1987-1991: 西南大學(xué) 生命科學(xué)學(xué)院 理學(xué)學(xué)士

1991-1994: 四川大學(xué) 生物系 碩士

1994-1999: 四川大學(xué) 生物系 助教、講師

1999-2003: 香港中文大學(xué)(The Chinese University of Hong Kong) 博士

2003-2004: 香港中文大學(xué) 博士后

2004-2007: 香港大學(xué) (The University of Hong Kong) 博士后

2007-2009: 香港大學(xué) 研究助理教授

2009- 四川大學(xué) 生命科學(xué)學(xué)院 教授

王亞軍教授博士期間(1999-2003)致力于動(dòng)物卵泡發(fā)育機(jī)制解析，以斑馬魚為模型，探究EGF、Activin等對(duì)卵泡發(fā)育的調(diào)節(jié)。完成博士學(xué)位攻讀后，王亞軍教授入職香港大學(xué)生物科學(xué)院，以家雞為模型，致力于基因功能鑒定，探究動(dòng)物生長、繁殖與代謝調(diào)控機(jī)理。

2009年，王亞軍教授全職回到四川大學(xué)，在“四川大學(xué)引進(jìn)人才基金”支持下，組建動(dòng)物功能基因組學(xué)研究平臺(tái)，主以家雞（或斑馬魚）等為模型，探究：1) 受體功能與信號(hào)傳導(dǎo)；2) 下丘腦神經(jīng)元對(duì)垂體功能的調(diào)節(jié)；3) 垂體激素對(duì)動(dòng)物生長，繁殖與代謝的影響；4) 腸道微生物對(duì)動(dòng)物免疫與代謝等過程的調(diào)節(jié)；5) 動(dòng)物基因編輯與轉(zhuǎn)基因技術(shù)。

動(dòng)物細(xì)胞生物學(xué)、 信號(hào)傳導(dǎo)、 內(nèi)分泌與代謝、分子遺傳學(xué)

擔(dān)任SCI雜志《Frontiers in Physiology》(IF=4.134)-Avian Physiology方向副主編(Associate Editor)

代表性論文：

1. Zhang J, Li X, Zhou Y, Cui L, Li J, Wu C, Wan Y, Li J,Wang Y(2017). The interaction of MC3R and MC4R with MRAP2, ACTH, α-MSH and AgRP in chickens.Journal of Endocrinology234: 234: 155-174 (通訊) (IF= 4.706)

2. Mo C, Huang L, Cui L, Lv C, Lin D, Song L, Zhu G, Li J,Wang Y(2017) Characterization of NMB, GRP and their receptors (BRS3, NMBR and GRPR) in chickens.Journal of Molecular Endocrinology, 59: 61-79. (通訊) (IF= 3.577)(雜志封面圖片)

3. Cui L, Lv C, Zhang J, Mo C, Lin D, Li J,Wang Y(2107). Characterization of melanin-concentrating hormone (MCH) and its receptor in chickens: Tissue expression, functional analysis, and fasting-induced up-regulation of hypothalamic MCH expression.Gene615:57-67. (通訊) (IF= 2.42)

4. Gao S, Zhang J, He C, Meng F, Bu G, Zhu G, Li J,Wang Y(2017). Molecular characterization of neuropeptide Y (NPY) receptors (Y1, Y4 and Y6) and investigation of the tissue expression of their ligands (NPY, PYY and PP) in chickens.General and Comparative Endocrinology240, 46u201360 (通訊) (IF= 2.585)

5. Bu G, Lin D, Cui L, Huang L, Lv C, Huang S, Wan Y, Fang C, Li J,Wang Y. (2016) Characterization of Neuropeptide B (NPB), Neuropeptide W (NPW), and Their Receptors in Chickens: Evidence for NPW Being a Novel Inhibitor of Pituitary GH and Prolactin Secretion.Endocrinology157:3562-76. (通訊)(獲Endocrinology雜志撰文評(píng)論)(IF= 4.286).

