基本情況
學(xué)習(xí)簡(jiǎn)歷
2002年9月至2006年7月四川大學(xué)化學(xué)學(xué)院獲學(xué)士學(xué)位
2006年9月至2011年6月 四川大學(xué)化學(xué)學(xué)院獲博士學(xué)位
工作經(jīng)歷
2011年7月至2013年6月 新加坡南洋理工大學(xué)博士后
2013年6月至今 武漢大學(xué)藥學(xué)院副教授
主要科研領(lǐng)域
研究領(lǐng)域
藥物合成、金屬有機(jī)化學(xué)。
研究興趣與方向
利用過渡金屬催化的多組分串聯(lián)反應(yīng)方法一鍋合成多官能團(tuán)的含氟藥物分子，以及通過在有機(jī)分子中的引入腈基從而制備得到各種α、β、γ、δ…氨基酸及其衍生物，和具有生理活性化合物的合成研究。
代表性論文
1. Zhigang Yang and Jianrong (Steve) Zhou*, “Palladium-Catalyzed, Asymmetric Mizoroki-Heck Reaction of Benzylic Electrophiles Using Phosphoramidites as Chiral Ligands” J. Am. Chem. Soc. 2012, 134, 11833u201311835.
2. Zhigang Yang, Zhen Wang, Sha Bai, Xiaohua Liu, Lili Lin, and Xiaoming Feng*. “Asymmet-ric α-Amination of 4-Substituted Pyrazolones Catalyzed by a Chiral Gd(OTf)3/N,Nu2019-Dioxide Complex: Highly Enantioselective Synthesis of 4-Amino-5-pyrazolone Derivatives”, Org. Lett. 2011, 13, 596u2013599.
3. Zhigang Yang, Zhen Wang, Sha Bai, Ke Shen, Donghui Chen, Xiaohua Liu, Lili Lin, and
Xiaoming Feng*. “Highly Enantioselective Synthesis of 3-Amino-2-oxindole Derivatives:
Catalytic Asymmetric α-Amination of 3-Substituted 2-Oxindoles with a Chiral Scandium Complex”, Chem. Eur. J. 2010, 16, 6632u20136637.
4. Zhigang Yang, Jie Liu, Xiaohua Liu, Zhen Wang, Xiaoming Feng*, Zhishan Su, and Changwei Hua*, “Highly Efficient Amine Organocatalysts Based on Bispidine for the Asymmetric Michael Addition of Ketones to Nitroolefins”, Adv. Synth. Catal. 2008, 350, 2001u20132006.
5. Jie Liu,u2021 Zhigang Yangu2021 (u2021 co-first author), Xiaohua Liu, Zhen Wang, Yanling Liu, Sha Bai, Lili Lin, Xiaoming Feng*, “Organocatalyzed highly stereoselective Michael addition of ketones to alkylidene malonates and nitroolefins using chiral primary-secondary diamine catalysts based on bispidine”, Org. Biomol. Chem., 2009, 7, 4120u20134127.
6. Jie Liu, Zhigang Yang, Zhen Wang, Fei Wang, Xiaohong Chen, Xiaohua Liu, Xiaoming Feng*, Zhishan Su, and Changwei Hu*, “Asymmetric Direct Aldol Reaction of Functionalized Ketones Catalyzed by Amine Organocatalysts Based on Bispidine”, J. Am. Chem. Soc. 2008, 130, 5654u20135655.
7. Zhen Wang, Zhigang Yang, Donghui Chen, Xiaohua Liu, Lili Lin, Xiaoming Feng*, “Highly Enantioselective Michael Addition of Pyrazolin-5-ones Catalyzed by Chiral N,N-dioxide- Lanth- anide(III) Complex: Metal Directed Reversal of Enantioselectivity” Angew. Chem. Int. Ed., 2011, 50, 4928u20134932.
8. Bo Gao, Yuehong Wen, Zhigang Yang, Xiao Huang, Xiaohua Liu, and Xiaoming Feng*, “Asymmetric Ring Opening of meso-Epoxides with Aromatic Amines Catalyzed by a NewProline-Based N,Nu2019-Dioxide-Indium Tris(triflate) Complex”, Adv. Synth. Catal. 2008, 350, 385u2013390.
9. Zhen Wang, Donghui Chen, Zhigang Yang, Sha Bai, Xiaohua Liu, Lili Lin, Xiaoming Feng*, “Highly Enantioselective Synthesis of α-Stereogenic Esters through Catalytic Asymmetric Michael Addition of 4-Oxo-4-Arylbutenoates”, Chem. Eur. J. 2010, 16, 10130u201310136.
10. Donghui Chen, Zhenling Chen, Xiao Xiao, Zhigang Yang, Lili Lin, Xiaohua Liu, and
Xiaoming Feng*, “Highly Enantioselective Michael Addition of Malonate Derivatives to Enones Catalyzed by an N,Nu2019-Dioxideu2013Scandium(III) Complex”, Chem. Eur. J. 2009, 15, 6807u20136810.
11. Donghui Chen, Zhen Wang, Jiangting Li, Zhigang Yang, Lili Lin, Xiaohua Liu, Xiaoming Feng*, “Catalytic Asymmetric 1,3-Dipolar Cycloaddition of Nitrones to Alkylidene Malonates: Highly Enantioselective Synthesis of Multisubstituted Isoxazolidines” Chem. Eur. J., 2011, 17, 5226u20135229.
