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  • 尹靖東

    尹靖東

    尹靖東,男,生于1970年10月,蒙古族,中國民盟盟員,博士,中國農(nóng)業(yè)大學(xué)動物科技學(xué)院教授、博士生導(dǎo)師,教育部新世紀(jì)優(yōu)秀人才,中國畜牧獸醫(yī)學(xué)會動物營養(yǎng)學(xué)分會秘書長,中國畜牧雜志副主編,Asia-Australian Journal of Animal Science的編委。研究方向為動物營養(yǎng)與飼料科學(xué)、動物分子營養(yǎng)與營養(yǎng)基因組學(xué)、動物肌肉與脂肪發(fā)育的營養(yǎng)調(diào)控。


    人物經(jīng)歷

    教育經(jīng)歷

    1988.9-1992.7 內(nèi)蒙古民族大學(xué),畜牧學(xué),獲學(xué)士學(xué)位

    1992.9-1995.7 西北農(nóng)林科技大學(xué),動物遺傳育種,獲碩士學(xué)位

    1997.9-2000.7 中國農(nóng)科院,動物營養(yǎng)與飼料科學(xué),獲博士學(xué)位

    2002.1-2004.6 中國農(nóng)業(yè)大學(xué)博士后流動站,動物分子營養(yǎng),博士后

    2012.10-2013.10加州大學(xué)洛杉磯分校(UCLA),干細(xì)胞分化機制,訪問學(xué)者

    尹靖東

    工作經(jīng)歷

    1995.7-2003.6 西北農(nóng)林科技大學(xué)助教、講師

    2003.6-2011.12 中國農(nóng)業(yè)大學(xué) 講師、副研究員

    2011.12-至今 中國農(nóng)業(yè)大學(xué) 研究員、教授

    研究方向

    動物營養(yǎng)與飼料科學(xué)、動物分子營養(yǎng)與遺傳學(xué)、動物營養(yǎng)與肉品質(zhì),主要以豬為試驗動物模型,研究動物脂肪和肌肉發(fā)育的營養(yǎng)調(diào)控,從群體、個體、細(xì)胞和分子水平,揭示動物重要生物過程中營養(yǎng)與基因的互作機制,為開發(fā)新型飼料資源、營養(yǎng)添加劑和動物分子育種提供科學(xué)依據(jù)。

    教學(xué)工作

    主講了研究生的“動物分子營養(yǎng)學(xué)”,參加了碩士研究生“豬的營養(yǎng)學(xué)”等課程

    學(xué)術(shù)成果

    科研工作

    先后主持了4項國家自然基金面上項目和1項北京市自然基金項目,主持了1項國家973項目課題(2013CB127302) ,1項國家科技支撐計劃項目課題,1項國家863課題,合作主持國家自然基金委—廣東省聯(lián)合資助重點項目1項。

    1、 豬肌肉充質(zhì)干細(xì)胞成脂分化的分子機制及其與肌內(nèi)脂肪生成的關(guān)系, 31272452,國家自然科學(xué)基金委面上項目,課題主持人,2013.1-2016.12;

    2、 小腸黏膜結(jié)構(gòu)、功能與氮營養(yǎng)素吸收利用,國家973計劃,2013CB127302,課題主持人, 2013.1-2017.12;

    3、 豬肌纖維發(fā)育與肌內(nèi)脂肪沉積的機制與營養(yǎng)調(diào)控,國家973計劃,2012CB124700,研究骨干,項目辦主任,2012.1-2016.12;

    4、 氯離子胞內(nèi)通道基因在豬肌內(nèi)脂肪沉積中的作用及其調(diào)控途徑的研究,國家自然科學(xué)基金委面上項目,30972113,課題主持人, [來源],[起止時間]2010.1-2012.12;

    5、鋅介導(dǎo)的腦腸肽分泌及其對仔豬生長調(diào)控的機理,30371042,國家自然科學(xué)基金面上項目,課題主持人,2004.1-2004.12;

