女，復(fù)旦大學(xué)物理系教授。

　　12/2009----至今：復(fù)旦大學(xué)物理系教授

　　9/2005-11/2009：復(fù)旦大學(xué)物理系副教授，2008 年1月起為博士生導(dǎo)師

　　8/2004--8/2005：美國加州大學(xué)圣芭芭拉分�；瘜W(xué)和生物化學(xué)系博士后，從事蛋白質(zhì)折疊和聚

　　集機制的分子動力學(xué)模擬

　　9/2001--8/2004：加拿大蒙特利爾大學(xué)物理系博士后，從事蛋白質(zhì)構(gòu)象搜索程序包的改進以及

　　蛋白質(zhì)折疊和聚集機制的理論和計算機模擬研究

　　7/1998--9/2001：復(fù)旦大學(xué)材料系講師，從事蛋白質(zhì)同源模建和構(gòu)象動力學(xué)研究

　　9/1995--6/1998：復(fù)旦大學(xué)物理系凝聚態(tài)物理專業(yè)，博士

　　9/1992--7/1995：河南師范大學(xué)物理系理論物理專業(yè)，碩士

　　9/1988--7/1992：河南師范大學(xué)物理系物理專業(yè)，學(xué)士

　　獎勵：榮獲“教育部新世紀優(yōu)秀人才支持計劃”（2008）

　　迄今為止，共發(fā)表學(xué)術(shù)論文30余篇，他引240余次。曾參加在中國、美國、加拿大、法國、意大利舉行的國際會議10余次，并做邀請報告和口頭報告。此外，還應(yīng)邀在加拿大、美國、和法國的多所大學(xué)和研究所做學(xué)術(shù)報告。

　　自2004年起應(yīng)邀為Journal of American Chemical Society，PLOS Computational Biology，Biophysical Journal，Journal of Physical Chemistry B, Biochemistry, Langmuir，Proteins，F(xiàn)rontiers in Bioscience，Journal of Physics：Condensed Matter，and Acta Physico-Chimica Sinica（物理化學(xué)學(xué)報）等國際和國內(nèi)學(xué)術(shù)期刊審稿。

　　物理生物學(xué)：致力于用物理學(xué)的理論和方法去解釋、驗證和預(yù)測生物學(xué)方面的問題。

　　蛋白質(zhì)是生物體內(nèi)一切功能的執(zhí)行者，它在復(fù)雜的生物大分子環(huán)境中進行折疊并行使其生物學(xué)功能。通常情況下蛋白質(zhì)折疊成能正確行使其生物功能的三維結(jié)構(gòu)，但在適當條件下，蛋白質(zhì)折疊會發(fā)生錯誤并導(dǎo)致病理性聚集而形成淀粉樣纖維。大約有二十多種疾病與蛋白質(zhì)聚集有關(guān)比如阿茲海莫氏癥、帕金森氏癥、Ⅱ型糖尿病和人血液透析病等。雖然這些疾病相關(guān)蛋白或多肽沒有明顯的氨基酸序列同源性，但x-ray衍射數(shù)據(jù)表明它們形成的淀粉樣沉積物有著共同的結(jié)構(gòu)特征:十字形β片層結(jié)構(gòu)。聚集體結(jié)構(gòu)特征的相同性意味著蛋白質(zhì)聚集可能遵從某種共同的機制。蛋白質(zhì)的病理性聚集不僅使其喪失了原有的正常功能，而且還對細胞具有特定毒性，最終導(dǎo)致細胞死亡。研究發(fā)現(xiàn)，具有細胞毒性的主要聚集體很可能是淀粉樣纖維和聚集早期形成的寡聚體。對蛋白質(zhì)聚集問題，特別是蛋白淀粉樣纖維和寡聚體結(jié)構(gòu)及其組裝過程的研究，以及細胞膜或納米顆粒與蛋白質(zhì)分子的相互作用，將有助于了解蛋白質(zhì)或多肽在溶液中和膜表面上聚集的生物物理機制，并將為認識淀粉樣沉積相關(guān)疾病發(fā)病機理和治療藥物的設(shè)計和開發(fā)提供理論基礎(chǔ)，以便最終有效地控制和治療這些疾病。

　　利用分子動力學(xué)模擬（Molecular Dynamics Simulation)與簡化蛋白質(zhì)模型和全原子蛋白質(zhì)模型相結(jié)合的方法來研究：