6. He C, Zhang J, Gao S, Meng F, Bu G, Li J,Wang Y(2016) Molecular characterization of three NPY receptors (Y2, Y5 and Y7) in chickens: Gene structure, tissue expression, promoter identification, and functional analysis.General and Comparative Endocrinology,236: 24u201334 (通訊) (IF= 2.585).

7. Tachibana T., Kubo S., Khan M.S.I., Masuda K., Ukena K.,Wang Y(2016). Peripheral injection of chicken growth hormone-releasing hormone inhibits feeding behavior in chicks.Journal of Poultry Science, 53, 29-33 (IF=0.771).

8. Mo C, Cai G, Huang L, Deng Q, Lin D, Cui L,Wang Y, Li J (2015). Corticotropin-releasing Hormone (CRH) Stimulates Cocaine- and amphetamine-regulated Transcript Gene (CART1) Expression through CRH Type 1 Receptor (CRHR1) in Chicken Anterior Pituitary.Molecular and Cellular Endocrinology417: 166-177 (IF= 3.859)

9. Cai G, Mo C, Huang L, Li J,Wang Y(2015). Characterization of the Two CART Genes (CART1 and CART2) in Chickens (Gallus gallus).PLoS One10(5):e0127107. doi: 10.1371 (通訊) (IF= 3.057).

10. Bu G, Liang X, Li J,Wang Y(2015). Extra-pituitary Prolactin (PRL) and Prolactin-like Protein (PRL-L) in Chickens and Zebrafish.General and Comparative Endocrinology220:143-153(通訊) (IF= 2.667).

11. Tachibana T, Sugimoto I, Ogino M, Khan MS, Masuda K, Ukena K,Wang Y(2015). Central administration of chicken growth hormone-releasing hormone decreases food intake in chicks.Physiology & Behavior. 139:195-201 (IF=2.461).

12. Li X, Fang W, Hu Y,Wang Y, Li J(2015).Characterization of fibronectin type III domain-containing protein 5 (FNDC5) gene in chickens: Cloning, tissue expression, and regulation of its expression in the muscle by fasting and cold exposure.Gene, 570: 221-229. (IF= 2.319).

13. Huang G, He C, Meng F, Li J, Zhang J,Wang Y(2014). Glucagon-Like Peptide (GCGL) Is a Novel Potential TSH-Releasing Factor (TRF) in Chickens: I) Evidence for Its Potent and Specific Action on Stimulating TSH mRNA Expression and Secretion.Endocrinology,155: 4568-4580 (通訊) (IF= 4.503)

14. Huang G, Li J, Wang H, Lan X, andWang Y(2014). Discovery of a Novel Functional Leptin Protein (LEP) in Zebra Finches: Evidence for the Existence of an Authentic Avian Leptin Gene Predominantly Expressed in the Brain and Pituitary.Endocrinology155: 3385-96 (通訊)(Endocrinology2014年9月封面論文，并獲雜志撰文評(píng)述)(IF= 4.503)

15. Meng F, Huang G, Gao S, Li J, Yan Z,Wang Y(2014). Identification of the receptors for somatostatin (SST) and cortistatin (CST) in chickens and investigation of the roles of cSST28, cSST14, and cCST14 in inhibiting cGHRH1u201327NH2-induced growth hormone secretion in cultured chicken pituitary cells.Molecular and Cellular Endocrinology384: 83-95 (通訊) (IF= 4.405)

16. Mo C, Zhong Y,Wang Y, Yan Z, Li J (2014). Characterization of glucagon-like peptide 2 receptor (GLP2R) gene in chickens: functional analysis, tissue distribution, and developmental expression profile ofGLP2Rin embryonic intestine.Domestic Animal Endocrinology48：1-6 (通訊) (IF= 2.171).