    6、氧化鋅介導(dǎo)的胃腸調(diào)節(jié)肽分泌及其在仔豬生長調(diào)控中的生物學(xué)意義,國家自然科學(xué)基金面上項目,30571343,課題主持人,2006.1-2008.12。

    7、榮昌豬肌內(nèi)脂肪超級沉積的分子機制及主效基因的鑒別, 2008AA10Z141,國家863課題,課題主持人,2008.3-2010.12

    8、藍(lán)塘豬肉質(zhì)性狀形成的分子機理及其在豬肉質(zhì)改良中的意義,u0731004,課題副主持人,國家自然科學(xué)基金委&shy;—廣東省聯(lián)合資助重點項目, 2008.1-2011.12;

    9、榮昌豬特色性狀研究與優(yōu)勢性狀基因的篩選和鑒定, 2007BAD51B02,國家科技支撐計劃,課題主持人,2007.7-2010.12;

    10、共軛亞油酸對豬肌內(nèi)前脂肪細(xì)胞分化的調(diào)控機理,6072016,北京市自然基金委項目,課題主持人,2007.1-2009.12;

    11、豬肌內(nèi)脂肪沉積的生物學(xué)基礎(chǔ)及其對營養(yǎng)調(diào)控的差異性響應(yīng),NCET-06-0115,教育部新世紀(jì)優(yōu)秀人才基金支持計劃資助,2007.1-2009.12。

    12、妊娠期母體營養(yǎng)對豬肌纖維發(fā)育的影響及機理,2004da125184 (青) 0811,動物營養(yǎng)學(xué)國家重點實驗室自主研究課題,課題主持人, 2008.9-2010.9。

    13、畜禽肉品質(zhì)形成的規(guī)律及其營養(yǎng)調(diào)控,2004CB117503,國家重點基礎(chǔ)研究項目,項目辦主任和學(xué)術(shù)骨干,2004.10-2009.10。

    發(fā)表論文

    1. Liu Y, Lv W, Yu B, Ju T, Yang F, Jiang M, Liu Z, Xu L, Sun W, Huang J, Li D, Yin JD&dagger;. 2013. S-Adenosylmethionine-induced adipogenesis is accompanied by suppression of Wnt/&beta;-catenin and Hedgehog signaling pathways. Mol Cell Biochem. 382(1-2):59-73.

    2. Liu Y, Chen F, Odle J, Lin X, Zhu H, Shi H, Hou Y, Yin JD&dagger;. 2013. Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge. J Nutr. 143(8):1331-9.

    3. Chen J, Fu R, Cui Y, Li YS, Pan JR, Liu JL, Luo HS, Yin JD, Li DF, Cui S. 2013. LIM-homeodomain transcription factor Isl-1 mediates the effect of leptin on insulin secretion in mice. J Biol Chem. 288(17):12395-405.

    4. Fu R, Liu JL, Fan JJ, Li RG, Li DF, Yin JD&dagger;, Cu S&dagger;. 2012. Evidence that testosterone promotes cell proliferation and differentiation via G protein-coupled receptors in the rat L6 skeletal muscle myoblast cell line. J. Cell Physiol. 227: 98u2013107.

    5. Lv W, Ju T, Dong B, Yu B, Yin JD&dagger;.2012. Effect of dietary stable isotopic ratios of carbon and nitrogen on the extent of their incorporation into tissues of rats. J Anim Sci Biotechnol., 3(1):14.

    6. Yang HS, Li FN, Kong XF, Yuan XX, Lian GQ, Geng MM, Li TJ, Yin JD&dagger;, and Yin YL&dagger;. 2012. Molecular cloning, tissue distribution and ontogenetic expression of Xiang pig Chemerin and its involvement in regulating energy metabolism through Akt and ERK1/2 signaling pathways. Mol Biol Rep., 39(2):1887-94.