　　1. 蛋白質(zhì)多肽的折疊和聚集研究（Protein/peptide folding and aggregation）

　　2.蛋白質(zhì)和細胞膜的相互作用機理研究（ Peptide-membrane interactions）

　　3. 蛋白質(zhì)和納米顆粒的相互作用機理研究（Protein-nanoparticle interactions）

　　(他引220余次)

　　(cided more than 220times)

　　1、Weixin Xu, Guanghong Wei, Lushan Wang, Xian Zhao, Yuguang Mu. Cholesterol regulates pore formation in lipid bilayer induced by hIAPP fragments: a coarse-grained molecular dynamics study. Journal of Physical Chemistry B(revised)

　　2、Rozita Laghaei, Normand Mousseau, and Guanghong Wei. The Effect of Disulfide Bond on the Monomeric Structure of Human Amylin Studied by Combined Hamiltonian and Temperature Replica Exchange Molecular Dynamics Simulations. Journal of Physical Chemistry B114: 7071-7077 (2010)

　　3.、 Guanghong Wei, Andrew Jewett, and Joan-Emma Shea. Structural diversity of dimers of the Alzheimer Amyloid-beta (25-35) peptide and polymorphism of the resulting fibrils. Physical Chemistry Chemical Physics12: 3622-3629 (2010).

　　4、Huiyu Li, Yin Luo, Philippe Derreumaux, and Guanghong Wei*. Effects of the RGTFEGKF Inhibitor on the Structures of the Transmembrane Fragment 70-86 of Glycophorin A: An All-Atom Molecular Dynamics Study. Journal of Physical Chemistry B114: 1004-1009 (2010).

　　5、Zhaoming Fu, Yin Luo, Philippe Derreumaux, and Guanghong Wei*. Induced β-barrel formation of the Alzheimer’s Aβ25-35 oligomers on carbon nanotube surfaces: implication for amyloid fibril inhibition. Biophysical Journal97: 1795-1803 (2009).

　　6、Yan Lu, Philippe Derreumaux, Zhi Guo, Normand Mousseau, and Guanghong Wei*. Thermodynamics and dynamics of amyloid peptide oligomerization are sequence dependent. Proteins: Structure, Function, and Bioinformatics75: 954-963 (2009).

　　7、Yuxiang Mo, Yan Lu, Guanghong Wei*and Philippe Derreumaux. Structural diversity of the soluble trimers of the human amylin(20-29) peptide revealed by molecular dynamics simulations. Journal of Chemical Physics130: 125101 (2009).

　　8、Chungwen Liang, Philippe Derreumaux, Normand Mousseau, and Guanghong Wei*. The β-strand-loop-β-strand conformation is marginally populated in β2-microglobulin (20-41) peptide in solution as revealed by replica exchange molecular dynamics simulations. Biophysical Journal95: 510-517 (2008).

　　9、Wei Song, Guanghong Wei*, Normand Mousseau, and Philippe Derreumaux. Self-assembly of the β2-microglobulin NHVTLSQ peptide using coarse-grained protein model reveals β-barrel species. Journal of Physical Chemistry B112: 4410-4418 (2008).

　　10、 Guanghong Wei*, Wei Song, Philippe Derreumaux, and Normand Mousseau. Self-assembly of amyloid-forming peptides using molecular dynamics simulations.< Frontiers in Bioscience13: 5681-5692 (2008).

　　11、Chungwen Liang, Philippe Derreumaux, Guanghong Wei*. Structure and aggregation mechanism of β2-microglobulin(83-99) peptides studied by molecular dynamics simulations. Biophysical Journal93: 3353-3362 (2007).

　　12、 Guanghong Wei, Normand Mousseau, and Philippe Derreumaux. Computational simulations of the early steps of protein aggregation. Prion1: 3-8 (2007).

　　13、 Guanghong Wei, Joan-Emma Shea. Solvent effects on the structure of Alzheimeru2019s amyloid-β(25-35) peptide. Biophysical Journal91: 1638-1647 (2006).

　　14、 Guanghong Wei, Normand Mousseau, and Philippe Derreumaux. Sampling the self-assembly pathways of KFFE hexamers. Biophysical Journal87: 3648-3656 (2004).

　　15、 Guanghong Wei, Normand Mousseau, and Philippe Derreumaux. Simulating the early steps of aggregation of amyloid-forming peptide KFFE. J. Phys.: Condens. Matter16: S5047-S5054 (2004).

