集團(tuán)（以下簡(jiǎn)稱(chēng)：華大）子公司——北京華大吉比愛(ài)生物技術(shù)有限公司，先后從事體外診斷試劑研發(fā)、產(chǎn)品注冊(cè)、生產(chǎn)管理、質(zhì)量管理、市場(chǎng)營(yíng)銷(xiāo)等工作，在生物產(chǎn)品研發(fā)、生產(chǎn)、質(zhì)控、申報(bào)注冊(cè)及生物技術(shù)臨床應(yīng)用推廣等方面有豐富的經(jīng)驗(yàn)，主持申報(bào)數(shù)十項(xiàng)體外診斷試劑及多項(xiàng)專(zhuān)利，對(duì)于GMP/IVD/ISO系列質(zhì)量管理體系有深刻理解。

2003年春，尹燁作為“非典型性肺炎”（SARS）早期診斷科研攻關(guān)的主要參與者之一，在華大高效完成SARS病毒測(cè)序和獲得診斷蛋白之后，率領(lǐng)團(tuán)隊(duì)在24小時(shí)內(nèi)即完成了SARS診斷試劑盒研發(fā)及申報(bào)材料的準(zhǔn)備，并順利獲得了國(guó)藥局（現(xiàn)食藥總局）的審批。隨后，華大及時(shí)將30萬(wàn)人份SARS檢測(cè)試劑盒無(wú)償捐贈(zèng)給國(guó)家非典防治指揮部，對(duì)疫情的防控起到了關(guān)鍵性作用。

2009年，尹燁調(diào)入華大集團(tuán)深圳總部，負(fù)責(zé)基因組學(xué)及生物信息學(xué)全球范圍內(nèi)的產(chǎn)業(yè)推廣，并先后出任華大基因科技合作事業(yè)部總裁、全球基因組平臺(tái)負(fù)責(zé)人、華大生命科學(xué)研究院助理院長(zhǎng)、華大集團(tuán)首席運(yùn)營(yíng)官、華大醫(yī)學(xué)執(zhí)行總裁等職。

2010年起，他開(kāi)始組建華大全球營(yíng)銷(xiāo)團(tuán)隊(duì)，打造華大全球化科研、產(chǎn)業(yè)平臺(tái)，完成了華大的全球化布局。期間，尹燁主持或參與了上百個(gè)國(guó)際基因組合作項(xiàng)目，包括“千種動(dòng)植物基因組計(jì)劃”“百萬(wàn)人重測(cè)序計(jì)劃”“蒙古族人基因組計(jì)劃”等大型項(xiàng)目，在Nature系列、Science、PNAS等國(guó)際頂級(jí)學(xué)術(shù)期刊發(fā)表近60篇論文（詳見(jiàn)主要論文部分），并促成華大與全球生命科學(xué)相關(guān)領(lǐng)域的機(jī)構(gòu)建立良好的合作關(guān)系，為推動(dòng)基因組學(xué)研究、分子育種、醫(yī)療健康、環(huán)境能源等領(lǐng)域的科研發(fā)展做出重要貢獻(xiàn)。

2013年，尹燁作為核心成員，參與完成華大對(duì)美國(guó)上市公司Complete Genomics的全資收購(gòu)。

2014年，尹燁出任華大醫(yī)學(xué)執(zhí)行總裁，全面貫徹“5P醫(yī)學(xué)”理念，降低出生缺陷及減少腫瘤等重大疾病對(duì)人類(lèi)健康的危害，推動(dòng)全球基因檢測(cè)的臨床應(yīng)用發(fā)展。

2017年7月14日，深圳華大基因股份有限公司在創(chuàng)業(yè)板上市，成為中國(guó)基因科技第一股。尹燁任深圳華大基因股份有限公司CEO，率領(lǐng)團(tuán)隊(duì)積極推動(dòng)前沿生物技術(shù)和基因組學(xué)研究成果的產(chǎn)業(yè)化應(yīng)用，向全球頂尖的醫(yī)療機(jī)構(gòu)、科研機(jī)構(gòu)、大學(xué)、藥廠、育種公司等提供完整的基因組學(xué)解決方案，為臨床行為提供診斷、干預(yù)和治療依據(jù)，為生命科學(xué)及醫(yī)學(xué)創(chuàng)新提供技術(shù)和研究服務(wù)，和團(tuán)隊(duì)一起致力于使華大基因成為全球基因科技、臨床應(yīng)用的行業(yè)領(lǐng)導(dǎo)者。

在尹燁的帶領(lǐng)下，華大基因一直積極踐行改善人類(lèi)健康的社會(huì)責(zé)任，心系公益事業(yè)。他與團(tuán)隊(duì)發(fā)起“生命周期表”等項(xiàng)目及活動(dòng)，長(zhǎng)期支持中國(guó)罕見(jiàn)病發(fā)展中心等罕見(jiàn)病專(zhuān)業(yè)組織，帶領(lǐng)團(tuán)隊(duì)發(fā)起并組建“同并相聯(lián)”網(wǎng)站，以期打造成為罕見(jiàn)病、遺傳病診治與交流第一平臺(tái)。與團(tuán)隊(duì)多次發(fā)起罕見(jiàn)病救助項(xiàng)目，致力于推動(dòng)對(duì)罕見(jiàn)病、血液疾病的關(guān)愛(ài)與救助。