    7. Wang Q, Ji C, Huang JX, Yang FY, Zhang HY, Liu L, Yin JD&dagger;.2011. The mRNA of lipin1 and its isoforms are differently expressed in the longissimus dorsi muscle of obese and lean pigs. Mol Biol Rep. 38(1):319-325.

    8. Li FN, Yin JD&dagger;, Ni JJ, Liu L, Zhang HY, and Du M. 2010. Chloride intracellular channel 5 modulates adipocyte accumulation in skeletal muscle by inhibiting preadipocytes differentiation. J Cell Biochem. 110 (4): 1013-1021

    9. Peng Y, Ren F, Yin JD&dagger;, Fang Q, Li F N, and Li DF. 2010. Transfer of conjugated linoleic acid from the sows to their offspring and its impact on the fatty acid profiles of plasma, muscle, and subcutaneous fat in piglets. J Anim Sci. 88:1741-1751.

    10. Li FN, Yin JD &dagger;, Yue T, Liu L and Zhang HY. 2010. The chloride intracellular channel 5 (CLIC5) involved in C2C12 myoblasts proliferation and differentiation. Cell Biol Internat. 34(4):379-384.

    11. Yue T, Fang Q, Yin JD&dagger;, Li FN. 2010. High glucose induces differentiation and adipogenesis in porcine muscle satellite cells via mTOR. BMB reports. 43(2): 140-145.

    12. Liu L, Yin JD&dagger;, Li W, Liu K, Peng Y, Tan PP, Ma RLZ *. 2010. Construction of a Bacterial Artificial Chromosome Library for the Rongchang Pig Breed and its Use for the Identification of Genes Involved in Intramuscular Fat Deposition. Biochem Bioph Res Co.,391: 1280u20131284.

    13. Yue T, Qian F, Yin JD&dagger;, Li DF, Li W. 2010. S-adenosylmethionine stimulates fatty acid metabolism-linked gene expression in porcine muscle satellite cells. Mol Biol Rep., 37(7):3143-3149. Epub 2009 Oct 14.

    14. Fang Q, Yin JD&dagger;, Li FN, Zhang JX, Watford M. 2010. Characterization of methionine adenosyltransferase 2b gene expression in skeletal muscle and subcutaneous adipose tissue from obese and lean pigs. Mol Biol Rep, 37:2517u20132524.

    15. Du M, Yin JD, Zhu MJ. 2010. Cellular signaling pathways regulating the initial stage of adipogenesis and arbling of skeletal muscle. Meat Sci. 2010: 86(1):103-109.

    16. Han P, Ma X, Yin JD. 2010. The effects of lipoic acid on soybean beta-conglycinin- induced anaphylactic reactions in a rat model. Arch Anim Nutr, 64(3):254-264.

    17. Yu J, Yin P, Yin JD, Liu F, Zhu X, Cheng G, Guo K, Yin Y, Xu J.2010. Involvement of ERK12 signalling and growth-related molecules’ expression in response to heat stress-induced damage in rat jejunum and IEC-6 cells. Int J Hyperthermia, 26(6): 538-555.

    18. Yin JD&dagger;, Li XL, Li DF, Yue T, Fang Q, Ni JJ, Zhou X, and Wu G. 2009. Dietary supplementation with zinc oxide stimulates ghrelin secretion from the stomach of pigs. J Nutr Biochem, 20 (10):783-790.

    19. Liu FH, Yin JD, Du M., Yan P, Xu JQ, Zhu X, and Yu J. 2009. Heat-stress-induced damage to porcine small intestinal epithelium associated with downregulation of epithelial growth factor signaling1. J Anim Sci., 87(6): 1941-1949.

    20. Yin JD and Li DF. 2009. Nutrigenomics Approach-A Strategy in Identification of Nutrition Responsive Genes Influencing Meat Edible Quality Traits in Swine. Asian- Austr J Anim Sci, 22 (4):605-610.

    21. Wang X, Ou D, Yin JD, Wu G, Wang J. 2009. Proteomic analysis reveals altered expression of proteins related to glutathione metabolism and apoptosis in the small intestine of zinc oxide- supplemented piglets. Amino Acids, 37(1):209-218.

