人物經(jīng)歷
博士學(xué)位 2003香港大學(xué); 碩士學(xué)位 1997 中科院華南植物所及微生物所; 學(xué)士學(xué)位1993 揚(yáng)州大學(xué)。
2008.10起任職于暨南大學(xué)生命科學(xué)與技術(shù)學(xué)院，教授; 2007u20132008, 香港大學(xué)生物科學(xué)學(xué)院，Croucher助理教授; 2003u20132007, 香港大學(xué)及香港中文大學(xué)，博士后研究員; 1993u20131998, 中科院華南植物所及微生物所，研究實(shí)習(xí)員、助理研究員。
中國(guó)海洋湖沼學(xué)會(huì)海洋生物技術(shù)分會(huì)理事、中國(guó)藻業(yè)協(xié)會(huì)工作指導(dǎo)委員會(huì)委員、中國(guó)植物生理與分子生物學(xué)學(xué)會(huì)能源植物專業(yè)委員會(huì)委員、FrontiersinMarineScience (IF3.1)等SCI期刊編委。
研究方向
1）海洋微藻生物技術(shù)；2）微藻脂類代謝機(jī)理及生物能源研發(fā)；3）微藻高附加值生物活性物質(zhì)合成途徑；4）微藻藻華。
主要貢獻(xiàn)
近 5 年作為通訊作者及第一單位，在Science子刊Science Advances、Metabolic Engineering、Environmental Microbiology、Biotechnology for Biofuels、Marine Biotechnology 等重要SCI期刊發(fā)表論文30余篇，其中SCI一區(qū)及二區(qū)期刊各12篇；獲授權(quán)專利5件；研究成果產(chǎn)生了廣泛影響，多篇論文被 ScienceDirect 等評(píng)為高閱讀量文章，入選 ESI 高被引論文。在主要國(guó)內(nèi)外學(xué)術(shù)會(huì)議上做了多次主題報(bào)告。主持成果獲教育部高等學(xué)�？茖W(xué)研究?jī)?yōu)秀成果獎(jiǎng)自然科學(xué)獎(jiǎng)二等獎(jiǎng)、廣東省第四屆南粵科技創(chuàng)新優(yōu)秀學(xué)術(shù)論文一等獎(jiǎng)、中國(guó)藻類學(xué)會(huì)優(yōu)論文二等獎(jiǎng)等獎(jiǎng)項(xiàng)。
近期代表性論文如下：
Li DW, Balamurugan S, Yang YF, Zheng JW, Huang D, Zou LG, Yang WD, Liu JS, Guan YF, Li HY. Transcriptional regulation of microalgae for concurrent lipid overproduction and secretion. Science Advances. 2019, 5: eaau3795.
Wang X, Dong HP, Wei W, Balamurugan S, Yang WD, Liu JS, Li HY. Dual expression ofplastidial GPAT1 andLPAT1 regulates triacylglycerol production andthefatty acid profile inPhaeodactylum tricornutum. Biotechnology for Biofuels. 2018. 11:318.
Yang YF, Li DW, Chen TT, Hao TB, Balamurugan S, Yang WD, Liu JS, Li HY.Overproduction of Bioactive Algal Chrysolaminarin by the Critical Carbon Flux Regulator Phosphoglucomutase. Biotechnology Journal. 2018. e1800220.
Da-Wei Li, Wei-Hong Xie, Ting-Bin Hao, Jia-Xi Cai, Tian-Bao Zhou, Srinivasan Balamurugan, Wei-Dong Yang, Jie-Sheng Liu, Hong-Ye Li. Constitutive and Chloroplast Targeted Expression of Acetyl-CoA Carboxylase in Oleaginous Microalgae Elevates Fatty Acid Biosynthesis. Marine Biotechnology. 2018. 20(5): 566-572.
Wang X, Wei W, Li NJ, Yuan W, Ding Y, Yang WD, Liu JS, Balamurugan S, Li HY. Heterogeneous expression of human PNPLA3 triggers algal lipid accumulation and lipid droplet enlargement. Algal Research. 2018, 31: 276-281.
Balamurugan S, Wang X, Wang HL, An CJ, Li H, Li DW, Yang WD, Liu JS, Li HY. Occurrence of plastidial triacylglycerol synthesis and the potential regulatory role of AGPAT in the model diatom Phaeodactylum tricornutum. Biotechnol Biofuels. 2017;10:97.
Xue J, Balamurugan S, Li DW, Liu YH, Zeng H, Wang L, Yang WD, Liu JS, Li HY. Glucose-6-phosphate dehydrogenase as a target for highly efficient fatty acid biosynthesis in microalgae by enhancing NADPH supply. Metab Eng. 2017. 41, 212u2013221.
Zheng JW, Li DW, Lu Y, Chen J, Liang JJ, Zhang L, Yang WD, Liu JS, Lu SH, Li HY. Molecular exploration of algal interaction between the diatom Phaeodactylum tricornutum and the dinoflagellate Alexandrium tamarense. Algal Research. 2016. 17: 132u2013141.
Niu YF, Wang X, Hu DX, Balamurugan S, Li DW, Yang WD, Liu JS, Li HY. Molecular characterization of a glycerol-3-phosphate acyltransferase reveals key features essential for triacylglycerol production in Phaeodactylum tricornutum. Biotechnology for Biofuels. 2016. 9:60.
Xue J, Niu YF, Huang T, Yang WD, Liu JS, Li HY. Genetic improvement of a microalga Phaeodactylum tricornutum for boosting neutral lipid accumulation. Metabolic Engineering. 2015. 27(1):1-9.
WangX,LiuYH,HuDX,BalamuruganS,LuY,YangWD,LiuJS,LiHY.Identification of a putative patatin-like phospholipase domain-containing protein3(PNPLA3) ortholog involved in lipid metabolism in microalga Phaeodactylum tricornutum, Algal Research,2015(12):274-279.
YangZK,ZhengJW,NiuYF,yangWD,LiuJS,LiHY.Systems-level analysis of metabolic responses of metabolic responses of the diatom Phaeodactylum tricornutum to phosphorus stress. Environmental Microbiology. 2014.16(6):1793-1807
Xie WH, ZhuCC,ZhangNS,LiDW,YangWD,LiuJS,LiHY. Construction of novel chloroplast expression vector and development of high efficient and economical transformation system for diatom Phaeodactylum tricornutum. Marine Biotechnology.2014.16:538-546
YangZK,NiuYF,MaYH,JiaoXue,ZhangMH,YangWD,LiuJS,LuSH,GuanY,LiHY.Molecular and cellular mechanisms of neutral lipid accumulation in diatom following nitrogen deprivation. Biotechnology for Biofuels. 2013.6:67