17. Zhang J, Cheng S,Wang Y, Yu X, Li J. (2014). Identification and characterization of the free fatty acid receptor 2 (FFA2) and a novel functional FFA2-like receptor (FFA2L) for short-chain fatty acids in pigs: Evidence for the existence of a duplicated FFA2 gene (FFA2L) in some mammalian species.Domestic Animal Endocrinology47:108-118 (通訊) (IF =2.171).

18. He X, Meng F,Wang Y, Li J (2014). Molecular Cloning and Characterization of Two Pig Vasoactive Intestinal Polypeptide Receptors (VPAC1-R and VPAC2-R).DNA Cell Biol.33：259-270 (IF=2.055).

19. Bu G, Wang CY, Cai G, Leung FC, Xu M, Wang H, Huang G, Li J,Wang Y(2013) Molecular Characterization of Prolactin Receptor (cPRLR) Gene in Chickens: Gene Structure, Tissue Expression, Promoter Analysis, and Its Interaction with Chicken Prolactin (cPRL) and Prolactin-like Protein (cPRL-L).Molecular and Cellular Endocrinology370: 149-62.（通訊）(IF= 4.241).

20. Bu G, Huang G, Fu H, Li J, Huang S.Wang Y（2013）Characterization of the novel duplicated PRLR gene at the late-feathering K locus in Lohmann chickens.JournalofMolecular Endocrinology51, 261u2013276（通訊）(IF= 3.621).

21. Song X,Wang Y, Tang Y (2013) Rapid Diversification of FoxP2 in Teleosts through Gene Duplication in the Teleost-Specific Whole Genome Duplication Event.PLoS One8 (12):e83858.（通訊）(IF = 3.534).

22.Wang Y, Meng F, Zhong Y, Huang G, Li J (2012) Discovery of a Novel Glucagon-like Peptide (GCGL) and its Receptor (GCGLR) in Chickens: Evidence for the Existence of GCGL and GCGLR Genes in Non-mammalian Vertebrates.Endocrinology153, 5247-5260 (通訊) (IF= 4.717).

23.Wang Y, Wang CY, Wu Y, Huang G, Li J, Leung FC (2012). Identification of the Receptors for Prolactin-releasing Peptide (PrRP) andCarassiusRFamide Peptide (C-RFa) in Chickens.Endocrinology153:1861-1874 (通訊) (IF= 4.717).

24.Wang Y, Huang G, Li J.,Meng F, He X. Leung F.C (2012) Characterization of Chicken Secretin (SCT) and Secretin Receptor (SCTR) Genes: A Novel Secretin-like Peptide (SCT-LP) and Secretin Encoded in a Single Gene.Molecular and Cellular Endocrinology348: 270-280 (通訊) (IF=4.192)

25. Ho JCW, Jacobs T,Wang Y, Leung FC (2012) Identification and characterization of the chicken galanin receptor GalR2 and a novel GalR2-like receptor (GalR2-L).General and comparative endocrinology179: 305-312 (通訊) (IF=2.823)

26. Kwok AHY,Wang Y, Leung FC (2012) Molecular characterization of prostaglandin F receptor (FP) and E receptor subtype 3 (EP3) in chickens.General and comparative Endocrinology179: 88-98 (通訊) (IF=2.823)

27. Kwok AHY,Wang Y, Leung FC (2012) Molecular characterization of prostaglandin F receptor (FP) and E receptor subtype 1 (EP1) in zebrafish.General and comparative Endocrinology178: 216-226 (通訊) (IF=2.823)

28. Huang G, Li J, Fu H, Yan Z, Bu G, He X,Wang Y(2012) Characterization of glucagon-like peptide 1 receptor (GLP1R) gene in chickens: functional analysis, tissue distribution, and identification of its transcript variants.Domestic Animal Endocrinology43: 1-15 (通訊) (IF=2.377).

29. Li J, Meng F, Song C,Wang Y, Leung FC (2012) Characterization of chicken visfatin gene: cDNA cloning, Tissue expression, and promoter analysis.Poultry Science91: 2885-94 (IF=1.728).