    22. Zhang JX, Yin JD&dagger;, Zhou X, Li FN, Ni JJ, Dong B. 2008. Effects of lower dietary lysine and energy content on carcass characteristics and meat quality in growing-finishing pigs. Asian- Austr J Anim Sci, 21(12):1785-1793.

    23. Yin JD, Shang XG, Li DF, Wang FL, Guang YF, Wang ZY. 2008. Effects of Dietary Conjugated Linoleic Acid on the Fatty Acid Profile and Cholesterol Content of Egg Yolks from Different Breeds of Layers. Poult Sci, 87:284-290.

    24. Li ZJ, Yi GF, Yin JD&dagger;, Sun P, Li DF and Chris Knight. 2008. Effects of organic acids on growth performance, gastrointestinal pH, intestinal microbial populations and immune responses of weaned pigs. Asian-Austr J of Anim Sci, 21:252-261.

    25. Lu P, Zhang LY, Yin JD, Everts AKR, Li DF*. 2008. Effects of soybean oil and linseed oil on fatty acid compositions of muscle lipids and cooked pork flavour. Meat Sci, 80: 910-918.

    26. Zhang HW, Yin JD, Li DF,Zhou X and Li XL. 2007. Tryptophan enhances ghrelin expression and secretion associated with increased food intake and weight gainin weaning pigs. Domest Anim Endocrinol, 33(1):47-61.

    27. Lu P, Defa Li , Yin JD, Liying Zhang, Zongyi Wang. 2007. Flavour differences of cooked longissimus muscle from Chinese indigenous pig breeds and hybrid pig breed (Duroc * Landrace * Large White). Food Chem, 107: 1529-1537.

    28. Zhou X, Li DF*, Yin JD&dagger;, Ni JJ, Dong B, Zhang JX and Du Min. 2007. Conjugated linoleic acid differently regulates adipogenesis in stromal vascular cells from subcantenous adipose tissue and skeletal muscle of neonatal pigs. J Lipid Res, 48(8):1701-1709.

    29. Ou DY, Li DF*,, Li XL, Yin JD&dagger;, Qiao SHY and Wu GY*.2007. Dietary supplementation with zinc oxide decrease expression of the stem cell factor in the small intestine of weaning pigs. J Nutr Biochem, 18(12):820-827.

    30. Chen XJ, Li DF*, Yin JD&dagger;, Ding YH, Zhang HL and Yi GF.2006. Regulation of dietary energy level and oil source on leptin and its long form receptor mRNA expression of the adipose tissues in growing pigs. Domest Anim Endocrinol, 31(3):269-283.

    31. Li XL, Yin JD, Li DF, Chen XJ, Zang JJ and Zhou X. 2006. Dietary supplementation with zinc oxide increases IGF-I and IGF-I receptor gene expression in the small intestine of weanling piglets. J Nutr, 136 (7): 1786-1791.

    32. Lai CHH, Yin JD, Li DF, Zhao LD, Piao XSH and Xing JJ.2005. Conjugated linoleic acid attenuates the production and gene expression of proinflammatory cytokines in weaned pigs with lipopolysaccharide. J Nutr, 135(2):239-244.

    33. Lai CHH, Yin JD, Li DF, Zhao LD, Chen XJ. 2005. Effects of dietary conjugated linoleic acid supplementation on performance and immune function of weaned pigs. Arch Anim Nutr, 59:41-51.

    34. Zhao LD, Yin JD, Li DF, Lai CHH, Chen XJ and Ma D. 2005. Conjugated linoleic acid can prevent tumor necrosis factor gene expression by inhibiting nuclear factor binding activity in peripheral blood mononuclear cells from weaned pigs challenged with lipopolysaccharide. Arch Anim Nutr, 59(6):429-438.

