工作經(jīng)歷
1998年畢業(yè)于上海復(fù)旦大學(xué)化學(xué)系，獲理學(xué)學(xué)士學(xué)位。后到中科院上海有機(jī)化學(xué)研究所金屬有機(jī)國(guó)家重點(diǎn)實(shí)驗(yàn)室工作。
2008年畢業(yè)于美國(guó)新墨西哥大學(xué)化學(xué)與化學(xué)生物學(xué)系，獲理學(xué)博士學(xué)位。
2009年1月至2012年12月間，在美國(guó)斯坦福大學(xué)醫(yī)學(xué)院分子影像中心（MIPS）從事博士后研究。
2013年1月加入華東理工大學(xué)藥學(xué)院藥物科學(xué)系。
迄今為止已發(fā)表SCI論文40余篇，其中包括Nature Chem.，Nature Commun.，J. Am. Chem. Soc.，Angew. Chem. Int. Ed. 等國(guó)際知名期刊。多篇論文被Nature, C&E News (美國(guó)化學(xué)化工新聞)，ChemCatChem，Scientific American等期刊作專(zhuān)文評(píng)論、介紹。
研究方向
1、發(fā)展針對(duì)生物體重要酶蛋白的分子探針研究；
2、藥物不對(duì)稱(chēng)合成方法研究。
發(fā)表論文
1.Zhou, D.; Huang, Z.; Yu, X.; Wang, Y.; Li, J.; Wang, W*; Xie, H.* “A Quinine-Squaramide Catalyzed Enantioselective Aza-Friedel-Crafts Reaction of Cyclic Trifluoromethyl Ketimines with Naphthols and Electron-Rich Phenols” Org. Lett., 2015, 17, 5554.
2.Cheng, Y. #; Xie, H.#; Sule, P.; Hassounah, H.; Graviss, E. A.; Kong, Y.; Cirillo, J. D. and Rao, J.* “Fluorogenic Probes with Substitutions at the 2 and 7 Positions of Cephalosporin are Highly BlaC-Specific for Rapid Mycobacterium Tuberculosis Detection” Angew. Chem. Int. Ed., 2014, 53, 9360. (Reported by “Cheap test slashes time taken to diagnose TB”, Nature? doi: 10.1038/nature.2014.15503) .
3.Xie, H. #, Mire, J. #, Kong, Y. #, Chang, M., Hassounah, H., Thornton, C.N., Sacchettini, J. C., Cirillo, J. D., Rao, J.* "Rapid point-of-care detection of the tuberculosis pathogen using a BlaC-specific fluorogenic probe ", Nature. Chem. 2012, 4, 802. (Reported by Nature (doi:10.1038/nature.2012. 11327) and Scientific American).
4.Xie, H.; Zhang, Y.; Zhang, S.; Chen, X.; Wang, W.* "Bifunctional Cinchona Alkaloid Thiourea Catalyzed Highly Efficient, Enantioselective Aza-Henry Reaction of Cyclic Trifluoromethyl Ketimines: Synthesis of Anti-HIV Drug DPC 083" Angew. Chem. Int. Ed., 2011, 50, 11773.
5.Zhang, S.-L. #, Xie, H. #; Zhu, J.; Li, H.; Zhang, X.-S.; Li, J.*; Wang, W.*, “Organocatalytic enantioselective β-functionalization of aldehydes by oxidation of enamines and their application in cascade reactions” Nature. Commun. 2011, 2, 211-218. (Reported by C&E News (2011, 89(10), 9), ChemCatChem (2012, 4, 612) and Synfacts (2011, 5, 0560))
6.Xie, H.; Zu, L.; Li, H.; Wang, J.; Wang, W.* “Organocatalytic Enantioselective Cascade Michael-Alkylation Reactions: Synthesis of Chiral Cyclopropanes and Investigation of Unexpected Organocatalyzed Stereoselective Ring Opening of Cyclopropanes”, J. Am. Chem. Soc., 2007, 129, 10886.
# equal contribution