30. Ho JC, Kwok AH, Zhao D,Wang Y, Leung FC. (2011) Characterization of the chicken galanin type I receptor (GalR1) and a novel GalR1-like receptor (GalR1-L).General and Comparative Endocrinology170: 391-400, (通訊) (IF=3.267).

31. Ruiqiang Li#, Wei Fan, Geng Tian, Hongmei Zhu, Lin He, ……,Yajun Wang… Lars Bolund, Karsten Kristiansen, Gane Ka-Shu Wong, Maynard Olson, Xiuqing Zhang, Songgang Li, Huanming Yang, Jian Wang & Jun Wang (2010). The sequence and de novo assembly of the giant panda genome.Nature463: 311-317 (IF=36.101).

32.Wang Y, Li J, Kwok AHY, Ge W, Leung FC (2010) A novel prolactin-like protein (PRL-L) gene in chickens and zebrafish: Cloning and Characterization of its tissue expression.General and Comparative Endocrinology166: 200-210 (IF=3.108).

33.Wang Y, Li J, Wang CY, Kwok AHY, Leung FC (2010) Characterization of the receptors for chicken GHRH and GHRH-related peptides: Identification of a novel receptor for GHRH and the receptor for GHRH-LP (PRP).Domestic Animal Endocrinology38:13-31. (IF=2.056).

34. Lynch VJ，Tanzer A,Wang Y, Leung FC, Gellersen B, Emera D, Wagner GP (2008), Adaptive changes in the transcription factor HoxA-11 are essential for the evolution of pregnancy in mammals.Proc. Natl. Acad. Sci. U S A.105:14925-14933 (IF=9.598).

35. Wang J,Wang Y, Li X, Li Juan, Leung FC (2008) Cloning, tissues distribution and functional characterization of chicken glucagon receptor.Poultry science87: 2678-2688 (IF=1.603).

36. Kwok AHY,Wang Y, Wang CY, Leung FC. (2008), Molecular cloning and characterization of chicken prostaglandin E receptor subtypes 2 and 4 (EP2 and EP4).General and Comparative Endocrinology,157: 99-106 (IF=2.823)

37.Wang Y, Li J, Wang CY, Kwok AHY, Leung FC (2007) Identification of the endogenous ligands for chicken growth hormone-releasing hormone (GHRH) receptor. Evidence for a separate gene encoding GHRH in submammalian vertebrates.Endocrinology148: 2405-2416 (IF=5.045)

38.Wang Y, Li J，Wang CY, Kwok AHY, Leung FC (2007) Epidermal growth factor receptor (EGFR) ligand in the chicken ovary: I) Evidence for heparin binding epidermal growth factor-like growth factor (HB-EGF) as a potential oocyte-derived factor to control granulosa cell proliferation and HB-EGF and Kit ligand expression.Endocrinology148: 3426 u2013 3440. (IF=5.045)

39. Wang Y, Wang Z, Li J,Wang Y, Leung FC (2007) A database for chicken full-length cDNAs.Physiological Genomics28:141-5 (IF=3.498)

40. Kwok AHY,Wang Y, Wang CY, Leung FC. (2007), Cloning of chicken glucocorticoid receptor (GR) and characterization of its expression in pituitary and extra-pituitary tissues.Poultry Science86: 423-430 (IF=1.603)

41. Wang CY#,Wang Y#, Kwok AHY, Leung FC (2007). Identification of two novel chicken GHRH receptor splice variants: implications for the roles of aspartate 56 in the receptor activation and direct ligand receptor interaction.Journal of Endocrinology195: 525-536 (IF=2.636)(#同等貢獻(xiàn)).