    35. Shang XG, Wang FL, Li DF, Yin JD, Li XJ and Yi GF.2005. Effect of dietary conjugated linoleic acid on the fatty acid composition of egg yolk, plasma and liver as well as hepatic stearoyl-coenzyme A desaturase activity and gene expression in laying hens. Poult Sci, 84 (12):1886-1892.

    36. Zhu YZ, Li DF, WANG FL, Yin JD and Jin H.2004. Nutritional assessment and fate of DNA of Soybean meal from Roundup ready or conventional soybeans using rats. Arch Anim Nutr, 58:295-310.

    37. Shang XG, Wang FL, Li DF, Yin JD and Li JY. 2004. Effects of dietary conjugated linoleic acid on the productivity of laying hens and egg quality during refrigerated storage. Poult Sci, 83 (10):1688-1695.

    38. Yin JD, Qi GH, Zheng JJ and Huo QG. 2002. Influence of dietary isoflavnoids on stability of egg yolk lipids, Agri Sci China, 1(10):1180-1184.

    39. 姜美華, 巨婷婷,劉 洋,許玲,孫文娟,趙泮峰,尹靖東&dagger;.2013.成肌細(xì)胞成脂過程中PPAR&gamma;、CEBPa和Myogenin基因啟動子的甲基化變化. 中國農(nóng)業(yè)科學(xué),46(14):3010-3021.

    40. 于渤洋, 呂文濤, 巨婷婷,劉 洋,姜美華,尹靖東&dagger;.2012.腺苷甲硫氨酸對成肌細(xì)胞成脂分化及脂肪沉積的影響. 中國農(nóng)業(yè)科學(xué),45(18):3841—3848.

    41. 朱元招,尹靖東&dagger;,李德發(fā),王鳳來.2005. 生長豬對轉(zhuǎn)基因豆粕外源DNA的代謝的研究. 畜牧獸醫(yī)學(xué)報,36(10):1083-1086.

    42. 尹靖東,齊廣海,張萍,霍啟光.2004.大豆黃酮對雞蛋膽固醇及其耐氧化性的影響,中國農(nóng)業(yè)科學(xué),37(5):756-761.

    43. 尹靖東,齊廣海,君杰,霍啟光.2003.類黃酮雞蛋蛋黃脂質(zhì)穩(wěn)定性的影響及其機理研究,中國農(nóng)業(yè)科學(xué),36(4):438-442.

    44. 尹靖東,齊廣海,霍啟光.2002.類黃酮對蛋雞脂類代謝的影響.畜牧獸醫(yī)學(xué)報,33(3):215-220.

    45. 尹靖東,齊廣海,霍啟光.2001.日糧中添加微量組分對雞蛋膽固醇含量的影響.西北農(nóng)林科技大學(xué)學(xué)報(自然科學(xué)版),29(3):13-18.

    發(fā)明專利

    1、豬肌內(nèi)脂肪沉積主效基因及其分子標(biāo)記(專利號:ZL200910077822.9),國家發(fā)明專利;

    2、與豬肌內(nèi)脂肪沉積相關(guān)的氯離子通道基因片段及其應(yīng)用(專利號:ZL200910076200.4),國家發(fā)明專利;

    3、一種與肌內(nèi)脂肪沉積量相關(guān)的DNA片段及其應(yīng)用(專利號:ZL200910076199.5),國家發(fā)明專利。

    發(fā)表著作

    1、編著《動物肌肉生物學(xué)與肉品科學(xué)》(主編)、

    2、《豬的營養(yǎng)》(副主編)

    3、可持續(xù)豬營養(yǎng)學(xué)(主譯)

    榮譽記錄

    1、2015年獲1項國家科技進(jìn)步二等獎(排名第四)2、2012年獲重慶市政府科技進(jìn)步一等獎,排名第三3、2011年獲陜西省政府科技進(jìn)步三等獎4、2006年獲湖北省政府科技進(jìn)步三等獎5、2005年陜西省政府科學(xué)技術(shù)進(jìn)步三等獎

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