　　16、Sebastien Santini, Guanghong Wei, Normand Mousseau, Philippe Derreumaux. Pathway complexity of Alzheimer’s β-amyloid Aβ16-22 peptide assembly. Structure12: 1245-1255 (2004).

　　17、Philippe Derreumaux, Guanghong Wei, Sebastien Santini, Normand Mousseau. Early steps of amyloid-petide oligomerisation explored by simulations. Neurobiology of Aging25: S143 (2004).

　　18、Sebastien Santini, Guanghong Wei, Normand Mousseau, Philippe Derreumaux. Exploring the folding and aggregation mechanisms of amyloid-forming peptides by computer simulations. Amyloid and Amyloidosis, ISBN: 0849335345, Publisher: CRC Pr I Llc, p379-381, 2004.

　　19、 Guanghong Wei, Normand Mousseau, and Philippe Derreumaux. Complex folding pathways in a simple beta-hairpin. Proteins: Structure, Function, and Bioinformatics56: 464-474 (2004).

　　20、Sebastien Santini, Guanghong Wei, Normand Mousseau, Philippe Derreumaux. Exploring the folding pathways of proteins through energy landscape sampling: application to Alzheimer’s β-amyloid Peptide. Internet Electron. J. Mol. Des. 2: 564 (2003).

　　21、Philippe Derreumaux , Guanghong Wei, Normand Mousseau. Protein Folding Simulations using the Activation-Relaxation Technique. Proceedings of the International Conference of computational methods in Sciences and Engineering 2003 (ICCMSE 2003), T.E. Simos editor, World Scientific, p. 678-681 (2003).

　　22、 Guanghong Wei, Philippe Derreumaux, Normand Mousseau. Sampling the complex energy landscape of a simple beta-hairpin. Journal of Chemical Physics119: 6403 (2003).

　　23、 Guanghong Wei, Normand Mousseau, Philippe Derreumaux. Exploring the energy landscape of proteins: A characterization of the activation-relaxation technique. Journal of Chemical Physics117: 11379 (2002).

　　24、 Guanghong Wei, Jian Zi, Kaiming Zhang and Xide Xie. Lattice dynamics of wurtzite semiconductors GaN and AlN. Acta Physica Sinica (Overseas Edition), 7: 841 (1998).

　　25、Y.G. Weng, Z.X. Yang, G.H. Wei, X.Q. Dai, S.Y. Wei, and T. Zhang. Ion neutralization on composite catalysts. Phys. Rev. B, 58: 10953 (1998).

　　26、 Guanghong Wei, Jian Zi, Kaiming Zhang and Xide Xie. Lattice dynamics of GaN/AlN superlattices. J. Appl. Phys.82: 622 (1997).

　　27、 Guanghong Wei, Jian Zi, Kaiming Zhang and Xide Xie. Zone-centre optical phonons in wurtzite GaN and AlN. J. Appl. Phys.82: 4693 (1997).

　　28、Jian Zi, Xin Wan, Guanghong Wei, Kaiming Zhang and Xide Xie. Lattice dynamics of Zinc-blende GaN and AlN: I. Bulk phonons. J. Phys.: Condens. Matter, 8: 6323 (1996).

　　29、Jian Zi, Guanghong Wei, Kaiming Zhang and Xide Xie. Lattice dynamics of Zinc-blende GaN and AlN: II. Superlattice phonons. J. Phys.: Condens. Matter, 8: 6329 (1996).

　　30、Z.X. Yang, G.H. Wei, X.Q. Dai, T. Zhang and M. Wang. Effect of impurity on ion neutralization. Phys. Rev. B, 52: 8483 (1995).

　　31、Z.X. Yang, G.H. Wei, X.Q. Dai, T. Zhang and M. Wang. Long-range effects on the ion neutralization process. Phys. Rev. B, 52: 10800 (1995).

　　32、 G.H. Wei, Z.X.Yang, X.Q. Dai, T. Zhang and M. Wang. Ion neutralization at an Si- or Ge-type semiconductor surface. J. Phys.: Condens. Matter, 6: 4991 (1994).

　　33、 G.H. Wei, Z.X.Yang, X.Q. Dai, S.Y. Wei, T. Zhang and M. Wang. Ion neutralization near a disordered binary alloy surface. J. Phys.: Condens. Matter, 6: 8133 (1994).

　　34、 G.H. Wei, Z.X.Yang, S.Y. Wei, X.Q. Dai, T. Zhang and M. Wang. Ion neutralization at an ionic crystal surface. Surf. Sci., 317: 269 (1994).