尹燁個(gè)人亦帶頭捐款發(fā)起成立公益基金——華基金，永久免費(fèi)為重癥地貧患兒提供HLA配型；牽頭發(fā)起成立“愛(ài)之光眼病基因檢測(cè)”“光基金”，意在免費(fèi)提供基因檢測(cè)救助先天性眼疾的患者；發(fā)起成立“狂犬病科研基金”等專(zhuān)項(xiàng)基金，旨在推進(jìn)狂犬病治療的臨床研究。

尹燁積極參與基因科普工作，多次受邀在WIRED、TEDx、一席、中國(guó)企業(yè)家論壇、亞布力企業(yè)家論壇、中歐EMBA、長(zhǎng)江EMBA、北大EMBA、湖南衛(wèi)視《我是未來(lái)》、混沌研習(xí)社、黑馬營(yíng)、科技部人才中心、深圳市市民大講堂等平臺(tái)授課，并在喜馬拉雅FM、懶人聽(tīng)書(shū)等新媒體開(kāi)設(shè)“天方燁談”基因科普欄目，通過(guò)多種渠道和途徑、上百集節(jié)目、上百篇文章，講大眾聽(tīng)得懂的生命科學(xué)，宣傳、推廣與廣大人民群眾相關(guān)的基因技術(shù)與知識(shí)。

2019年11月被評(píng)為“2019科創(chuàng)榜·最具影響力人物 POWER 20”?

2019年9月獲評(píng)第二屆廣東十大科學(xué)傳播達(dá)人?

2019年被選為中國(guó)抗癌協(xié)會(huì)腫瘤科普防治專(zhuān)業(yè)委員會(huì)常務(wù)委員?

2019年2月入選第四批國(guó)家“萬(wàn)人計(jì)劃”科技創(chuàng)業(yè)領(lǐng)軍人才?

2018年12月成為深圳市標(biāo)準(zhǔn)化協(xié)會(huì)第七屆理事會(huì)會(huì)長(zhǎng)

2018年9月獲評(píng)《財(cái)富》“中國(guó)40位40歲以下商界精英”

2018年9月獲頒第三屆民企盛典企業(yè)家公益人物

2018年3月獲評(píng)“感動(dòng)深圳2018十佳愛(ài)心人物”

2017年12月獲頒“2017年21世紀(jì)中國(guó)最佳商業(yè)模式先鋒人物獎(jiǎng)”

2017年11月獲頒“2017中國(guó)上市公司口碑榜最佳上市公司領(lǐng)袖獎(jiǎng)”

2017年5月獲評(píng)十大“深圳好青年”

2017年4月成為科技部第三屆人類(lèi)遺傳資源管理專(zhuān)家組成員

2017年1月獲評(píng)“深圳市國(guó)家級(jí)領(lǐng)軍人才”

2017年1月獲“2016年度公益人物獎(jiǎng)”

2016年12月獲“中國(guó)杰出質(zhì)量人（全國(guó)質(zhì)量獎(jiǎng)個(gè)人獎(jiǎng)）”

2016年12月任中國(guó)計(jì)量測(cè)試學(xué)會(huì)生物計(jì)量專(zhuān)業(yè)委員會(huì)委員

2016年11月獲“2016時(shí)代深士”稱(chēng)號(hào)

2016年7月獲“深圳市鹽田區(qū)優(yōu)秀共產(chǎn)黨員”榮譽(yù)稱(chēng)號(hào)

2015年11月被大連理工大學(xué)聘請(qǐng)為兼職教授

2015年9月獲“第二屆國(guó)際罕見(jiàn)病大會(huì)貢獻(xiàn)獎(jiǎng)”

2015年4月獲大連理工大學(xué)“2014校友年度人物”獎(jiǎng)

2015年獲“深圳市科技進(jìn)步獎(jiǎng)”

2014年12月獲深圳市企業(yè)首席質(zhì)量官

2014年9月獲“2014中國(guó)十大經(jīng)濟(jì)潮流人物獎(jiǎng)”

2013年9月獲評(píng)“深圳市鹽田區(qū)生物產(chǎn)業(yè)高層次人才”

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(2015) Molecular signatures of major depression.Current Biology.2015 May 4;25(9):1146-56. doi: 10.1016/j.cub.2015.03.008. Epub 2015 Apr 23.B?ckhed F, Roswall J, Peng Y,...Yin Y,... (2015) Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life.Cell Host Microbe.2015 May 13;17(5):690-703. doi: 10.1016/j.chom.2015.04.004.Xu Y, Guan L, Xiao X,...Yin Y,... (2015) Mutation analysis in 129 genes associated with other forms of retinal dystrophy in 157 families with retinitis pigmentosa based on exome sequencing.Molecular Vision.2015 Apr 28;21:477-86. eCollection 2015.Xu Y, Guan L, Xiao X,...Yin Y,... (2015) ALMS1 null mutations: a common cause of Leber congenital amaurosis and early-onset severe cone-rod dystrophy.Clinical Genetics.2015 May 22. doi: 10.1111/cge.12617.Zhang W, Yu Y, Hertwig F,...Yin Y,... 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Mingzhi Ye, Shiyong Li, Weizhe Huang,...,Ye Yin, ... (2018)Comprehensive targeted super-deep next generation sequencing enhances differential diagnosis of solitary pulmonary nodules.Journal of thoracic disease.10.21037/jtd.2018.04.09.

《生命密碼》，尹燁 著，中信出版社，2018年11月。?