研究方向
病毒免疫與分子病毒學(xué)、神經(jīng)免疫與分子神經(jīng)病學(xué)
人物經(jīng)歷
學(xué)習(xí)經(jīng)歷
1990.09~1994.07 武漢大學(xué),攻讀學(xué)士學(xué)位
1999.09~2002.07 武漢大學(xué),攻讀碩士學(xué)位
2002.09~2005.06 武漢大學(xué),攻讀博士學(xué)位
2007.03~2008.12 新加坡國立大學(xué)醫(yī)學(xué)院及Temasek Life Sciences Laboratory,博士后
2014.02~2015.02 美國Texas A&M University生理與藥理學(xué)系,訪問學(xué)者
工作經(jīng)歷
1994.7~1999.9,武漢大學(xué)生命科學(xué)學(xué)院,助教,院學(xué)生黨支部書記、院團(tuán)委副書記、教學(xué)秘書等
1998.5~1998.10 國家自然科學(xué)基金委員會生命科學(xué)部,辦事員(借調(diào))
2005.7~2007.11武漢大學(xué)基礎(chǔ)醫(yī)學(xué)院免疫學(xué)系,講師,科研秘書
2007.11~2011.5 武漢大學(xué)基礎(chǔ)醫(yī)學(xué)院免疫學(xué)系,副教授,碩士生導(dǎo)師,系黨支部宣傳委員
2011.6~2012.11 武漢大學(xué)基礎(chǔ)醫(yī)學(xué)院免疫學(xué)系,副教授,博士生導(dǎo)師
2012.12~至今 武漢大學(xué)基礎(chǔ)醫(yī)學(xué)院免疫學(xué)系,教授,博士生導(dǎo)師,院長助理(2013.5~2017.6)
社會兼職
中華醫(yī)學(xué)會微生物與免疫學(xué)分會青年委員會委員(2012年當(dāng)選)、武漢市免疫學(xué)會第六屆理事會理事(2010年當(dāng)選)、中國免疫學(xué)學(xué)會會員、中國細(xì)胞生物學(xué)學(xué)會會員、中國微生物學(xué)學(xué)會會員。曾受邀擔(dān)任FEBS Journal , Nanoscale, Viruses, Neuroscience Letters、Transboundary and Emerging Diseases, British Microbiology Research Journal, African Journal of Microbiology Research、Journal of Pain Research等10多種國際期刊雜志審稿專家以及國家自然科學(xué)基金評審專家。
研究領(lǐng)域
1、研究人泡沫病毒(human foamy virus, HFV)的感染及其作用機(jī)制,以及HFV載體的構(gòu)建及其在神經(jīng)系統(tǒng)疾病中的應(yīng)用。
2、研究腸道病毒71型(Human enterovirus 71, EV71)和柯薩奇病毒A16型(Coxsachievirus A16, CA16)等病毒的感染及其致病機(jī)制,特別是其導(dǎo)致手足口病患兒腦部神經(jīng)系統(tǒng)疾病的作用機(jī)理;同時(shí)致力于EV71/ CA16病毒新型疫苗和免疫診斷的研發(fā)。
教學(xué)情況
主要承擔(dān)醫(yī)學(xué)各專業(yè)五年制/七年制/八年制/留學(xué)生的《醫(yī)學(xué)免疫學(xué)》、醫(yī)學(xué)碩士研究生的《分子醫(yī)學(xué)免疫學(xué)》、醫(yī)學(xué)博士研究生的《醫(yī)學(xué)免疫學(xué)前沿進(jìn)展》等;指導(dǎo)多名本科生獲得國家級/校級大學(xué)生科研創(chuàng)新課題、省級/校級自然科學(xué)獎(jiǎng)及發(fā)表多篇SCI/中文核心等論文;發(fā)表多篇教學(xué)論文并承擔(dān)/參與多項(xiàng)國家級/校級教學(xué)項(xiàng)目。
代表論文
1.Wang Z, Fan Y, Xu J, Li L, Heng D, Han S, Yin J, Peng B, Liu W*(劉萬紅), He X*. Transcriptome analysis of the hippocampus in novel rat model of febrile seizures. PLoS One. 2014 Apr 15;9(4):e95237.
2.Liu Y, Fu C, Wu S, Chen X, Shi Y, Zhou B, Zhang L, Zhang F, Wang Z, Zhang Y, Fan C, Han S, Yin J, Peng B, Liu W*(劉萬紅), He X*. A novel finding for enterovirus virulence from the capsid protein VP1 of EV71 circulating in Chinese mainland. Virus Genes. 2014 Apr;48(2):260-72.