　　35、 G.H. Wei, Z.X.Yang, X.Q. Dai, S.Y. Wei, T. Zhang and M.Wang. Charge transfer during reflection of ions from disordered binary alloy. Phys. Lett. A, 193: 293 (1994).

　　 (一) 學(xué)術(shù)會議(2004年以后)

　　1. Workshop on Water at Biological Interfaces. Oct. 27-28, 2008, Hangzhou, China. u2018Free energy landscape of trans- and cis-K3 peptides in explicit wateru2019(Invited Talk).

　　2. International Conference of Computational Protein Structure and Mechanics. Sept. 12-13, 2008, Shanghai, China. u2018Folding and aggregation of b2-microglobulin fragment studied by MD simulationsu2019(Invited Talk).

　　3. Workshop on Molecular Structure and Dynamics of Interfacial Water, 14-18 Dec., 2007, Shanghai, China. u2018Peptide aggregation studied by MD simulations in explicit wateru2019(Invited Talk).

　　4. The 6th International Conference of Condensed Matter Theory and Computational Materials. 14-18 July, 2007, Zhengzhou, China. u2018Computational Studies of the Early Steps of Peptide Aggregationu2019(Invited Talk).

　　5. The 5th International Conference of Condensed Matter Theory and Computational Materials. 10-15 July, 2006, Lanzhou, China. u2018Peptide aggregation studied by all-atom MD simulationsu2019(Invited Talk).

　　6. Workshop on Protein Aggregation. 22-24 May 2006, Lyon, France. u2018Structural characterization of dimeric states of the Alzheimer amyloidβ(25-35) peptide studied by replica exchange molecular dynamics simulations in explicit solvent: implication for the protofibril structureu2019(Invited Talk).

　　7. Workshop on flexibility in biomolecules, Tempe, Arizona, 15-18 May, 2005. “Exploration of the conformational space of the Alzheimeru2019s amyloid-β(25-35) peptide in water and in HFIP/water cosolvent through replica exchange molecular dynamics simulations.

　　8. A workshop in honor of professor Mike Thorpeu2019s 60th birthday: flexibility in complex materials: glasses, amorphous and proteins, Sainte-Adele, Quebec, Canada, 7-10 August, 2004. "Simulating the early steps of aggregation of amyloid-forming peptide KFFE” (Talk).

　　9. The 9th International Conference on “Alzheimer’s Disease and Related Disorders”, Philadelphia, PA, USA, 17-22 July, 2004.“Early steps of amyloid-peptide oligomerisation explored by simulations” (Poster).

　　10. RQMP scientific meeting, Montreal, Quebec, Canada, 29 June, 2004.“Early steps of amyloid-peptide oligomerisation explored by simulations” (Poster).

　　11. Second comparative and integrative bioinformatics meeting, Montreal, Canada, June 4, 2004.“Sampling the self-assembly pathways of KFFE hexamers” (Talk).

　　12. American Physical Society Meeting of 2004 in Montreal, Canada, 22-26 March, 2004.“Exploring the assembly pathways of tetrapeptide oligomers by the activation-relaxation technique” (Talk).

　　 (二) 學(xué)術(shù)報告(2004年以后)

　　1. Seminar at Laboratoire de Biochimie Theorique, CNRS, IBPC, Paris, France 9 Apr., 2009. u2018Computational studies of peptide folding, aggregation, peptide-carbon nanotube interactionsu2019.

　　2. Seminar at Department of Physics, University of Montreal, Canada, 9 Feb., 2009. u2018Peptide folding, aggregation, and the interactions with nanoparticles: a molecular dynamics studyu2019.

　　3. Seminar in CAS-MPG Partner Institute for Computational Biology in Shanghai, China, 27 Oct. 2007. u2018Computational studies of peptide folding and aggregationu2019.

　　4. Seminar in Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Oct. 29, 2007 u2018Computational studies of peptide self-assemblyu2019.

　　5. Sminar at Laboratoire de Biochimie Theorique, CNRS, IBPC, Paris, France, 18 May, 2006. u2018Structural characterization of dimeric states of the Alzheimer amyloid β(25-35) peptide studied by replica exchange molecular dynamics simulations in explicit solvent: implication for the protofibril structureu2019.

　　6. Seminar at Department of Physics, California State University at Northridge，USA, 27 April, 2005. “Understanding folding and aggregation of amyloid-forming peptides by computer simulations”.