學(xué)習(xí)經(jīng)歷
1980-1986年 上海醫(yī)科大學(xué)醫(yī)學(xué)士
1986-1991年 美國(guó)斯坦福大學(xué)腫瘤生物學(xué)博士
1991-1994年 哈佛大學(xué)生物化學(xué)和分子生物學(xué)系博士后
參考資料
工作經(jīng)歷
1994年起 任華盛頓大學(xué)兒科系和分子生物與藥理學(xué)系助理教授分子遺傳學(xué)、分子細(xì)胞生物、發(fā)育生物學(xué)等學(xué)科博士生導(dǎo)師
1998年起 兼上海醫(yī)科大學(xué)教授
2001年起 參與中國(guó)科學(xué)院上海生命科學(xué)研究院分子生物學(xué)研究 生課程教學(xué)，后升副教授并獲終身教職
2003-2005 美國(guó)Vanderbilt大學(xué)，教授
2005-2008 美國(guó)西北大學(xué)醫(yī)學(xué)院，Lurie 癌癥中心，Charles Luis Mix 教授
2008-至今 中國(guó)科學(xué)院生物物理研究所，高級(jí)顧問(wèn)研究員
研究領(lǐng)域
研究方向
吳瑛研究員所在課題組主要研究參與神經(jīng)發(fā)育和神經(jīng)推行性病變的基因調(diào)控的分子機(jī)制
具體研究?jī)?nèi)容
1）RNA調(diào)控
2）細(xì)胞遷移的分子機(jī)制
擔(dān)任職務(wù)
為Science、Nature、Cell、MCB、PNAS等15個(gè)雜志審稿，為美國(guó)國(guó)立健康研究院、老年癡呆基金會(huì)、加拿大醫(yī)學(xué)研究委員會(huì)、意大利Telethon基金會(huì)等評(píng)審基金。在哈佛大學(xué)參與生物化學(xué)教學(xué)、在華盛頓大學(xué)參與核酸與蛋白質(zhì)、細(xì)胞生物學(xué)博士生課程教學(xué), 在英國(guó)劍橋、美國(guó)哈佛大學(xué)、賓州大學(xué)、布朗大學(xué)等做過(guò)學(xué)術(shù)報(bào)告。
現(xiàn)任美國(guó)西北大學(xué)講座教授，清華大學(xué)長(zhǎng)江講座教授，中國(guó)科學(xué)院生物物理研究所研究員。吳瑛以研究RNA剪接的分子生物學(xué)著名。曾獲中國(guó) 國(guó)家自然科學(xué)基金委員會(huì)“國(guó)家杰出青年基金”B類。
學(xué)術(shù)成果
論文發(fā)表于Cell、Nature、Science、MCB、J.Neuroscience,、JBC。曾獲美國(guó)白血病學(xué)會(huì)連續(xù)十二年資助(從博士后、特別研究員到學(xué)者獎(jiǎng))
發(fā)表論文
G?hrig A, Detjen KM, Hilfenhaus G, K?rner J, Arsenic R, Welzel M, Schmuck R, Bahra M, Wu JY, Wiedenmann B, Fischer C(2014). The Axon Guidance Factor Slit2 inhibits Pancreatic Cancer Metastasis and Cell Movement along Neurites. Cancer Res.74(5):1529-40
Li Y, Yang M, Huang Z, Chen X, Maloney M, Zhu L, Liu J, Yang Y, Du S, Jiang X,Wu JY.(2014) AxonQuant: a microfluidic chamber culture-coupled algorithm that allows high-throughput quantification of axonal damage. NeuroSignalsFeb28.
RNA and Cancer. Wu JY (ed.) ISBN 978-3-642-316586; Library of Congress Control Number 2012946188 (Springer, 2013) [book summary]
POST-TRANSCRIPTIONAL GENE REGULATION-RNA PROCESSING IN EUKARYOTES. Wu JY (ed.) ISBN 978-3527322022 (Wiley-Blackwell, 2013) [book summary]
Bigio EH,Wu JY, Deng HX, Bit-Ivan EN, Mao Q, Ganti R, Peterson M, Siddique N, Geula C, Siddique T, Mesulam M.(2013) Inclusions in frontotemporal lobar degeneration with TDP-43 proteinopathy (FTLD-TDP) and amyotrophic lateral sclerosis (ALS), but not FTLD with FUS proteinopathy (FTLD-FUS), have properties of amyloid. Acta Neuropathol. 125(3):463-5.
Xu M, Zhu L, Liu J, Yang Y,Wu JY, Wang C(2013) Characterization ofβ-domains in C-terminal fragments of TDP-43 by scanning tunneling microscopy. J Struct Biol.181(1):11-6.