3.Zhang Y, Chen X, Lian H, Liu J, Zhou B, Han S, Peng B, Yin J, Liu W*(劉萬紅), He X*. MicroRNA-503 acts as a tumor suppressor in glioblastoma for multiple antitumor effects by targeting IGF-1R. Oncol Rep. 2014 Mar;31(3):1445-52.
4.Zhu G, Zheng Y, Zhang L, Shi Y, Li W, Liu Z, Peng B, Yin J, Liu W*(劉萬紅), He X. Coxsackievirus A16 infection triggers apoptosis in RD cells by inducing ER stress. BiochemBiophys Res Commun. 2013 Nov 29;441(4):856-61.
5.Li Z#, Liu WH#(劉萬紅), Han S, Peng BW, Yin J, Wu YL, He XH, Li WX. Selective inhibition of CCR7(-) effector memory T cell activation by a novel peptide targeting Kv1.3 channel in a rat experimental autoimmune encephalomyelitis model. J Biol Chem. 2012 Aug 24;287(35):29479-94.(#Co-first Author)
6.He Y, Wu Q, Xu Z, Wang Q, Wang W, Li D, Liu W*(劉萬紅), He X*. Hereditary neuropathy with liability to pressure palsy: an investigation in a rare and large Chinese family. Eur Neurol. 2012;68(5):322-8.
7.Liu W(劉萬紅), Luo F, He J, Cao Z, Miao L. Molecular cloning and characterization of a new cDNA sequence encoding a venom peptide from the centipede Scolopendrasubspinipesmutilans. Mol Biol (Mosk). 2012 Jul-Aug;46(4):570-5.
8.Dong L, Liu Y, Qiu Y, Peng B, Yin J, Liu W*(劉萬紅), He X. Identification of Pirh2E and Pirh2F, two additional novel isoforms of Pirh2 ubiquitin ligase from human hepatocellular liver carcinoma cell line. Biomed Mater Eng. 2012;22(1-3):89-95.
9.Zhang C, Wang Z, Zheng H, Qiu Y, He X, Yang H, Liu W*(劉萬紅). Self-expanding stents in the treatment of carotid artery subtotal occlusion: a clinical study on the patients of Hubei and Sichuan in China. Biomed Mater Eng. 2012;22(1-3):27-33.
10.Xiao Z#, Liu W#(劉萬紅), Gao K, Wan Q, Yang C, Wang H, Wang X, Wang G, Liu Z. Interaction between CRHR1 and BDNF genes increases the risk of recurrent major depressive disorder in Chinese population. PLoS One. 2011;6(12):e28733.(#Co-first Author)
11.Huang Y, Liu X, Dong L, Liu Z, He X*, Liu W*(劉萬紅). Development of viral vectors for gene therapy for chronic pain. Pain Res Treat. 2011;2011:968218.
12.Wang X, Su B, Liu W(劉萬紅), He X, Gao Y, Castellani RJ, Perry G, Smith MA, Zhu X. DLP1-dependent mitochondrial fragmentation mediates 1-methyl-4-phenylpyridinium toxicity in neurons: implications for Parkinson’s disease. Aging Cell. 2011 Oct;10(5):807-23.
13.Wang Z, Yang B, Dong L, Peng B, He X*, Liu W*(劉萬紅). A novel oncoprotein Pirh2: rising from the shadow of MDM2. Cancer Sci. 2011 May;102(5):909-17.
14.Zhang Y, Liu Y, Zhu G, Qiu Y, Peng B, Yin J, Liu W*(劉萬紅), He X*. Foamy virus: an available vector for gene transfer in neural cells and other nondividing cells. J Neurovirol. 2010 Nov;16(6):419-26.
15.Liu W*(劉萬紅), Liu Z, Liu L, Xiao Z, Cao X, Cao Z, Xue L, Miao L, He X*, Li W. A novel human foamy virus mediated gene transfer of GAD67 reduces neuropathic pain following spinal cord injury. Neurosci Lett. 2008 Feb 13;432(1):13-8.
16.Liu W(劉萬紅), Liu Z, Cao X, Cao Z, Xue L, Zhu F, He X, Li W. Recombinant human foamy virus, a novel vector for neurological disorders gene therapy, drives production of GAD in cultured astrocytes. Mol Ther. 2007 Oct;15(10):1834-41.