42. Wang CY,Wang Y, Li J, Leung FC (2006) Expression profiles of chicken growth hormone-releasing hormone (GHRH) and growth hormone-releasing hormone receptor (GHRHR) during chicken embryonic pituitary development.Poultry Science85: 569-576 (IF=1.603)

43. Kwok HF, So WK,Wang Y, Ge W (2005) Zebrafish gonadotropins and their receptors: I. Cloning and characterization of zebrafish follicle-stimulating hormone and luteinizing hormone receptors: Evidence for their distinct functions in follicle development.Biology of Reproduction72: 1370-1381 (IF=3.670)

44.Wang Y& Ge W (2004) Cloning of Epidermal growth factor (EGF) and EGF receptor from the zebrafish ovary: evidence for EGF as a potential paracrine factor from the oocyte to regulate activin/follistatin system in the follicle cells.Biology of Reproduction71: 749-760 (IF=3.670)

45.Wang Y& Ge W (2004). Developmental profiles of activin βA, βB, and follistatin expression in the zebrafish ovary: evidence for their differential roles during sexual maturation and ovulatory cycle.Biology of Reproduction71: 2056-2064 (IF=3.670)

46.Wang Y& Ge W (2004). Cloning of zebrafish ovarian P450c17 (CYP17, 17α-hydroxylase/ 17,20- lyase) and characterization of its expression in gonadal and extra-gonadal tissues.General and Comparative Endocrinology135: 241-249 (IF=3.108).

47.Wang Y& Ge W (2003) Involvement of cyclic adenosine 3u2019,5u2019-monophosphate in the differential regulation of activin βA and βB expression by gonadotropin in the zebrafish ovarian follicle cells.Endocrinology144: 491-499 (IF=5.045).

48.Wang Y, Wong AOL & Ge W (2003) Cloning, regulation of mRNA expression and function of a new isoform of pituitary adenylate cyclase-activating polypeptide (PACAP) in the zebrafish ovary.Endocrinology144: 4799-4810 (IF=5.045).

49.Wang Y& Ge W (2003) Spatial expression patterns of activin and its signaling system in the zebrafish ovarian follicle: Evidence for paracrine action of activin on the oocytes.Biology of Reproduction69: 1998-2006 (IF=3.670).

50.Wang Y& Ge W (2003) Gonadotropin regulation of follistatin expression in the cultured ovarian follicle cells of zebrafish, Danio rerio.General and Comparative Endocrinology134: 308-315 (IF=3.108).

51.Wang Y& Ge W (2002) Cloning of zebrafish ovarian carbonyl reductase-like 20β-hydroxysteroid dehydrogenase and characterization of its spatial and temporal expression.General and Comparative Endocrinology127: 209-216 (IF=3.108).

科研用書章節(jié)撰寫(Book Chapter)

1.Wang Yajun(2017):Chapter 12: Novel Peptides in Poultry：A case study of the expanding glucagon peptide superfamily in chickens (Gallus gallus).Book Title: <Biology of Domestic Animals>, Edited by Scanes CG & Hill R，p343-352 (CRC Press, 1st Edition).

國際會(huì)議報(bào)告

1. 王亞軍 The 11th International Symposium on Avian Endocrinology 2016 (ISAE2016) (Canada,2016) (大會(huì)報(bào)告, 25 min. Invited Speaker).

Title:Molecular Characterization of the Key Regulators in Avian Energy Balance: A Tale in Birds.

2. 王亞軍 Physiology2014 (London UK, The Physiological Society,2014) (Invited Speaker)Title:Extra-pituitary Prolactin and Prolactin-like Hormone in Zebrafish and Chickens.

3. 王亞軍 The 10th International Symposium on Avian Endocrinology 2012 (ISAE2012) (Japan,2012). (大會(huì)報(bào)告, 25min. Invited Speaker).

Title:Molecular Characterization of the Receptors for Chicken GHRH, PrRP, and Their Related Peptides: An Emerging Evolutionary Story.

2003年度“香港中文大學(xué)研究生最佳研究成績獎(jiǎng)”