Chen Q, Sun X, Zhou XH, Liu JH,Wu J, Zhang Y, Wang JH(2013) N-terminal horseshoe conformation of DCC is functionally required for axon guidance and might be shared by other neural receptors.J Cell Sci. 126:186-95.
Zhu K, Chen XP, Liu JH, Ye Hh, Zhu L,Wu JY(2013) AMPK interacts with DSCAM and plays an important role in Netrin-1 induced neurite outgrowth. Protein Cell4 (2): 155u2013161.
Chen Y, Yang M, Deng J, Chen X, Ye Y, Zhu L, Liu J, Ye H, Shen Y, Li Y, Rao EJ, Fushimi K, Zhou X, Bigio EH, Mesulam M,Wu JY.(2011) Expression of human FUS protein in Drosophila leads to progressive neurodegeneration. Protein Cell2(6):477u2013486.
Ray P, Kar A, Fushimi K, Havlioglu N, Chen X,Wu JY(2011) PSF Suppresses Tau Exon 10 Inclusion by Interacting with a Stem-Loop Structure Downstream of Exon 10.J Mol Neurosci.45(3):453-66.
Xu Y, Ye H, Shen Y, Xu Q, Zhu L, Liu J, Wu JY.(2011) Dscam mutation leads to hydrocephalus and decreased motor function.Protein Cell.2(8):647-55.
Yu B, Fey P, Kestin-Pilcher KE, Fedorov A, Prakash A, Chisholm RL, Wu JY.(2011) Spliceosomal genes in the D. discoideum genome: a comparison with those in H. sapiens, D. melanogaster, A. thaliana and S. cerevisiae.Protein Cell.2(5):395-409.
Guo W, Chen Y, Zhou X, Kar A, Ray P, Chen X, Rao EJ, Yang M, Ye H, Zhu L, Liu J, Xu M, Yang Y, Wang C, Zhang D, Bigio EH, Mesulam M, Shen Y, Xu Q, Fushimi K, Wu JY.(2011) An ALS-associated mutation affecting TDP-43 enhances protein aggregation, fibril formation and neurotoxicity.Nat Struct Mol Biol.18(7):822-30.
Kar A, Fushimi K, Zhou X, Ray P, Shi C, Chen X, Liu Z, Chen S, Wu JY.(2011) RNA Helicase p68 (DDX5) regulates tau exon 10 splicing by modulating a stem-loop structure at the 5’ splice site.Mol Cell Biol.31(9):1812-21.
Fushimi K, Long C, Jayaram N, Chen X, Li L, Wu JY.(2011) Expression of human FUS/TLS in yeast leads to protein aggregation and cytotoxicity, recapitulating key features of FUS proteinopathy.Protein Cell.2(2):141-9.
Dunaway CM, Hwang Y, Lindsley CW, Cook RS, Wu JY, Boothby M, Chen J, Brantley-Sieders DM.(2011) Cooperative signaling between Slit2 and Ephrin-A1 regulates a balance between angiogenesis and angiostasis.Mol Cell Biol.31(3):404-16.
Brantley-Sieders DM, Dunaway CM, Rao M, Short S, Hwang Y, Gao Y, Li D, Jiang A, Shyr Y, Wu JY, Chen J.(2011) Angiocrine Factors Modulate Tumor Proliferation and Motility through EphA2 Repression of Slit2 Tumor Suppressor Function in Endothelium.Cancer Res.71(3):976-987.
Gao X, Joselin AP, Wang L, Kar A, Ray P, Bateman A, Goate AM, Wu JY.(2010) Progranulin promotes neurite outgrowth and neuronal differentiation by regulating GSK-3β.Protein Cell.1(6):552-62.
Guo W, Li JT, Pan X, Wei L, Wu JY.(2010) Candidate Mycobacterium tuberculosis genes targeted by human microRNAs.Protein Cell.1(5):419-21.
Kaneko N, Marín O, Koike M, Hirota Y, Uchiyama Y, Wu JY, Lu Q, Tessier-Lavigne M, Alvarez-Buylla A, Okano H, Rubenstein JL, Sawamoto K.(2010) New neurons clear the path of astrocytic processes for their rapid migration in the adult brain.Neuron.67(2):213-23.
Yu J, Cao Q, Yu J, Wu L, Dallol A, Li J, Chen G, Grasso C, Cao X, Lonigro RJ, Varambally S, Mehra R, Palanisamy N, Wu JY, Latif F, Chinnaiyan AM.(2010) The neuronal repellent SLIT2 is a target for repression by EZH2 in prostate cancer.Oncogene.29(39):5370-80.
Ray P, Luo XY, Rao EJ, Basha A, Woodruff EA, Wu JY.(2010) The splicing factor Prp31 is essential for photoreceptor development in Drosophila.Protein Cell1(3):267-274.
